ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

1061–1080 of 2,420 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Biopersistence and systemic distribution of intramuscularly injected particles: what impact on long-term tolerability of alum adjuvants?].

Gherardi, Romain K, Cadusseau, Josette, Authier, François-jérôme·Bulletin de l'Academie nationale de medecine·2014

This review examines how aluminum-based vaccine adjuvants (immune-boosting ingredients) may rarely cause long-term health problems in susceptible people, including muscle pain, exhaustion, and brain fog that can last years. The researchers found that aluminum particles can travel from the injection site through the body to distant organs and the brain, and that a specific immune protein called MCP-1 may control how much this happens. For most people, aluminum adjuvants are safe, but genetic and environmental differences may make some individuals more vulnerable to prolonged effects.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

The developmental basis of epigenetic regulation of HTR2A and psychiatric outcomes.

Paquette, Alison G, Marsit, Carmen J·Journal of cellular biochemistry·2014

This article examines how a gene called HTR2A, which helps control serotonin (a brain chemical), can be chemically modified in ways that affect brain development and mental health. Researchers found that these modifications can happen before birth—even in the placenta—and may influence how our brains develop, potentially affecting conditions like depression, anxiety, and other mental health disorders. The article suggests these changes might also be linked to chronic fatigue syndrome, though more research is needed to understand how and why.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Competences required for the delivery of high and low-intensity cognitive behavioural interventions for chronic fatigue, chronic fatigue syndrome/ME and irritable bowel syndrome.

Rimes, Katharine A, Wingrove, Janet, Moss-Morris, Rona et al.·Behavioural and cognitive psychotherapy·2014

This study developed clear guidelines describing what skills therapists need to deliver cognitive behavioural therapy (CBT) for ME/CFS and related conditions. Researchers gathered input from experienced therapists to create competence frameworks for both brief interventions and longer, more intensive treatments. These guidelines can help train new therapists and identify what skills they need to learn.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic Fatigue Syndrome: Case Definitions and Diagnostic Assessment.

Williams, Yolonda J, Jantke, Rachel L, Jason, Leonard A·New York State psychologist·2014

This article explains why doctors have difficulty diagnosing ME/CFS and why patients often struggle to get proper care. The researchers found that there are disagreements about how to define and diagnose the illness, which makes it harder for healthcare providers to recognize it and treat it correctly. They call for better education of doctors and clearer diagnostic guidelines.

Diagnostics

E3 PreliminaryMechanismPEM unclearObservational

Clinical features in patients with long-lasting macrophagic myofasciitis.

Rigolet, Muriel, Aouizerate, Jessie, Couette, Maryline et al.·Frontiers in neurology·2014

This study describes macrophagic myofasciitis (MMF), a condition where aluminum from vaccines persists in muscle tissue and causes long-lasting symptoms similar to ME/CFS, including widespread pain, severe fatigue, and significant problems with thinking and memory. Patients show patterns of brain abnormalities on imaging scans, and their cognitive problems appear to be caused by brain dysfunction rather than just pain or depression. The researchers found that standard treatments don't work well for these patients, making their condition particularly disabling.

Neuroinflammation

E3 PreliminaryMechanismPEM not requiredMechanistic

Restraint Induces Sickness Responses Independent of Injection with Epstein-Barr Virus (EBV)-Encoded dUTPase.

Aubrecht, Taryn G, Abi Salloum, Bachir, Ariza, Maria Eugenia et al.·Journal of behavioral and brain science·2014

This study looked at how stress and a virus protein linked to ME/CFS affect sickness symptoms in mice. Researchers gave mice either saline or a protein made by Epstein-Barr virus, then exposed some mice to restraint stress for either 1 or 3 days. Surprisingly, restraint stress alone caused sickness-like symptoms after 3 days, regardless of whether mice received the virus protein, and the virus protein didn't make stress effects worse.

E3 PreliminaryCohortPEM not requiredCase-Control

A case of femoral arteriovenous fistula causing high-output cardiac failure, originally misdiagnosed as chronic fatigue syndrome.

Porter, J, Al-Jarrah, Q, Richardson, S·Case reports in vascular medicine·2014

This case study describes a 34-year-old marathon runner who was initially diagnosed with chronic fatigue syndrome but actually had a rare blood vessel problem called a femoral arteriovenous fistula. This condition, caused by a small injury during a heart catheterization procedure years earlier, created an abnormal connection between an artery and vein in the leg that forced the heart to work much harder than normal. Surgery to repair this fistula completely resolved the patient's fatigue and heart problems, showing that careful medical evaluation is important when fatigue symptoms don't improve with standard treatment.

E3 PreliminaryReviewPEM unclearReview-Narrative

The glutathione system: a new drug target in neuroimmune disorders.

