ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

1181–1200 of 2,422 studies

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Developing resources to support the diagnosis and management of Chronic Fatigue Syndrome/Myalgic Encephalitis (CFS/ME) in primary care: a qualitative study.

Hannon, Kerin, Peters, Sarah, Fisher, Louise et al.·BMC family practice·2012

This study asked patients, carers, and doctors in North West England what would help them better diagnose and manage ME/CFS in general practice. The researchers found that patients want to be believed and taken seriously, while doctors said they need better training and support. Based on everyone's feedback, the team created practical tools including a DVD for patients, information leaflets, and online training for doctors.

Diagnostics

E3 PreliminaryMechanismPEM not requiredMechanistic

Xpr1 is an atypical G-protein-coupled receptor that mediates xenotropic and polytropic murine retrovirus neurotoxicity.

Vaughan, Andrew E, Mendoza, Ramon, Aranda, Ramona et al.·Journal of virology·2012

This study explored how a virus called XMRV might damage nerve cells in people with ME/CFS. Researchers found that when this virus enters cells, it blocks an important communication system (called cAMP signaling) that normally keeps cells healthy, leading them to die. However, it's now known that XMRV detection in human samples was likely due to contamination rather than actual infection.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Reduction of [11C](+)3-MPB binding in brain of chronic fatigue syndrome with serum autoantibody against muscarinic cholinergic receptor.

Yamamoto, Shigeyuki, Ouchi, Yasuomi, Nakatsuka, Daisaku et al.·PloS one·2012

Some people with ME/CFS have antibodies in their blood that target a chemical receptor in the brain called the muscarinic cholinergic receptor. This study used brain imaging (PET scans) to compare the brains of ME/CFS patients with and without these antibodies. Patients with these antibodies showed lower levels of these receptors in their brains, but this difference did not affect their thinking or memory performance.

Neuroinflammation

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Comparison of two quantitative assays for xenotropic murine leukemia virus-related virus.

Sato, Eiji, Yoshikawa, Rokusuke, Miyazawa, Takayuki·The Journal of veterinary medical science·2012

Researchers developed two new laboratory tests to detect and measure XMRV, a virus that was discovered in some people with chronic fatigue syndrome and prostate cancer. They compared a newer, simpler test called a 'focus assay' with an older test called a 'LacZ marker rescue assay' and found that both tests detected the virus equally well, though the newer test was easier to use.

E3 PreliminaryCohortPEM not requiredCase-Control

Adult presentation of arterial tortuosity syndrome in a 51-year-old woman with a novel homozygous c.1411+1G>A mutation in the SLC2A10 gene.

Castori, Marco, Ritelli, Marco, Zoppi, Nicoletta et al.·American journal of medical genetics. Part A·2012

This case describes a 51-year-old woman diagnosed with arterial tortuosity syndrome (ATS), a rare genetic condition affecting blood vessel structure and strength. She presented with chronic pain, fatigue, joint problems, and heart valve issues. Genetic testing found a new mutation in the SLC2A10 gene responsible for this condition, which is usually diagnosed in children but was discovered here in an adult.

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome or myalgic encephalomyelitis.

Burns, Dianne·Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2012

ME/CFS is a serious illness that affects many body systems, especially the nervous and immune systems, and can impact anyone regardless of age, race, or background. This guideline article helps nurses and healthcare workers recognize and support ME/CFS patients by providing practical knowledge and management strategies. The recommendations can be used by healthcare professionals in different settings to better care for people living with this condition.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome.

Tracy, Mooney·Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2012

This article provides an overview of chronic fatigue syndrome (ME/CFS), describing what the condition is and how it affects patients. The authors discuss the symptoms people experience, including severe tiredness that doesn't improve with rest, and other health problems that often occur alongside it. The article aims to help healthcare providers, particularly nurses, understand ME/CFS better so they can provide appropriate care and support.

E3 PreliminaryPEM unclearRegistry-Resource

Worst Cases Reported to the NAFKAM International Registry of Exceptional Courses of Disease.

Fønnebø, Vinjar, Drageset, Brit J, Salamonsen, Anita·Global advances in health and medicine·2012

This study reviewed detailed case reports from a registry that documented the most severe cases of ME/CFS—patients whose illness followed unusual or particularly debilitating courses. The researchers examined these exceptional cases to better understand the range and severity of disease progression in ME/CFS. By studying the worst-case scenarios, the team aimed to identify patterns that might help doctors recognize and support the most severely affected patients.

E3 PreliminaryCohortPEM not requiredObservational

Amisulpride in the treatment of fibromyalgia: an uncontrolled study.

