ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

2321–2340 of 2,807 studies

E2 ModerateCohortPEM not requiredCross-Sectional

Neuropsychological function in patients with chronic fatigue syndrome, multiple sclerosis, and depression.

Daly, E, Komaroff, A L, Bloomingdale, K et al.·Applied neuropsychology·2001

This study compared thinking and memory skills in people with ME/CFS, multiple sclerosis, depression, and healthy controls. Researchers found that all three patient groups had trouble with memory, language, and spatial skills. Importantly, even after accounting for depression symptoms, people with ME/CFS still showed memory problems, suggesting their cognitive difficulties are not simply caused by depression.

Cognitive Impairment

E2 ModerateCohortPEM unclearCross-Sectional

Multiple chemical sensitivity and chronic fatigue syndrome in British Gulf War veterans.

Reid, S, Hotopf, M, Hull, L et al.·American journal of epidemiology·2001

This study looked at how often ME/CFS and multiple chemical sensitivity (MCS—a condition where people react badly to everyday chemicals) occurred in British military personnel who served in the Gulf War. Researchers compared three groups: those deployed to the Gulf, those sent to Bosnia, and those who served during the Gulf War period but weren't deployed. They found that both conditions were more common in Gulf veterans, and MCS was strongly linked to pesticide exposure.

Pain and Sensitization

E2 ModerateCohortPEM not requiredObservational

A twin study of chronic fatigue.

Buchwald, D, Herrell, R, Ashton, S et al.·Psychosomatic medicine·2001

This study looked at whether chronic fatigue runs in families by comparing identical twins to fraternal twins. Researchers found that identical twins were more likely to both have chronic fatigue than fraternal twins, suggesting that genes play a role in who develops the condition. The findings suggest that genetics may account for about half of the reason some people develop chronic fatigue syndrome.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Interpretation of symptoms in chronic fatigue syndrome.

Dendy, C, Cooper, M, Sharpe, M·Behaviour research and therapy·2001

This study looked at how people with ME/CFS interpret their physical symptoms—whether they tend to see them as signs of physical illness versus emotional stress. Researchers gave patients with ME/CFS, depression, multiple sclerosis, and healthy people a questionnaire about how they understand their symptoms. They found that people with ME/CFS were more likely to attribute their symptoms to physical causes and less likely to see them as related to emotional feelings, even compared to MS patients.

E2 ModerateBehavioralPEM not requiredCase-Control

Frequency of attendance in general practice and symptoms before development of chronic fatigue syndrome: a case-control study.

Hamilton, W T, Hall, G H, Round, A P·The British journal of general practice : the journal of the Royal College of General Practitioners·2001

This study looked at whether people who later developed ME/CFS visited their doctor more often in the 15 years before they got sick. Researchers compared 49 ME/CFS patients with 49 similar people who didn't develop the condition, reviewing their medical records. They found that people who developed ME/CFS had visited their GP significantly more often and reported more various symptoms, particularly respiratory infections, tiredness, and dizziness, suggesting that illness behavior or symptom reporting patterns may play a role in how the condition develops.

E2 ModerateCohortPEM not requiredCross-Sectional

Normal carnitine levels in patients with chronic fatigue syndrome.

Soetekouw, P M, Wevers, R A, Vreken, P et al.·The Netherlands journal of medicine·2000

This study tested whether a chemical called carnitine, which helps muscles produce energy, was missing in people with ME/CFS. Researchers measured carnitine levels in 25 women with ME/CFS and compared them to 25 healthy women. They found that carnitine levels were actually normal in the ME/CFS patients, which contradicted earlier studies that suggested carnitine deficiency might cause the condition.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredObservational

Chronic fatigue syndrome in patients with Lyme borreliosis.

Treib, J, Grauer, M T, Haass, A et al.·European neurology·2000

This study looked at whether past or current Lyme disease infection might be connected to chronic fatigue. Researchers tested 1,156 young men for evidence of past Lyme disease exposure. They found that men who had been exposed to Lyme disease bacteria but never had noticeable symptoms reported more fatigue and general malaise than those without exposure. The researchers suggested it might be worth testing people with chronic fatigue for Lyme disease antibodies and considering antibiotic treatment.

E2 ModerateCohortPEM not requiredCross-Sectional

Self-reported sensitivity to chemical exposures in five clinical populations and healthy controls.

