ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

2421–2440 of 2,807 studies

E2 ModerateCohortPEM unclearCross-Sectional

Chronic Fatigue Syndrome and Primary Fibromyalgia Syndrome as recognized by GPs.

Bazelmans, E, Vercoulen, J H, Swanink, C M et al.·Family practice·1999

This Dutch study surveyed general practitioners (GPs) to understand how often they see patients with chronic fatigue syndrome (CFS) and fibromyalgia syndrome (FMS) in their practices. About 60% of GPs responded, and most reported seeing patients with these conditions. The study estimated that roughly 112 out of every 100,000 people have CFS and 157 have FMS, though these numbers are likely underestimates since some cases may go unrecognized.

Diagnostics

E2 ModerateBehavioralPEM not requiredCase-Control

Critical life events, infections, and symptoms during the year preceding chronic fatigue syndrome (CFS): an examination of CFS patients and subjects with a nonspecific life crisis.

Theorell, T, Blomkvist, V, Lindh, G et al.·Psychosomatic medicine·1999

This study looked at whether stressful life events and infections in the months before ME/CFS develops might play a role in triggering the illness. Researchers interviewed 46 people with ME/CFS and 46 matched control subjects without the illness, asking them to recall what happened and how they felt month-by-month for a year. They found that people who developed ME/CFS experienced more infections and stressful events—especially in the 3 months right before onset—and their fatigue, pain, and fever symptoms stayed very high even after diagnosis, unlike the control group who recovered.

E2 ModerateCohortPEM not requiredCross-Sectional

The 1microg short Synacthen test in chronic fatigue syndrome.

Hudson, M, Cleare, A J·Clinical endocrinology·1999

This study tested whether people with ME/CFS have lower levels of cortisol (a stress hormone) or weaker adrenal gland responses compared to healthy people. Researchers gave small doses of a hormone called Synacthen to 20 ME/CFS patients and 20 healthy controls, then measured cortisol levels over an hour. They found no significant differences between the two groups, suggesting that reduced adrenal reserve may not explain ME/CFS symptoms.

Endocrine Disruption

E2 ModerateBehavioralPEM unclearCross-Sectional

Psychiatric diagnoses in Gulf War veterans with fatiguing illness.

Lange, G, Tiersky, L, DeLuca, J et al.·Psychiatry research·1999

Researchers studied Gulf War veterans with severe fatigue to see whether psychiatric disorders could explain their illness. About half of the veterans with Gulf War Illness had similar rates of psychiatric diagnoses as healthy veterans, while the other half had more psychiatric problems. The study found that psychiatric conditions alone cannot account for the fatiguing illness these veterans experience.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

[Patients with fatigue in family practice: prevalence and treatment].

Kenter, E G, Okkes, I M·Nederlands tijdschrift voor geneeskunde·1999

This study looked at how often people visit their doctor complaining of fatigue and what doctors do about it. Researchers tracked visits from general practitioners across the Netherlands over 10 years, involving over 93,000 patient visits. They found that about 92 out of every 1,000 patients saw their doctor each year because of fatigue, but only about 4% had fatigue lasting 6 months or longer.

Diagnostics

E2 ModerateCohortPEM unclearCross-Sectional

Multiple mycoplasmal infections detected in blood of patients with chronic fatigue syndrome and/or fibromyalgia syndrome.

Nasralla, M, Haier, J, Nicolson, G L·European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·1999

Researchers tested blood samples from 91 patients with ME/CFS and/or fibromyalgia who already tested positive for mycoplasma bacteria. They found that most patients carried multiple types of mycoplasma—particularly Mycoplasma pneumoniae and Mycoplasma fermentans—and some patients had two or even three different mycoplasma species at the same time. Patients with multiple infections tended to have been sick longer, suggesting they may have picked up additional infections over time.

E2 ModerateCohortPEM not requiredObservational

Metal-specific lymphocytes: biomarkers of sensitivity in man.

Stejskal, Vera DM, Danersund, Antero, Lindvall, Anders et al.·Neuro endocrinology letters·1999

This study tested whether people with ME/CFS-like symptoms had immune reactions to metals in their dental fillings and other restorations. Researchers found that many patients had immune cells that reacted to metals like mercury, nickel, and gold, and that 76% of patients who replaced their metal restorations with non-metal alternatives reported feeling better. The study suggests that metal sensitivity might trigger inflammatory responses that contribute to chronic fatigue and related conditions.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Psychological states and neuropsychological performances in chronic Lyme disease.

