ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2785 studies

2441–2460 of 2,785 studies

E2 ModerateCohortPEM not requiredCross-Sectional

Comparison of SPET brain perfusion and 18F-FDG brain metabolism in patients with chronic fatigue syndrome.

Abu-Judeh, H H, Levine, S, Kumar, M et al.·Nuclear medicine communications·1998

Researchers used two different types of brain scans to look at blood flow and energy use in patients with ME/CFS. They found that these two scans gave different results: many patients had abnormal blood flow patterns, but most had normal energy metabolism. This suggests that ME/CFS may affect how blood moves through the brain differently than how the brain uses glucose for energy.

E2 ModerateReviewPEM not requiredReview-Narrative

Relationship Between Chronic Fatigue Syndrome and Neurally Mediated Hypotension.

Calkins, H, Rowe, PC·Cardiology in review·1998

This study explored a possible connection between ME/CFS and a condition called neurally mediated hypotension, where blood pressure drops suddenly due to problems with nerve signals that control blood vessels. Researchers found that when they treated patients for this blood pressure problem, about two-thirds of ME/CFS patients felt better. While these early results were promising, the study notes that larger, more rigorous trials were needed to confirm whether this treatment truly helps.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Basal activity of the hypothalamic-pituitary-adrenal axis in patients with the chronic fatigue syndrome (neurasthenia).

Young, A H, Sharpe, M, Clements, A et al.·Biological psychiatry·1998

This study tested whether people with ME/CFS have abnormal levels of cortisol, a stress hormone, by measuring it in saliva and urine over 24 hours. The researchers found no difference in cortisol levels between people with ME/CFS and healthy controls, suggesting that the baseline cortisol system may not be impaired in this condition.

Endocrine Disruption

E2 ModerateCohortPEM not requiredCross-Sectional

Relation between neuropsychological impairment and functional disability in patients with chronic fatigue syndrome.

Christodoulou, C, DeLuca, J, Lange, G et al.·Journal of neurology, neurosurgery, and psychiatry·1998

This study looked at whether memory and attention problems in ME/CFS patients are linked to how much their daily activities are limited. Researchers tested 53 ME/CFS patients and 32 healthy people on memory and concentration, and found that patients with more failing test scores reported spending significantly more days inactive. Importantly, this connection held true even when accounting for depression, suggesting the cognitive problems themselves—not just mood—contribute to disability.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredCross-Sectional

The relationship between temporomandibular disorders and stress-associated syndromes.

Korszun, A, Papadopoulos, E, Demitrack, M et al.·Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics·1998

This study looked at how often jaw joint problems (temporomandibular disorder) occur together with ME/CFS and fibromyalgia. Researchers found that 42% of patients with these conditions also had jaw problems, and most of these patients had developed their general symptoms before their jaw pain started. Interestingly, most were treated only for the jaw problem with bite splints, even though they had multiple related conditions.

Endocrine Disruption

E2 ModerateBehavioralPEM not requiredCross-Sectional

Coping and adaptive outcome in chronic fatigue syndrome: importance of illness cognitions.

Heijmans, M J·Journal of psychosomatic research·1998

This study looked at how 98 ME/CFS patients' beliefs about their illness affected how they coped with it and their quality of life. The researchers found that patients who believed their illness was serious, couldn't be controlled, and couldn't be cured tended to cope passively and experienced worse physical functioning, social problems, and mental health issues. Importantly, these beliefs about the illness itself were stronger predictors of these outcomes than the coping strategies people used.

E2 ModerateCohortPEM not requiredCross-Sectional

Exploring the validity of the Chalder Fatigue scale in chronic fatigue syndrome.

Morriss, R K, Wearden, A J, Mullis, R·Journal of psychosomatic research·1998

This study tested whether the Chalder Fatigue Scale—a common questionnaire used to measure tiredness in ME/CFS patients—actually measures what it claims to measure. Researchers analyzed responses from 136 ME/CFS patients and found that fatigue has four distinct components: mental tiredness (linked to thinking problems), sleep difficulties, physical weakness (linked to low fitness), and depression. The results suggest the 11-item version of the scale works better than the original 14-item version for measuring fatigue in ME/CFS.

SleepCognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Serum neopterin and somatization in women with chemical intolerance, depressives, and normals.