Rico-Villademoros, Fernando, Rodriguez-Lopez, Carmen Maria, Morillas-Arques, Piedad et al.·Clinical rheumatology·2012

Researchers tested whether a medication called amisulpride, which is sometimes used to treat pain and mood problems, could help people with fibromyalgia. Over 12 weeks, 40 patients took this medication along with their regular treatments. The medication did not significantly reduce pain or other fibromyalgia symptoms, and many patients stopped taking it because of side effects.

Pain and Sensitization

E3 PreliminaryMechanismPEM not requiredMechanistic

Characterization, mapping, and distribution of the two XMRV parental proviruses.

Cingöz, Oya, Paprotka, Tobias, Delviks-Frankenberry, Krista A et al.·Journal of virology·2012

This study investigated XMRV, a virus that was once thought to be linked to ME/CFS. Researchers discovered that XMRV was not created naturally in mice but instead was accidentally made in a laboratory when two different mouse viruses combined during a cancer experiment. The study shows that XMRV could not have originated in nature because its two parent viruses are found in different geographic mouse populations and have never naturally occurred together in the wild.

E3 PreliminaryBehavioralPEM not required

Subjective concepts of chronically ill patients using distant healing.

Güthlin, Corina, Anton, Andreas, Kruse, Jan et al.·Qualitative health research·2012

This study interviewed 17 ME/CFS and multiple chemical sensitivity patients who received distant healing (spiritual intentions or prayers) as part of a research trial. Researchers found that patients struggled with a conflict: they wanted to try distant healing for help, but felt uncertain or judged because mainstream medicine doesn't recognize it as effective. Patients often tried to justify their choice to themselves and others.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Diet and its role in interstitial cystitis/bladder pain syndrome (IC/BPS) and comorbid conditions.

Friedlander, Justin I, Shorter, Barbara, Moldwin, Robert M·BJU international·2012

This review examined how food and beverages affect bladder pain syndrome (IC/BPS) and related conditions like fibromyalgia and chronic fatigue. Nearly 90% of patients report that certain foods make their symptoms worse—especially acidic foods like citrus and tomatoes, caffeine, alcohol, and spicy foods—while some substances like calcium and baking soda may help. The researchers recommend that patients work with their doctors to identify their personal food triggers through careful elimination diets rather than avoiding foods unnecessarily.

Interventions

E3 PreliminaryCohortPEM not requiredCase-Control

Improved chronic fatigue symptoms after removal of mercury in patient with increased mercury concentration in hair toxic mineral assay: a case.

Shin, Sae-Ron, Han, A-Lum·Korean journal of family medicine·2012

This case report describes one patient whose chronic fatigue symptoms improved after receiving treatment to remove mercury from their body. The patient had eaten large amounts of raw tuna, which can contain mercury, and testing showed mercury levels in their hair that were higher than normal but below what's considered poisoning. After mercury removal therapy, the patient's fatigue got better.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Postural neurocognitive and neuronal activated cerebral blood flow deficits in young chronic fatigue syndrome patients with postural tachycardia syndrome.

Stewart, Julian M, Medow, Marvin S, Messer, Zachary R et al.·American journal of physiology. Heart and circulatory physiology·2012

When people with ME/CFS try to stand upright or tilt backward, their brain doesn't get enough blood flow to think clearly, and their thinking problems get worse as their body position changes. In healthy people, brain blood flow increases during hard thinking tasks, but in ME/CFS patients, this normal response is broken—their brains don't increase blood flow when doing difficult mental tasks.

Autonomic Nervous SystemCognitive Impairment

E3 PreliminaryCohortPEM not requiredCase-Control

Aluminium overload after 5 years in skin biopsy following post-vaccination with subcutaneous pseudolymphoma.

Guillard, Olivier, Fauconneau, Bernard, Pineau, Alain et al.·Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)·2012

This case report describes a woman who developed a small lump under her skin at a vaccine injection site years after vaccination. Researchers tested the tissue and found very high levels of aluminum compared to control samples. The study suggests that aluminum from vaccine adjuvants might accumulate in the body and potentially cause long-term problems like chronic fatigue syndrome.

Immune System

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Development of sensitive single-round pol or env RT-PCR assays to screen for XMRV in multiple sample types.

Tang, Ning, Frank, Andrea, Leckie, Gregor et al.·Journal of virological methods·2012

Researchers developed laboratory tests to detect XMRV, a virus that was proposed as a possible cause of ME/CFS. They tested these new detection methods on blood, urine, and other samples from healthy people, HIV-positive people, and prostate cancer patients. The tests worked well in the lab, but when applied to real patient samples, they did not find any confirmed cases of XMRV.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Linking disease symptoms and subtypes with personalized systems-based phenotypes: a proof of concept study.