Elkins, L E, Pollina, D A, Scheffer, S R et al.·Applied neuropsychology·1999

This study looked at mood and thinking abilities in 30 people with post-Lyme syndrome (a condition that can develop after Lyme disease). Researchers found that these patients had lower levels of positive feelings (like happiness or hopefulness) compared to the general population, but their actual thinking and memory skills tested normally. The study suggests that reduced positive mood, rather than depression or other psychiatric conditions, may be the most important psychological marker of this illness.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Attention and information processing efficiency in patients with Chronic Fatigue Syndrome.

Michiels, V, de Gucht, V, Cluydts, R et al.·Journal of clinical and experimental neuropsychology·1999

This study tested thinking and memory skills in 29 people with ME/CFS and compared them to 22 healthy people of similar age and education. The results showed that people with ME/CFS had slower thinking speed and difficulty processing information efficiently, but their ability to shift attention or focus on specific visual tasks was not notably impaired. Interestingly, memory problems appeared to stem from difficulty storing new information initially, rather than trouble recalling it later.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Melatonin levels in women with fibromyalgia and chronic fatigue syndrome.

Korszun, A, Sackett-Lundeen, L, Papadopoulos, E et al.·The Journal of rheumatology·1999

This study looked at melatonin—a hormone that helps control sleep and daily rhythms—in women with fibromyalgia and chronic fatigue syndrome. Researchers collected blood samples every 10 minutes over 24 hours and found that women with fibromyalgia had higher melatonin levels at night compared to healthy controls, but women with chronic fatigue syndrome did not. The authors concluded there is no evidence that taking melatonin supplements would help these patients.

Sleep

E2 ModerateCohortPEM not requiredCross-Sectional

Comparison of Euroqol EQ-5D and SF-36 in patients with chronic fatigue syndrome.

Myers, C, Wilks, D·Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·1999

This study compared two common questionnaires that measure quality of life and health status in people with ME/CFS. Researchers gave both questionnaires to 85 patients and found that the results from the two tests were very similar to each other. The study found that people with ME/CFS reported high levels of physical disability and moderate emotional or psychological problems.

E2 ModerateCohortPEM not requiredCross-Sectional

Prevalence of chronic fatigue and chemical sensitivities in Gulf Registry Veterans.

Kipen, H M, Hallman, W, Kang, H et al.·Archives of environmental health·1999

This study looked at symptoms reported by Gulf War veterans to see how many experienced chronic fatigue and chemical sensitivities. Researchers found that about 16% of veterans met the standard criteria for ME/CFS, about 13% had multiple chemical sensitivities, and a small percentage had both conditions. The findings suggest these conditions were common among Gulf War veterans, though the study was based only on questionnaire responses rather than medical exams.

Pain and Sensitization

E2 ModerateBehavioralPEM unclearCross-Sectional

Examination of Cloninger's basic dimensions of personality in fatiguing illness: chronic fatigue syndrome and multiple sclerosis.

Christodoulou, C, Deluca, J, Johnson, S K et al.·Journal of psychosomatic research·1999

This study looked at personality traits in people with ME/CFS compared to healthy people and those with multiple sclerosis (MS). The researchers used a personality framework that measures how people respond to harm, seek rewards, and persist with goals. Both ME/CFS and MS patients showed similar patterns: they were more cautious about potential harm and less focused on social rewards than healthy controls.

E2 ModerateCohortPEM not requiredCross-Sectional

Orthostatic intolerance in the chronic fatigue syndrome.

Schondorf, R, Benoit, J, Wein, T et al.·Journal of the autonomic nervous system·1999

This study looked at whether ME/CFS patients experience problems with blood pressure and heart rate when standing up quickly, a condition called orthostatic intolerance. Researchers tested 75 ME/CFS patients and 48 healthy controls using a tilt table test and other physical challenges. They found that 40% of ME/CFS patients had orthostatic intolerance compared to fewer healthy controls, suggesting this may be an important symptom in some patients that could be treated.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

[31P-mr spectroscopy of peripheral skeletal musculature under load: demonstration of normal energy metabolites compared with metabolic muscle diseases].

Block, W, Träber, F, Kuhl, C K et al.·RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin·1998

Researchers used a special MRI scanner to measure how muscles use energy during exercise by looking at chemical changes in the calf. They found that healthy people used two different types of energy pathways during exercise, while people with ME/CFS showed unusual resting energy levels but normal recovery after exercise—unlike patients with genetic metabolic disorders, whose muscles recovered very slowly.

Biomarkers

E2 ModerateCohortPEM not requiredCross-Sectional

Long- and short-term blood pressure and RR-interval variability and psychosomatic distress in chronic fatigue syndrome.