Morris, Gerwyn, Anderson, George, Dean, Olivia et al.·Molecular neurobiology·2014

This review examines glutathione (GSH), a naturally occurring substance in our cells that protects against damage and helps our immune system work properly. When glutathione levels drop, cells become more stressed and inflamed, which may contribute to ME/CFS and other conditions affecting the brain and immune system. The authors suggest several potential treatments—including supplements like N-acetyl cysteine and natural compounds like curcumin—that might help restore glutathione levels.

NeuroinflammationImmune System

E3 PreliminaryCohortPEM not requiredObservational

Multiple Sclerosis/Chronic Fatigue Syndrome overlap: When two common disorders collide.

Gaber, Tarek A-Z K, Oo, Wah Wah, Ringrose, Hollie·NeuroRehabilitation·2014

This study looked at whether people with Multiple Sclerosis (MS) might also have ME/CFS at the same time. Researchers examined 64 MS patients and found that 14% of them—all women—also met the diagnostic criteria for ME/CFS. Their fatigue and other symptoms like pain and headaches couldn't be fully explained by their MS alone, suggesting the two conditions can occur together in the same person.

E3 PreliminaryReviewPEM unclearReview-Narrative

Hepatitis B vaccination and associated oral manifestations: a non-systematic review of literature and case reports.

Tarakji, B, Ashok, N, Alakeel, R et al.·Annals of medical and health sciences research·2014

This review looked at reported side effects from the Hepatitis B vaccine given to children and adults. While the vaccine is generally considered safe, researchers found reports of various health complications that occurred after vaccination, including some that affect the mouth and jaw. The authors note that most side effects go away on their own, but a few can be serious and need hospital care.

E3 PreliminaryReviewPEM unclearReview-Narrative

The emerging role of autoimmunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/cfs).

Morris, Gerwyn, Berk, Michael, Galecki, Piotr et al.·Molecular neurobiology·2014

This study explores how ME/CFS may involve the immune system attacking the body's own tissues (autoimmunity). Researchers found that up to 60% of ME/CFS patients show signs of autoimmune responses, likely triggered by a combination of stress on cells, viral infections, and problems with how the body produces energy. The study identifies several pathways that could lead to these harmful immune reactions and discusses potential treatments.

Immune System

E3 PreliminaryDiagnosticPEM requiredMethods-Paper

Comparing and Contrasting Consensus versus Empirical Domains.

Jason, Leonard A, Kot, Bobby, Sunnquist, Madison et al.·Fatigue : biomedicine, health & behavior·2014

Researchers compared different sets of diagnostic criteria used to identify ME/CFS patients. They looked at criteria developed by expert groups (like the Canadian Consensus Criteria) and compared them to criteria identified through statistical analysis of actual patient data. The study found that the fatigue and post-exertional malaise domain (worsening symptoms after activity) was the best feature for distinguishing ME/CFS patients from healthy people, and that older diagnostic criteria were less accurate.

Post-Exertional Malaise

E3 PreliminaryCohortPEM not requiredCross-Sectional

Diagnosis and management of chronic fatigue syndrome/myalgic encephalitis in black and minority ethnic people: a qualitative study.

Bayliss, Kerin, Riste, Lisa, Fisher, Louise et al.·Primary health care research & development·2014

This study looked at why people from Black and minority ethnic backgrounds are diagnosed with ME/CFS less often than White British people, even though they may have the condition more frequently. Researchers interviewed 35 healthcare workers and stakeholders in northwest England and found many barriers, including lack of awareness about ME/CFS, language difficulties, cultural differences in how symptoms are discussed, and unfair stereotypes about laziness. The study recommends better training for doctors and culturally sensitive patient information to help improve diagnosis rates.

E3 PreliminaryCohortPEM not requiredCross-Sectional

Adolescents and mothers value referral to a specialist service for chronic fatigue syndrome or myalgic encephalopathy (CFS/ME).

Beasant, Lucy, Mills, Nicola, Crawley, Esther·Primary health care research & development·2014

This study asked 13 mothers and 12 teenagers with ME/CFS about their experiences getting help from a specialist ME/CFS service. Most families found it difficult and took a long time to access the specialist clinic, but once they got there, both teenagers and mothers felt it was valuable. The specialist service helped confirm the diagnosis, improved symptom management, and helped communication between doctors and schools.

InterventionsDiagnostics

E3 PreliminaryMechanismPEM requiredObservational

Inability of myalgic encephalomyelitis/chronic fatigue syndrome patients to reproduce VO₂peak indicates functional impairment.

Keller, Betsy A, Pryor, John Luke, Giloteaux, Ludovic·Journal of translational medicine·2014

This study tested whether people with ME/CFS can perform the same on an exercise test when it's repeated the next day, similar to how healthy people typically do. The researchers found that ME/CFS patients performed significantly worse on the second test—using about 14% less oxygen and doing about 12% less work—even though they were trying their hardest both times. This suggests that doing one exercise test may give doctors an unrealistic picture of what ME/CFS patients can actually do.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM unclearObservational

High-throughput sequencing of plasma microRNA in chronic fatigue syndrome/myalgic encephalomyelitis.

