ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

1081–1100 of 2,420 studies

E3 PreliminaryBehavioralPEM unclearCross-Sectional

Experiences of daily activity in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) and their implications for rehabilitation programmes.

Pemberton, Sue, Cox, Diane L·Disability and rehabilitation·2014

This study interviewed 14 people with ME/CFS to understand how they experience daily activities. Researchers found that before becoming ill, most participants were very active and had difficulty taking breaks. When they got sick, they tried to keep pushing themselves to do as much as before, which led to worsening symptoms. The study suggests that rehabilitation programs should take into account people's attitudes toward activity and rest, not just focus on changing what they do.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredMechanistic

Phenylephrine alteration of cerebral blood flow during orthostasis: effect on n-back performance in chronic fatigue syndrome.

Medow, Marvin S, Sood, Shilpa, Messer, Zachary et al.·Journal of applied physiology (Bethesda, Md. : 1985)·2014

Many ME/CFS patients experience dizziness and cognitive problems when standing up because blood flow to the brain decreases. This study tested whether a medication called phenylephrine, which raises blood pressure, could help restore brain blood flow and improve thinking tasks during standing. The researchers found that phenylephrine reduced the brain blood flow drop and helped ME/CFS patients perform better on memory tests while upright.

Autonomic Nervous SystemCognitive Impairment

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome, fibromyalgia, and myalgic encephalomyelitis: a clinical perspective.

Teitelbaum, Jacob·Alternative therapies in health and medicine·2014

This article reviews how chronic fatigue syndrome (ME/CFS), fibromyalgia, and related conditions present in clinical practice. Dr. Teitelbaum, an experienced clinician, discusses the symptoms and practical aspects of these overlapping illnesses that affect energy, pain, and sleep. The piece offers a clinical perspective on recognizing and understanding these conditions from a doctor's viewpoint.

E3 PreliminaryReviewPEM unclearReview-Narrative

Discerning primary and secondary factors responsible for clinical fatigue in multisystem diseases.

Maughan, David, Toth, Michael·Biology·2014

This review examines why fatigue happens in chronic diseases like ME/CFS, multiple sclerosis, and heart failure. The authors point out that fatigue comes from a mix of problems in how the body uses energy, how the nervous system works, and how muscles function. They emphasize that inactivity and loss of fitness may contribute significantly to fatigue, and this is often overlooked when researchers only focus on the disease itself.

E3 PreliminaryMechanismPEM unclearCross-Sectional

Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An ¹¹C-(R)-PK11195 PET Study.

Nakatomi, Yasuhito, Mizuno, Kei, Ishii, Akira et al.·Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2014

This study used a special brain imaging technique called PET scans to look for signs of inflammation in the brains of ME/CFS patients. Researchers found that people with ME/CFS had higher levels of brain inflammation markers in several key brain regions compared to healthy controls. The amount of inflammation was linked to how severe patients' cognitive problems, pain, and depression were.

Neuroinflammation

E3 PreliminaryMechanismPEM not requiredMechanistic

[Effect of manual acupuncture stimulation of "Baihui" (GV 20), etc. on serum IFN-gamma and IL-4 contents in rats with chronic fatigue syndrome].

Wang, Chao, Xie, Wen-juan, Liu, Mi et al.·Zhen ci yan jiu = Acupuncture research·2014

Researchers tested whether acupuncture could help rats with fatigue by measuring immune system markers called IFN-gamma and IL-4. Rats that received acupuncture showed improved balance in these immune markers compared to untreated rats with fatigue, suggesting acupuncture may help restore immune function in chronic fatigue syndrome.

Immune System

E3 PreliminaryDiagnosticPEM not requiredCross-Sectional

Assessment of fatigue using the Multidimensional Fatigue Inventory in patients with major depressive disorder.

Chung, Ka-Fai, Yu, Branda Yee-Man, Yung, Kam-Ping et al.·Comprehensive psychiatry·2014

This study tested whether a fatigue measurement tool called the MFI-20 works well for people with depression. Researchers gave the test to 137 people with depression and found it reliably measured different types of tiredness—physical and mental exhaustion, reduced energy, and loss of motivation. The tool successfully tracked changes in fatigue over time and correlated with other health measures.

E3 PreliminaryReviewPEM unclearReview-Narrative

Oxidative and Nitrosative Stress and Immune-Inflammatory Pathways in Patients with Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS).