Nawab, S S, Miller, C S, Dale, J K et al.·Psychiatry research·2000

This study asked 225 people—including those with ME/CFS, SAD, and other conditions, plus healthy volunteers—to report how sensitive they are to everyday chemical exposures like perfumes, cleaning products, and other odors. People with ME/CFS reported significantly higher chemical sensitivity than healthy controls, and women reported more sensitivity than men. The researchers suggest that chemical sensitivity may be connected to how the body's stress-response system (the HPA axis) functions.

Pain and Sensitization

E2 ModerateCohortPEM unclearCross-Sectional

Neurally mediated hypotension in fatigued Gulf War veterans: a preliminary report.

Davis, S D, Kator, S F, Wonnett, J A et al.·The American journal of the medical sciences·2000

This study tested whether fatigued Gulf War veterans have problems with blood pressure control when standing up quickly (a condition called neurally mediated hypotension), similar to what researchers have seen in ME/CFS patients. The researchers tilted 14 fatigued Gulf War veterans on a special table and compared their responses to two groups of unfatigued veterans and non-veterans. They found that fatigued veterans were more likely to experience dangerous drops in blood pressure during the test, suggesting their autonomic nervous system (the part that automatically controls heart rate and blood pressure) may not be working properly.

Autonomic Nervous System

E2 ModerateCohortPEM unclearCase-Control

Dysautonomia in chronic fatigue syndrome vs. fibromyalgia.

Rosner, I, Rozenbaum, M, Naschitz, J E et al.·The Israel Medical Association journal : IMAJ·2000

This study compared how the nervous systems of people with ME/CFS and fibromyalgia function differently, focusing on dysautonomia—problems with the automatic nervous system that controls heart rate, blood pressure, and other body functions. Researchers used a case-control design to examine whether these two conditions show distinct patterns of autonomic dysfunction. The findings help clarify whether ME/CFS and fibromyalgia are separate conditions with different underlying nervous system problems.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Cerebral perfusion in chronic fatigue syndrome and depression.

MacHale, S M, Lawŕie, S M, Cavanagh, J T et al.·The British journal of psychiatry : the journal of mental science·2000

Researchers used brain imaging to measure blood flow in different areas of the brain in people with ME/CFS, people with depression, and healthy volunteers. They found that people with ME/CFS had increased blood flow in certain deep brain structures (the thalamus and related areas), which was similar to what they saw in depressed patients. However, people with ME/CFS had a different pattern than depressed patients in other brain regions, suggesting these are related but distinct conditions.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Coping strategies in twins with chronic fatigue and chronic fatigue syndrome.

Afari, N, Schmaling, K B, Herrell, R et al.·Journal of psychosomatic research·2000

This study looked at how twins handle stress when one twin has chronic fatigue or ME/CFS and the other doesn't. Researchers found that twins with fatigue tend to cope by avoiding problems more often than their healthy siblings do. While both groups used similar overall coping methods, the fatigued twins relied more heavily on avoidance strategies rather than trying to solve problems directly.

E2 ModerateCohortPEM unclearObservational

Frequent HHV-6 reactivation in multiple sclerosis (MS) and chronic fatigue syndrome (CFS) patients.

Ablashi, D V, Eastman, H B, Owen, C B et al.·Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2000

This study looked at whether a common virus called HHV-6 might be reactivated in ME/CFS patients. Researchers found that ME/CFS and MS patients had higher levels of antibodies (immune markers) to HHV-6 compared to healthy people, and they detected active virus in blood cells from these patients. The findings suggest that HHV-6 reactivation might play a role in causing or worsening ME/CFS symptoms.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Significant other responses are associated with fatigue and functional status among patients with chronic fatigue syndrome.

Schmaling, K B, Smith, W R, Buchwald, D S·Psychosomatic medicine·2000

This study looked at how partners' responses to ME/CFS symptoms affect patients' outcomes. Researchers found that when partners were very helpful and supportive (called 'solicitous' responses), patients actually reported worse fatigue and disability—especially in relationships that were otherwise satisfying. The study couldn't determine whether supportive partners inadvertently discourage activity, or whether sicker patients simply receive more support.

E2 ModerateCohortPEM unclearCross-Sectional

Antibodies to squalene in Gulf War syndrome.

