ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2786 studies

2621–2640 of 2,786 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

Chronic fatigue syndrome in the community. Prevalence and associations.

Lawrie, S M, Pelosi, A J·The British journal of psychiatry : the journal of mental science·1995

This study surveyed over 1,000 people in a community to understand how common ME/CFS is and what it's associated with. Researchers found that about 0.56% of people met the criteria for ME/CFS, and they discovered a strong connection between fatigue and psychological distress. However, the authors concluded that ME/CFS should not be dismissed as purely a psychiatric disorder.

E2 ModerateCohortPEM not requiredCross-Sectional

Quality of life in chronic fatigue syndrome.

Schweitzer, R, Kelly, B, Foran, A et al.·Social science & medicine (1982)·1995

This 1995 study compared 47 people with ME/CFS to 30 healthy controls to understand how the condition affects daily life and well-being. Using surveys and interviews, researchers found that ME/CFS patients experienced significantly worse quality of life, particularly in social activities and relationships. The findings showed that isolation and loss of ability to work or participate in hobbies were major impacts that deserved more clinical attention.

E2 ModerateCohortPEM not requiredCross-Sectional

Prevalence of IgM antibodies to human herpesvirus 6 early antigen (p41/38) in patients with chronic fatigue syndrome.

Patnaik, M, Komaroff, A L, Conley, E et al.·The Journal of infectious diseases·1995

Researchers tested whether people with ME/CFS have more signs of a virus called human herpesvirus 6 (HHV-6) compared to healthy people. They found that 77% of ME/CFS patients had antibodies suggesting exposure to or active HHV-6 infection, compared to only 12% of healthy controls. This suggests HHV-6 may be more common in people with ME/CFS, though it's unclear whether the virus causes the illness or is simply more active in these patients.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

General practitioners' attitudes to patients with a self diagnosis of myalgic encephalomyelitis.

Scott, S, Deary, I, Pelosi, A J·BMJ (Clinical research ed.)·1995

This study looked at what general practitioners (GPs) think about patients who diagnose themselves with ME/CFS. Researchers surveyed GPs in Scotland to understand their attitudes toward self-diagnosed ME/CFS patients. The findings revealed important gaps between patient experiences and how some doctors view the condition.

Diagnostics

E2 ModerateCohortPEM not requiredCase-Control

The relationship between neurally mediated hypotension and the chronic fatigue syndrome.

Bou-Holaigah, I, Rowe, P C, Kan, J et al.·JAMA·1995

Researchers tested whether ME/CFS patients have an abnormal blood pressure response when standing upright. They tilted 23 ME/CFS patients and 14 healthy controls on a special table and monitored their vital signs. Nearly all ME/CFS patients showed an abnormal response, and about 9 patients felt much better after taking medications to treat low blood pressure.

Autonomic Nervous System

E2 ModerateBehavioralPEM unclearObservational

Can the chronic fatigue syndrome be defined by distinct clinical features?

Hickie, I, Lloyd, A, Hadzi-Pavlovic, D et al.·Psychological medicine·1995

This study examined whether all people diagnosed with ME/CFS have the same illness or whether they actually have different types. Researchers analyzed symptoms from 565 patients and found that ME/CFS is not one uniform condition—instead, they identified two distinct patient groups with different symptom patterns, illness duration, and recovery rates.

Diagnostics

E2 ModerateCohortPEM not requiredCase-Control

Seroepidemiology of chronic fatigue syndrome: a case-control study.

Mawle, A C, Nisenbaum, R, Dobbins, J G et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1995

Researchers tested people with ME/CFS and healthy control groups for antibodies to many common viruses, including herpesviruses and enteroviruses. They found no differences between the two groups—patients with ME/CFS did not have higher levels of antibodies to any of the viruses tested. This suggests that recent or past infection with these particular viruses is not a distinguishing feature of ME/CFS.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Detection of human herpesvirus 6 in plasma of children with primary infection and immunosuppressed patients by polymerase chain reaction.

Secchiero, P, Carrigan, D R, Asano, Y et al.·The Journal of infectious diseases·1995

Researchers developed a sensitive test to detect human herpesvirus 6 (HHV-6) DNA in blood. They tested blood samples from children with a specific rash illness, bone marrow transplant patients, HIV-infected patients, people with chronic fatigue syndrome (ME/CFS), and healthy adults. The test found HHV-6 DNA most often in children with the rash illness, less commonly in transplant and HIV patients, rarely in ME/CFS patients, and not at all in healthy people.

