ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2768 studies

2221–2240 of 2,768 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

Physicians' diagnoses of psychiatric disorders for people with chronic fatigue syndrome.

Torres-Harding, Susan R, Jason, Leonard A, Cane, Victoria et al.·International journal of psychiatry in medicine·2002

This study looked at whether doctors correctly identify psychiatric conditions (like depression or anxiety) in patients with ME/CFS compared to other groups. Researchers found that doctors often missed psychiatric disorders when they were present, but they rarely incorrectly diagnosed someone as having a psychiatric condition when they didn't. Interestingly, patients themselves were often better at recognizing their own psychiatric symptoms than their physicians were.

E2 ModerateCohortPEM not requiredCross-Sectional

Maximal oxygen uptake and lactate metabolism are normal in chronic fatigue syndrome.

Sargent, Charli, Scroop, Garry C, Nemeth, Peter M et al.·Medicine and science in sports and exercise·2002

This study tested whether people with ME/CFS have reduced oxygen processing ability compared to healthy people. Researchers had 33 ME/CFS patients and 33 matched healthy controls perform exercise tests on stationary bikes while measuring heart rate and oxygen use. The results showed that ME/CFS patients had normal oxygen uptake capacity similar to sedentary healthy people of the same age and gender, contrary to what some earlier studies had reported.

E2 ModerateCohortPEM not requiredCase-Control

Cellular immunity in monozygotic twins discordant for chronic fatigue syndrome.

Sabath, Daniel E, Barcy, Serge, Koelle, David M et al.·The Journal of infectious diseases·2002

This study looked at immune system differences in identical twins where one twin had ME/CFS and the other didn't. By comparing identical twins, researchers could focus on immune changes related to the illness rather than genetic differences. The study found that certain immune cells were more variable in twins with ME/CFS, suggesting the immune system may be less stable in this condition.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Fatigue in chronic migraine patients.

Peres, M F P, Zukerman, E, Young, W B et al.·Cephalalgia : an international journal of headache·2002

This study looked at fatigue in 63 patients with chronic migraine headaches. The researchers found that most of these patients experienced significant fatigue, and many met the diagnostic criteria for chronic fatigue syndrome (CFS). The study suggests that fatigue and migraines may be connected conditions that should be recognized and treated together.

E2 ModerateCohortPEM unclearCross-Sectional

Latent class analysis of symptoms associated with chronic fatigue syndrome and fibromyalgia.

Sullivan, P F, Smith, W, Buchwald, D·Psychological medicine·2002

Researchers studied 646 patients with ME/CFS and/or fibromyalgia to see if these are truly separate conditions or if they overlap significantly. Using statistical analysis of 32 common symptoms, they found that patients fell into four groups that differed in severity rather than type—suggesting these conditions are more similar to each other than previously thought. This challenges the traditional belief that ME/CFS and fibromyalgia are distinct disorders.

Diagnostics

E2 ModerateBehavioralPEM not requiredObservational

Radiophobia: long-term psychological consequences of Chernobyl.

Pastel, Ross H·Military medicine·2002

After the Chernobyl nuclear accident, many people experienced psychological distress and developed symptoms like extreme fatigue, sleep problems, mood changes, memory difficulties, and muscle or joint pain. These symptom patterns resembled chronic fatigue syndrome and fibromyalgia. Importantly, these symptoms appeared in people across both highly and minimally contaminated areas and didn't increase with radiation exposure levels, suggesting psychological stress rather than radiation damage caused the illness.

E2 ModerateDiagnosticPEM not requiredMethods-Paper

Validation of a telephone cognitive assessment test battery for use in chronic fatigue syndrome.

McCue, P, Scholey, A B, Herman, C et al.·Journal of telemedicine and telecare·2002

This study tested whether a telephone-based brain function test could accurately detect thinking problems in people with ME/CFS. Researchers compared two versions of the same test—one on a computer and one done by telephone—in 30 people with ME/CFS and 30 healthy people. Both versions showed that people with ME/CFS were significantly slower at thinking tasks involving attention, memory, and focus, confirming that cognitive problems are real and measurable in this illness.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCase-Control

Joint hypermobility is more common in children with chronic fatigue syndrome than in healthy controls.

Barron, Diana F, Cohen, Bernard A, Geraghty, Michael T et al.·The Journal of pediatrics·2002

This study compared how flexible the joints are in children with ME/CFS versus healthy children. Researchers found that children with ME/CFS had much more joint flexibility than healthy children—60% of children with ME/CFS had highly flexible joints compared to only 24% of healthy children. This suggests that joint hypermobility (unusually flexible joints) may be more common in ME/CFS.

