ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2768 studies

2321–2340 of 2,768 studies

E2 ModerateCohortPEM not requiredObservational

Magnesium status and parameters of the oxidant-antioxidant balance in patients with chronic fatigue: effects of supplementation with magnesium.

Manuel y Keenoy, B, Moorkens, G, Vertommen, J et al.·Journal of the American College of Nutrition·2000

This study looked at whether magnesium deficiency and oxidative stress (cellular damage from unstable molecules) are connected in people with chronic fatigue. Researchers tested 93 patients, about half of whom had CFS, and found that people lacking magnesium had lower antioxidant protection in their blood. When these patients took magnesium supplements, some improved antioxidant markers and vitamin E levels, suggesting magnesium may help protect cells from damage.

E2 ModerateCohortPEM unclearCross-Sectional

Neurally mediated hypotension in fatigued Gulf War veterans: a preliminary report.

Davis, S D, Kator, S F, Wonnett, J A et al.·The American journal of the medical sciences·2000

This study tested whether fatigued Gulf War veterans have problems with blood pressure control when standing up quickly (a condition called neurally mediated hypotension), similar to what researchers have seen in ME/CFS patients. The researchers tilted 14 fatigued Gulf War veterans on a special table and compared their responses to two groups of unfatigued veterans and non-veterans. They found that fatigued veterans were more likely to experience dangerous drops in blood pressure during the test, suggesting their autonomic nervous system (the part that automatically controls heart rate and blood pressure) may not be working properly.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

How significant are primary sleep disorders and sleepiness in the chronic fatigue syndrome?

Le Bon, O, Fischler, B, Hoffmann, G et al.·Sleep research online : SRO·2000

This study looked at whether sleep problems might explain ME/CFS symptoms in 46 patients. Researchers found that many CFS patients did have sleep disorders like sleep apnea, but these sleep problems were not connected to how severe their CFS was or their other symptoms. Importantly, over half of the CFS patients had no sleep disorders at all, suggesting that ME/CFS is a distinct condition separate from typical sleep problems.

Sleep

E2 ModerateCohortPEM not requiredCross-Sectional

Cerebral perfusion in chronic fatigue syndrome and depression.

MacHale, S M, Lawŕie, S M, Cavanagh, J T et al.·The British journal of psychiatry : the journal of mental science·2000

Researchers used brain imaging to measure blood flow in different areas of the brain in people with ME/CFS, people with depression, and healthy volunteers. They found that people with ME/CFS had increased blood flow in certain deep brain structures (the thalamus and related areas), which was similar to what they saw in depressed patients. However, people with ME/CFS had a different pattern than depressed patients in other brain regions, suggesting these are related but distinct conditions.

E2 ModerateCohortPEM unclearCross-Sectional

Abnormal neuropsychological findings are not necessarily a sign of cerebral impairment: a matched comparison between chronic fatigue syndrome and multiple sclerosis.

van der Werf, S P, Prins, J B, Jongen, P J et al.·Neuropsychiatry, neuropsychology, and behavioral neurology·2000

This study compared how people with ME/CFS and people with multiple sclerosis (MS) performed on memory and thinking tests. The researchers found that people with ME/CFS were more likely to show signs of reduced effort on memory tests, but both groups had similar rates of poor performance on standard cognitive tests. This suggests that poor test results in ME/CFS patients might sometimes reflect how hard they're trying during the test, rather than actual brain damage.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredCross-Sectional

Coping strategies in twins with chronic fatigue and chronic fatigue syndrome.

Afari, N, Schmaling, K B, Herrell, R et al.·Journal of psychosomatic research·2000

This study looked at how twins handle stress when one twin has chronic fatigue or ME/CFS and the other doesn't. Researchers found that twins with fatigue tend to cope by avoiding problems more often than their healthy siblings do. While both groups used similar overall coping methods, the fatigued twins relied more heavily on avoidance strategies rather than trying to solve problems directly.

E2 ModerateCohortPEM unclearObservational

Frequent HHV-6 reactivation in multiple sclerosis (MS) and chronic fatigue syndrome (CFS) patients.

Ablashi, D V, Eastman, H B, Owen, C B et al.·Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2000

This study looked at whether a common virus called HHV-6 might be reactivated in ME/CFS patients. Researchers found that ME/CFS and MS patients had higher levels of antibodies (immune markers) to HHV-6 compared to healthy people, and they detected active virus in blood cells from these patients. The findings suggest that HHV-6 reactivation might play a role in causing or worsening ME/CFS symptoms.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

The difference in patterns of motor and cognitive function in chronic fatigue syndrome and severe depressive illness.

