ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2768 studies

2621–2640 of 2,768 studies

E2 ModerateReviewPEM unclearReview-Narrative

A comparative review of systemic and neurological symptomatology in 12 outbreaks collectively described as chronic fatigue syndrome, epidemic neuromyasthenia, and myalgic encephalomyelitis.

Briggs, N C, Levine, P H·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

This study reviewed 12 documented outbreaks of ME/CFS-like illness from 1934 to the 1980s to understand how symptoms varied between them. While all outbreaks shared common features like extreme fatigue, muscle pain, and headaches, the neurological symptoms (affecting the nervous system) differed significantly. The researchers found that older outbreaks (1930s-1950s) showed more severe objective nerve damage, while later outbreaks (1960s-1980s) had milder neurological findings, possibly because doctors weren't looking for these symptoms as carefully.

E2 ModerateCohortPEM not requiredCross-Sectional

Sympathetic overactivity in subjects complaining of unexplained fatigue.

Pagani, M, Lucini, D, Mela, G S et al.·Clinical science (London, England : 1979)·1994

This study examined how the nervous system controls heart rate in people with unexplained fatigue compared to healthy people. Using heart rate recordings, researchers found that fatigue patients showed an imbalance in their autonomic nervous system—specifically, the part that triggers the "fight or flight" response was overactive while the calming part was underactive, even at rest.

Autonomic Nervous System

E2 ModerateCohortPEM unclearCross-Sectional

Chronic fatigue syndrome and a disorder resembling Sjögren's syndrome: preliminary report.

Calabrese, L H, Davis, M E, Wilke, W S·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

This study looked at whether people diagnosed with ME/CFS might actually have a condition similar to Sjögren's syndrome, a disease that causes dry mouth and eyes along with immune system problems. Researchers found that many patients in their ME/CFS clinic had signs of this Sjögren's-like illness, including abnormal tests and certain antibodies in their blood. The study suggests these two conditions may overlap more often than doctors realize.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

[Viral infection and fibromyalgia].

Branco, J C, Tavares, V, Abreu, I et al.·Acta medica portuguesa·1994

This study looked at whether a common virus called parvovirus B19 might be responsible for fibromyalgia, a condition similar to ME/CFS that causes widespread pain and fatigue. Researchers compared blood antibodies (which show past infection) in 52 fibromyalgia patients versus 39 healthy people. They found slightly higher rates of past parvovirus infection in fibromyalgia patients, but the difference was too small to be meaningful, so they concluded the virus is probably not the cause of fibromyalgia.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

[Epidemiologic study of chronic fatigue in primary care (general practice)].

Mann, A H, Mc Donald, E, Cope, H et al.·L'Encephale·1994

Researchers studied fatigue in patients visiting regular doctors' offices to understand how common it is and what causes it. They found that some patients had long-lasting, disabling fatigue, but these patients were very different from each other in why they thought they were tired. Most of these patients also had depression or other mental health conditions alongside their fatigue.

Diagnostics

E2 ModerateBehavioralPEM not requiredCross-Sectional

Psychosocial correlates of illness burden in chronic fatigue syndrome.

Antoni, M H, Brickman, A, Lutgendorf, S et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

This study looked at how thoughts, feelings, and coping strategies affect how sick ME/CFS patients feel and function day-to-day. Researchers found that negative thinking patterns and avoidance-based coping (like denial) were linked to worse symptoms and lower quality of life, while active problem-solving strategies did not improve outcomes. These relationships held true whether or not patients also had depression.

Cognitive Impairment

E2 ModerateBehavioralPEM unclearCross-Sectional

Psychosocial factors and chronic fatigue syndrome.

Lewis, S, Cooper, C L, Bennett, D·Psychological medicine·1994

This study looked at whether psychological and social factors differ between people with ME/CFS, people with irritable bowel syndrome, and healthy people without these conditions. Researchers examined life stressors, personality traits, how people cope with stress, and their social support systems. They found that while stressful life events were similar across groups, differences appeared in how people handled stress and their personality patterns.

E2 ModerateCohortPEM not requiredCross-Sectional

Immunological abnormalities in patients with chronic fatigue syndrome.