E2 ModerateCohortPEM not requiredCase-Control

IgM serum antibodies to human cytomegalovirus nonstructural gene products p52 and CM2(UL44 and UL57) are uniquely present in a subset of patients with chronic fatigue syndrome.

Lerner, A Martin, Beqaj, Safedin H, Deeter, Robert G et al.·In vivo (Athens, Greece)·2002

Researchers tested blood samples from ME/CFS patients and healthy controls for specific antibodies to cytomegalovirus (CMV), a common virus. They found that 16 ME/CFS patients had unique antibodies to two CMV proteins (p52 and CM2) that were not found in 77 control subjects, including other ME/CFS patients and healthy people. This suggests these antibodies might be a specific marker for a subset of ME/CFS patients and could indicate an ongoing or incomplete CMV infection in this group.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

[Relationship between chronic fatigue and subjective symptoms of fatigue with performance status (P.S.) and subjective fatigue scale for young adults (SFS-Y)].

Kobayashi, Hidetsugu, Demura, Shinichi·[Nihon koshu eisei zasshi] Japanese journal of public health·2002

This study looked at whether a new questionnaire (the SFS-Y) could help identify young people experiencing chronic fatigue by measuring different types of tiredness symptoms. Researchers gave the questionnaire to over 1,100 teenagers and found that the tool was quite good at spotting chronic fatigue, especially when it measured difficulty concentrating. The results suggest this questionnaire might be useful for screening young people who could develop ME/CFS-like conditions.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredCross-Sectional

Fatigue after breast cancer and in chronic fatigue syndrome: similarities and differences.

Servaes, Petra, Prins, Judith, Verhagen, Stans et al.·Journal of psychosomatic research·2002

This study compared 57 women with ME/CFS to 57 women who had breast cancer and were experiencing severe fatigue after treatment. Researchers measured fatigue, physical activity, mood, sleep, and concentration using questionnaires, tests, and activity monitors worn for 12 days. While both groups experienced significant fatigue, ME/CFS patients generally had more severe symptoms overall, though some breast cancer survivors reported similar problems with sleep and concentration.

SleepCognitive Impairment

E2 ModerateCohortPEM not requiredCase-Control

Chronic fatigue in a population-based study of Gulf War veterans.

McCauley, Linda A, Joos, Sandra K, Barkhuizen, Andre et al.·Archives of environmental health·2002

Researchers studied Gulf War veterans to see how many had chronic fatigue that couldn't be explained by standard medical tests. They found that about 2.2% of veterans met the official criteria for ME/CFS, and another 5.1% had unexplained fatigue. Women veterans were more likely to have these conditions than men. Unlike some other ME/CFS patients, most of these veterans developed their fatigue gradually rather than suddenly.

Diagnostics

E2 ModerateBehavioralPEM not requiredCross-Sectional

Daily hassles reported by chronic fatigue syndrome and fibromyalgia patients in tertiary care: a controlled quantitative and qualitative study.

Van Houdenhove, Boudewijn, Neerinckx, Eddy, Onghena, Patrick et al.·Psychotherapy and psychosomatics·2002

This study looked at the everyday frustrations and worries that ME/CFS and fibromyalgia patients experience compared to people with other chronic illnesses like multiple sclerosis and rheumatoid arthritis. Researchers found that ME/CFS and fibromyalgia patients reported more frequent daily hassles and felt more emotionally distressed by them. The main worries for ME/CFS and fibromyalgia patients centered on feeling bad about themselves, feeling uncertain, and not being recognized or understood by others.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Perception of cognitive performance in patients with chronic fatigue syndrome.

Metzger, Fredric A, Denney, Douglas R·Annals of behavioral medicine : a publication of the Society of Behavioral Medicine·2002

This study looked at how accurately people with ME/CFS judge their own mental performance. When patients with ME/CFS completed a challenging thinking task, they consistently thought they did worse than they actually did, even though their actual performance matched healthy people's performance. This gap between what they thought they could do and what they actually accomplished was linked to how mentally tired and fatigued the task made them feel.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredCross-Sectional

Cognitive functioning in chronic fatigue syndrome and the role of depression, anxiety, and fatigue.

Short, Keryn, McCabe, Marita, Tooley, Greg·Journal of psychosomatic research·2002

This study tested whether people with ME/CFS have actual problems with memory and thinking skills, or whether the difficulty they experience is mainly related to depression, anxiety, or fatigue. Researchers compared 23 people with ME/CFS to 23 healthy people using both objective tests (like memory tasks) and subjective reports (how people felt their thinking was affected). The findings showed that on actual cognitive tests, people with ME/CFS performed just as well as healthy controls, though they reported feeling that their thinking was worse.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

High rates of autoimmune and endocrine disorders, fibromyalgia, chronic fatigue syndrome and atopic diseases among women with endometriosis: a survey analysis.