Duprez, D A, De Buyzere, M L, Drieghe, B et al.·Clinical science (London, England : 1979)·1998

Researchers compared blood pressure and heart rate patterns in people with ME/CFS to healthy controls. They found that people with ME/CFS had normal blood pressure readings, but their heart rates were consistently higher. When lying down, people with ME/CFS also showed reduced variability in blood pressure patterns compared to healthy controls.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCase-Control

Reproductive correlates of chronic fatigue syndrome.

Harlow, B L, Signorello, L B, Hall, J E et al.·The American journal of medicine·1998

This study compared reproductive and menstrual histories in women with ME/CFS to healthy women without the condition. Women with ME/CFS reported more gynecologic problems and irregular menstrual cycles, and researchers found signs suggesting ovarian dysfunction—such as polycystic ovary syndrome (PCOS)—occurred more often in the ME/CFS group. The authors propose that hormonal imbalances affecting egg release may contribute to ME/CFS by reducing protective immune effects from certain hormones.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Attention and verbal learning in patients with chronic fatigue syndrome.

Michiels, V, Cluydts, R, Fischler, B·Journal of the International Neuropsychological Society : JINS·1998

This study tested thinking and memory skills in 20 people with ME/CFS and compared them to 22 healthy people. The researchers found that people with ME/CFS had difficulty with attention tasks that required handling multiple pieces of information at once, and they performed worse on remembering spoken information. However, their ability to focus on a single thing while ignoring distractions appeared to work normally.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Factor analysis of unexplained severe fatigue and interrelated symptoms: overlap with criteria for chronic fatigue syndrome.

Nisenbaum, R, Reyes, M, Mawle, A C et al.·American journal of epidemiology·1998

Researchers surveyed over 1,500 people to understand how severe fatigue and related symptoms cluster together. They found that when fatigue lasts 6 months or longer, it tends to occur alongside three groups of symptoms: mood and thinking problems, flu-like symptoms, and vision problems. This pattern of symptoms matches what doctors use to diagnose ME/CFS, suggesting these conditions share common features.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Early life stress, negative paternal relationships, and chemical intolerance in middle-aged women: support for a neural sensitization model.

Bell, I R, Baldwin, C M, Russek, L G et al.·Journal of women's health·1998

This study looked at whether women with chemical sensitivity (difficulty tolerating everyday chemicals) had experienced more childhood stress or difficult relationships with their fathers compared to women with depression alone or women without these conditions. The researchers found that women with chemical sensitivity had weaker relationships with their fathers and showed signs of nervous system overactivity. The study suggests that repeated exposure to stress early in life might train the nervous system to react more strongly to chemicals and other triggers.

Autonomic Nervous System

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Evidence browser

Chronic Fatigue Syndrome and Primary Fibromyalgia Syndrome as recognized by GPs.

Critical life events, infections, and symptoms during the year preceding chronic fatigue syndrome (CFS): an examination of CFS patients and subjects with a nonspecific life crisis.

The 1microg short Synacthen test in chronic fatigue syndrome.

Psychiatric diagnoses in Gulf War veterans with fatiguing illness.

[Patients with fatigue in family practice: prevalence and treatment].

Multiple mycoplasmal infections detected in blood of patients with chronic fatigue syndrome and/or fibromyalgia syndrome.

Metal-specific lymphocytes: biomarkers of sensitivity in man.

Psychological states and neuropsychological performances in chronic Lyme disease.

Attention and information processing efficiency in patients with Chronic Fatigue Syndrome.

Melatonin levels in women with fibromyalgia and chronic fatigue syndrome.

Comparison of Euroqol EQ-5D and SF-36 in patients with chronic fatigue syndrome.

Prevalence of chronic fatigue and chemical sensitivities in Gulf Registry Veterans.

Examination of Cloninger's basic dimensions of personality in fatiguing illness: chronic fatigue syndrome and multiple sclerosis.

Orthostatic intolerance in the chronic fatigue syndrome.

[31P-mr spectroscopy of peripheral skeletal musculature under load: demonstration of normal energy metabolites compared with metabolic muscle diseases].

Long- and short-term blood pressure and RR-interval variability and psychosomatic distress in chronic fatigue syndrome.

Reproductive correlates of chronic fatigue syndrome.

Attention and verbal learning in patients with chronic fatigue syndrome.

Factor analysis of unexplained severe fatigue and interrelated symptoms: overlap with criteria for chronic fatigue syndrome.

Early life stress, negative paternal relationships, and chemical intolerance in middle-aged women: support for a neural sensitization model.

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