Tirelli, U, Marotta, G, Improta, S et al.·Scandinavian journal of immunology·1994

Researchers studied 265 ME/CFS patients and found unusual patterns in their immune cells compared to healthy people. They discovered that certain types of white blood cells called natural killer (NK) cells and B cells were abnormally increased, and these cells showed signs of being overly activated. These immune abnormalities appeared consistent with what other researchers had found in different countries.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Alpha-delta sleep in patients with a chief complaint of chronic fatigue.

Manu, P, Lane, T J, Matthews, D A et al.·Southern medical journal·1994

This study looked at sleep patterns in 30 patients with chronic fatigue to understand what might be causing their exhaustion. Researchers found that a specific type of abnormal sleep pattern called 'alpha-delta sleep' appeared in about 26% of patients, but it was not clearly linked to ME/CFS or fibromyalgia. The study also found that one-third of the patients had other primary sleep disorders like sleep apnea that may have been contributing to their fatigue.

Sleep

E2 ModerateCohortPEM not requiredCross-Sectional

A potential role for human herpesvirus type 6 in nervous system disease.

Wilborn, F, Schmidt, C A, Brinkmann, V et al.·Journal of neuroimmunology·1994

This study looked for evidence that human herpesvirus type 6 (HHV-6), a common virus, might be involved in nervous system diseases including ME/CFS. Researchers tested blood and spinal fluid samples from patients with different neurological conditions and compared them to healthy controls. They found that a small number of multiple sclerosis patients had HHV-6 DNA in their spinal fluid, and MS patients had higher antibodies to HHV-6 in their blood, suggesting the virus may play a role in that disease.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

Lack of evidence for infection with known human and animal retroviruses in patients with chronic fatigue syndrome.

Heneine, W, Woods, T C, Sinha, S D et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

Researchers tested blood samples from 21 ME/CFS patients and 21 healthy control volunteers to see if several types of retroviruses (viruses that can insert themselves into human DNA) might cause ME/CFS. They looked for eight different retroviruses using sensitive laboratory tests. None of the viruses were found in either patients or controls, suggesting these particular viruses are not responsible for ME/CFS in this group.

E2 ModerateCohortPEM not requiredObservational

Clinical studies with the NOVA ISE for IMg2+.

Altura, B T, Burack, J L, Cracco, R Q et al.·Scandinavian journal of clinical and laboratory investigation. Supplementum·1994

Researchers used a specialized test to measure magnesium levels in the blood of people with various conditions, including ME/CFS. The study found that many conditions like migraines, diabetes, and asthma showed low levels of a specific form of magnesium, but interestingly, people with ME/CFS did not show these same magnesium changes. This suggests that magnesium abnormalities may not be a key feature of ME/CFS.

E2 ModerateCohortPEM not requiredCross-Sectional

Immunologic abnormalities associated with chronic fatigue syndrome.

Barker, E, Fujimura, S F, Fadem, M B et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

This study examined immune cells in the blood of ME/CFS patients and compared them to healthy people. Researchers found that ME/CFS patients had normal numbers of immune cells overall, but the cells showed signs of being overactive and tired. Most notably, patients had significantly reduced natural killer cell activity—these are immune cells that normally help fight infections and abnormal cells.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Psychobehavioral and immunological characteristics of adult people with chronic fatigue and patients with chronic fatigue syndrome.

Masuda, A, Nozoe, S I, Matsuyama, T et al.·Psychosomatic medicine·1994

This study compared immune system function and psychological stress levels in three groups: healthy people, those with chronic fatigue (but not ME/CFS), and patients with ME/CFS. All three groups showed differences in how stressed they felt, their activity levels, and how well their immune cells (specifically natural killer cells) worked. Importantly, the chronic fatigue group fell somewhere between healthy people and ME/CFS patients in terms of both psychological stress and immune function.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

Gender differences in patients with chronic fatigue syndrome.

Buchwald, D, Pearlman, T, Kith, P et al.·Journal of general internal medicine·1994

This study looked at whether ME/CFS affects men and women differently by comparing 348 patients seen at a specialized clinic. While women more often had swollen lymph nodes and fibromyalgia alongside ME/CFS, and men more often had sore throats, the researchers found that overall, men and women with ME/CFS are quite similar in most ways, including their symptoms, psychological well-being, and how the illness affects their daily functioning.

