ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

1981–2000 of 2,807 studies

E2 ModerateCohortPEM not requiredLongitudinal

Chronic fatigue syndrome-like caseness as a predictor of work status in fatigued employees on sick leave: four year follow up study.

Huibers, M J H, Leone, S S, Kant, I J et al.·Occupational and environmental medicine·2006

This study followed people on sick leave due to fatigue for four years to see whether those who met the clinical criteria for ME/CFS were more likely to remain unable to work. Researchers found that employees meeting CFS criteria at the start were about three times more likely to still be unable to work four years later compared to those with fatigue who didn't meet CFS criteria. This suggests that CFS-like illness is associated with longer-term work disability.

E2 ModerateBehavioralPEM not requiredLongitudinal

In search of a new balance. Can high "action-proneness" in patients with chronic fatigue syndrome be changed by a multidisciplinary group treatment?

Van Houdenhove, Boudewijn, Bruyninckx, Karolien, Luyten, Patrick·Journal of psychosomatic research·2006

This study looked at whether people with ME/CFS who tend to be very action-oriented or driven can change this trait through treatment. Researchers asked 62 patients to recall how active and driven they were before getting sick, when they started treatment, and after completing a multidisciplinary program (which included cognitive behavioral therapy and graded exercise). The treatment did help increase action-proneness, though patients didn't return to their pre-illness levels.

E2 ModerateCohortPEM not requiredCross-Sectional

Activation of human herpesviruses 6 and 7 in patients with chronic fatigue syndrome.

Chapenko, S, Krumina, A, Kozireva, S et al.·Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2006

This study looked at whether two common viruses (HHV-6 and HHV-7) that usually stay dormant in the body might be reactivating in people with ME/CFS. Researchers found that people with ME/CFS were more likely to have both viruses active at the same time, and when both were active, their immune cells showed signs of stress. This suggests these viruses might play a role in ME/CFS, though the study cannot prove they cause the disease.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Cognitive dysfunction relates to subjective report of mental fatigue in patients with chronic fatigue syndrome.

Capuron, Lucile, Welberg, Leonie, Heim, Christine et al.·Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2006

People with ME/CFS often report trouble thinking clearly, but researchers haven't always found proof of this on tests. This study found that cognitive problems are real, but mainly in patients who experience significant mental fatigue. When researchers gave cognitive tests to ME/CFS patients, those with high mental fatigue showed genuine difficulties with memory and attention, while those with low mental fatigue performed normally.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredLongitudinal

How relevant are exercise capacity measures for evaluating treatment effects in chronic fatigue syndrome? Results from a prospective, multidisciplinary outcome study.

Pardaens, K, Haagdorens, L, Van Wambeke, P et al.·Clinical rehabilitation·2006

This study tested whether a 6-month rehabilitation program combining cognitive therapy and graded exercise improved ME/CFS patients' quality of life and physical fitness. Patients reported significant improvements in how they felt and functioned in daily life, but their measured physical capacity (like strength and endurance on a bike test) only improved modestly. Importantly, feeling better didn't require becoming noticeably fitter—especially for patients who started out less fit.

Interventions

E2 ModerateBehavioralPEM not requiredLongitudinal

Long-term predictors of outcome in fatigued employees on sick leave: a 4-year follow-up study.

Leone, Stephanie S, Huibers, Marcus J H, Kant, Ijmert et al.·Psychological medicine·2006

This study followed 127 people who were on sick leave due to fatigue for 4 years to see who would recover and return to work. After 4 years, about one-quarter of the participants were still unable to work due to disability. The study found that people with lower physical functioning at the start were more likely to remain disabled and continue experiencing fatigue.

E2 ModerateCohortPEM not requiredCross-Sectional

The influence of aerobic fitness and fibromyalgia on cardiorespiratory and perceptual responses to exercise in patients with chronic fatigue syndrome.

Cook, Dane B, Nagelkirk, Paul R, Poluri, Ashok et al.·Arthritis and rheumatism·2006

This study compared how people with ME/CFS respond to exercise on a stationary bike, looking at heart rate, breathing, and how hard the exercise felt. People with ME/CFS alone had similar physical responses to healthy controls, but those with ME/CFS and fibromyalgia showed different breathing patterns and found exercise much more painful and exhausting.

E2 ModerateCohortPEM not requiredCross-Sectional

Linear data mining the Wichita clinical matrix suggests sleep and allostatic load involvement in chronic fatigue syndrome.

Gurbaxani, Brian M, Jones, James F, Goertzel, Benjamin N et al.·Pharmacogenomics·2006

Researchers analyzed clinical data from 164 ME/CFS patients and controls to identify patterns that distinguish the condition from health. Using mathematical techniques to find which body measurements best separated the two groups, they found that sleep problems and markers of physical stress (allostatic load) were important—though no single measurement was strongly predictive on its own. The study suggests that ME/CFS may involve multiple interconnected biological changes rather than one simple cause.

