ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2768 studies

1981–2000 of 2,768 studies

E2 ModerateCohortPEM unclearObservational

[Effect of physical factors on bioelectric properties of cell nuclei of buccal epithelium in students with chronic fatigue syndrome].

Samoĭlovych, V A, Hutarieva, N V, Tondiĭ, L D·Likars'ka sprava·2005

Researchers studied 60 students with chronic fatigue syndrome at a health facility, dividing them into two groups receiving different types of physical activity: one group did water-based exercise therapy while the other did conventional exercise classes and contrast showers. By measuring changes in the electrical properties of cells from the mouth's lining, researchers found that the water-based therapy group showed improved electrical cell activity that matched their clinical improvement, suggesting physical treatments may help restore normal body function in ME/CFS.

E2 ModerateCohortPEM not requiredCross-Sectional

Reliability of physiological, psychological, and cognitive variables in chronic fatigue syndrome.

Wallman, Karen E, Morton, Alan R, Goodman, Carmel et al.·Research in sports medicine (Print)·2005

Researchers tested whether measurements of fatigue, mood, thinking ability, and physical performance in ME/CFS patients were reliable when checked weekly over four weeks. Most measurements were reliable and consistent, but fatigue ratings—both mental and physical—varied too much week-to-week to be fully trusted. Interestingly, how well people performed during exercise didn't match up well with their reported depression or mood, suggesting the problem may be in how the brain processes fatigue rather than actual muscle weakness.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCross-Sectional

Fatigue and regulation of the hypothalamo-pituitary-adrenal axis in multiple sclerosis.

Gottschalk, Michaela, Kümpfel, Tania, Flachenecker, Peter et al.·Archives of neurology·2005

This study looked at fatigue in multiple sclerosis (MS) patients and examined whether their stress hormone system (HPA axis) might be involved. Researchers tested 31 MS patients using three different fatigue questionnaires and a special hormone test. They found that MS patients with severe fatigue had higher levels of a stress hormone called ACTH compared to MS patients without fatigue.

Endocrine Disruption

E2 ModerateCohortPEM unclearCross-Sectional

Awareness and knowledge of fibromyalgia among French rheumatologists and general practitioners.

Blotman, F, Thomas, E, Myon, E et al.·Clinical and experimental rheumatology·2005

This study asked French doctors (both general practitioners and specialists called rheumatologists) how much they knew about fibromyalgia, a condition with widespread muscle pain and fatigue. The results showed that most doctors had never formally learned about this condition in medical school, and many did not fully recognize it as a legitimate disease. The study highlights that doctors need better training to understand and properly diagnose fibromyalgia.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

The definition of disabling fatigue in children and adolescents.

Fowler, Tom, Duthie, Pamela, Thapar, Anita et al.·BMC family practice·2005

This study looked at how disabling fatigue in children and teens should be defined, since the current definition used for adults might not fit young people well. Researchers found that children with disabling fatigue that didn't quite meet the strict adult criteria still suffered just as much and missed just as much school as those who did meet the strict criteria. The study suggests that doctors should use a broader, less restrictive definition to catch all children who need help.

Diagnostics

E2 ModerateBehavioralPEM not requiredCross-Sectional

Chronic fatigue syndrome of childhood. Comparative study with emotional disorders.

Garralda, M Elena, Rangel, Luiza·European child & adolescent psychiatry·2005

This study compared children diagnosed with ME/CFS to children with emotional disorders like anxiety and depression to see how these conditions differ. While both groups of children experienced some similar emotional challenges, children with ME/CFS reported more severe tiredness and physical symptoms, and were more likely to have had infections or medical problems before getting sick. The results show that ME/CFS and emotional disorders can look similar in some ways but have important differences.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

[Cognitive function and psychological characteristics of patients with chronic fatigue syndrome].

Li, Yong-jie, Gao, Xu-guang, Wang, De-Xin et al.·Zhonghua yi xue za zhi·2005

This study looked at how ME/CFS affects thinking and memory in 91 Chinese patients compared to 30 healthy people. Researchers found that 90% of ME/CFS patients had problems with memory and attention, and most also experienced depression, anxiety, and obsessive thoughts. The results show that ME/CFS causes real cognitive problems that are different from those seen in psychiatric illnesses alone.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCase-Control

Orthostatic instability in a population-based study of chronic fatigue syndrome.