Bell, I R, Patarca, R, Baldwin, C M et al.·Neuropsychobiology·1998

This study looked at a marker in the blood called neopterin, which may indicate immune system activation, in women with chemical sensitivity (difficulty tolerating everyday chemicals at low levels), women with depression, and healthy women. The researchers found that neopterin levels themselves were similar across groups, but in women with chemical sensitivity, higher neopterin levels were linked with more physical symptoms—a connection not seen in the other groups.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Impaired associative learning in chronic fatigue syndrome.

Servatius, R J, Tapp, W N, Bergen, M T et al.·Neuroreport·1998

This study tested whether people with ME/CFS have problems with how their brain learns and forms connections between different pieces of information. Researchers measured brain learning using a test where a gentle puff of air is paired with an eye blink stimulus. While ME/CFS patients could hear and feel the stimuli normally, they had difficulty learning to associate the two stimuli together—suggesting their brain's ability to form certain types of connections may be affected.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Detection of Mycoplasma genus and Mycoplasma fermentans by PCR in patients with Chronic Fatigue Syndrome.

Vojdani, A, Choppa, P C, Tagle, C et al.·FEMS immunology and medical microbiology·1998

Researchers tested blood samples from 100 ME/CFS patients and 50 healthy people to see if a bacterium called Mycoplasma fermentans was present. They found this bacterium's genetic material in more than a third of ME/CFS patients compared to only 8% of healthy controls. Patients with higher amounts of the bacterium also had stronger immune responses against it, suggesting their bodies were reacting to the infection.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Influence of exhaustive treadmill exercise on cognitive functioning in chronic fatigue syndrome.

LaManca, J J, Sisto, S A, DeLuca, J et al.·The American journal of medicine·1998

This study looked at how exercise affects thinking and mental processing in people with ME/CFS compared to healthy people. Both groups did exhausting exercise on a treadmill, then took thinking tests right after and 24 hours later. People with ME/CFS performed worse on these thinking tests after exercise, particularly on tasks involving speed and attention, and their thinking stayed impaired the next day.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredObservational

Alteration of spatial-temporal parameters of gait in Chronic Fatigue Syndrome patients.

Saggini, R, Pizzigallo, E, Vecchiet, J et al.·Journal of the neurological sciences·1998

This study looked at how people with ME/CFS walk compared to healthy people. Researchers used specialized movement analysis tools to measure walking patterns in 12 patients and found clear differences in how smoothly and symmetrically they walked. Interestingly, these walking problems appeared right from the start of walking, not after fatigue set in, suggesting the issue may be related to how the brain controls movement rather than muscle tiredness.

E2 ModerateCohortPEM not requiredObservational

A study of the immunology of the chronic fatigue syndrome: correlation of immunologic parameters to health dysfunction.

Hassan, I S, Bannister, B A, Akbar, A et al.·Clinical immunology and immunopathology·1998

This study examined immune system markers in 44 people with ME/CFS to see how these markers related to symptom severity and mental health. Researchers found that ME/CFS patients had unusual patterns in their immune cells—specifically, signs of increased immune activation and changes in how lymphocytes (white blood cells) behave. These immune changes correlated with worse physical function, pain, and mental health symptoms.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Correlations among Epworth Sleepiness Scale scores, multiple sleep latency tests and psychological symptoms.

Olson, L G, Cole, M F, Ambrogetti, A·Journal of sleep research·1998

This study looked at whether a simple questionnaire about daytime sleepiness (the Epworth Sleepiness Scale) actually measures the same thing as a more complex sleep test that measures how quickly people fall asleep. The researchers found that these two tests don't measure the same thing—the questionnaire is influenced by mood and psychological symptoms, while the objective sleep test is not.

Sleep

E2 ModerateBehavioralPEM not requiredCase-Control

Chronic fatigue syndrome: identification of distinct subgroups on the basis of allergy and psychologic variables.

Borish, L, Schmaling, K, DiClementi, J D et al.·The Journal of allergy and clinical immunology·1998

This study looked at whether allergies and psychological factors play a role in ME/CFS. Researchers compared 18 people with ME/CFS to healthy controls, people with allergies, and people with depression. They found that people with ME/CFS had different immune molecules (called cytokines) in their blood compared to healthy people, similar to those with allergies. Interestingly, people with ME/CFS who also had certain psychological profiles showed different immune patterns, suggesting that both allergies and how the mind responds to them may contribute to ME/CFS in some patients.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Urinary free cortisol excretion in chronic fatigue syndrome, major depression and in healthy volunteers.

