ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

121–140 of 2,420 studies

E3 PreliminaryMechanismPEM not requiredMechanistic

Ultrasound-assisted preparation of sweet corn cob polysaccharide selenium nanoparticles alleviates symptoms of chronic fatigue syndrome.

Wang, Jingyang, Wang, Xin, Xiu, Weiye et al.·Food & function·2025

Researchers created tiny particles made from selenium and sweet corn cob material and tested whether they could help reduce fatigue symptoms in mice with chronic fatigue syndrome. The particles appeared to improve energy production in cells and reduce harmful oxidative stress, while also making positive changes to the bacteria in the digestive system.

Energy Metabolism

E3 PreliminaryMechanismPEM requiredPreprintPreprint

Heightened innate immunity may trigger chronic inflammation, fatigue and post-exertional malaise in ME/CFS.

Che, Xiaoyu, Ranjan, Amit, Guo, Cheng et al.·medRxiv : the preprint server for health sciences·2025

This study found that people with ME/CFS may have an overactive immune system that responds too strongly to germs and infections. The research showed problems with how the body produces energy and manages inflammation, and these problems got worse after exercise in ME/CFS patients but not in healthy people. The findings suggest multiple biological systems are working abnormally in ME/CFS, which could help doctors develop better treatments.

Energy MetabolismImmune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM requiredPreprintPreprint

Dissecting the genetic complexity of myalgic encephalomyelitis/chronic fatigue syndrome via deep learning-powered genome analysis.

Zhang, Sai, Jahanbani, Fereshteh, Chander, Varuna et al.·medRxiv : the preprint server for health sciences·2025

Researchers used advanced artificial intelligence to analyze the genes of ME/CFS patients and discovered 115 genes that may contribute to the disease. They found that people with ME/CFS have lower levels of these risk genes active in their immune cells and nervous system. This genetic analysis could eventually help doctors diagnose ME/CFS more accurately and identify new treatment targets.

BiomarkersImmune SystemCognitive ImpairmentPost-Exertional Malaise

E3 PreliminaryPEM unclear

Wearable Devices Enable Long COVID Patients to Decrease Symptom Severity: A Case Series From Pilot User Testing.

Goosen, Andrea, Foster-Bonds, Romina, Vogel, Julia Moore·Cardiopulmonary physical therapy journal·2025

This small study looked at whether fitness trackers (Garmin watches) could help Long COVID patients manage their symptoms through pacing—carefully controlling activity levels to avoid overexertion. Eleven patients received a tracker, educational materials about pacing, and were asked about their experience. Most participants found the information helpful for managing their symptoms, and none had difficulty using the device, even those who had never used a wearable before.

E3 PreliminaryPEM unclear

Static and Kinetic Disequilibrium are Central Neural Signs in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-Therapeutic Effect of Repetitive Transcranial Magnetic Stimulation.

Miwa, Kunihisa·Journal of integrative neuroscience·2025

This study found that nearly half of ME/CFS patients experience balance problems—either when standing still (static disequilibrium) or when walking (kinetic disequilibrium). These balance issues were linked to difficulty standing upright and limitations in daily activities. When researchers used a brain stimulation treatment called repetitive transcranial magnetic stimulation (rTMS) on specific brain regions, most patients' balance problems improved, suggesting the root cause is in the central nervous system rather than the inner ear alone.

Autonomic Nervous System

E3 PreliminaryCohortPEM unclearCross-Sectional

Patient experiences of remote consulting with chronic fatigue syndrome/myalgic encephalomyelitis and fibromyalgia: a qualitative study.

Leach, Helen, Eccles, Abi, Chew-Graham, Carolyn A et al.·BJGP open·2025

This study asked 13 people with ME/CFS and fibromyalgia about their experiences using phone and video appointments with their doctors during and after 2020. Patients said the most important thing was feeling believed and listened to by their doctor. While remote appointments had some benefits (like being easier when symptoms were bad), many people found it harder to communicate without face-to-face visits, though having a trusted, familiar doctor made a big difference.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Quantitative Proteomics on Immune Cells of ME/CFS Patients Using SWATH-MS.

Kumar, Abhishek, Peppercorn, Katie, Kleffmann, Torsten·Methods in molecular biology (Clifton, N.J.)·2025

This study describes a detailed scientific method for examining proteins in immune cells taken from the blood of ME/CFS patients. Researchers used advanced technology called SWATH-MS (a type of mass spectrometry) to identify and measure thousands of proteins at once. The paper explains the step-by-step process they used so that other researchers can use the same method to find protein abnormalities in ME/CFS.

Immune System

E3 PreliminaryCommentaryPEM unclearEditorial

Post-infective myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and post-COVID as two puzzling faces of the same medal. Recent insights.

Chirumbolo, Salvatore, Franzini, Marianno, Tirelli, Umberto·International immunopharmacology·2025

This editorial examines the similarities between ME/CFS (a long-term illness causing extreme fatigue and other symptoms) and post-COVID syndrome (long-term effects some people experience after COVID-19 infection). The authors suggest these two conditions may share common underlying biological mechanisms, even though they arise from different infections. Understanding these connections could help doctors better recognize and treat both conditions.

