E2 ModerateCohortPEM not requiredCross-Sectional
In major dysmood disorder, physiosomatic, chronic fatigue and fibromyalgia symptoms are driven by immune activation and increased immune-associated neurotoxicity.
Maes, Michael, Almulla, Abbas F, Zhou, Bo et al.·Scientific reports·2024
This study found that people with severe depression often experience fatigue and pain symptoms similar to ME/CFS, and these symptoms are linked to overactive immune responses in the body. Researchers measured immune molecules in the blood of severely depressed patients and healthy controls, and discovered that specific immune markers—particularly IL-16 and IL-8—were associated with how severe the fatigue and physical symptoms were. The study suggests that difficult life experiences and traumatic childhood events may trigger these immune changes, leading to the physical symptoms that patients experience.
Immune System