E2 ModerateCohortPEM not requiredCross-Sectional

Silicone breast implant--associated musculoskeletal manifestations.

Cuellar, M L, Gluck, O, Molina, J F et al.·Clinical rheumatology·1995

This study looked at 300 women with silicone breast implants who came to a rheumatology clinic with muscle and joint pain. The researchers found that over 80% of these women had signs of connective tissue disease, and more than half met criteria for fibromyalgia or chronic fatigue syndrome. When some women had their implants removed, over 70% reported improvement in their overall symptoms.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Cognitive functioning and magnetic resonance imaging in chronic fatigue.

Cope, H, Pernet, A, Kendall, B et al.·The British journal of psychiatry : the journal of mental science·1995

This study tested whether people with chronic fatigue have real problems with thinking and memory, or whether these complaints are mainly due to depression and anxiety. Researchers gave cognitive tests and brain scans (MRI) to people with chronic fatigue, people with depression, and healthy controls. They found that people with chronic fatigue performed similarly to controls on objective tests, and brain scans showed no consistent abnormalities. The researchers concluded that complaints of cognitive problems were likely related to mood symptoms rather than physical brain changes.

Cognitive Impairment

E2 ModerateCohortPEM not requiredObservational

Diagnosis in chronic illness: disabling or enabling--the case of chronic fatigue syndrome.

Woodward, R V, Broom, D H, Legge, D G·Journal of the Royal Society of Medicine·1995

This study looked at whether giving someone a CFS diagnosis helps or hurts them. Researchers interviewed 20 doctors and 50 CFS patients over 2 years. Most doctors were reluctant to diagnose CFS because they worried it might make patients feel worse, but patients actually found the diagnosis helpful because it finally explained what was wrong with them.

Diagnostics

E2 ModerateBehavioralPEM unclearObservational

Exercise responses and psychiatric disorder in chronic fatigue syndrome.

Lane, R J, Burgess, A P, Flint, J et al.·BMJ (Clinical research ed.)·1995

This study looked at how people with ME/CFS respond to exercise and whether they experience psychiatric problems like depression or anxiety. Researchers examined whether exercise responses and psychiatric symptoms are connected in ME/CFS patients. The study helps clarify the relationship between physical symptoms and mental health in this condition.

E2 ModerateBehavioralPEM not requiredObservational

A clinical study of chronic fatigue syndrome.

Shanks, M F, Ho-Yen, D O·The British journal of psychiatry : the journal of mental science·1995

This study looked at 64 ME/CFS patients to understand whether psychiatric conditions (like depression or anxiety) are part of ME/CFS itself or develop separately. Researchers found that patients without pre-existing psychiatric disorders had milder illness overall, suggesting that ME/CFS can occur on its own. Most patients improved with counseling and by staying within their energy limits.

E2 ModerateBehavioralPEM not requiredCross-Sectional

The impact of catastrophic beliefs on functioning in chronic fatigue syndrome.

Petrie, K, Moss-Morris, R, Weinman, J·Journal of psychosomatic research·1995

This study looked at whether how people think about ME/CFS affects how disabled they become. Researchers asked 282 people with ME/CFS what they thought would happen if they pushed themselves too hard, and sorted their answers into catastrophic (very negative) or non-catastrophic thinking. People who had catastrophic thoughts about pushing themselves were significantly more fatigued and more disabled in work, household tasks, sleep, socializing, and hobbies—even though they had been sick for similar lengths of time as others.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Estimating rates of chronic fatigue syndrome from a community-based sample: a pilot study.

Jason, L A, Taylor, R, Wagner, L et al.·American journal of community psychology·1995

This study looked at how many people in the general community have ME/CFS by calling over 1,000 randomly selected households by telephone. Instead of relying on patients referred by doctors (which may miss people who can't afford care or distrust doctors), the researchers directly asked community members about their symptoms. They found that ME/CFS may be more common than previously thought, affecting about 0.2% of the population.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

P300 assessment of chronic fatigue syndrome.

