ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2768 studies

2421–2440 of 2,768 studies

E2 ModerateCohortPEM unclearCross-Sectional

Effects of exercise on cognitive and motor function in chronic fatigue syndrome and depression.

Blackwood, S K, MacHale, S M, Power, M J et al.·Journal of neurology, neurosurgery, and psychiatry·1998

This study compared how people with ME/CFS, people with depression, and healthy people performed on thinking and strength tests before and after exercise on a treadmill. People with ME/CFS reported feeling much more tired and struggling harder during the exercise than the other groups. After exercising, people with ME/CFS had bigger drops in their ability to focus and pay attention compared to healthy people, suggesting that exercise affects their thinking ability in a specific way.

Post-Exertional Malaise

E2 ModerateBehavioralPEM not requiredLongitudinal

Longitudinal changes associated with improvement in chronic fatigue patients.

Russo, J, Katon, W, Clark, M et al.·Journal of psychosomatic research·1998

Researchers followed people with chronic fatigue for 2.5 years to see what changes were linked to getting better. They found that improvements in mood, reduction in psychiatric symptoms, and disappearance of physical examination findings were connected to people feeling less fatigued, functioning better, and returning to work. People who either never had chronic fatigue syndrome or only had it at the start of the study showed the most improvement.

E2 ModerateCohortPEM not requiredCross-Sectional

Relation between neuropsychological impairment and functional disability in patients with chronic fatigue syndrome.

Christodoulou, C, DeLuca, J, Lange, G et al.·Journal of neurology, neurosurgery, and psychiatry·1998

This study looked at whether memory and attention problems in ME/CFS patients are linked to how much their daily activities are limited. Researchers tested 53 ME/CFS patients and 32 healthy people on memory and concentration, and found that patients with more failing test scores reported spending significantly more days inactive. Importantly, this connection held true even when accounting for depression, suggesting the cognitive problems themselves—not just mood—contribute to disability.

Cognitive Impairment

E2 ModerateCohortPEM not requiredObservational

Alteration of spatial-temporal parameters of gait in Chronic Fatigue Syndrome patients.

Saggini, R, Pizzigallo, E, Vecchiet, J et al.·Journal of the neurological sciences·1998

This study looked at how people with ME/CFS walk compared to healthy people. Researchers used specialized movement analysis tools to measure walking patterns in 12 patients and found clear differences in how smoothly and symmetrically they walked. Interestingly, these walking problems appeared right from the start of walking, not after fatigue set in, suggesting the issue may be related to how the brain controls movement rather than muscle tiredness.

E2 ModerateCohortPEM not requiredCross-Sectional

Multiplex PCR for the detection of Mycoplasma fermentans, M. hominis and M. penetrans in cell cultures and blood samples of patients with chronic fatigue syndrome.

Choppa, P C, Vojdani, A, Tagle, C et al.·Molecular and cellular probes·1998

Researchers developed a test to detect three types of bacteria called mycoplasmas in blood samples from ME/CFS patients and healthy people. They found these bacteria were much more common in ME/CFS patients (52% had some mycoplasma species) compared to healthy controls (15%), suggesting a possible link between these infections and ME/CFS.

E2 ModerateBehavioralPEM not requiredCross-Sectional

The relationship between temporomandibular disorders and stress-associated syndromes.

Korszun, A, Papadopoulos, E, Demitrack, M et al.·Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics·1998

This study looked at how often jaw joint problems (temporomandibular disorder) occur together with ME/CFS and fibromyalgia. Researchers found that 42% of patients with these conditions also had jaw problems, and most of these patients had developed their general symptoms before their jaw pain started. Interestingly, most were treated only for the jaw problem with bite splints, even though they had multiple related conditions.

Endocrine Disruption

E2 ModerateCohortPEM not requiredCross-Sectional

Immunologic parameters in chronic fatigue syndrome, major depression, and multiple sclerosis.

Natelson, B H, LaManca, J J, Denny, T N et al.·The American journal of medicine·1998

Researchers compared blood immune system markers between ME/CFS patients, people with depression, people with multiple sclerosis, and healthy controls. They measured 18 different immune system measurements, looking for signs that ME/CFS involves immune system problems. The study found only minor differences in one immune protein between ME/CFS patients and healthy controls, and these differences disappeared when comparing across all three disease groups.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

Post-infection fatigue syndrome following Q fever.

Ayres, J G, Flint, N, Smith, E G et al.·QJM : monthly journal of the Association of Physicians·1998

This study followed 71 people in the UK who were infected with Q fever (a bacterial infection) in 1989 and compared them to 142 similar people who were not infected. Five years later, the infected group reported significantly more fatigue, sweating, breathlessness, and blurred vision than the control group. About 42% of the infected patients met the diagnostic criteria for chronic fatigue syndrome, suggesting that a single Q fever infection can lead to long-lasting tiredness and related symptoms in some people.

