ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

1181–1200 of 2,420 studies

E3 PreliminaryMechanismPEM not requiredMechanistic

Characterization, mapping, and distribution of the two XMRV parental proviruses.

Cingöz, Oya, Paprotka, Tobias, Delviks-Frankenberry, Krista A et al.·Journal of virology·2012

This study investigated XMRV, a virus that was once thought to be linked to ME/CFS. Researchers discovered that XMRV was not created naturally in mice but instead was accidentally made in a laboratory when two different mouse viruses combined during a cancer experiment. The study shows that XMRV could not have originated in nature because its two parent viruses are found in different geographic mouse populations and have never naturally occurred together in the wild.

E3 PreliminaryMechanismPEM unclearCross-Sectional

Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrome and Fibromyalgia Syndrome.

Light, A R, Bateman, L, Jo, D et al.·Journal of internal medicine·2012

This study looked at how genes are turned on and off in people with ME/CFS before and after moderate exercise. Researchers found that about 71% of ME/CFS patients showed increased activity in genes related to nerve signaling and stress response after exercise, which correlated with their fatigue and pain levels. A smaller subgroup (29%) showed a different pattern, with decreased activity in one specific gene, and these patients were more likely to have orthostatic intolerance (dizziness when standing).

BiomarkersPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Carnitine derivatives: clinical usefulness.

Malaguarnera, Mariano·Current opinion in gastroenterology·2012

This review article discusses carnitine and its chemical cousins (acetyl-L-carnitine and propionyl-L-carnitine), which are natural substances your body uses to convert food into energy. The authors explain that these compounds may help with various conditions including chronic fatigue syndrome, depression, memory problems, and heart disease, and appear to be safe with few side effects.

Energy Metabolism

E3 PreliminaryGuidelinePEM not requiredGuideline

[Persistent fatigue following Q fever].

Keijmel, Stephan P, Morroy, Gabriëlla, Delsing, Corine E et al.·Nederlands tijdschrift voor geneeskunde·2012

After a bacterial infection called Q fever, about 1 in 5 patients develop long-lasting fatigue and other symptoms called Q fever fatigue syndrome (QFS). This guideline from the Netherlands helps doctors diagnose and treat QFS consistently. Many patients recover on their own within six months, but those who don't may benefit from cognitive behavioral therapy, a type of talk therapy that helps people manage chronic fatigue.

Diagnostics

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Comparison of two quantitative assays for xenotropic murine leukemia virus-related virus.

Sato, Eiji, Yoshikawa, Rokusuke, Miyazawa, Takayuki·The Journal of veterinary medical science·2012

Researchers developed two new laboratory tests to detect and measure XMRV, a virus that was discovered in some people with chronic fatigue syndrome and prostate cancer. They compared a newer, simpler test called a 'focus assay' with an older test called a 'LacZ marker rescue assay' and found that both tests detected the virus equally well, though the newer test was easier to use.

E3 PreliminaryCohortPEM not requiredObservational

Amisulpride in the treatment of fibromyalgia: an uncontrolled study.

Rico-Villademoros, Fernando, Rodriguez-Lopez, Carmen Maria, Morillas-Arques, Piedad et al.·Clinical rheumatology·2012

Researchers tested whether a medication called amisulpride, which is sometimes used to treat pain and mood problems, could help people with fibromyalgia. Over 12 weeks, 40 patients took this medication along with their regular treatments. The medication did not significantly reduce pain or other fibromyalgia symptoms, and many patients stopped taking it because of side effects.

Pain and Sensitization

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

Metacognitive factors in chronic fatigue syndrome.

Maher-Edwards, Lorraine, Fernie, Bruce A, Murphy, Gabrielle et al.·Clinical psychology & psychotherapy·2012

This study explored how ME/CFS patients think about their thinking—specifically, their beliefs about analyzing and solving problems related to their symptoms. Researchers found that patients have both helpful and unhelpful thoughts about trying to understand their illness, and they often focus on either distracting themselves or monitoring their symptoms closely. The study suggests that these thought patterns may play a role in how ME/CFS symptoms develop or persist.

Cognitive Impairment

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Development and application of a high-throughput microneutralization assay: lack of xenotropic murine leukemia virus-related virus and/or murine leukemia virus detection in blood donors.

Zhou, Yanchen, Steffen, Imke, Montalvo, Leilani et al.·Transfusion·2012

Researchers developed a new test to look for viruses called XMRV and related MLVs in blood donors, since these viruses had been suggested as possible causes of ME/CFS. They tested 354 blood samples and found that about 6.5% showed some ability to block the virus in the lab, but when they did more detailed testing, they found no actual virus or antibodies against it—suggesting the blocking was likely due to something other than a real infection.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Phylogenetic and biological analysis of a laboratory-generated gammaretrovirus xenotropic murine leukemia virus-related virus (XMRV).

