ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2768 studies

2301–2320 of 2,768 studies

E2 ModerateCohortPEM not requiredCross-Sectional

Cerebral perfusion in chronic fatigue syndrome and depression.

MacHale, S M, Lawŕie, S M, Cavanagh, J T et al.·The British journal of psychiatry : the journal of mental science·2000

Researchers used brain imaging to measure blood flow in different areas of the brain in people with ME/CFS, people with depression, and healthy volunteers. They found that people with ME/CFS had increased blood flow in certain deep brain structures (the thalamus and related areas), which was similar to what they saw in depressed patients. However, people with ME/CFS had a different pattern than depressed patients in other brain regions, suggesting these are related but distinct conditions.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Psychiatric morbidity and illness experience of primary care patients with chronic fatigue in Hong Kong.

Lee, S, Yu, H, Wing, Y et al.·The American journal of psychiatry·2000

This study looked at 100 people in Hong Kong who had severe tiredness lasting at least 6 months to understand how common mental health conditions like depression and anxiety were in this group. Researchers found that over half of these patients had experienced depression or anxiety at some point in their lives, and about a quarter had these conditions at the time of the study. Interestingly, patients' main complaints were often pain, sleep problems, and worry—not just fatigue—and most believed their illness started from stressful life events.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Coping strategies in twins with chronic fatigue and chronic fatigue syndrome.

Afari, N, Schmaling, K B, Herrell, R et al.·Journal of psychosomatic research·2000

This study looked at how twins handle stress when one twin has chronic fatigue or ME/CFS and the other doesn't. Researchers found that twins with fatigue tend to cope by avoiding problems more often than their healthy siblings do. While both groups used similar overall coping methods, the fatigued twins relied more heavily on avoidance strategies rather than trying to solve problems directly.

E2 ModerateCohortPEM not requiredCross-Sectional

Normal carnitine levels in patients with chronic fatigue syndrome.

Soetekouw, P M, Wevers, R A, Vreken, P et al.·The Netherlands journal of medicine·2000

This study tested whether a chemical called carnitine, which helps muscles produce energy, was missing in people with ME/CFS. Researchers measured carnitine levels in 25 women with ME/CFS and compared them to 25 healthy women. They found that carnitine levels were actually normal in the ME/CFS patients, which contradicted earlier studies that suggested carnitine deficiency might cause the condition.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Use of alternative treatments by chronic fatigue syndrome discordant twins.

Afari, N, Eisenberg, DM, Herrell, R et al.·Integrative medicine : integrating conventional and alternative medicine·2000

This study looked at how often people with ME/CFS use alternative treatments compared to their identical twins who don't have the illness. Researchers surveyed 63 twin pairs and found that 91% of people with ME/CFS had tried at least one alternative therapy (such as herbs, vitamins, massage, or meditation), compared to 71% of their healthy twins. While many people found these treatments helpful, most didn't tell their doctors they were using them.

E2 ModerateCohortPEM not requiredObservational

Chronic fatigue syndrome in patients with Lyme borreliosis.

Treib, J, Grauer, M T, Haass, A et al.·European neurology·2000

This study looked at whether past or current Lyme disease infection might be connected to chronic fatigue. Researchers tested 1,156 young men for evidence of past Lyme disease exposure. They found that men who had been exposed to Lyme disease bacteria but never had noticeable symptoms reported more fatigue and general malaise than those without exposure. The researchers suggested it might be worth testing people with chronic fatigue for Lyme disease antibodies and considering antibiotic treatment.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Couples' perceptions of wives' CFS symptoms, symptom change, and impact on the marital relationship.

Goodwin, S S·Issues in mental health nursing·2000

This study looked at how 131 couples with wives who have ME/CFS perceived the illness differently. Wives reported more severe physical symptoms (like fatigue, brain fog, and muscle pain) than their husbands noticed, while husbands were more concerned about mood changes. When symptoms got worse, both partners reported more relationship conflict and less emotional support from each other.

E2 ModerateCohortPEM not requiredCross-Sectional

Odor perception: multiple chemical sensitivities, chronic fatigue, and asthma.