Lawrie, S M, MacHale, S M, Cavanagh, J T et al.·Psychological medicine·2000

This study compared thinking and physical abilities in people with ME/CFS, people with depression, and healthy individuals. Researchers found that people with ME/CFS had worse memory and thinking skills than healthy people, but generally better than those with depression. Both ME/CFS and depression groups showed significant problems with muscle strength and motor control compared to healthy controls.

Cognitive Impairment

E2 ModerateCohortPEM unclearObservational

[Relationship between fatigue in multiple sclerosis and the chronic fatigue syndrome].

Grimaud, J·Revue neurologique·2000

This study examined whether the severe tiredness experienced by people with multiple sclerosis (MS) is similar to the fatigue seen in ME/CFS. The research looked at how fatigue presents differently in these two conditions and whether they share common features. Understanding these similarities and differences can help doctors better recognize and treat fatigue in both diseases.

E2 ModerateCohortPEM not requiredCross-Sectional

Exercise capacity in chronic fatigue syndrome.

De Becker, P, Roeykens, J, Reynders, M et al.·Archives of internal medicine·2000

This study measured how much exercise women with ME/CFS could tolerate compared to healthy women without the condition. Patients with ME/CFS were able to exercise at only about half the capacity of healthy controls—they couldn't reach high heart rates and couldn't sustain heavy workloads. The findings show that ME/CFS significantly limits physical ability in ways that can be objectively measured.

Post-Exertional Malaise

E2 ModerateDiagnosticPEM not requiredMethods-Paper

Screening for prolonged fatigue syndromes: validation of the SOFA scale.

Hadzi-Pavlovic, D, Hickie, I B, Wilson, A J et al.·Social psychiatry and psychiatric epidemiology·2000

This study developed and tested two screening tools (called SOFA/CFS and SOFA/GP) to help doctors identify patients with chronic fatigue syndrome and prolonged fatigue conditions. Researchers tested these tools with 770 CFS patients in specialist clinics and 1,593 people in regular primary care settings, and found that both instruments could reliably spot these fatigue syndromes. The study also showed that fatigue syndromes have distinct patterns that are separate from anxiety and depression, and these patterns remained stable over a 12-month follow-up.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

Self-reported sensitivity to chemical exposures in five clinical populations and healthy controls.

Nawab, S S, Miller, C S, Dale, J K et al.·Psychiatry research·2000

This study asked 225 people—including those with ME/CFS, SAD, and other conditions, plus healthy volunteers—to report how sensitive they are to everyday chemical exposures like perfumes, cleaning products, and other odors. People with ME/CFS reported significantly higher chemical sensitivity than healthy controls, and women reported more sensitivity than men. The researchers suggest that chemical sensitivity may be connected to how the body's stress-response system (the HPA axis) functions.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCase-Control

Integrity of the growth hormone/insulin-like growth factor system is maintained in patients with chronic fatigue syndrome.

Cleare, A J, Sookdeo, S S, Jones, J et al.·The Journal of clinical endocrinology and metabolism·2000

This study investigated whether people with ME/CFS have problems with growth hormone (GH), a chemical in the body that affects energy and metabolism. Researchers compared 37 ME/CFS patients to 37 healthy controls by measuring various growth hormone-related substances in their blood and urine, and tested how their bodies responded to specific hormone challenges. They found no significant differences between the two groups, suggesting that ME/CFS is not caused by growth hormone deficiency.

Energy Metabolism

E2 ModerateCohortPEM unclearCross-Sectional

Bone density and body composition in young women with chronic fatigue syndrome.

Hoskin, L, Clifton-Bligh, P, Hansen, R et al.·Annals of the New York Academy of Sciences·2000

This study looked at bone health and body composition in young women with ME/CFS compared to healthy controls. Researchers used specialized scanning technology to measure bone density and muscle/fat distribution. The findings help us understand whether ME/CFS affects physical body structure in ways that might contribute to health concerns.

E2 ModerateCohortPEM not requiredObservational

Chronic fatigue syndrome in patients with Lyme borreliosis.

Treib, J, Grauer, M T, Haass, A et al.·European neurology·2000

This study looked at whether past or current Lyme disease infection might be connected to chronic fatigue. Researchers tested 1,156 young men for evidence of past Lyme disease exposure. They found that men who had been exposed to Lyme disease bacteria but never had noticeable symptoms reported more fatigue and general malaise than those without exposure. The researchers suggested it might be worth testing people with chronic fatigue for Lyme disease antibodies and considering antibiotic treatment.

E2 ModerateBehavioralPEM not requiredCase-Control

Personality in adolescents with chronic fatigue syndrome.