Ma, Xiaochu, Zhou, Shiying, Wei, Meili et al.·Virus genes·2012

This study investigated whether XMRV, a virus previously thought to be associated with chronic fatigue syndrome, could actually infect human cells. Researchers found that XMRV is a laboratory-made virus created accidentally during experiments with mouse tissues, not a naturally occurring pathogen. Testing showed that XMRV cannot infect human immune cells, suggesting it is unlikely to cause disease in people.

E3 PreliminaryCohortPEM not requiredCase-Control

Aluminium overload after 5 years in skin biopsy following post-vaccination with subcutaneous pseudolymphoma.

Guillard, Olivier, Fauconneau, Bernard, Pineau, Alain et al.·Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)·2012

This case report describes a woman who developed a small lump under her skin at a vaccine injection site years after vaccination. Researchers tested the tissue and found very high levels of aluminum compared to control samples. The study suggests that aluminum from vaccine adjuvants might accumulate in the body and potentially cause long-term problems like chronic fatigue syndrome.

Immune System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Postural neurocognitive and neuronal activated cerebral blood flow deficits in young chronic fatigue syndrome patients with postural tachycardia syndrome.

Stewart, Julian M, Medow, Marvin S, Messer, Zachary R et al.·American journal of physiology. Heart and circulatory physiology·2012

When people with ME/CFS try to stand upright or tilt backward, their brain doesn't get enough blood flow to think clearly, and their thinking problems get worse as their body position changes. In healthy people, brain blood flow increases during hard thinking tasks, but in ME/CFS patients, this normal response is broken—their brains don't increase blood flow when doing difficult mental tasks.

Autonomic Nervous SystemCognitive Impairment

E3 PreliminaryCohortPEM not requiredCase-Control

Improved chronic fatigue symptoms after removal of mercury in patient with increased mercury concentration in hair toxic mineral assay: a case.

Shin, Sae-Ron, Han, A-Lum·Korean journal of family medicine·2012

This case report describes one patient whose chronic fatigue symptoms improved after receiving treatment to remove mercury from their body. The patient had eaten large amounts of raw tuna, which can contain mercury, and testing showed mercury levels in their hair that were higher than normal but below what's considered poisoning. After mercury removal therapy, the patient's fatigue got better.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome, the immune system and viral infection.

Bansal, A S, Bradley, A S, Bishop, K N et al.·Brain, behavior, and immunity·2012

This review examines whether immune system problems and viral infections play a role in ME/CFS. Researchers found modest signs of increased inflammation and cytokines (immune signaling molecules) in some patients, along with weakened natural killer cells that normally fight infections. While patients don't have more herpes virus exposure than healthy people, some evidence suggests their bodies struggle to fully control and clear these viruses, which could explain why symptoms persist.

Immune System

E3 PreliminaryMechanismPEM not requiredObservational

Lack of endogenous pain inhibition during exercise in people with chronic whiplash associated disorders: an experimental study.

Van Oosterwijck, Jessica, Nijs, Jo, Meeus, Mira et al.·The journal of pain·2012

This study compared how the body responds to exercise in people with chronic whiplash injury versus healthy people. Researchers found that pain sensitivity actually increased (got worse) after exercise in whiplash patients, while it decreased (improved) in healthy controls. Importantly, gentle, self-paced exercise caused fewer symptom flare-ups than harder, fixed-intensity exercise, suggesting that how exercise is done matters greatly for people with this condition.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome or myalgic encephalomyelitis.

Burns, Dianne·Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2012

ME/CFS is a serious illness that affects many body systems, especially the nervous and immune systems, and can impact anyone regardless of age, race, or background. This guideline article helps nurses and healthcare workers recognize and support ME/CFS patients by providing practical knowledge and management strategies. The recommendations can be used by healthcare professionals in different settings to better care for people living with this condition.

Diagnostics

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Developing resources to support the diagnosis and management of Chronic Fatigue Syndrome/Myalgic Encephalitis (CFS/ME) in primary care: a qualitative study.

Hannon, Kerin, Peters, Sarah, Fisher, Louise et al.·BMC family practice·2012

This study asked patients, carers, and doctors in North West England what would help them better diagnose and manage ME/CFS in general practice. The researchers found that patients want to be believed and taken seriously, while doctors said they need better training and support. Based on everyone's feedback, the team created practical tools including a DVD for patients, information leaflets, and online training for doctors.

Diagnostics

E3 PreliminaryMechanismPEM not requiredMechanistic

Evaluation of protective effect of Aegle marmelos Corr. in an animal model of chronic fatigue syndrome.

