ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2808 studies

2621–2640 of 2,808 studies

E2 ModerateCohortPEM not requiredCross-Sectional

Detection of human herpesvirus 6 in plasma of children with primary infection and immunosuppressed patients by polymerase chain reaction.

Secchiero, P, Carrigan, D R, Asano, Y et al.·The Journal of infectious diseases·1995

Researchers developed a sensitive test to detect human herpesvirus 6 (HHV-6) DNA in blood. They tested blood samples from children with a specific rash illness, bone marrow transplant patients, HIV-infected patients, people with chronic fatigue syndrome (ME/CFS), and healthy adults. The test found HHV-6 DNA most often in children with the rash illness, less commonly in transplant and HIV patients, rarely in ME/CFS patients, and not at all in healthy people.

E2 ModerateBehavioralPEM unclearObservational

Exercise responses and psychiatric disorder in chronic fatigue syndrome.

Lane, R J, Burgess, A P, Flint, J et al.·BMJ (Clinical research ed.)·1995

This study looked at how people with ME/CFS respond to exercise and whether they experience psychiatric problems like depression or anxiety. Researchers examined whether exercise responses and psychiatric symptoms are connected in ME/CFS patients. The study helps clarify the relationship between physical symptoms and mental health in this condition.

E2 ModerateCohortPEM not requiredCross-Sectional

Quality of life in chronic fatigue syndrome.

Schweitzer, R, Kelly, B, Foran, A et al.·Social science & medicine (1982)·1995

This 1995 study compared 47 people with ME/CFS to 30 healthy controls to understand how the condition affects daily life and well-being. Using surveys and interviews, researchers found that ME/CFS patients experienced significantly worse quality of life, particularly in social activities and relationships. The findings showed that isolation and loss of ability to work or participate in hobbies were major impacts that deserved more clinical attention.

E2 ModerateCohortPEM not requiredCross-Sectional

Comparison of coxsackie B neutralisation and enteroviral PCR in chronic fatigue patients.

Nairn, C, Galbraith, D N, Clements, G B·Journal of medical virology·1995

Researchers tested whether two different methods of detecting enterovirus (a type of virus) could identify it in ME/CFS patients. One method looked for antibodies (immune proteins) the body makes against Coxsackie B virus, while the other used PCR to directly detect viral genetic material. They found that the PCR test was better at distinguishing ME/CFS patients from healthy people, but the antibody test could not tell the two groups apart.

E2 ModerateCohortPEM not requiredLongitudinal

[The Epstein-Barr virus and chronic fatigue syndrome].

Jovanović, J, Cvjetković, D, Brkić, S et al.·Medicinski pregled·1995

This small study looked at whether ME/CFS symptoms develop after people recover from infectious mononucleosis caused by Epstein-Barr virus (EBV). Researchers followed 31 patients who had recovered from mono and found that several developed ongoing fatigue, sore throats, and sleep problems in the months and years after their acute illness. The results suggest a possible connection between EBV infection and ME/CFS symptoms.

E2 ModerateCohortPEM not requiredCross-Sectional

Estimating rates of chronic fatigue syndrome from a community-based sample: a pilot study.

Jason, L A, Taylor, R, Wagner, L et al.·American journal of community psychology·1995

This study looked at how many people in the general community have ME/CFS by calling over 1,000 randomly selected households by telephone. Instead of relying on patients referred by doctors (which may miss people who can't afford care or distrust doctors), the researchers directly asked community members about their symptoms. They found that ME/CFS may be more common than previously thought, affecting about 0.2% of the population.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

Sleep disturbances and fatigue in women with fibromyalgia and chronic fatigue syndrome.

Schaefer, K M·Journal of obstetric, gynecologic, and neonatal nursing : JOGNN·1995

This study looked at sleep problems in women with fibromyalgia and chronic fatigue syndrome (CFS). Researchers found that both groups had significant sleep difficulties, and that trouble staying asleep was the most common sleep problem reported. There was a clear link between poor sleep and fatigue—women who slept poorly felt more tired.

Sleep

E2 ModerateCohortPEM not requiredCross-Sectional

Serum levels of carnitine in chronic fatigue syndrome: clinical correlates.