E2 ModerateCohortPEM not requiredObservational

Epstein-Barr virus infection in Desert Storm reservists.

Carver, L A, Connallon, P F, Flanigan, S J et al.·Military medicine·1994

This study looked at U.S. Army reservists who developed ME/CFS-like symptoms after returning from the Gulf War. Researchers tested 37 of these service members for Epstein-Barr virus (a common virus that can reactivate in the body) and found that 73% had signs of either a new or reactivated infection. This suggests that viral infections might be making ME/CFS symptoms worse or last longer in some people.

Immune System

E2 ModerateBehavioralPEM not requiredLongitudinal

Chronic fatigue syndrome: a follow up study.

Bonner, D, Ron, M, Chalder, T et al.·Journal of neurology, neurosurgery, and psychiatry·1994

Researchers followed up with 46 ME/CFS patients four years after their initial diagnosis to see how they were doing. Patients who had improved with treatment generally stayed better, while those who didn't benefit from treatment were unlikely to recover on their own. Patients who still had ME/CFS symptoms four years later tended to have had more physical health problems, greater fatigue levels, and a history of mental health conditions when first diagnosed.

Interventions

E2 ModerateCohortPEM not requiredObservational

Low grade pyrexia: is it chronic fatigue syndrome?

Anand, A C, Kumar, R, Rao, M K et al.·The Journal of the Association of Physicians of India·1994

This study followed 87 patients who had a persistent low-grade fever (99-101°F) along with fatigue, muscle pain, and joint pain. Doctors ran many tests looking for infections, autoimmune diseases, or cancer, but found nothing abnormal. Most patients gradually improved over time, with about half becoming symptom-free within three years. The researchers suggest this condition might be related to ME/CFS.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Seasonal symptom variation in patients with chronic fatigue: comparison with major mood disorders.

Zubieta, J K, Engleberg, N C, Yargiç, L I et al.·Journal of psychiatric research·1994

This study compared how much ME/CFS and chronic fatigue symptoms vary by season in different groups of patients. The researchers found that people with ME/CFS and chronic fatigue had much less seasonal symptom variation than people with seasonal depression or other mood disorders. Even when fatigue patients did experience some seasonal changes, they didn't find it particularly distressing.

E2 ModerateCohortPEM not requiredCase-Control

Enteroviruses and the chronic fatigue syndrome.

Swanink, C M, Melchers, W J, van der Meer, J W et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

Researchers investigated whether a common virus called enterovirus might be causing ME/CFS by hiding in the body. They tested 76 ME/CFS patients and 76 healthy controls using multiple methods, including blood tests, stool samples, and genetic analysis. The study found no evidence that enterovirus plays a role in ME/CFS—only one patient showed traces of the virus in one test, which disappeared three months later.

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A comparative review of systemic and neurological symptomatology in 12 outbreaks collectively described as chronic fatigue syndrome, epidemic neuromyasthenia, and myalgic encephalomyelitis.

Sympathetic overactivity in subjects complaining of unexplained fatigue.

Chronic fatigue syndrome and a disorder resembling Sjögren's syndrome: preliminary report.

[Viral infection and fibromyalgia].

[Epidemiologic study of chronic fatigue in primary care (general practice)].

Psychosocial correlates of illness burden in chronic fatigue syndrome.

Psychosocial factors and chronic fatigue syndrome.

Immunological abnormalities in patients with chronic fatigue syndrome.

Alpha-delta sleep in patients with a chief complaint of chronic fatigue.

A potential role for human herpesvirus type 6 in nervous system disease.

Lack of evidence for infection with known human and animal retroviruses in patients with chronic fatigue syndrome.

Clinical studies with the NOVA ISE for IMg2+.

Immunologic abnormalities associated with chronic fatigue syndrome.

Psychobehavioral and immunological characteristics of adult people with chronic fatigue and patients with chronic fatigue syndrome.

Gender differences in patients with chronic fatigue syndrome.

Epstein-Barr virus infection in Desert Storm reservists.

Chronic fatigue syndrome: a follow up study.

Low grade pyrexia: is it chronic fatigue syndrome?

Seasonal symptom variation in patients with chronic fatigue: comparison with major mood disorders.

Enteroviruses and the chronic fatigue syndrome.

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