Lalremruta, Vanphawng, Prasanna, Gurunath S·Indian journal of pharmacology·2012

Researchers tested whether an extract from the leaves of a plant called Aegle marmelos (also known as bael fruit) could help reduce fatigue-like symptoms in rats. Rats that were forced to swim daily developed fatigue-like behaviors, and when treated with the plant extract, they showed improvement in activity levels, reduced anxiety, and better stress markers in their blood compared to untreated rats.

E3 PreliminaryMechanismPEM not requiredMechanistic

Shilajit attenuates behavioral symptoms of chronic fatigue syndrome by modulating the hypothalamic-pituitary-adrenal axis and mitochondrial bioenergetics in rats.

Surapaneni, Dinesh Kumar, Adapa, Sree Rama Shiva Shanker, Preeti, Kumari et al.·Journal of ethnopharmacology·2012

Researchers tested a natural substance called shilajit in rats with fatigue symptoms similar to ME/CFS. The shilajit appeared to reduce fatigue-like behaviors and anxiety, and improved how well the rats' cells produced energy. This suggests shilajit might work by helping the body's stress response system and protecting mitochondria—the 'powerhouses' inside cells.

Energy Metabolism

E3 PreliminaryReviewPEM not requiredReview-Narrative

Diet and its role in interstitial cystitis/bladder pain syndrome (IC/BPS) and comorbid conditions.

Friedlander, Justin I, Shorter, Barbara, Moldwin, Robert M·BJU international·2012

This review examined how food and beverages affect bladder pain syndrome (IC/BPS) and related conditions like fibromyalgia and chronic fatigue. Nearly 90% of patients report that certain foods make their symptoms worse—especially acidic foods like citrus and tomatoes, caffeine, alcohol, and spicy foods—while some substances like calcium and baking soda may help. The researchers recommend that patients work with their doctors to identify their personal food triggers through careful elimination diets rather than avoiding foods unnecessarily.

Interventions

E3 PreliminaryMechanismPEM not requiredMechanistic

[Effect of acupuncture on serum malonaldehyde content, superoxide dismutase and glutathione peroxidase activity in chronic fatigue syndrome rats].

Liu, Chang-Zheng, Lei, Bo·Zhen ci yan jiu = Acupuncture research·2012

This study tested whether acupuncture could help rats with chronic fatigue syndrome by reducing harmful molecules in the blood called free radicals. Researchers created a rat model of CFS using stress and cold water swimming, then treated some rats with acupuncture at specific points. The results showed that acupuncture reduced damaging molecules and restored the body's natural antioxidant defenses in the treated rats.

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Evidence Atlas

Evidence browser

Characterization, mapping, and distribution of the two XMRV parental proviruses.

Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrome and Fibromyalgia Syndrome.

Carnitine derivatives: clinical usefulness.

[Persistent fatigue following Q fever].

Comparison of two quantitative assays for xenotropic murine leukemia virus-related virus.

Amisulpride in the treatment of fibromyalgia: an uncontrolled study.

Metacognitive factors in chronic fatigue syndrome.

Development and application of a high-throughput microneutralization assay: lack of xenotropic murine leukemia virus-related virus and/or murine leukemia virus detection in blood donors.

Phylogenetic and biological analysis of a laboratory-generated gammaretrovirus xenotropic murine leukemia virus-related virus (XMRV).

Aluminium overload after 5 years in skin biopsy following post-vaccination with subcutaneous pseudolymphoma.

Postural neurocognitive and neuronal activated cerebral blood flow deficits in young chronic fatigue syndrome patients with postural tachycardia syndrome.

Improved chronic fatigue symptoms after removal of mercury in patient with increased mercury concentration in hair toxic mineral assay: a case.

Chronic fatigue syndrome, the immune system and viral infection.

Lack of endogenous pain inhibition during exercise in people with chronic whiplash associated disorders: an experimental study.

Chronic fatigue syndrome or myalgic encephalomyelitis.

Developing resources to support the diagnosis and management of Chronic Fatigue Syndrome/Myalgic Encephalitis (CFS/ME) in primary care: a qualitative study.

Evaluation of protective effect of Aegle marmelos Corr. in an animal model of chronic fatigue syndrome.

Shilajit attenuates behavioral symptoms of chronic fatigue syndrome by modulating the hypothalamic-pituitary-adrenal axis and mitochondrial bioenergetics in rats.

Diet and its role in interstitial cystitis/bladder pain syndrome (IC/BPS) and comorbid conditions.

[Effect of acupuncture on serum malonaldehyde content, superoxide dismutase and glutathione peroxidase activity in chronic fatigue syndrome rats].

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