ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

1081–1100 of 2,422 studies

E3 PreliminaryMechanismPEM not requiredMechanistic

[Effect of manual acupuncture stimulation of "Baihui" (GV 20), etc. on serum IFN-gamma and IL-4 contents in rats with chronic fatigue syndrome].

Wang, Chao, Xie, Wen-juan, Liu, Mi et al.·Zhen ci yan jiu = Acupuncture research·2014

Researchers tested whether acupuncture could help rats with fatigue by measuring immune system markers called IFN-gamma and IL-4. Rats that received acupuncture showed improved balance in these immune markers compared to untreated rats with fatigue, suggesting acupuncture may help restore immune function in chronic fatigue syndrome.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

A Study of the Protective Effect of Triticum aestivum L. in an Experimental Animal Model of Chronic Fatigue Syndrome.

Borah, Mukundam, Sarma, Phulen, Das, Swarnamoni·Pharmacognosy research·2014

Researchers tested whether wheat leaf extract could help mice recover from exhaustion caused by repeated stress. The stressed mice that received the extract showed improved activity levels and reduced anxiety compared to untreated stressed mice, and their brain chemistry improved. This suggests the extract's antioxidant properties may help protect against some effects of chronic fatigue.

E3 PreliminaryBehavioralPEM unclearCross-Sectional

Experiences of daily activity in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) and their implications for rehabilitation programmes.

Pemberton, Sue, Cox, Diane L·Disability and rehabilitation·2014

This study interviewed 14 people with ME/CFS to understand how they experience daily activities. Researchers found that before becoming ill, most participants were very active and had difficulty taking breaks. When they got sick, they tried to keep pushing themselves to do as much as before, which led to worsening symptoms. The study suggests that rehabilitation programs should take into account people's attitudes toward activity and rest, not just focus on changing what they do.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic Fatigue Syndrome: Case Definitions and Diagnostic Assessment.

Williams, Yolonda J, Jantke, Rachel L, Jason, Leonard A·New York State psychologist·2014

This article explains why doctors have difficulty diagnosing ME/CFS and why patients often struggle to get proper care. The researchers found that there are disagreements about how to define and diagnose the illness, which makes it harder for healthcare providers to recognize it and treat it correctly. They call for better education of doctors and clearer diagnostic guidelines.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome, fibromyalgia, and myalgic encephalomyelitis: a clinical perspective.

Teitelbaum, Jacob·Alternative therapies in health and medicine·2014

This article reviews how chronic fatigue syndrome (ME/CFS), fibromyalgia, and related conditions present in clinical practice. Dr. Teitelbaum, an experienced clinician, discusses the symptoms and practical aspects of these overlapping illnesses that affect energy, pain, and sleep. The piece offers a clinical perspective on recognizing and understanding these conditions from a doctor's viewpoint.

E3 PreliminaryCohortPEM unclearObservational

A qualitative natural history study of ME/CFS in the community.

Anderson, Valerie R, Jason, Leonard A, Hlavaty, Laura E·Health care for women international·2014

This study interviewed 19 people with ME/CFS who were living in their communities (rather than patients seen at specialty clinics) to understand their experiences with the illness over time. The researchers found that ME/CFS affects people in multiple ways—physically, emotionally, and socially—and that how communities and healthcare providers respond to patients can significantly impact their illness progression and quality of life.

E3 PreliminaryCohortPEM not requiredCross-Sectional

Evaluating Interactive Fatigue Management Workshops for Occupational Health Professionals in the United Kingdom.

Ali, Sheila, Chalder, Trudie, Madan, Ira·Safety and health at work·2014

This study tested whether one-day training workshops could help occupational health professionals (doctors and nurses who work with employers) better understand and manage fatigue and chronic fatigue syndrome (CFS). After the training, these professionals knew more about fatigue and felt more confident diagnosing and treating it in working people, with improvements that lasted at least 4 months.

E3 PreliminaryMechanismPEM not requiredMechanistic

Phenylephrine alteration of cerebral blood flow during orthostasis: effect on n-back performance in chronic fatigue syndrome.

Medow, Marvin S, Sood, Shilpa, Messer, Zachary et al.·Journal of applied physiology (Bethesda, Md. : 1985)·2014

Many ME/CFS patients experience dizziness and cognitive problems when standing up because blood flow to the brain decreases. This study tested whether a medication called phenylephrine, which raises blood pressure, could help restore brain blood flow and improve thinking tasks during standing. The researchers found that phenylephrine reduced the brain blood flow drop and helped ME/CFS patients perform better on memory tests while upright.

Autonomic Nervous SystemCognitive Impairment

E3 PreliminaryReviewPEM unclearReview-Narrative

Oxidative and Nitrosative Stress and Immune-Inflammatory Pathways in Patients with Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS).