Asa, P B, Cao, Y, Garry, R F·Experimental and molecular pathology·2000

Researchers tested whether Gulf War veterans with illness had antibodies (immune proteins) against a substance called squalene in their blood. They found that 95% of sick Gulf War veterans had these antibodies, while veterans who served but stayed healthy had none. Interestingly, even military personnel who were vaccinated for the Gulf War but never deployed also had these antibodies if they developed the same symptoms.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Exercise capacity in chronic fatigue syndrome.

De Becker, P, Roeykens, J, Reynders, M et al.·Archives of internal medicine·2000

This study measured how much exercise women with ME/CFS could tolerate compared to healthy women without the condition. Patients with ME/CFS were able to exercise at only about half the capacity of healthy controls—they couldn't reach high heart rates and couldn't sustain heavy workloads. The findings show that ME/CFS significantly limits physical ability in ways that can be objectively measured.

Post-Exertional Malaise

E2 ModerateBehavioralPEM not requiredCross-Sectional

Stressors, personality traits, and coping of Gulf War veterans with chronic fatigue.

Fiedler, N, Lange, G, Tiersky, L et al.·Journal of psychosomatic research·2000

This study looked at Gulf War veterans to understand why some developed chronic fatigue syndrome (CFS) while others stayed healthy. Researchers compared three groups: healthy veterans, veterans with CFS who also had other mental health conditions, and veterans with CFS alone. They found that personality traits, how people cope with stress, war-related exposures (like oil fires and pesticides), and life stress after the war were all connected to who developed CFS.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Symptom patterns in long-duration chronic fatigue syndrome.

Friedberg, F, Dechene, L, McKenzie, M J et al.·Journal of psychosomatic research·2000

This study looked at how ME/CFS symptoms change over time by comparing people who had been ill for 10+ years with those ill for only a few years. Researchers found that people with longer illness duration reported more severe cognitive problems (like memory and concentration issues), while both groups had immune-related symptoms and flu-like symptoms. The study suggests that ME/CFS symptoms may shift and worsen in specific ways as the illness persists.

Cognitive Impairment

E2 ModerateCohortPEM not requiredLongitudinal

Antibodies to parvovirus B19 non-structural protein are associated with chronic but not acute arthritis following B19 infection.

Kerr, J R, Cunniffe, V S·Rheumatology (Oxford, England)·2000

This study tracked people who had parvovirus B19 infection to see if certain antibodies (immune proteins) in their blood were linked to lasting joint pain and arthritis. Researchers found that antibodies to a specific viral protein called NS1 were more common in people who developed chronic arthritis months or years after the infection, but were not associated with arthritis during the acute illness itself.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

Bone density and body composition in young women with chronic fatigue syndrome.

Hoskin, L, Clifton-Bligh, P, Hansen, R et al.·Annals of the New York Academy of Sciences·2000

This study looked at bone health and body composition in young women with ME/CFS compared to healthy controls. Researchers used specialized scanning technology to measure bone density and muscle/fat distribution. The findings help us understand whether ME/CFS affects physical body structure in ways that might contribute to health concerns.

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Neuropsychological function in patients with chronic fatigue syndrome, multiple sclerosis, and depression.

Multiple chemical sensitivity and chronic fatigue syndrome in British Gulf War veterans.

A twin study of chronic fatigue.

Interpretation of symptoms in chronic fatigue syndrome.

Frequency of attendance in general practice and symptoms before development of chronic fatigue syndrome: a case-control study.

Normal carnitine levels in patients with chronic fatigue syndrome.

Chronic fatigue syndrome in patients with Lyme borreliosis.

Self-reported sensitivity to chemical exposures in five clinical populations and healthy controls.

Neurally mediated hypotension in fatigued Gulf War veterans: a preliminary report.

Dysautonomia in chronic fatigue syndrome vs. fibromyalgia.

Cerebral perfusion in chronic fatigue syndrome and depression.

Coping strategies in twins with chronic fatigue and chronic fatigue syndrome.

Frequent HHV-6 reactivation in multiple sclerosis (MS) and chronic fatigue syndrome (CFS) patients.

Significant other responses are associated with fatigue and functional status among patients with chronic fatigue syndrome.

Antibodies to squalene in Gulf War syndrome.

Exercise capacity in chronic fatigue syndrome.

Stressors, personality traits, and coping of Gulf War veterans with chronic fatigue.

Symptom patterns in long-duration chronic fatigue syndrome.

Antibodies to parvovirus B19 non-structural protein are associated with chronic but not acute arthritis following B19 infection.

Bone density and body composition in young women with chronic fatigue syndrome.

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