Jones, James F, Nicholson, Ainsley, Nisenbaum, Rosane et al.·The American journal of medicine·2005

This study tested whether people with ME/CFS have problems with their body's ability to regulate blood pressure and heart rate when changing positions (like standing up). Researchers compared 58 people with ME/CFS to 55 healthy people using a tilt table test. Surprisingly, they found that both groups had similar rates of these problems, suggesting that this particular type of autonomic dysfunction may not be a primary cause of ME/CFS.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Brain 5-HT1A receptor binding in chronic fatigue syndrome measured using positron emission tomography and [11C]WAY-100635.

Cleare, Anthony J, Messa, Cristina, Rabiner, Eugenii A et al.·Biological psychiatry·2005

This study used brain imaging to measure a specific receptor (5-HT1A) that helps regulate serotonin, a chemical messenger in the brain. Researchers compared 10 ME/CFS patients with 10 healthy people and found that ME/CFS patients had significantly fewer of these receptors, especially in a brain region called the hippocampus (involved in memory and emotion). This suggests that serotonin regulation in the brain may work differently in ME/CFS.

E2 ModerateCohortPEM unclearCross-Sectional

Urinary and plasma organic acids and amino acids in chronic fatigue syndrome.

Jones, Mark G, Cooper, Elizabeth, Amjad, Saira et al.·Clinica chimica acta; international journal of clinical chemistry·2005

Researchers tested blood and urine samples from ME/CFS patients and compared them to healthy people, those with depression, and those with rheumatoid arthritis. Previous studies claimed certain chemicals in urine were markers for ME/CFS, but this study could not confirm those earlier findings. However, the study did find some signs of inflammation and possible muscle changes that might explain why ME/CFS patients experience fatigue and muscle pain.

Energy Metabolism

E2 ModerateCohortPEM not requiredCross-Sectional

Chronic fatigue in a population sample: definitions and heterogeneity.

Sullivan, Patrick F, Pedersen, Nancy L, Jacks, Andreas et al.·Psychological medicine·2005

This study looked at how doctors define ME/CFS by surveying over 31,000 Swedish adults about their fatigue symptoms. The researchers found that the current official checklist for diagnosing ME/CFS (requiring 4 out of 8 specific symptoms) doesn't match how fatigue actually varies in real populations. Using statistical analysis, they identified a recognizable ME/CFS-like illness pattern, but concluded that a simpler definition focusing on severe, disabling fatigue might work better.

Diagnostics

E2 ModerateCohortPEM not requiredObservational

Evaluation of autoantibodies to common and neuronal cell antigens in Chronic Fatigue Syndrome.

Vernon, Suzanne D, Reeves, William C·Journal of autoimmune diseases·2005

Researchers tested blood samples from people with ME/CFS and healthy controls to look for autoantibodies—proteins the immune system makes that can attack the body's own cells. They found that some people with ME/CFS had higher levels of antibodies against two specific targets: a brain protein called MAP2 and a component of DNA. However, most common autoantibodies were not elevated in ME/CFS patients.

BiomarkersImmune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

[A preliminary epidemiological study and discussion on traditional Chinese medicine pathogenesis of chronic fatigue syndrome in Hong Kong].

Yiu, Yan-Mun, Qiu, Ming-Yi·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·2005

This study surveyed over 1,000 adults in Hong Kong to see how common ME/CFS is and how it appears according to traditional Chinese medicine (TCM) principles. Researchers found that about 6.4% of adults aged 20-50 met ME/CFS diagnostic criteria. According to TCM assessment, most patients showed patterns related to low energy reserves and poor circulation, with symptoms including fatigue, weak knees, poor sleep, and memory problems.

E2 ModerateCohortPEM not requiredCross-Sectional

Employment status in chronic fatigue syndrome. A cross-sectional study examining the value of exercise testing and self-reported measures for the assessment of employment status.

Nijs, Jo, Van de Putte, Karen, Louckx, Fred et al.·Clinical rehabilitation·2005

This study looked at whether exercise tests and questionnaires could predict which ME/CFS patients could work. Researchers tested 54 employed patients with ME/CFS and asked them about their work status and quality of life. They found that while some measures weakly related to employment, neither exercise testing nor self-reported disability measures were strong enough to reliably predict who could work.

E2 ModerateCohortPEM not requiredCross-Sectional

[Clinical characteristics of patients with chronic fatigue syndrome: analysis of 82 cases].

Li, Yong-Jie, Wang, De-Xin, Bai, Xiao-Li et al.·Zhonghua yi xue za zhi·2005

This study examined 82 Chinese patients with ME/CFS to understand what symptoms they experience and what might be causing their illness. Researchers found that most patients had memory and attention problems alongside fatigue, many showed signs of anxiety or depression, and some had low levels of a substance called L-carnitine (which helps produce energy) or evidence of a viral infection. When patients took L-carnitine supplements, their levels improved and symptoms got better.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Stress-induced changes in LPS-induced pro-inflammatory cytokine production in chronic fatigue syndrome.