Morris, Gerwyn, Maes, Michael·Current neuropharmacology·2014

This study proposes that ME/CFS involves a harmful cycle where the body's immune system becomes overactive and produces damaging molecules called oxidative stress. These problems can be triggered by infections, gut bacteria leaking into the bloodstream, or problems with the energy-producing parts of cells called mitochondria. Once started, this cycle feeds on itself, causing brain inflammation, reduced blood flow to the brain, and damage to cells throughout the body.

NeuroinflammationImmune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Stress triggers coronary mast cells leading to cardiac events.

Alevizos, Michail, Karagkouni, Anna, Panagiotidou, Smaro et al.·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2014

When we experience stress, our body releases chemicals that can activate immune cells in the heart called mast cells. These activated mast cells release inflammatory substances that can trigger heart problems or make existing heart disease worse. This review found that stress-related activation of heart mast cells may be a key pathway connecting emotional stress to heart attacks and coronary artery disease.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic Fatigue Syndrome: The Current Status and Future Potentials of Emerging Biomarkers.

Fischer, David Benjamin, William, Arsani Hany, Strauss, Adam Campbell et al.·Fatigue : biomedicine, health & behavior·2014

This review examines potential blood tests and biological markers that could help doctors better understand and diagnose ME/CFS. Currently, ME/CFS is diagnosed mainly based on symptoms because we lack clear objective tests. The authors suggest that identifying specific biomarkers—measurable biological signs—could help identify different subtypes of ME/CFS, which might respond better to different treatments.

BiomarkersImmune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Main neuroendocrine features, diagnosis and therapeutic possibilities in the chronic fatigue syndrome, an underdiagnosed entity.

Amihăesei, Ioana Cristina, Cojocaru, Elena·Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi·2014

ME/CFS is a serious illness marked by extreme tiredness that doesn't improve with rest, along with problems concentrating, pain, and worsening symptoms after activity. Diagnosis requires at least six months of severe fatigue plus four or more other specific symptoms. Current treatments focus on behavioral approaches and pacing rather than medications, though only about 5% of people fully recover, and more than half become unable to work.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

What is called symptom?

Eriksen, Thor Eirik, Risør, Mette Bech·Medicine, health care, and philosophy·2014

This paper explores what we actually mean by the word 'symptom' in medicine. The authors argue that when doctors can't find a clear medical cause for illness—like ME/CFS—our usual way of thinking about symptoms breaks down. They suggest we need to understand symptoms in broader ways, including how patients' social lives, personal experiences, and individual circumstances shape how they experience illness.

Diagnostics

E3 PreliminaryCohortPEM unclearObservational

A qualitative natural history study of ME/CFS in the community.

Anderson, Valerie R, Jason, Leonard A, Hlavaty, Laura E·Health care for women international·2014

This study interviewed 19 people with ME/CFS who were living in their communities (rather than patients seen at specialty clinics) to understand their experiences with the illness over time. The researchers found that ME/CFS affects people in multiple ways—physically, emotionally, and socially—and that how communities and healthcare providers respond to patients can significantly impact their illness progression and quality of life.

E3 PreliminaryCohortPEM not required

Complete eradication of chronic long standing eczema and keratosis pilaris following treatment with dextroamphetamine sulfate.

Check, J H, Chan, S·Clinical and experimental obstetrics & gynecology·2014

This study describes two patients with ME/CFS who also had long-standing skin conditions (eczema and keratosis pilaris) that improved significantly when treated with dextroamphetamine, a stimulant medication. The authors suggest these skin problems may be related to an underactive nervous system that is also involved in ME/CFS, and that stimulant treatment may help both conditions.

Interventions

E3 PreliminaryReviewPEM unclearReview-Narrative

Mitochondrial dysfunctions in myalgic encephalomyelitis/chronic fatigue syndrome explained by activated immuno-inflammatory, oxidative and nitrosative stress pathways.

Morris, Gerwyn, Maes, Michael·Metabolic brain disease·2014

This study explains how ME/CFS may damage the mitochondria—the energy-producing units inside our cells. The researchers found that inflammation, immune system overactivity, and harmful molecules called oxidative stress can interfere with how mitochondria produce energy (ATP), which is why ME/CFS patients experience extreme fatigue and post-exertional malaise. Low levels of protective vitamins and minerals also make this problem worse.

Immune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredMechanistic

A chronic fatigue syndrome model demonstrates mechanical allodynia and muscular hyperalgesia via spinal microglial activation.

Yasui, Masaya, Yoshimura, Takashi, Takeuchi, So et al.·Glia·2014

This study used rats exposed to continuous stress to model ME/CFS and fibromyalgia, finding that stress caused pain sensitivity without any actual tissue damage or infection. The researchers discovered that immune cells in the spinal cord called microglia became activated in stressed animals, and blocking this activation with a drug called minocycline reduced their pain. This suggests that abnormal pain in ME/CFS may stem from brain and spinal cord inflammation rather than damage to muscles or skin.