Scott, L V, Dinan, T G·Journal of affective disorders·1998

This study measured a stress hormone called cortisol in urine samples from people with ME/CFS, people with depression, and healthy individuals. The researchers found that people with ME/CFS had lower cortisol levels than healthy people, while people with depression had higher levels. This suggests that ME/CFS and depression affect the body's stress response system in opposite ways.

Endocrine Disruption

E2 ModerateBehavioralPEM not requiredObservational

A naturalistic study of the chronic fatigue syndrome among women in primary care.

Saltzstein, B J, Wyshak, G, Hubbuch, J T et al.·General hospital psychiatry·1998

This study interviewed 15 women with ME/CFS about their experiences and what helped them cope with the illness. Researchers found that 60% of the women reported improvement or recovery. Having strong support from family and friends, a supportive doctor who believed in the diagnosis, and lower depression symptoms were associated with better outcomes.

E2 ModerateBehavioralPEM not requiredCross-Sectional

The persistence of fatigue in chronic fatigue syndrome and multiple sclerosis: development of a model.

Vercoulen, J H, Swanink, C M, Galama, J M et al.·Journal of psychosomatic research·1998

This study tested whether thoughts, behaviors, and emotions affect how severe fatigue becomes and stays in ME/CFS patients. Researchers found that when patients believe their symptoms are purely physical, they tend to be less active, which makes fatigue worse. They also found that how much control patients felt they had over symptoms and how much they focused on body sensations directly affected fatigue levels. Importantly, the patterns that explained fatigue in ME/CFS were different from those in MS patients.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCase-Control

Yersinia enterocolitica and the chronic fatigue syndrome.

Swanink, C M, Stolk-Engelaar, V M, van der Meer, J W et al.·The Journal of infection·1998

This study looked for signs that a bacterium called Yersinia enterocolitica might cause ME/CFS by testing blood samples from 88 ME/CFS patients and 77 healthy people. Researchers found that antibodies (immune markers) to this bacterium were equally common in both groups, suggesting this particular infection is unlikely to be a major cause of ME/CFS.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Prevalence of chronic fatigue syndrome in a community population in Japan.

Kawakami, N, Iwata, N, Fujihara, S et al.·The Tohoku journal of experimental medicine·1998

This Japanese study looked at how common ME/CFS is in everyday communities by interviewing 137 people. Researchers found that about 1 in 67 people had severe, persistent fatigue that met ME/CFS criteria and significantly disrupted their daily life. The findings suggested ME/CFS might be more common in Japan than in Western countries studied previously.

Diagnostics

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Comparison of SPET brain perfusion and 18F-FDG brain metabolism in patients with chronic fatigue syndrome.

Relationship Between Chronic Fatigue Syndrome and Neurally Mediated Hypotension.

Basal activity of the hypothalamic-pituitary-adrenal axis in patients with the chronic fatigue syndrome (neurasthenia).

Relation between neuropsychological impairment and functional disability in patients with chronic fatigue syndrome.

The relationship between temporomandibular disorders and stress-associated syndromes.

Coping and adaptive outcome in chronic fatigue syndrome: importance of illness cognitions.

Exploring the validity of the Chalder Fatigue scale in chronic fatigue syndrome.

Serum neopterin and somatization in women with chemical intolerance, depressives, and normals.

Impaired associative learning in chronic fatigue syndrome.

Detection of Mycoplasma genus and Mycoplasma fermentans by PCR in patients with Chronic Fatigue Syndrome.

Influence of exhaustive treadmill exercise on cognitive functioning in chronic fatigue syndrome.

Alteration of spatial-temporal parameters of gait in Chronic Fatigue Syndrome patients.

A study of the immunology of the chronic fatigue syndrome: correlation of immunologic parameters to health dysfunction.

Correlations among Epworth Sleepiness Scale scores, multiple sleep latency tests and psychological symptoms.

Chronic fatigue syndrome: identification of distinct subgroups on the basis of allergy and psychologic variables.

Urinary free cortisol excretion in chronic fatigue syndrome, major depression and in healthy volunteers.

A naturalistic study of the chronic fatigue syndrome among women in primary care.

The persistence of fatigue in chronic fatigue syndrome and multiple sclerosis: development of a model.

Yersinia enterocolitica and the chronic fatigue syndrome.

Prevalence of chronic fatigue syndrome in a community population in Japan.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research