Morris, Gerwyn, Maes, Michael·Current neuropharmacology·2014

This study proposes that ME/CFS involves a harmful cycle where the body's immune system becomes overactive and produces damaging molecules called oxidative stress. These problems can be triggered by infections, gut bacteria leaking into the bloodstream, or problems with the energy-producing parts of cells called mitochondria. Once started, this cycle feeds on itself, causing brain inflammation, reduced blood flow to the brain, and damage to cells throughout the body.

NeuroinflammationImmune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Biopersistence and systemic distribution of intramuscularly injected particles: what impact on long-term tolerability of alum adjuvants?].

Gherardi, Romain K, Cadusseau, Josette, Authier, François-jérôme·Bulletin de l'Academie nationale de medecine·2014

This review examines how aluminum-based vaccine adjuvants (immune-boosting ingredients) may rarely cause long-term health problems in susceptible people, including muscle pain, exhaustion, and brain fog that can last years. The researchers found that aluminum particles can travel from the injection site through the body to distant organs and the brain, and that a specific immune protein called MCP-1 may control how much this happens. For most people, aluminum adjuvants are safe, but genetic and environmental differences may make some individuals more vulnerable to prolonged effects.

Immune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Decreased basal ganglia activation in subjects with chronic fatigue syndrome: association with symptoms of fatigue.

Miller, Andrew H, Jones, James F, Drake, Daniel F et al.·PloS one·2014

This study used brain imaging to look at a specific part of the brain called the basal ganglia, which helps control movement and reward responses. Researchers found that people with ME/CFS had less activity in certain regions of this brain area compared to healthy people, and the amount of reduced activity was related to how severe their fatigue symptoms were.

E3 PreliminaryReviewPEM unclearReview-Narrative

Mitochondrial dysfunctions in myalgic encephalomyelitis/chronic fatigue syndrome explained by activated immuno-inflammatory, oxidative and nitrosative stress pathways.

Morris, Gerwyn, Maes, Michael·Metabolic brain disease·2014

This study explains how ME/CFS may damage the mitochondria—the energy-producing units inside our cells. The researchers found that inflammation, immune system overactivity, and harmful molecules called oxidative stress can interfere with how mitochondria produce energy (ATP), which is why ME/CFS patients experience extreme fatigue and post-exertional malaise. Low levels of protective vitamins and minerals also make this problem worse.

Immune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredMechanistic

Restraint Induces Sickness Responses Independent of Injection with Epstein-Barr Virus (EBV)-Encoded dUTPase.

Aubrecht, Taryn G, Abi Salloum, Bachir, Ariza, Maria Eugenia et al.·Journal of behavioral and brain science·2014

This study looked at how stress and a virus protein linked to ME/CFS affect sickness symptoms in mice. Researchers gave mice either saline or a protein made by Epstein-Barr virus, then exposed some mice to restraint stress for either 1 or 3 days. Surprisingly, restraint stress alone caused sickness-like symptoms after 3 days, regardless of whether mice received the virus protein, and the virus protein didn't make stress effects worse.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic Fatigue Syndrome: The Current Status and Future Potentials of Emerging Biomarkers.

Fischer, David Benjamin, William, Arsani Hany, Strauss, Adam Campbell et al.·Fatigue : biomedicine, health & behavior·2014

This review examines potential blood tests and biological markers that could help doctors better understand and diagnose ME/CFS. Currently, ME/CFS is diagnosed mainly based on symptoms because we lack clear objective tests. The authors suggest that identifying specific biomarkers—measurable biological signs—could help identify different subtypes of ME/CFS, which might respond better to different treatments.

BiomarkersImmune System

E3 PreliminaryMechanismPEM unclearObservational

Clinical features in patients with long-lasting macrophagic myofasciitis.

Rigolet, Muriel, Aouizerate, Jessie, Couette, Maryline et al.·Frontiers in neurology·2014

This study describes macrophagic myofasciitis (MMF), a condition where aluminum from vaccines persists in muscle tissue and causes long-lasting symptoms similar to ME/CFS, including widespread pain, severe fatigue, and significant problems with thinking and memory. Patients show patterns of brain abnormalities on imaging scans, and their cognitive problems appear to be caused by brain dysfunction rather than just pain or depression. The researchers found that standard treatments don't work well for these patients, making their condition particularly disabling.

Neuroinflammation

E3 PreliminaryMechanismPEM unclearObservational

High-throughput sequencing of plasma microRNA in chronic fatigue syndrome/myalgic encephalomyelitis.