Aschbacher, Kirstin, Adam, Emma K, Crofford, Leslie J et al.·Brain, behavior, and immunity·2012

This study examined how the body's stress-response system (the HPA axis) works differently in people with ME/CFS and fibromyalgia compared to healthy people. Researchers measured stress hormones (cortisol and ACTH) every 10 minutes for 24 hours and used computer modeling to understand each person's unique hormone patterns. They found that nighttime hormone patterns were different in patients versus healthy controls, and these patterns were linked to symptoms like pain, fatigue, and poor sleep.

Sleep

E3 PreliminaryCohortPEM not requiredObservational

Cervical neuro-muscular syndrome: discovery of a new disease group caused by abnormalities in the cervical muscles.

Matsui, Takayoshi, Ii, Kunio, Hojo, Shuntaro et al.·Neurologia medico-chirurgica·2012

This study suggests that problems in the neck muscles may cause or contribute to a range of symptoms including headaches, dizziness, fatigue, and autonomic problems (issues with automatic body functions like heart rate and blood pressure). The researchers treated patients with neck muscle abnormalities and reported that most patients improved significantly, with success rates ranging from 84-88% depending on the symptom.

Autonomic Nervous System

E3 PreliminaryMechanismPEM unclearCross-Sectional

Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrome and Fibromyalgia Syndrome.

Light, A R, Bateman, L, Jo, D et al.·Journal of internal medicine·2012

This study looked at how genes are turned on and off in people with ME/CFS before and after moderate exercise. Researchers found that about 71% of ME/CFS patients showed increased activity in genes related to nerve signaling and stress response after exercise, which correlated with their fatigue and pain levels. A smaller subgroup (29%) showed a different pattern, with decreased activity in one specific gene, and these patients were more likely to have orthostatic intolerance (dizziness when standing).

BiomarkersPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Biological underpinnings of the commonalities in depression, somatization, and Chronic Fatigue Syndrome.

Anderson, George, Maes, Michael, Berk, Michael·Medical hypotheses·2012

This review examines why people with ME/CFS, depression, and somatization (a condition involving unexplained body symptoms) often experience similar physical symptoms like fatigue, pain, and autonomic problems. The researchers found evidence that these symptoms arise from real biological changes in the body, including immune system activation and changes in how the body processes an amino acid called tryptophan. This suggests these seemingly different conditions may share common biological pathways rather than being purely psychological.

Immune System

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Evidence Atlas

Evidence browser

Developing resources to support the diagnosis and management of Chronic Fatigue Syndrome/Myalgic Encephalitis (CFS/ME) in primary care: a qualitative study.

Xpr1 is an atypical G-protein-coupled receptor that mediates xenotropic and polytropic murine retrovirus neurotoxicity.

Reduction of [11C](+)3-MPB binding in brain of chronic fatigue syndrome with serum autoantibody against muscarinic cholinergic receptor.

Comparison of two quantitative assays for xenotropic murine leukemia virus-related virus.

Adult presentation of arterial tortuosity syndrome in a 51-year-old woman with a novel homozygous c.1411+1G>A mutation in the SLC2A10 gene.

Chronic fatigue syndrome or myalgic encephalomyelitis.

Chronic fatigue syndrome.

Worst Cases Reported to the NAFKAM International Registry of Exceptional Courses of Disease.

Amisulpride in the treatment of fibromyalgia: an uncontrolled study.

Characterization, mapping, and distribution of the two XMRV parental proviruses.

Subjective concepts of chronically ill patients using distant healing.

Diet and its role in interstitial cystitis/bladder pain syndrome (IC/BPS) and comorbid conditions.

Improved chronic fatigue symptoms after removal of mercury in patient with increased mercury concentration in hair toxic mineral assay: a case.

Postural neurocognitive and neuronal activated cerebral blood flow deficits in young chronic fatigue syndrome patients with postural tachycardia syndrome.

Aluminium overload after 5 years in skin biopsy following post-vaccination with subcutaneous pseudolymphoma.

Development of sensitive single-round pol or env RT-PCR assays to screen for XMRV in multiple sample types.

Linking disease symptoms and subtypes with personalized systems-based phenotypes: a proof of concept study.

Cervical neuro-muscular syndrome: discovery of a new disease group caused by abnormalities in the cervical muscles.

Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrome and Fibromyalgia Syndrome.

Biological underpinnings of the commonalities in depression, somatization, and Chronic Fatigue Syndrome.

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