ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

1061–1080 of 2,423 studies

E3 PreliminaryMechanismPEM not requiredObservational

Deficient EBV-specific B- and T-cell response in patients with chronic fatigue syndrome.

Loebel, Madlen, Strohschein, Kristin, Giannini, Carolin et al.·PloS one·2014

This study looked at how the immune system responds to Epstein-Barr virus (EBV), a common virus that causes mono, in people with ME/CFS compared to healthy controls. Researchers found that ME/CFS patients have a weaker immune response to EBV, particularly in their B cells and T cells—the immune cells that normally fight off this virus. The findings suggest that ME/CFS patients may have difficulty controlling EBV reactivation in their bodies.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Validating a measure of myalgic encephalomyelitis/chronic fatigue syndrome symptomatology.

Brown, Abigail A, Jason, Leonard A·Fatigue : biomedicine, health & behavior·2014

This study tested whether a questionnaire called the DePaul Symptom Questionnaire (DSQ) accurately measures the symptoms people with ME/CFS experience. Researchers found that ME/CFS symptoms naturally group into three main categories: problems with the nervous system and immune system, problems with thinking and memory, and a worsening of symptoms after physical activity. The questionnaire was shown to be a reliable tool for identifying and measuring these symptom patterns in ME/CFS patients.

Post-Exertional Malaise

E3 PreliminaryCohortPEM not requiredCross-Sectional

Diagnosis and management of chronic fatigue syndrome/myalgic encephalitis in black and minority ethnic people: a qualitative study.

Bayliss, Kerin, Riste, Lisa, Fisher, Louise et al.·Primary health care research & development·2014

This study looked at why people from Black and minority ethnic backgrounds are diagnosed with ME/CFS less often than White British people, even though they may have the condition more frequently. Researchers interviewed 35 healthcare workers and stakeholders in northwest England and found many barriers, including lack of awareness about ME/CFS, language difficulties, cultural differences in how symptoms are discussed, and unfair stereotypes about laziness. The study recommends better training for doctors and culturally sensitive patient information to help improve diagnosis rates.

E3 PreliminaryMechanismPEM not requiredMechanistic

Restraint Induces Sickness Responses Independent of Injection with Epstein-Barr Virus (EBV)-Encoded dUTPase.

Aubrecht, Taryn G, Abi Salloum, Bachir, Ariza, Maria Eugenia et al.·Journal of behavioral and brain science·2014

This study looked at how stress and a virus protein linked to ME/CFS affect sickness symptoms in mice. Researchers gave mice either saline or a protein made by Epstein-Barr virus, then exposed some mice to restraint stress for either 1 or 3 days. Surprisingly, restraint stress alone caused sickness-like symptoms after 3 days, regardless of whether mice received the virus protein, and the virus protein didn't make stress effects worse.

E3 PreliminaryMechanismPEM unclearObservational

High-throughput sequencing of plasma microRNA in chronic fatigue syndrome/myalgic encephalomyelitis.

Brenu, Ekua W, Ashton, Kevin J, Batovska, Jana et al.·PloS one·2014

This study looked for tiny molecular messages called microRNAs in the blood of ME/CFS patients to see if they might work as a diagnostic tool. Researchers compared blood samples from ME/CFS patients and healthy people, and found three microRNAs that were higher in ME/CFS patients. This is an early-stage discovery that could eventually help doctors identify ME/CFS more easily through a simple blood test.

Biomarkers

E3 PreliminaryReviewPEM not requiredReview-Narrative

The developmental basis of epigenetic regulation of HTR2A and psychiatric outcomes.

Paquette, Alison G, Marsit, Carmen J·Journal of cellular biochemistry·2014

This article examines how a gene called HTR2A, which helps control serotonin (a brain chemical), can be chemically modified in ways that affect brain development and mental health. Researchers found that these modifications can happen before birth—even in the placenta—and may influence how our brains develop, potentially affecting conditions like depression, anxiety, and other mental health disorders. The article suggests these changes might also be linked to chronic fatigue syndrome, though more research is needed to understand how and why.

E3 PreliminaryCohortPEM not requiredCase-Control

Valacyclovir treatment of chronic fatigue in adolescents.

Henderson, Theodore A·Advances in mind-body medicine·2014

This study looked at 15 young people who were referred for treatment-resistant depression but were found to have ME/CFS instead. When treated with an antiviral medication called valacyclovir, 93% of them improved significantly, with fatigue scores dropping substantially. The study suggests that some cases of depression in teenagers may actually be undiagnosed ME/CFS caused by chronic viral infections.

Immune System

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

Orthostatic responses in adolescent chronic fatigue syndrome: contributions from expectancies as well as gravity.