Plioplys, A V, Plioplys, S·Neuropsychobiology·1995

This study looked at carnitine, a substance that helps cells produce energy. Researchers found that people with ME/CFS have lower levels of carnitine in their blood compared to what would be expected. They also discovered that patients with higher carnitine levels reported better ability to function in daily life, suggesting a link between this energy-related chemical and symptom severity.

Energy Metabolism

E2 ModerateCohortPEM not requiredCross-Sectional

Vagal tone is reduced during paced breathing in patients with the chronic fatigue syndrome.

Sisto, S A, Tapp, W, Drastal, S et al.·Clinical autonomic research : official journal of the Clinical Autonomic Research Society·1995

This study looked at how the vagus nerve—which helps control heart rate and relaxation—works differently in people with ME/CFS compared to healthy people. Researchers had women with ME/CFS and healthy women breathe at different controlled rates while measuring their heart rate patterns. They found that people with ME/CFS had weaker vagal nerve activity overall, suggesting their nervous system may not be able to relax and recover as effectively as healthy people's.

Autonomic Nervous System

E2 ModerateBehavioralPEM not requiredCross-Sectional

"Abnormal" illness behaviour in chronic fatigue syndrome and multiple sclerosis.

Trigwell, P, Hatcher, S, Johnson, M et al.·BMJ (Clinical research ed.)·1995

This study compared how patients with ME/CFS and patients with multiple sclerosis (MS) responded to questions about their illness and health beliefs. Both groups showed similar patterns of thinking about their conditions, scoring high on worry about disease and low on recognizing psychological factors. The researchers concluded that these thinking patterns alone cannot prove ME/CFS is a psychological condition, since MS patients—who have a clearly physical disease—showed the same patterns.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Cognitive functioning and magnetic resonance imaging in chronic fatigue.

Cope, H, Pernet, A, Kendall, B et al.·The British journal of psychiatry : the journal of mental science·1995

This study tested whether people with chronic fatigue have real problems with thinking and memory, or whether these complaints are mainly due to depression and anxiety. Researchers gave cognitive tests and brain scans (MRI) to people with chronic fatigue, people with depression, and healthy controls. They found that people with chronic fatigue performed similarly to controls on objective tests, and brain scans showed no consistent abnormalities. The researchers concluded that complaints of cognitive problems were likely related to mood symptoms rather than physical brain changes.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredObservational

Life-events and the course of chronic fatigue syndrome.

Ray, C, Jefferies, S, Weir, W R·The British journal of medical psychology·1995

This study looked at whether major life events affect how ME/CFS progresses in patients. Researchers asked 130 patients about positive and negative events they experienced over a year and compared these to their fatigue, disability, anxiety, and depression levels. They found that positive life events were linked to less fatigue and better emotional wellbeing, while negative events were mainly associated with increased anxiety.

E2 ModerateCohortPEM not requiredObservational

Diagnosis in chronic illness: disabling or enabling--the case of chronic fatigue syndrome.

Woodward, R V, Broom, D H, Legge, D G·Journal of the Royal Society of Medicine·1995

This study looked at whether giving someone a CFS diagnosis helps or hurts them. Researchers interviewed 20 doctors and 50 CFS patients over 2 years. Most doctors were reluctant to diagnose CFS because they worried it might make patients feel worse, but patients actually found the diagnosis helpful because it finally explained what was wrong with them.

Diagnostics

E2 ModerateBehavioralPEM not requiredCross-Sectional

Coping with chronic fatigue syndrome: illness responses and their relationship with fatigue, functional impairment and emotional status.

Ray, C, Jefferies, S, Weir, W R·Psychological medicine·1995

This study looked at how different ways of coping with ME/CFS affected patients' symptoms and daily functioning. Researchers found that trying to stay active was linked to better functioning, while accepting the illness as permanent was linked to more disability. Giving up or withdrawing from activities was connected to both worse disability and emotional problems like depression or anxiety.

E2 ModerateBehavioralPEM unclearObservational

Can the chronic fatigue syndrome be defined by distinct clinical features?

Hickie, I, Lloyd, A, Hadzi-Pavlovic, D et al.·Psychological medicine·1995

This study examined whether all people diagnosed with ME/CFS have the same illness or whether they actually have different types. Researchers analyzed symptoms from 565 patients and found that ME/CFS is not one uniform condition—instead, they identified two distinct patient groups with different symptom patterns, illness duration, and recovery rates.

Diagnostics

E2 ModerateCohortPEM unclearCross-Sectional

Brainstem perfusion is impaired in chronic fatigue syndrome.