Caccappolo, E, Kipen, H, Kelly-McNeil, K et al.·Journal of occupational and environmental medicine·2000

This study tested whether people with chemical sensitivities, chronic fatigue, and asthma have unusually sensitive noses. Researchers measured how well different groups could smell odors and identify them. While people with chemical sensitivities didn't actually detect odors at lower levels than others, they did report feeling more physical symptoms and found certain smells more unpleasant than other groups did.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCross-Sectional

The capnography head-up tilt test for evaluation of chronic fatigue syndrome.

Naschitz, J E, Rosner, I, Rozenbaum, M et al.·Seminars in arthritis and rheumatism·2000

This study tested whether a special tilt table test that measures blood pressure, heart rate, breathing, and carbon dioxide levels could help diagnose ME/CFS. Researchers compared 32 ME/CFS patients to 32 healthy people during this test. ME/CFS patients showed abnormal responses—like drops in blood pressure, increases in heart rate, faster breathing, and lower carbon dioxide levels—while healthy people did not, suggesting this test might help identify ME/CFS.

Autonomic Nervous System

E2 ModerateCohortPEM unclearObservational

[Relationship between fatigue in multiple sclerosis and the chronic fatigue syndrome].

Grimaud, J·Revue neurologique·2000

This study examined whether the severe tiredness experienced by people with multiple sclerosis (MS) is similar to the fatigue seen in ME/CFS. The research looked at how fatigue presents differently in these two conditions and whether they share common features. Understanding these similarities and differences can help doctors better recognize and treat fatigue in both diseases.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Chronic fatigue syndrome: an examination of the phases.

Jason, L A, Fricano, G, Taylor, R R et al.·Journal of clinical psychology·2000

This study tested a tool called the Fennell Phase Inventory, which measures four distinct phases that people with ME/CFS typically go through: Crisis, Stabilization, Resolution, and Integration. Researchers gave 65 patients diagnosed by doctors the inventory along with other questionnaires about their symptoms, daily functioning, and coping strategies. The results supported the theory that ME/CFS patients progress through these predictable phases, with each phase showing different levels of disability and different ways of coping.

E2 ModerateCohortPEM not requiredCase-Control

Results of isoproterenol tilt table testing in monozygotic twins discordant for chronic fatigue syndrome.

Poole, J, Herrell, R, Ashton, S et al.·Archives of internal medicine·2000

This study tested whether a condition called neurally mediated hypotension (a sudden drop in blood pressure) might be causing ME/CFS. Researchers compared identical twins where one had ME/CFS and one was healthy, using a tilt table test to measure blood pressure responses. They found that healthy twins and twins with ME/CFS had similar rates of this blood pressure problem, suggesting it is probably not a main cause of ME/CFS.

Autonomic Nervous System

E2 ModerateBehavioralPEM not requiredCase-Control

Personality in adolescents with chronic fatigue syndrome.

Rangel, L, Garralda, E, Levin, M et al.·European child & adolescent psychiatry·2000

This study looked at personality traits in teenagers with ME/CFS and compared them to healthy teenagers. Researchers found that adolescents with ME/CFS were more likely to show certain personality features like being very conscientious, feeling vulnerable, experiencing worthlessness, and having unstable emotions. While personality difficulties were linked to worse social skills and more psychological symptoms, the study suggests these traits are separate from having psychiatric disorders.

E2 ModerateCohortPEM not requiredCross-Sectional

Chronic fatigue syndrome, fibromyalgia, and multiple chemical sensitivities in a community-based sample of persons with chronic fatigue syndrome-like symptoms.

Jason, L A, Taylor, R R, Kennedy, C L·Psychosomatic medicine·2000

This study looked at how often people with ME/CFS (chronic fatigue syndrome) also have fibromyalgia or chemical sensitivities, and how these conditions affect daily functioning. Researchers interviewed nearly 19,000 people in Chicago and then examined those with CFS-like symptoms in more detail. They found that people with multiple conditions experienced worse fatigue and disability than those with just one condition.

E2 ModerateBehavioralPEM not requiredCross-Sectional

The genetic aetiology of somatic distress.

Gillespie, N A, Zhu, G, Heath, A C et al.·Psychological medicine·2000

This study looked at whether the physical and mental exhaustion seen in chronic fatigue syndrome runs in families and whether it's genetically distinct from depression and anxiety. Researchers surveyed nearly 3,500 Australian twins and found that about one-third of the genetic factors affecting somatic distress (physical symptoms and fatigue) are unique to those symptoms and not shared with depression or anxiety, suggesting these are separate conditions with different causes.