Neuroinflammation

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Decreased basal ganglia activation in subjects with chronic fatigue syndrome: association with symptoms of fatigue.

Miller, Andrew H, Jones, James F, Drake, Daniel F et al.·PloS one·2014

This study used brain imaging to look at a specific part of the brain called the basal ganglia, which helps control movement and reward responses. Researchers found that people with ME/CFS had less activity in certain regions of this brain area compared to healthy people, and the amount of reduced activity was related to how severe their fatigue symptoms were.

E3 PreliminaryMechanismPEM not requiredObservational

Deficient EBV-specific B- and T-cell response in patients with chronic fatigue syndrome.

Loebel, Madlen, Strohschein, Kristin, Giannini, Carolin et al.·PloS one·2014

This study looked at how the immune system responds to Epstein-Barr virus (EBV), a common virus that causes mono, in people with ME/CFS compared to healthy controls. Researchers found that ME/CFS patients have a weaker immune response to EBV, particularly in their B cells and T cells—the immune cells that normally fight off this virus. The findings suggest that ME/CFS patients may have difficulty controlling EBV reactivation in their bodies.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Effect of trimethylgallic acid esters against chronic stress-induced anxiety-like behavior and oxidative stress in mice.

Dhingra, Mamta Sachdeva, Dhingra, Sameer, Kumria, Rachna et al.·Pharmacological reports : PR·2014

This study tested whether a new compound derived from gallic acid (a plant antioxidant) could help reverse the harmful effects of chronic stress in mice. Researchers stressed mice by making them swim daily for 15 days, then treated them with the compound and measured changes in anxiety, memory, and harmful molecules in the brain. The treated mice showed improvements in movement, reduced anxiety, better memory, and lower levels of inflammation compared to untreated stressed mice.

E3 PreliminaryReviewPEM unclearReview-Narrative

The saga of XMRV: a virus that infects human cells but is not a human virus.

Arias, Maribel, Fan, Hung·Emerging microbes & infections·2014

In 2006, scientists discovered a virus called XMRV and thought it might cause both prostate cancer and chronic fatigue syndrome (ME/CFS). After years of research and controversy, it became clear that XMRV was not actually infecting humans naturally. Instead, the virus had accidentally been created in a laboratory when human cancer cells were grown inside immunocompromised mice, where two mouse viruses combined to form XMRV. This discovery was important because it showed why initial findings linking XMRV to these diseases were false.

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Experiences of daily activity in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) and their implications for rehabilitation programmes.

Phenylephrine alteration of cerebral blood flow during orthostasis: effect on n-back performance in chronic fatigue syndrome.

Chronic fatigue syndrome, fibromyalgia, and myalgic encephalomyelitis: a clinical perspective.

Discerning primary and secondary factors responsible for clinical fatigue in multisystem diseases.

Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An ¹¹C-(R)-PK11195 PET Study.

[Effect of manual acupuncture stimulation of "Baihui" (GV 20), etc. on serum IFN-gamma and IL-4 contents in rats with chronic fatigue syndrome].

Assessment of fatigue using the Multidimensional Fatigue Inventory in patients with major depressive disorder.

Oxidative and Nitrosative Stress and Immune-Inflammatory Pathways in Patients with Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS).

Stress triggers coronary mast cells leading to cardiac events.

Chronic Fatigue Syndrome: The Current Status and Future Potentials of Emerging Biomarkers.

Main neuroendocrine features, diagnosis and therapeutic possibilities in the chronic fatigue syndrome, an underdiagnosed entity.

What is called symptom?

A qualitative natural history study of ME/CFS in the community.

Complete eradication of chronic long standing eczema and keratosis pilaris following treatment with dextroamphetamine sulfate.

Mitochondrial dysfunctions in myalgic encephalomyelitis/chronic fatigue syndrome explained by activated immuno-inflammatory, oxidative and nitrosative stress pathways.

A chronic fatigue syndrome model demonstrates mechanical allodynia and muscular hyperalgesia via spinal microglial activation.

Decreased basal ganglia activation in subjects with chronic fatigue syndrome: association with symptoms of fatigue.

Deficient EBV-specific B- and T-cell response in patients with chronic fatigue syndrome.

Effect of trimethylgallic acid esters against chronic stress-induced anxiety-like behavior and oxidative stress in mice.

The saga of XMRV: a virus that infects human cells but is not a human virus.

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