Costa, D C, Tannock, C, Brostoff, J·QJM : monthly journal of the Association of Physicians·1995

Researchers used a brain imaging technique to measure blood flow in the brains of ME/CFS patients and compared it to healthy people, as well as people with depression and epilepsy. They found that ME/CFS patients had consistently lower blood flow throughout their brains, especially in the brainstem—a critical area at the base of the brain that controls basic functions like breathing and heart rate. This pattern was distinct from what they saw in depressed patients, suggesting it may be a specific feature of ME/CFS.

E2 ModerateCohortPEM not requiredCross-Sectional

Abnormalities of carnitine metabolism in chronic fatigue syndrome.

Majeed, T, de Simone, C, Famularo, G et al.·European journal of neurology·1995

This study examined carnitine, a substance that helps cells produce energy, in people with ME/CFS. Researchers found that while carnitine levels in the blood were normal, the levels inside immune cells were significantly lower in ME/CFS patients compared to healthy people. This finding suggests that ME/CFS patients might benefit from taking carnitine supplements to restore normal energy production.

Immune System

E2 ModerateBehavioralPEM not requiredObservational

Postinfectious fatigue: prospective cohort study in primary care.

Wessely, S, Chalder, T, Hirsch, S et al.·Lancet (London, England)·1995

This study followed over 2,000 people in the UK to see whether common infections like colds and flu lead to chronic fatigue or ME/CFS. Researchers compared people who had recent infections with those who didn't, and checked them again 6 months later. They found no evidence that routine infections trigger ME/CFS—instead, people who were already tired or stressed before getting sick were more likely to experience fatigue afterward.

E2 ModerateCohortPEM not requiredCase-Control

The relationship between neurally mediated hypotension and the chronic fatigue syndrome.

Bou-Holaigah, I, Rowe, P C, Kan, J et al.·JAMA·1995

Researchers tested whether ME/CFS patients have an abnormal blood pressure response when standing upright. They tilted 23 ME/CFS patients and 14 healthy controls on a special table and monitored their vital signs. Nearly all ME/CFS patients showed an abnormal response, and about 9 patients felt much better after taking medications to treat low blood pressure.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCase-Control

Post-hepatitis syndrome revisited.

Berelowitz, G J, Burgess, A P, Thanabalasingham, T et al.·Journal of viral hepatitis·1995

This study followed 40 patients who had recovered from hepatitis A or B infection and compared them to 47 patients who recovered from other infections. Researchers found that people who had viral hepatitis reported significantly more fatigue, muscle pain, and mood changes even 6 months to 2.5 years after their liver function returned to normal. These symptoms were worse than in the comparison group, suggesting that hepatitis infection can trigger lasting fatigue and other problems even after the acute illness has passed.

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Detection of human herpesvirus 6 in plasma of children with primary infection and immunosuppressed patients by polymerase chain reaction.

Exercise responses and psychiatric disorder in chronic fatigue syndrome.

Quality of life in chronic fatigue syndrome.

Comparison of coxsackie B neutralisation and enteroviral PCR in chronic fatigue patients.

[The Epstein-Barr virus and chronic fatigue syndrome].

Estimating rates of chronic fatigue syndrome from a community-based sample: a pilot study.

Sleep disturbances and fatigue in women with fibromyalgia and chronic fatigue syndrome.

Serum levels of carnitine in chronic fatigue syndrome: clinical correlates.

Vagal tone is reduced during paced breathing in patients with the chronic fatigue syndrome.

"Abnormal" illness behaviour in chronic fatigue syndrome and multiple sclerosis.

Cognitive functioning and magnetic resonance imaging in chronic fatigue.

Life-events and the course of chronic fatigue syndrome.

Diagnosis in chronic illness: disabling or enabling--the case of chronic fatigue syndrome.

Coping with chronic fatigue syndrome: illness responses and their relationship with fatigue, functional impairment and emotional status.

Can the chronic fatigue syndrome be defined by distinct clinical features?

Brainstem perfusion is impaired in chronic fatigue syndrome.

Abnormalities of carnitine metabolism in chronic fatigue syndrome.

Postinfectious fatigue: prospective cohort study in primary care.

The relationship between neurally mediated hypotension and the chronic fatigue syndrome.

Post-hepatitis syndrome revisited.

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