Sleep

E2 ModerateCohortPEM not requiredCross-Sectional

Spectroscopic diagnosis of chronic fatigue syndrome by visible and near-infrared spectroscopy in serum samples.

Sakudo, Akikazu, Kuratsune, Hirohiko, Kobayashi, Takanori et al.·Biochemical and biophysical research communications·2006

Researchers used a special light-based scanning technique to analyze blood samples from ME/CFS patients and healthy people. The scans could correctly identify which samples came from ME/CFS patients about 93% of the time. This suggests that a simple blood test using this technology might one day help doctors diagnose ME/CFS objectively, rather than relying only on symptoms and other tests.

Biomarkers

E2 ModerateBehavioralPEM not requiredCross-Sectional

Coping styles in people with chronic fatigue syndrome identified from the general population of Wichita, KS.

Nater, Urs M, Wagner, Dieter, Solomon, Laura et al.·Journal of psychosomatic research·2006

This study looked at how people with ME/CFS cope with their illness compared to people without ME/CFS. Researchers found that people with ME/CFS tend to use more escape-avoiding coping strategies (like avoidance or wishful thinking) than healthy controls. Interestingly, people with unexplained fatigue that didn't meet full ME/CFS criteria used similar coping styles to those with ME/CFS, suggesting this pattern may be common across fatiguing illnesses.

E2 ModerateCohortPEM not requiredCross-Sectional

Differential diagnosis of chronic fatigue syndrome and major depressive disorder.

Hawk, Caroline, Jason, Leonard A, Torres-Harding, Susan·International journal of behavioral medicine·2006

This study compared people with ME/CFS, people with depression, and healthy controls to find which symptoms best tell these conditions apart. Researchers found that post-exertional malaise (worsening after activity), unrefreshing sleep, and memory problems were the strongest differences. When they used a combination of symptoms including fatigue duration and severity of various symptoms, they could correctly identify which group each person belonged to nearly 100% of the time.

Post-Exertional Malaise

E2 ModeratePEM not requiredRegistry-Resource

Update on the NAS-NRC Twin Registry.

Page, William F·Twin research and human genetics : the official journal of the International Society for Twin Studies·2006

This article describes an ongoing study of twin brothers who served in World War II, tracking their health over many decades. Researchers have collected detailed health information on over 15,900 pairs of twins and are studying various diseases including chronic fatigue syndrome, as well as how people age and stay healthy. The study is now organizing and combining all their collected data to better understand what factors influence disease risk.

E2 ModerateCohortPEM not requiredCross-Sectional

Generalized joint hypermobility is more common in chronic fatigue syndrome than in healthy control subjects.

Nijs, Jo, Aerts, Annemie, De Meirleir, Kenny·Journal of manipulative and physiological therapeutics·2006

This study found that people with ME/CFS are about 5 times more likely than healthy people to have loose, overly flexible joints (joint hypermobility). Researchers tested 68 ME/CFS patients and 69 healthy volunteers using physical exams and knee movement tests. Most ME/CFS patients in the study had joint hypermobility, but surprisingly, this looseness did not seem to be connected to how much pain they experienced.

E2 ModerateCohortPEM not requiredCase-Control

Urinary cortisol and cortisol metabolite excretion in chronic fatigue syndrome.

Jerjes, Walid K, Taylor, Norman F, Peters, Timothy J et al.·Psychosomatic medicine·2006

This study measured stress hormone levels in urine from people with ME/CFS and healthy controls to see if ME/CFS patients produce less cortisol (a hormone made during stress). The researchers found no major difference in total cortisol output between the two groups when measuring both cortisol and its breakdown products, though free cortisol levels were slightly lower in patients and related to fatigue severity.

Endocrine Disruption

E2 ModerateBehavioralPEM not requiredObservational

To "lump" or to "split" the functional somatic syndromes: can infectious and emotional risk factors differentiate between the onset of chronic fatigue syndrome and irritable bowel syndrome?

Moss-Morris, Rona, Spence, Meagan·Psychosomatic medicine·2006

This study followed nearly 600 people who had food poisoning and 240 people who had infectious mononucleosis to see which infections were more likely to lead to chronic fatigue syndrome (CFS) or irritable bowel syndrome (IBS). They found that food poisoning was more likely to trigger IBS, while mononucleosis was more likely to trigger CFS. Anxiety and depression before infection were stronger predictors of developing CFS, while the type of infection itself was the strongest predictor of IBS.

E2 ModerateBehavioralPEM not requiredCase-Control

Early adverse experience and risk for chronic fatigue syndrome: results from a population-based study.