Long COVID Overlap

E3 PreliminaryMechanismPEM not requiredMechanistic

HLA and pathogens in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and other post-infection conditions.

Georgopoulos, Apostolos P, James, Lisa M, Peterson, Philip K·Scientific reports·2025

This study explores why some people develop ME/CFS after viral infections while others don't. Researchers looked at immune system genes (HLA types) and tested how well they recognize and fight nine common human herpes viruses. They found that people with certain HLA types have weak immune recognition of these viruses, potentially allowing the viruses to persist and cause ME/CFS, while people with other HLA types have strong recognition and protection.

Immune System

E3 PreliminaryDiagnosticPEM unclear

Analysis of Transient Receptor Potential Ion Channels in ME/CFS.

Eaton-Fitch, Natalie, Muraki, Katsuhiko, Sasso, Etianne Martini et al.·Methods in molecular biology (Clifton, N.J.)·2025

This study describes the scientific methods used to examine special proteins called ion channels (specifically TRPM3) in the cells of ME/CFS patients. Researchers took blood samples, isolated specific immune cells, and used advanced techniques like imaging and electrical measurements to see how these ion channels work. This work provides a detailed handbook for scientists studying how ion channel problems might contribute to ME/CFS.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Rasch analysis of the hospital anxiety and depression scale in patients with chronic fatigue syndrome.

Bartholomew, Emerson J, Medvedev, Oleg N, Petrie, Keith J et al.·Journal of psychosomatic research·2025

This study tested whether a common questionnaire called the Hospital Anxiety and Depression Scale (HADS) accurately measures anxiety and depression in people with ME/CFS. Researchers analyzed responses from 286 ME/CFS patients and found that the questionnaire works reasonably well, but they discovered that converting the scores into a different format makes the results more precise and reliable for clinical use.

E3 PreliminaryReviewPEM not requiredReview-Narrative

A Direct Relationship Between 'Blood Stasis' and Fibrinaloid Microclots in Chronic, Inflammatory, and Vascular Diseases, and Some Traditional Natural Products Approaches to Treatment.

Kell, Douglas B, Pretorius, Etheresia, Zhao, Huihui·Pharmaceuticals (Basel, Switzerland)·2025

This study proposes that tiny blood clots called fibrinaloid microclots may be the physical basis behind a traditional Chinese medicine concept called 'blood stasis,' which describes sluggish blood flow. The authors suggest that these microclots block small blood vessels and reduce oxygen delivery to tissues, and that certain Chinese herbal remedies—particularly a formula called Xue Fu Zhu Yu—may help by reducing microclot formation. If correct, this could open new treatment avenues for ME/CFS, long COVID, and other chronic inflammatory conditions.

E3 PreliminaryReviewPEM unclearReview-Narrative

Does Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Represent a Poly-Herpesvirus Post-Virus Infectious Disease?

Ariza, Maria Eugenia, Mena Palomo, Irene, Williams, Marshall V·Viruses·2025

This review examines whether ME/CFS might be caused by multiple herpes viruses working together, rather than a single virus. The researchers point out that many people develop ME/CFS after flu-like illnesses, suggesting viruses play a role, but scientists haven't found just one virus responsible. The study suggests that herpes viruses might cause ME/CFS through a special type of incomplete replication that hasn't been fully studied before.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Profiling Antibody Reactivity to Gut Microbes in ME/CFS Patients.

Seton, Katharine A, Carding, Simon R·Methods in molecular biology (Clifton, N.J.)·2025

This study looks at how the immune system of ME/CFS patients reacts to bacteria in the gut. Many ME/CFS patients have changes in their gut bacteria and a leaky gut lining that allows bacteria and their toxic products to enter the bloodstream, potentially triggering widespread inflammation. The researchers developed methods to measure specific immune proteins (antibodies) that ME/CFS patients produce in response to these gut bacteria, compared to healthy household members.

Gut MicrobiomeImmune System

E3 PreliminaryCohortPEM unclearCross-Sectional

Diagnostic overshadowing in systemic lupus erythematosus (SLE): A qualitative study.

Harwood, Rupert, Wincup, Chris, D'Cruz, David et al.·Lupus·2025

This study looked at why people with lupus (SLE) often wait a long time to get diagnosed. Researchers found that doctors sometimes overlook or misinterpret lupus symptoms, attributing them instead to other causes like mental health problems, ME/CFS, or fibromyalgia. This "diagnostic overshadowing" can add years to someone's diagnostic journey and delay the treatment they need.

Diagnostics

E3 PreliminaryCohortPEM unclearCase-Control

A Case of Psoriasis Concurrently Complicated by Sacroiliitis and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Iijima, Mami, Miyagaki, Tomomitsu, Nakajima, Kaori et al.·Cureus·2025

This case report describes one patient who developed psoriasis (a skin condition), sacroiliitis (inflammation of joints in the lower back), and ME/CFS all around the same time. The researchers reviewed what is known about how these three conditions might be connected through shared immune system problems. The study suggests that people with psoriasis may be at higher risk of developing ME/CFS, possibly because both conditions involve similar types of inflammatory immune responses.