Brenu, Ekua W, Ashton, Kevin J, Batovska, Jana et al.·PloS one·2014

This study looked for tiny molecular messages called microRNAs in the blood of ME/CFS patients to see if they might work as a diagnostic tool. Researchers compared blood samples from ME/CFS patients and healthy people, and found three microRNAs that were higher in ME/CFS patients. This is an early-stage discovery that could eventually help doctors identify ME/CFS more easily through a simple blood test.

Biomarkers

E3 PreliminaryCohortPEM not requiredObservational

'Sometimes it feels as if the world goes on without me': adolescents' experiences of living with chronic fatigue syndrome.

Winger, Anette, Ekstedt, Mirjam, Wyller, Vegard B et al.·Journal of clinical nursing·2014

This study listened to 18 teenagers with ME/CFS about what life is really like living with this illness. The teenagers described feeling left behind by the world, isolated from friends and school, struggling to be seen and understood by others, and dealing with a body that doesn't work the way they expect. Despite these challenges, most young people expressed hope for improvement in the future.

E3 PreliminaryReviewPEM not requiredReview-Narrative

The developmental basis of epigenetic regulation of HTR2A and psychiatric outcomes.

Paquette, Alison G, Marsit, Carmen J·Journal of cellular biochemistry·2014

This article examines how a gene called HTR2A, which helps control serotonin (a brain chemical), can be chemically modified in ways that affect brain development and mental health. Researchers found that these modifications can happen before birth—even in the placenta—and may influence how our brains develop, potentially affecting conditions like depression, anxiety, and other mental health disorders. The article suggests these changes might also be linked to chronic fatigue syndrome, though more research is needed to understand how and why.

E3 PreliminaryMechanismPEM not requiredObservational

Deficient EBV-specific B- and T-cell response in patients with chronic fatigue syndrome.

Loebel, Madlen, Strohschein, Kristin, Giannini, Carolin et al.·PloS one·2014

This study looked at how the immune system responds to Epstein-Barr virus (EBV), a common virus that causes mono, in people with ME/CFS compared to healthy controls. Researchers found that ME/CFS patients have a weaker immune response to EBV, particularly in their B cells and T cells—the immune cells that normally fight off this virus. The findings suggest that ME/CFS patients may have difficulty controlling EBV reactivation in their bodies.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Hepatitis B vaccination and associated oral manifestations: a non-systematic review of literature and case reports.

Tarakji, B, Ashok, N, Alakeel, R et al.·Annals of medical and health sciences research·2014

This review looked at reported side effects from the Hepatitis B vaccine given to children and adults. While the vaccine is generally considered safe, researchers found reports of various health complications that occurred after vaccination, including some that affect the mouth and jaw. The authors note that most side effects go away on their own, but a few can be serious and need hospital care.

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[Effect of manual acupuncture stimulation of "Baihui" (GV 20), etc. on serum IFN-gamma and IL-4 contents in rats with chronic fatigue syndrome].

A Study of the Protective Effect of Triticum aestivum L. in an Experimental Animal Model of Chronic Fatigue Syndrome.

Experiences of daily activity in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) and their implications for rehabilitation programmes.

Chronic Fatigue Syndrome: Case Definitions and Diagnostic Assessment.

Chronic fatigue syndrome, fibromyalgia, and myalgic encephalomyelitis: a clinical perspective.

A qualitative natural history study of ME/CFS in the community.

Evaluating Interactive Fatigue Management Workshops for Occupational Health Professionals in the United Kingdom.

Phenylephrine alteration of cerebral blood flow during orthostasis: effect on n-back performance in chronic fatigue syndrome.

Oxidative and Nitrosative Stress and Immune-Inflammatory Pathways in Patients with Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS).

[Biopersistence and systemic distribution of intramuscularly injected particles: what impact on long-term tolerability of alum adjuvants?].

Decreased basal ganglia activation in subjects with chronic fatigue syndrome: association with symptoms of fatigue.

Mitochondrial dysfunctions in myalgic encephalomyelitis/chronic fatigue syndrome explained by activated immuno-inflammatory, oxidative and nitrosative stress pathways.

Restraint Induces Sickness Responses Independent of Injection with Epstein-Barr Virus (EBV)-Encoded dUTPase.

Chronic Fatigue Syndrome: The Current Status and Future Potentials of Emerging Biomarkers.

Clinical features in patients with long-lasting macrophagic myofasciitis.

High-throughput sequencing of plasma microRNA in chronic fatigue syndrome/myalgic encephalomyelitis.

'Sometimes it feels as if the world goes on without me': adolescents' experiences of living with chronic fatigue syndrome.

The developmental basis of epigenetic regulation of HTR2A and psychiatric outcomes.

Deficient EBV-specific B- and T-cell response in patients with chronic fatigue syndrome.

Hepatitis B vaccination and associated oral manifestations: a non-systematic review of literature and case reports.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research