Sinaii, N, Cleary, S D, Ballweg, M L et al.·Human reproduction (Oxford, England)·2002

This study found that women with endometriosis—a painful condition where tissue grows outside the uterus—have much higher rates of ME/CFS, fibromyalgia, and autoimmune diseases compared to the general population. Researchers surveyed nearly 3,700 women with endometriosis and compared their health conditions to published data about women without endometriosis. Women with endometriosis were 150 times more likely to have ME/CFS and nearly twice as likely to have fibromyalgia.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

The effect of exercise on gait and balance in patients with chronic fatigue syndrome.

Paul, L M, Wood, L, Maclaren, W·Gait & posture·2001

This study looked at whether people with ME/CFS have problems with walking and balance, and whether light exercise makes these problems worse. Researchers compared 11 ME/CFS patients with 11 healthy people and found that while ME/CFS patients did show different walking patterns, their balance was similar to healthy controls, and the exercise test did not worsen either group's balance or gait.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Relationship of brain MRI abnormalities and physical functional status in chronic fatigue syndrome.

Cook, D B, Lange, G, DeLuca, J et al.·The International journal of neuroscience·2001

This study looked at brain MRI scans from 48 ME/CFS patients to see if visible abnormalities in the brain were related to how physically impaired they felt. Researchers found that patients whose brain scans showed abnormalities reported being significantly more physically limited than those with normal-looking scans. This suggests ME/CFS may involve real, measurable changes in the brain rather than being purely psychological.

E2 ModerateCohortPEM not requiredCross-Sectional

Neuropsychological function in patients with chronic fatigue syndrome, multiple sclerosis, and depression.

Daly, E, Komaroff, A L, Bloomingdale, K et al.·Applied neuropsychology·2001

This study compared thinking and memory skills in people with ME/CFS, multiple sclerosis, depression, and healthy controls. Researchers found that all three patient groups had trouble with memory, language, and spatial skills. Importantly, even after accounting for depression symptoms, people with ME/CFS still showed memory problems, suggesting their cognitive difficulties are not simply caused by depression.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredCross-Sectional

Thoroughly modern worries: the relationship of worries about modernity to reported symptoms, health and medical care utilization.

Petrie, K J, Sivertsen, B, Hysing, M et al.·Journal of psychosomatic research·2001

This study looked at whether worries about modern health threats (like pollution, food safety, and radiation) are linked to symptom reporting and chronic fatigue syndrome (CFS). Researchers surveyed over 8,000 people and found that those with higher worries about modernity reported more physical symptoms, food intolerances, and CFS diagnoses. The study suggests that health anxiety about modern threats may influence how people interpret body signals and perceive their health.

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Physicians' diagnoses of psychiatric disorders for people with chronic fatigue syndrome.

Maximal oxygen uptake and lactate metabolism are normal in chronic fatigue syndrome.

Cellular immunity in monozygotic twins discordant for chronic fatigue syndrome.

Fatigue in chronic migraine patients.

Latent class analysis of symptoms associated with chronic fatigue syndrome and fibromyalgia.

Radiophobia: long-term psychological consequences of Chernobyl.

Validation of a telephone cognitive assessment test battery for use in chronic fatigue syndrome.

Joint hypermobility is more common in children with chronic fatigue syndrome than in healthy controls.

IgM serum antibodies to human cytomegalovirus nonstructural gene products p52 and CM2(UL44 and UL57) are uniquely present in a subset of patients with chronic fatigue syndrome.

[Relationship between chronic fatigue and subjective symptoms of fatigue with performance status (P.S.) and subjective fatigue scale for young adults (SFS-Y)].

Fatigue after breast cancer and in chronic fatigue syndrome: similarities and differences.

Chronic fatigue in a population-based study of Gulf War veterans.

Daily hassles reported by chronic fatigue syndrome and fibromyalgia patients in tertiary care: a controlled quantitative and qualitative study.

Perception of cognitive performance in patients with chronic fatigue syndrome.

Cognitive functioning in chronic fatigue syndrome and the role of depression, anxiety, and fatigue.

High rates of autoimmune and endocrine disorders, fibromyalgia, chronic fatigue syndrome and atopic diseases among women with endometriosis: a survey analysis.

The effect of exercise on gait and balance in patients with chronic fatigue syndrome.

Relationship of brain MRI abnormalities and physical functional status in chronic fatigue syndrome.

Neuropsychological function in patients with chronic fatigue syndrome, multiple sclerosis, and depression.

Thoroughly modern worries: the relationship of worries about modernity to reported symptoms, health and medical care utilization.

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