Immune System

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Using the Ratio of Phosphorylated to Non-phosphorylated Forms of Stress Kinase PKR as a Potential Diagnostic Test for ME/CFS.

Sweetman, Eiren, Tate, Warren P·Methods in molecular biology (Clifton, N.J.)·2025

Researchers developed a new blood test that measures a specific immune protein called PKR in white blood cells to help diagnose ME/CFS. The test looks at whether PKR is in an active or inactive form—people with ME/CFS appear to have different patterns of active PKR compared to healthy people. If this method works well in larger studies, it could provide doctors with a simple, quick way to diagnose ME/CFS instead of waiting months while ruling out other illnesses.

Immune System

E3 PreliminaryCommentaryPEM unclearEditorial

Chronic Fatigue in Cancer Survivorship: Psychiatry Versus Oncology or Psychiatry with Oncology?

Kafetzopoulos, Vasilios, Pittaka, Maria, Ioannidis, Georgios et al.·Current oncology reports·2025

This review examines fatigue in breast cancer survivors and how it's treated. The authors found that non-drug treatments like exercise, talk therapy, and mindfulness work best for cancer-related fatigue. They point out that cancer doctors and psychiatrists approach fatigue differently, and suggest that a combined team approach—mixing cancer care with mental health support—would help patients most.

E3 PreliminaryMechanismPEM not requiredMechanistic

Oxidative stress is a shared characteristic of ME/CFS and Long COVID.

Shankar, Vishnu, Wilhelmy, Julie, Curtis, Ellis J et al.·Proceedings of the National Academy of Sciences of the United States of America·2025

Researchers found that both ME/CFS and Long COVID patients have higher levels of oxidative stress—a harmful buildup of unstable molecules—in their immune cells, particularly in a type of white blood cell called memory T cells. The study identified specific problems with how the body clears this oxidative stress and showed that the existing medication metformin might help reduce overgrowth of these immune cells. Importantly, they discovered these problems show different patterns in men and women, suggesting that sex-specific treatment approaches may be needed.

Immune System

E3 PreliminaryCohortPEM unclearCross-Sectional

'She thought the same way I that I thought:' a qualitative study of patient-provider concordance among Gulf War Veterans with Gulf War Illness.

Lesnewich, Laura M, Hyde, Justeen K, McFarlin, Mikhaela L et al.·Psychology & health·2025

This study talked to 31 Gulf War Veterans with Gulf War Illness to understand what makes them feel heard and supported by their doctors. The researchers found that patients feel better about their care when doctors believe their symptoms are real, show they understand the condition, and build trust with them. When doctors dismissed patients' experiences or didn't know much about Gulf War Illness, it damaged the relationship and made treatment harder.

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Ultrasound-assisted preparation of sweet corn cob polysaccharide selenium nanoparticles alleviates symptoms of chronic fatigue syndrome.

Heightened innate immunity may trigger chronic inflammation, fatigue and post-exertional malaise in ME/CFS.

Dissecting the genetic complexity of myalgic encephalomyelitis/chronic fatigue syndrome via deep learning-powered genome analysis.

Wearable Devices Enable Long COVID Patients to Decrease Symptom Severity: A Case Series From Pilot User Testing.

Static and Kinetic Disequilibrium are Central Neural Signs in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-Therapeutic Effect of Repetitive Transcranial Magnetic Stimulation.

Patient experiences of remote consulting with chronic fatigue syndrome/myalgic encephalomyelitis and fibromyalgia: a qualitative study.

Quantitative Proteomics on Immune Cells of ME/CFS Patients Using SWATH-MS.

Post-infective myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and post-COVID as two puzzling faces of the same medal. Recent insights.

HLA and pathogens in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and other post-infection conditions.

Analysis of Transient Receptor Potential Ion Channels in ME/CFS.

Rasch analysis of the hospital anxiety and depression scale in patients with chronic fatigue syndrome.

A Direct Relationship Between 'Blood Stasis' and Fibrinaloid Microclots in Chronic, Inflammatory, and Vascular Diseases, and Some Traditional Natural Products Approaches to Treatment.

Does Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Represent a Poly-Herpesvirus Post-Virus Infectious Disease?

Profiling Antibody Reactivity to Gut Microbes in ME/CFS Patients.

Diagnostic overshadowing in systemic lupus erythematosus (SLE): A qualitative study.

A Case of Psoriasis Concurrently Complicated by Sacroiliitis and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Using the Ratio of Phosphorylated to Non-phosphorylated Forms of Stress Kinase PKR as a Potential Diagnostic Test for ME/CFS.

Chronic Fatigue in Cancer Survivorship: Psychiatry Versus Oncology or Psychiatry with Oncology?

Oxidative stress is a shared characteristic of ME/CFS and Long COVID.

'She thought the same way I that I thought:' a qualitative study of patient-provider concordance among Gulf War Veterans with Gulf War Illness.

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