E2 ModerateBehavioralPEM not requiredObservational

A naturalistic study of the chronic fatigue syndrome among women in primary care.

Saltzstein, B J, Wyshak, G, Hubbuch, J T et al.·General hospital psychiatry·1998

This study interviewed 15 women with ME/CFS about their experiences and what helped them cope with the illness. Researchers found that 60% of the women reported improvement or recovery. Having strong support from family and friends, a supportive doctor who believed in the diagnosis, and lower depression symptoms were associated with better outcomes.

E2 ModerateCohortPEM not requiredCross-Sectional

Long- and short-term blood pressure and RR-interval variability and psychosomatic distress in chronic fatigue syndrome.

Duprez, D A, De Buyzere, M L, Drieghe, B et al.·Clinical science (London, England : 1979)·1998

Researchers compared blood pressure and heart rate patterns in people with ME/CFS to healthy controls. They found that people with ME/CFS had normal blood pressure readings, but their heart rates were consistently higher. When lying down, people with ME/CFS also showed reduced variability in blood pressure patterns compared to healthy controls.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

The epidemiology of chronic fatigue in San Francisco.

Steele, L, Dobbins, J G, Fukuda, K et al.·The American journal of medicine·1998

Researchers surveyed nearly 17,000 people in San Francisco to understand how common ME/CFS and related chronic fatigue conditions are. They found that about 2% of adults reported unexplained chronic fatigue, with only 0.2% meeting criteria for ME/CFS-like illness. The conditions were more common in women, people with lower incomes, and certain racial groups, but did not run in families.

E2 ModerateBehavioralPEM not requiredCase-Control

Chronic fatigue syndrome: identification of distinct subgroups on the basis of allergy and psychologic variables.

Borish, L, Schmaling, K, DiClementi, J D et al.·The Journal of allergy and clinical immunology·1998

This study looked at whether allergies and psychological factors play a role in ME/CFS. Researchers compared 18 people with ME/CFS to healthy controls, people with allergies, and people with depression. They found that people with ME/CFS had different immune molecules (called cytokines) in their blood compared to healthy people, similar to those with allergies. Interestingly, people with ME/CFS who also had certain psychological profiles showed different immune patterns, suggesting that both allergies and how the mind responds to them may contribute to ME/CFS in some patients.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

Naloxone-mediated activation of the hypothalamic-pituitary-adrenal axis in chronic fatigue syndrome.

Scott, L V, Burnett, F, Medbak, S et al.·Psychological medicine·1998

This study looked at whether an opioid-blocking drug called naloxone could trigger the body's stress hormone system in ME/CFS patients versus healthy people. The researchers found that when given naloxone, ME/CFS patients had a blunted response in one stress hormone (ACTH) compared to healthy controls, suggesting that excess opioids are not the primary cause of the stress hormone problems seen in ME/CFS.

Endocrine Disruption

E2 ModerateCohortPEM not requiredCross-Sectional

Diurnal variation of adrenocortical activity in chronic fatigue syndrome.

MacHale, S M, Cavanagh, J T, Bennie, J et al.·Neuropsychobiology·1998

This study measured stress hormone (cortisol) levels in 30 ME/CFS patients and 15 healthy controls at different times of day. The researchers found that while individual cortisol measurements were similar between groups, ME/CFS patients showed a flattened pattern—their cortisol levels didn't drop as much in the evening as they should. Higher evening cortisol levels were connected to worse overall health and physical functioning in ME/CFS patients.

Endocrine Disruption

E2 ModerateBehavioralPEM not requiredCross-Sectional

Adaptive tasks, coping and quality of life of chronically ill patients: the cases of Parkinson's disease and chronic fatigue syndrome.

De Ridder, D T, Schreurs, K M, Bensing, J M·Journal of health psychology·1998

This study compared how people with Parkinson's disease and ME/CFS cope with the challenges their illnesses create and how this affects their quality of life. Researchers found that while both groups face similar types of challenges (like managing symptoms and adjusting daily life), the way these challenges affect quality of life differs between the two diseases. For people with ME/CFS, how patients think about and evaluate their illness challenges was more important in predicting their quality of life than the actual severity of their symptoms.

E2 ModerateCohortPEM not requiredCross-Sectional

Muscle fibre characteristics and lactate responses to exercise in chronic fatigue syndrome.