E2 ModerateCohortPEM not requiredCase-Control

Salivary gland changes in chronic fatigue syndrome: a case-controlled preliminary histologic study.

Woo, S B, Schacterle, R S, Komaroff, A L et al.·Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics·2000

Researchers examined tiny salivary glands in the lips of 11 ME/CFS patients and compared them to healthy controls. They found that ME/CFS patients had various changes in these glands, including swelling, scarring, and immune cell infiltration. Most notably, ME/CFS patients had significantly more mast cells (immune cells) in their salivary glands than controls, suggesting these glands may be damaged in ME/CFS.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Chronic fatigue syndrome: a woman's dilemma.

Tuck, I, Wallace, D·Health care for women international·2000

This study looked at how ME/CFS affects women's lives by interviewing 22 women and surveying 42 others about their experiences. The researchers found that the illness significantly disrupts women's work, relationships, and how they see themselves. The study highlights that living with ME/CFS and managing its symptoms has a major impact on quality of life beyond just the medical aspects of the disease.

E2 ModerateCohortPEM not requiredCase-Control

Human herpesviruses 6 and 7 in chronic fatigue syndrome: a case-control study.

Reeves, W C, Stamey, F R, Black, J B et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2000

Researchers tested whether three common viruses (HHV-6A, HHV-6B, and HHV-7) might be linked to ME/CFS. They compared blood samples from 26 ME/CFS patients with 52 healthy people and looked for signs of active or dormant virus infection. The study found no meaningful differences between the two groups, suggesting these particular viruses are not associated with ME/CFS.

E2 ModerateCohortPEM unclearCross-Sectional

Antibodies to squalene in Gulf War syndrome.

Asa, P B, Cao, Y, Garry, R F·Experimental and molecular pathology·2000

Researchers tested whether Gulf War veterans with illness had antibodies (immune proteins) against a substance called squalene in their blood. They found that 95% of sick Gulf War veterans had these antibodies, while veterans who served but stayed healthy had none. Interestingly, even military personnel who were vaccinated for the Gulf War but never deployed also had these antibodies if they developed the same symptoms.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Diagnosis of psychiatric disorder in clinical evaluation of chronic fatigue syndrome.

Deale, A, Wessely, S·Journal of the Royal Society of Medicine·2000

This study looked at how often ME/CFS patients are incorrectly diagnosed with psychiatric conditions like depression. Researchers found that about two-thirds of patients who had been labeled with a psychiatric diagnosis actually didn't have one, while about one-third of patients without a psychiatric diagnosis did have a treatable mental health condition. The study shows that distinguishing between ME/CFS and psychiatric disorders can be difficult, and doctors need better tools and training to get the diagnosis right.

Diagnostics

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Cerebral perfusion in chronic fatigue syndrome and depression.

Psychiatric morbidity and illness experience of primary care patients with chronic fatigue in Hong Kong.

Coping strategies in twins with chronic fatigue and chronic fatigue syndrome.

Normal carnitine levels in patients with chronic fatigue syndrome.

Use of alternative treatments by chronic fatigue syndrome discordant twins.

Chronic fatigue syndrome in patients with Lyme borreliosis.

Couples' perceptions of wives' CFS symptoms, symptom change, and impact on the marital relationship.

Odor perception: multiple chemical sensitivities, chronic fatigue, and asthma.

The capnography head-up tilt test for evaluation of chronic fatigue syndrome.

[Relationship between fatigue in multiple sclerosis and the chronic fatigue syndrome].

Chronic fatigue syndrome: an examination of the phases.

Results of isoproterenol tilt table testing in monozygotic twins discordant for chronic fatigue syndrome.

Personality in adolescents with chronic fatigue syndrome.

Chronic fatigue syndrome, fibromyalgia, and multiple chemical sensitivities in a community-based sample of persons with chronic fatigue syndrome-like symptoms.

The genetic aetiology of somatic distress.

Salivary gland changes in chronic fatigue syndrome: a case-controlled preliminary histologic study.

Chronic fatigue syndrome: a woman's dilemma.

Human herpesviruses 6 and 7 in chronic fatigue syndrome: a case-control study.

Antibodies to squalene in Gulf War syndrome.

Diagnosis of psychiatric disorder in clinical evaluation of chronic fatigue syndrome.

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