Rangel, L, Garralda, E, Levin, M et al.·European child & adolescent psychiatry·2000

This study looked at personality traits in teenagers with ME/CFS and compared them to healthy teenagers. Researchers found that adolescents with ME/CFS were more likely to show certain personality features like being very conscientious, feeling vulnerable, experiencing worthlessness, and having unstable emotions. While personality difficulties were linked to worse social skills and more psychological symptoms, the study suggests these traits are separate from having psychiatric disorders.

E2 ModerateCohortPEM not requiredCross-Sectional

The capnography head-up tilt test for evaluation of chronic fatigue syndrome.

Naschitz, J E, Rosner, I, Rozenbaum, M et al.·Seminars in arthritis and rheumatism·2000

This study tested whether a special tilt table test that measures blood pressure, heart rate, breathing, and carbon dioxide levels could help diagnose ME/CFS. Researchers compared 32 ME/CFS patients to 32 healthy people during this test. ME/CFS patients showed abnormal responses—like drops in blood pressure, increases in heart rate, faster breathing, and lower carbon dioxide levels—while healthy people did not, suggesting this test might help identify ME/CFS.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Normal carnitine levels in patients with chronic fatigue syndrome.

Soetekouw, P M, Wevers, R A, Vreken, P et al.·The Netherlands journal of medicine·2000

This study tested whether a chemical called carnitine, which helps muscles produce energy, was missing in people with ME/CFS. Researchers measured carnitine levels in 25 women with ME/CFS and compared them to 25 healthy women. They found that carnitine levels were actually normal in the ME/CFS patients, which contradicted earlier studies that suggested carnitine deficiency might cause the condition.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredObservational

Identifying physical activity patterns in chronic fatigue syndrome using actigraphic assessment.

van der Werf, S P, Prins, J B, Vercoulen, J H et al.·Journal of psychosomatic research·2000

Researchers used a motion-tracking device to measure physical activity patterns in 277 ME/CFS patients over 12 days and compared them to 47 healthy people. Patients with ME/CFS showed less intense bursts of activity, shorter activity periods, and longer rest times afterward. About one-fourth of patients were identified as 'pervasively passive'—meaning they had very low activity levels throughout the entire study period.

Post-Exertional Malaise

E2 ModerateBehavioralPEM not requiredCross-Sectional

Attributions in chronic fatigue syndrome and fibromyalgia syndrome in tertiary care.

Neerinckx, E, Van Houdenhove, B, Lysens, R et al.·The Journal of rheumatology·2000

This study looked at what 192 patients with ME/CFS, fibromyalgia, or chronic pain believed was causing their illness. Most patients thought their condition had both physical causes (like a virus or chemical imbalance) and emotional causes (like stress). The researchers found that patients' beliefs about what caused their illness were quite varied, and these beliefs did not differ much based on their specific diagnosis.

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Magnesium status and parameters of the oxidant-antioxidant balance in patients with chronic fatigue: effects of supplementation with magnesium.

Neurally mediated hypotension in fatigued Gulf War veterans: a preliminary report.

How significant are primary sleep disorders and sleepiness in the chronic fatigue syndrome?

Cerebral perfusion in chronic fatigue syndrome and depression.

Abnormal neuropsychological findings are not necessarily a sign of cerebral impairment: a matched comparison between chronic fatigue syndrome and multiple sclerosis.

Coping strategies in twins with chronic fatigue and chronic fatigue syndrome.

Frequent HHV-6 reactivation in multiple sclerosis (MS) and chronic fatigue syndrome (CFS) patients.

The difference in patterns of motor and cognitive function in chronic fatigue syndrome and severe depressive illness.

[Relationship between fatigue in multiple sclerosis and the chronic fatigue syndrome].

Exercise capacity in chronic fatigue syndrome.

Screening for prolonged fatigue syndromes: validation of the SOFA scale.

Self-reported sensitivity to chemical exposures in five clinical populations and healthy controls.

Integrity of the growth hormone/insulin-like growth factor system is maintained in patients with chronic fatigue syndrome.

Bone density and body composition in young women with chronic fatigue syndrome.

Chronic fatigue syndrome in patients with Lyme borreliosis.

Personality in adolescents with chronic fatigue syndrome.

The capnography head-up tilt test for evaluation of chronic fatigue syndrome.

Normal carnitine levels in patients with chronic fatigue syndrome.

Identifying physical activity patterns in chronic fatigue syndrome using actigraphic assessment.

Attributions in chronic fatigue syndrome and fibromyalgia syndrome in tertiary care.

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