Heim, Christine, Wagner, Dieter, Maloney, Elizabeth et al.·Archives of general psychiatry·2006

This study found that people with ME/CFS reported experiencing more childhood trauma (such as abuse or neglect) than people without the illness. The more types of trauma someone experienced as a child, the higher their risk of developing ME/CFS later in life. The connection between childhood trauma and ME/CFS risk was stronger when people also had depression, anxiety, or PTSD.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Severe fatigue in adolescents: a common phenomenon?

ter Wolbeek, Maike, van Doornen, Lorenz J P, Kavelaars, Annemieke et al.·Pediatrics·2006

This study looked at how common severe tiredness is in teenagers and whether it's connected to depression, anxiety, and other symptoms seen in ME/CFS patients. Researchers surveyed over 3,400 teenagers about their fatigue, mood, sleep, and daily habits. They found that severe fatigue is quite common in adolescents—especially in girls—and that it often clusters with depression, anxiety, and ME/CFS-like symptoms.

Sleep

E2 ModerateGuidelinePEM unclearGuideline

Management of patients presenting with Sjogren's syndrome.

Venables, P J·Best practice & research. Clinical rheumatology·2006

Sjögren's syndrome is an autoimmune disease where the body attacks its own glands that produce tears and saliva, causing dry eyes and mouth. This article explains how doctors diagnose and treat Sjögren's syndrome, emphasizing that most patients do well with local treatments (like eye drops) and a medication called hydroxychloroquine, while stronger drugs are reserved for patients with more serious complications.

E2 ModerateBehavioralPEM not requiredLongitudinal

Long-term outcomes of an integrative rehabilitation program on quality of life: a follow-up study.

Taylor, Renee R, Thanawala, Sachi G, Shiraishi, Yukiko et al.·Journal of psychosomatic research·2006

This study tested whether a counseling program could improve quality of life for people with ME/CFS. Twenty-three participants attended 8 group sessions about managing their illness, followed by 7 months of one-on-one counseling. When researchers checked in at multiple points over a year, they found that people reported better quality of life for up to 12 months after completing the program.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Screening for psychological distress using internet administration of the Hospital Anxiety and Depression Scale (HADS) in individuals with chronic fatigue syndrome.

McCue, Patricia, Buchanan, Tom, Martin, Colin R·The British journal of clinical psychology·2006

This study tested whether an online questionnaire called the HADS (Hospital Anxiety and Depression Scale) accurately measures anxiety and depression in people with ME/CFS. Researchers found that people with ME/CFS did have higher anxiety and depression scores than healthy controls, but the online format may have artificially inflated these scores. The questionnaire appears useful for screening but measures three different aspects of emotional distress rather than just two as previously thought.

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Chronic fatigue syndrome-like caseness as a predictor of work status in fatigued employees on sick leave: four year follow up study.

In search of a new balance. Can high "action-proneness" in patients with chronic fatigue syndrome be changed by a multidisciplinary group treatment?

Activation of human herpesviruses 6 and 7 in patients with chronic fatigue syndrome.

Cognitive dysfunction relates to subjective report of mental fatigue in patients with chronic fatigue syndrome.

How relevant are exercise capacity measures for evaluating treatment effects in chronic fatigue syndrome? Results from a prospective, multidisciplinary outcome study.

Long-term predictors of outcome in fatigued employees on sick leave: a 4-year follow-up study.

The influence of aerobic fitness and fibromyalgia on cardiorespiratory and perceptual responses to exercise in patients with chronic fatigue syndrome.

Linear data mining the Wichita clinical matrix suggests sleep and allostatic load involvement in chronic fatigue syndrome.

Spectroscopic diagnosis of chronic fatigue syndrome by visible and near-infrared spectroscopy in serum samples.

Coping styles in people with chronic fatigue syndrome identified from the general population of Wichita, KS.

Differential diagnosis of chronic fatigue syndrome and major depressive disorder.

Update on the NAS-NRC Twin Registry.

Generalized joint hypermobility is more common in chronic fatigue syndrome than in healthy control subjects.

Urinary cortisol and cortisol metabolite excretion in chronic fatigue syndrome.

To "lump" or to "split" the functional somatic syndromes: can infectious and emotional risk factors differentiate between the onset of chronic fatigue syndrome and irritable bowel syndrome?

Early adverse experience and risk for chronic fatigue syndrome: results from a population-based study.

Severe fatigue in adolescents: a common phenomenon?

Management of patients presenting with Sjogren's syndrome.

Long-term outcomes of an integrative rehabilitation program on quality of life: a follow-up study.

Screening for psychological distress using internet administration of the Hospital Anxiety and Depression Scale (HADS) in individuals with chronic fatigue syndrome.

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