Brenu, Ekua W, Ashton, Kevin J, Batovska, Jana et al.·PloS one·2014

This study looked for tiny molecular messages called microRNAs in the blood of ME/CFS patients to see if they might work as a diagnostic tool. Researchers compared blood samples from ME/CFS patients and healthy people, and found three microRNAs that were higher in ME/CFS patients. This is an early-stage discovery that could eventually help doctors identify ME/CFS more easily through a simple blood test.

Biomarkers

E3 PreliminaryCohortPEM not requiredObservational

'Sometimes it feels as if the world goes on without me': adolescents' experiences of living with chronic fatigue syndrome.

Winger, Anette, Ekstedt, Mirjam, Wyller, Vegard B et al.·Journal of clinical nursing·2014

This study listened to 18 teenagers with ME/CFS about what life is really like living with this illness. The teenagers described feeling left behind by the world, isolated from friends and school, struggling to be seen and understood by others, and dealing with a body that doesn't work the way they expect. Despite these challenges, most young people expressed hope for improvement in the future.

E3 PreliminaryReviewPEM unclearReview-Narrative

Evidence supporting a link between dental amalgams and chronic illness, fatigue, depression, anxiety, and suicide.

Kern, Janet K, Geier, David A, Bjørklund, Geir et al.·Neuro endocrinology letters·2014

This review article examines whether mercury vapor released from dental fillings (amalgams) might cause or worsen ME/CFS, fibromyalgia, depression, and anxiety. The authors found that studies linking mercury exposure to fatigue, anxiety, and depression symptoms are similar to what people experience with ME/CFS, and that some patients improved after having their amalgam fillings removed. The authors conclude that mercury from dental fillings deserves serious consideration when investigating chronic fatigue and related conditions.

E3 PreliminaryMechanismPEM not requiredMechanistic

Isoflavones inhibit poly(I:C)-induced serum, brain, and skin inflammatory mediators - relevance to chronic fatigue syndrome.

Vasiadi, Magdalini, Newman, Jennifer, Theoharides, Theoharis C·Journal of neuroinflammation·2014

This study tested whether isoflavones (plant compounds found in soy) could reduce inflammation and fatigue-like symptoms in mice exposed to immune triggers and stress. Mice given a high-isoflavone diet showed less activity loss and lower inflammation markers in their blood, brain, and skin compared to mice on regular diet. The findings suggest isoflavones might help reduce some ME/CFS symptoms by calming the body's immune response.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

Epstein-barr virus infection masquerading as acute leukemia: a report of two cases and review of literature.

Chhabra, Puneet, Law, Arjun Dutt, Sharma, Upender et al.·Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion·2014

This study describes two cases where patients were initially thought to have acute leukemia based on blood tests, but they actually had Epstein-Barr virus (EBV) infections instead. One patient had infectious mononucleosis, and the other had a rare EBV-related immune condition. The study shows that EBV can sometimes look like leukemia under a microscope, which can lead to misdiagnosis.

Diagnostics

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[Biopersistence and systemic distribution of intramuscularly injected particles: what impact on long-term tolerability of alum adjuvants?].

The developmental basis of epigenetic regulation of HTR2A and psychiatric outcomes.

Competences required for the delivery of high and low-intensity cognitive behavioural interventions for chronic fatigue, chronic fatigue syndrome/ME and irritable bowel syndrome.

Chronic Fatigue Syndrome: Case Definitions and Diagnostic Assessment.

Clinical features in patients with long-lasting macrophagic myofasciitis.

Restraint Induces Sickness Responses Independent of Injection with Epstein-Barr Virus (EBV)-Encoded dUTPase.

A case of femoral arteriovenous fistula causing high-output cardiac failure, originally misdiagnosed as chronic fatigue syndrome.

The glutathione system: a new drug target in neuroimmune disorders.

Multiple Sclerosis/Chronic Fatigue Syndrome overlap: When two common disorders collide.

Hepatitis B vaccination and associated oral manifestations: a non-systematic review of literature and case reports.

The emerging role of autoimmunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/cfs).

Comparing and Contrasting Consensus versus Empirical Domains.

Diagnosis and management of chronic fatigue syndrome/myalgic encephalitis in black and minority ethnic people: a qualitative study.

Adolescents and mothers value referral to a specialist service for chronic fatigue syndrome or myalgic encephalopathy (CFS/ME).

Inability of myalgic encephalomyelitis/chronic fatigue syndrome patients to reproduce VO₂peak indicates functional impairment.

High-throughput sequencing of plasma microRNA in chronic fatigue syndrome/myalgic encephalomyelitis.

'Sometimes it feels as if the world goes on without me': adolescents' experiences of living with chronic fatigue syndrome.

Evidence supporting a link between dental amalgams and chronic illness, fatigue, depression, anxiety, and suicide.

Isoflavones inhibit poly(I:C)-induced serum, brain, and skin inflammatory mediators - relevance to chronic fatigue syndrome.

Epstein-barr virus infection masquerading as acute leukemia: a report of two cases and review of literature.

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