Lane, R J, Barrett, M C, Woodrow, D et al.·Journal of neurology, neurosurgery, and psychiatry·1998

Researchers examined muscle samples from 105 ME/CFS patients to understand why they have abnormal responses to exercise, particularly high lactate levels. They found that patients with high lactate responses had fewer type 1 muscle fibres (which are energy-efficient), but this wasn't because they were inactive—it appeared to be a specific muscle problem related to ME/CFS itself.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Low levels of serum acylcarnitine in chronic fatigue syndrome and chronic hepatitis type C, but not seen in other diseases.

Kuratsune, H, Yamaguti, K, Lindh, G et al.·International journal of molecular medicine·1998

Researchers measured a substance called acylcarnitine in the blood of people with ME/CFS and compared it to healthy people and those with other diseases. They found that people with ME/CFS had significantly lower levels of this substance, and this same pattern appeared in both Japanese and Swedish patients. Importantly, this low level was only seen in ME/CFS and one other condition (chronic hepatitis C), not in other common diseases like diabetes or high blood pressure.

BiomarkersEnergy Metabolism

E2 ModerateCohortPEM not requiredCross-Sectional

Serum neopterin and somatization in women with chemical intolerance, depressives, and normals.

Bell, I R, Patarca, R, Baldwin, C M et al.·Neuropsychobiology·1998

This study looked at a marker in the blood called neopterin, which may indicate immune system activation, in women with chemical sensitivity (difficulty tolerating everyday chemicals at low levels), women with depression, and healthy women. The researchers found that neopterin levels themselves were similar across groups, but in women with chemical sensitivity, higher neopterin levels were linked with more physical symptoms—a connection not seen in the other groups.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

Reproductive correlates of chronic fatigue syndrome.

Harlow, B L, Signorello, L B, Hall, J E et al.·The American journal of medicine·1998

This study compared reproductive and menstrual histories in women with ME/CFS to healthy women without the condition. Women with ME/CFS reported more gynecologic problems and irregular menstrual cycles, and researchers found signs suggesting ovarian dysfunction—such as polycystic ovary syndrome (PCOS)—occurred more often in the ME/CFS group. The authors propose that hormonal imbalances affecting egg release may contribute to ME/CFS by reducing protective immune effects from certain hormones.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

Nasal secretion analysis in allergic rhinitis, cystic fibrosis, and nonallergic fibromyalgia/chronic fatigue syndrome subjects.

Baraniuk, J N, Clauw, D, Yuta, A et al.·American journal of rhinology·1998

Many people with ME/CFS experience nasal congestion and rhinitis symptoms, but don't test positive for allergies. This study analyzed nasal fluid from ME/CFS patients and compared it to people with allergies, cystic fibrosis, and healthy controls to understand what might be causing these symptoms. The researchers found that ME/CFS patients' nasal fluid looked similar to healthy controls, suggesting that the constant baseline secretion processes in the nose are not abnormal in ME/CFS.

Immune System

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Effects of exercise on cognitive and motor function in chronic fatigue syndrome and depression.

Longitudinal changes associated with improvement in chronic fatigue patients.

Relation between neuropsychological impairment and functional disability in patients with chronic fatigue syndrome.

Alteration of spatial-temporal parameters of gait in Chronic Fatigue Syndrome patients.

Multiplex PCR for the detection of Mycoplasma fermentans, M. hominis and M. penetrans in cell cultures and blood samples of patients with chronic fatigue syndrome.

The relationship between temporomandibular disorders and stress-associated syndromes.

Immunologic parameters in chronic fatigue syndrome, major depression, and multiple sclerosis.

Post-infection fatigue syndrome following Q fever.

A naturalistic study of the chronic fatigue syndrome among women in primary care.

Long- and short-term blood pressure and RR-interval variability and psychosomatic distress in chronic fatigue syndrome.

The epidemiology of chronic fatigue in San Francisco.

Chronic fatigue syndrome: identification of distinct subgroups on the basis of allergy and psychologic variables.

Naloxone-mediated activation of the hypothalamic-pituitary-adrenal axis in chronic fatigue syndrome.

Diurnal variation of adrenocortical activity in chronic fatigue syndrome.

Adaptive tasks, coping and quality of life of chronically ill patients: the cases of Parkinson's disease and chronic fatigue syndrome.

Muscle fibre characteristics and lactate responses to exercise in chronic fatigue syndrome.

Low levels of serum acylcarnitine in chronic fatigue syndrome and chronic hepatitis type C, but not seen in other diseases.

Serum neopterin and somatization in women with chemical intolerance, depressives, and normals.

Reproductive correlates of chronic fatigue syndrome.

Nasal secretion analysis in allergic rhinitis, cystic fibrosis, and nonallergic fibromyalgia/chronic fatigue syndrome subjects.

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