Gaab, Jens, Rohleder, Nicolas, Heitz, Vera et al.·Psychoneuroendocrinology·2005

This study tested how ME/CFS patients' immune systems respond to stress compared to healthy people. Researchers gave both groups a stressful public speaking task, then exposed their blood samples to a bacterial substance to measure immune response. Unlike healthy controls whose immune response increased after stress, ME/CFS patients showed a decreased immune response, suggesting their bodies may not mobilize infection-fighting chemicals normally during stress.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Primary healthcare provision and Chronic Fatigue Syndrome: a survey of patients' and General Practitioners' beliefs.

Thomas, Marie A, Smith, Andrew P·BMC family practice·2005

This study asked both ME/CFS patients and general practitioners (GPs) in Wales what they knew about ME/CFS. Researchers found that many GPs had very little specialist knowledge about the condition, and concerningly, only about half of the GPs surveyed actually believed ME/CFS was a real illness. The study suggested that creating better educational materials for both GPs and patients could help improve understanding and care.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

The epidemiology of chronic fatigue in the Swedish Twin Registry.

Evengård, Birgitta, Jacks, Andreas, Pedersen, Nancy L et al.·Psychological medicine·2005

This Swedish study contacted over 31,000 people and found that about 2.4% had symptoms matching chronic fatigue syndrome. Women were nearly four times more likely to have these symptoms than men. The researchers were surprised to find that ME/CFS may be more common than doctors previously thought.

E2 ModerateCohortPEM not requiredObservational

Salivary cortisol as a predictor of postoperative fatigue.

Rubin, G James, Hotopf, Matthew, Papadopoulos, Andrew et al.·Psychosomatic medicine·2005

This study tested whether low cortisol (a stress hormone) causes or predicts chronic fatigue by following 161 patients before and after surgery. The researchers measured cortisol levels and fatigue at multiple time points, but found that low cortisol before or after surgery did not predict who would develop fatigue. This suggests that if low cortisol is connected to chronic fatigue, it develops after symptoms begin rather than causing them.

Biomarkers

E2 ModerateCohortPEM not requiredObservational

Prospective observational study of treatments for unexplained chronic fatigue.

Bentler, Suzanne E, Hartz, Arthur J, Kuhn, Evelyn M·The Journal of clinical psychiatry·2005

This study followed 155 people with chronic fatigue over 2 years to see which treatments they found helpful. Researchers asked participants about medications, supplements, exercise, yoga, and support groups they tried. While some treatments like yoga and vitamins were associated with feeling better, other treatments like magnesium and support groups were linked to feeling worse—though it's unclear why.

Interventions

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[Effect of physical factors on bioelectric properties of cell nuclei of buccal epithelium in students with chronic fatigue syndrome].

Reliability of physiological, psychological, and cognitive variables in chronic fatigue syndrome.

Fatigue and regulation of the hypothalamo-pituitary-adrenal axis in multiple sclerosis.

Awareness and knowledge of fibromyalgia among French rheumatologists and general practitioners.

The definition of disabling fatigue in children and adolescents.

Chronic fatigue syndrome of childhood. Comparative study with emotional disorders.

[Cognitive function and psychological characteristics of patients with chronic fatigue syndrome].

Orthostatic instability in a population-based study of chronic fatigue syndrome.

Brain 5-HT1A receptor binding in chronic fatigue syndrome measured using positron emission tomography and [11C]WAY-100635.

Urinary and plasma organic acids and amino acids in chronic fatigue syndrome.

Chronic fatigue in a population sample: definitions and heterogeneity.

Evaluation of autoantibodies to common and neuronal cell antigens in Chronic Fatigue Syndrome.

[A preliminary epidemiological study and discussion on traditional Chinese medicine pathogenesis of chronic fatigue syndrome in Hong Kong].

Employment status in chronic fatigue syndrome. A cross-sectional study examining the value of exercise testing and self-reported measures for the assessment of employment status.

[Clinical characteristics of patients with chronic fatigue syndrome: analysis of 82 cases].

Stress-induced changes in LPS-induced pro-inflammatory cytokine production in chronic fatigue syndrome.

Primary healthcare provision and Chronic Fatigue Syndrome: a survey of patients' and General Practitioners' beliefs.

The epidemiology of chronic fatigue in the Swedish Twin Registry.

Salivary cortisol as a predictor of postoperative fatigue.

Prospective observational study of treatments for unexplained chronic fatigue.

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