Polich, J, Moore, A P, Wiederhold, M D·Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·1995

This study measured electrical activity in the brains of people with ME/CFS and healthy controls using a simple listening task where they had to identify specific sounds. Researchers found no differences in brain wave patterns (called P300) between the two groups, even though many ME/CFS patients report problems with memory and attention. This suggests that brain electrical activity measured this way may not be a reliable marker for ME/CFS.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Frequency of deviant immunological test values in chronic fatigue syndrome patients.

Natelson, B H, Ellis, S P, Braonáin, P J et al.·Clinical and diagnostic laboratory immunology·1995

Researchers tested 11 different immune system markers in ME/CFS patients and compared them to fatigued people without ME/CFS. They found that three immune tests (protein A binding, Raji cell test, and complement proteins C3 or C4) showed different results between the groups. However, most other immune tests they looked at, including antibody levels and other complement markers, did not reliably distinguish ME/CFS patients from those with other causes of fatigue.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Psychobehavioral and immunological characteristics of adult people with chronic fatigue and patients with chronic fatigue syndrome.

Masuda, A, Nozoe, S I, Matsuyama, T et al.·Psychosomatic medicine·1994

This study compared immune system function and psychological stress levels in three groups: healthy people, those with chronic fatigue (but not ME/CFS), and patients with ME/CFS. All three groups showed differences in how stressed they felt, their activity levels, and how well their immune cells (specifically natural killer cells) worked. Importantly, the chronic fatigue group fell somewhere between healthy people and ME/CFS patients in terms of both psychological stress and immune function.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Fatigue secondary to chronic illness: postpolio syndrome, chronic fatigue syndrome, and multiple sclerosis.

Packer, T L, Sauriol, A, Brouwer, B·Archives of physical medicine and rehabilitation·1994

This study compared fatigue in people with three different chronic illnesses: postpolio syndrome, ME/CFS, and multiple sclerosis. Researchers found that people with all three conditions experienced much higher levels of fatigue than healthy people, and those with ME/CFS and MS also had greater difficulty doing everyday activities. The study highlights how serious and disabling fatigue can be across these different conditions.

E2 ModerateCohortPEM unclearCross-Sectional

Comparison of patients with chronic fatigue syndrome, fibromyalgia, and multiple chemical sensitivities.

Buchwald, D, Garrity, D·Archives of internal medicine·1994

This study compared 90 patients with three conditions that cause fatigue and other symptoms: ME/CFS, fibromyalgia, and multiple chemical sensitivities. The researchers found that these three conditions are very similar in many ways—patients often report overlapping symptoms, and many people meet the criteria for more than one condition. All three groups used a lot of healthcare services, visiting doctors about 22-40 times per year on average.

Diagnostics

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Evidence browser

Chronic fatigue syndrome in the community. Prevalence and associations.

Quality of life in chronic fatigue syndrome.

Prevalence of IgM antibodies to human herpesvirus 6 early antigen (p41/38) in patients with chronic fatigue syndrome.

General practitioners' attitudes to patients with a self diagnosis of myalgic encephalomyelitis.

The relationship between neurally mediated hypotension and the chronic fatigue syndrome.

Can the chronic fatigue syndrome be defined by distinct clinical features?

Seroepidemiology of chronic fatigue syndrome: a case-control study.

Detection of human herpesvirus 6 in plasma of children with primary infection and immunosuppressed patients by polymerase chain reaction.

Silicone breast implant--associated musculoskeletal manifestations.

Cognitive functioning and magnetic resonance imaging in chronic fatigue.

Diagnosis in chronic illness: disabling or enabling--the case of chronic fatigue syndrome.

Exercise responses and psychiatric disorder in chronic fatigue syndrome.

A clinical study of chronic fatigue syndrome.

The impact of catastrophic beliefs on functioning in chronic fatigue syndrome.

Estimating rates of chronic fatigue syndrome from a community-based sample: a pilot study.

P300 assessment of chronic fatigue syndrome.

Frequency of deviant immunological test values in chronic fatigue syndrome patients.

Psychobehavioral and immunological characteristics of adult people with chronic fatigue and patients with chronic fatigue syndrome.

Fatigue secondary to chronic illness: postpolio syndrome, chronic fatigue syndrome, and multiple sclerosis.

Comparison of patients with chronic fatigue syndrome, fibromyalgia, and multiple chemical sensitivities.

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