Wyller, Vegard Bruun, Fagermoen, Even, Sulheim, Dag et al.·BioPsychoSocial medicine·2014

When people with ME/CFS stand up or imagine standing, their body's nervous system responds differently than in healthy people. This study found that teenagers with ME/CFS have higher resting heart rate and blood pressure, and their nervous system shows stronger stress responses when they think about standing upright, even though their actual physical response to tilting was similar to healthy peers. This suggests that both the physical challenge of gravity and a person's expectations or anxiety about standing may contribute to the symptoms they experience.

Autonomic Nervous System

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Competences required for the delivery of high and low-intensity cognitive behavioural interventions for chronic fatigue, chronic fatigue syndrome/ME and irritable bowel syndrome.

Rimes, Katharine A, Wingrove, Janet, Moss-Morris, Rona et al.·Behavioural and cognitive psychotherapy·2014

This study developed clear guidelines describing what skills therapists need to deliver cognitive behavioural therapy (CBT) for ME/CFS and related conditions. Researchers gathered input from experienced therapists to create competence frameworks for both brief interventions and longer, more intensive treatments. These guidelines can help train new therapists and identify what skills they need to learn.

E3 PreliminaryMechanismPEM unclearCross-Sectional

Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An ¹¹C-(R)-PK11195 PET Study.

Nakatomi, Yasuhito, Mizuno, Kei, Ishii, Akira et al.·Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2014

This study used a special brain imaging technique called PET scans to look for signs of inflammation in the brains of ME/CFS patients. Researchers found that people with ME/CFS had higher levels of brain inflammation markers in several key brain regions compared to healthy controls. The amount of inflammation was linked to how severe patients' cognitive problems, pain, and depression were.

Neuroinflammation

E3 PreliminaryReviewPEM unclearReview-Narrative

Mitochondrial dysfunctions in myalgic encephalomyelitis/chronic fatigue syndrome explained by activated immuno-inflammatory, oxidative and nitrosative stress pathways.

Morris, Gerwyn, Maes, Michael·Metabolic brain disease·2014

This study explains how ME/CFS may damage the mitochondria—the energy-producing units inside our cells. The researchers found that inflammation, immune system overactivity, and harmful molecules called oxidative stress can interfere with how mitochondria produce energy (ATP), which is why ME/CFS patients experience extreme fatigue and post-exertional malaise. Low levels of protective vitamins and minerals also make this problem worse.

Immune SystemPost-Exertional Malaise

E3 PreliminaryCohortPEM not requiredCross-Sectional

Adolescents and mothers value referral to a specialist service for chronic fatigue syndrome or myalgic encephalopathy (CFS/ME).

Beasant, Lucy, Mills, Nicola, Crawley, Esther·Primary health care research & development·2014

This study asked 13 mothers and 12 teenagers with ME/CFS about their experiences getting help from a specialist ME/CFS service. Most families found it difficult and took a long time to access the specialist clinic, but once they got there, both teenagers and mothers felt it was valuable. The specialist service helped confirm the diagnosis, improved symptom management, and helped communication between doctors and schools.

InterventionsDiagnostics

E3 PreliminaryCohortPEM unclearObservational

A qualitative natural history study of ME/CFS in the community.

Anderson, Valerie R, Jason, Leonard A, Hlavaty, Laura E·Health care for women international·2014

This study interviewed 19 people with ME/CFS who were living in their communities (rather than patients seen at specialty clinics) to understand their experiences with the illness over time. The researchers found that ME/CFS affects people in multiple ways—physically, emotionally, and socially—and that how communities and healthcare providers respond to patients can significantly impact their illness progression and quality of life.

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome, fibromyalgia, and myalgic encephalomyelitis: a clinical perspective.

Teitelbaum, Jacob·Alternative therapies in health and medicine·2014

This article reviews how chronic fatigue syndrome (ME/CFS), fibromyalgia, and related conditions present in clinical practice. Dr. Teitelbaum, an experienced clinician, discusses the symptoms and practical aspects of these overlapping illnesses that affect energy, pain, and sleep. The piece offers a clinical perspective on recognizing and understanding these conditions from a doctor's viewpoint.

E3 PreliminaryCohortPEM not requiredCase-Control

A case of femoral arteriovenous fistula causing high-output cardiac failure, originally misdiagnosed as chronic fatigue syndrome.

Porter, J, Al-Jarrah, Q, Richardson, S·Case reports in vascular medicine·2014

This case study describes a 34-year-old marathon runner who was initially diagnosed with chronic fatigue syndrome but actually had a rare blood vessel problem called a femoral arteriovenous fistula. This condition, caused by a small injury during a heart catheterization procedure years earlier, created an abnormal connection between an artery and vein in the leg that forced the heart to work much harder than normal. Surgery to repair this fistula completely resolved the patient's fatigue and heart problems, showing that careful medical evaluation is important when fatigue symptoms don't improve with standard treatment.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Decreased basal ganglia activation in subjects with chronic fatigue syndrome: association with symptoms of fatigue.

Miller, Andrew H, Jones, James F, Drake, Daniel F et al.·PloS one·2014

This study used brain imaging to look at a specific part of the brain called the basal ganglia, which helps control movement and reward responses. Researchers found that people with ME/CFS had less activity in certain regions of this brain area compared to healthy people, and the amount of reduced activity was related to how severe their fatigue symptoms were.

E3 PreliminaryMechanismPEM requiredObservational

Inability of myalgic encephalomyelitis/chronic fatigue syndrome patients to reproduce VO₂peak indicates functional impairment.

Keller, Betsy A, Pryor, John Luke, Giloteaux, Ludovic·Journal of translational medicine·2014

This study tested whether people with ME/CFS can perform the same on an exercise test when it's repeated the next day, similar to how healthy people typically do. The researchers found that ME/CFS patients performed significantly worse on the second test—using about 14% less oxygen and doing about 12% less work—even though they were trying their hardest both times. This suggests that doing one exercise test may give doctors an unrealistic picture of what ME/CFS patients can actually do.

Post-Exertional Malaise

E3 PreliminaryCohortPEM not requiredCase-Control

Epstein-barr virus infection masquerading as acute leukemia: a report of two cases and review of literature.

Chhabra, Puneet, Law, Arjun Dutt, Sharma, Upender et al.·Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion·2014

This study describes two cases where patients were initially thought to have acute leukemia based on blood tests, but they actually had Epstein-Barr virus (EBV) infections instead. One patient had infectious mononucleosis, and the other had a rare EBV-related immune condition. The study shows that EBV can sometimes look like leukemia under a microscope, which can lead to misdiagnosis.

Diagnostics

E3 PreliminaryMechanismPEM not requiredMechanistic

A Study of the Protective Effect of Triticum aestivum L. in an Experimental Animal Model of Chronic Fatigue Syndrome.

Borah, Mukundam, Sarma, Phulen, Das, Swarnamoni·Pharmacognosy research·2014

Researchers tested whether wheat leaf extract could help mice recover from exhaustion caused by repeated stress. The stressed mice that received the extract showed improved activity levels and reduced anxiety compared to untreated stressed mice, and their brain chemistry improved. This suggests the extract's antioxidant properties may help protect against some effects of chronic fatigue.

E3 PreliminaryReviewPEM unclearReview-Narrative

The emerging role of autoimmunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/cfs).

Morris, Gerwyn, Berk, Michael, Galecki, Piotr et al.·Molecular neurobiology·2014

This study explores how ME/CFS may involve the immune system attacking the body's own tissues (autoimmunity). Researchers found that up to 60% of ME/CFS patients show signs of autoimmune responses, likely triggered by a combination of stress on cells, viral infections, and problems with how the body produces energy. The study identifies several pathways that could lead to these harmful immune reactions and discusses potential treatments.

Immune System

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Deficient EBV-specific B- and T-cell response in patients with chronic fatigue syndrome.

Validating a measure of myalgic encephalomyelitis/chronic fatigue syndrome symptomatology.

Diagnosis and management of chronic fatigue syndrome/myalgic encephalitis in black and minority ethnic people: a qualitative study.

Restraint Induces Sickness Responses Independent of Injection with Epstein-Barr Virus (EBV)-Encoded dUTPase.

High-throughput sequencing of plasma microRNA in chronic fatigue syndrome/myalgic encephalomyelitis.

The developmental basis of epigenetic regulation of HTR2A and psychiatric outcomes.

Valacyclovir treatment of chronic fatigue in adolescents.

Orthostatic responses in adolescent chronic fatigue syndrome: contributions from expectancies as well as gravity.

Competences required for the delivery of high and low-intensity cognitive behavioural interventions for chronic fatigue, chronic fatigue syndrome/ME and irritable bowel syndrome.

Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An ¹¹C-(R)-PK11195 PET Study.

Mitochondrial dysfunctions in myalgic encephalomyelitis/chronic fatigue syndrome explained by activated immuno-inflammatory, oxidative and nitrosative stress pathways.

Adolescents and mothers value referral to a specialist service for chronic fatigue syndrome or myalgic encephalopathy (CFS/ME).

A qualitative natural history study of ME/CFS in the community.

Chronic fatigue syndrome, fibromyalgia, and myalgic encephalomyelitis: a clinical perspective.

A case of femoral arteriovenous fistula causing high-output cardiac failure, originally misdiagnosed as chronic fatigue syndrome.

Decreased basal ganglia activation in subjects with chronic fatigue syndrome: association with symptoms of fatigue.

Inability of myalgic encephalomyelitis/chronic fatigue syndrome patients to reproduce VO₂peak indicates functional impairment.

Epstein-barr virus infection masquerading as acute leukemia: a report of two cases and review of literature.

A Study of the Protective Effect of Triticum aestivum L. in an Experimental Animal Model of Chronic Fatigue Syndrome.

The emerging role of autoimmunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/cfs).

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research