ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

1241–1260 of 2,420 studies

E3 PreliminaryMechanismPEM unclearCase-Control

Cytotoxic lymphocyte microRNAs as prospective biomarkers for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Brenu, Ekua W, Ashton, Kevin J, van Driel, Mieke et al.·Journal of affective disorders·2012

Researchers studied tiny molecules called microRNAs in immune cells from people with ME/CFS and healthy controls. They found that people with ME/CFS have lower levels of certain microRNAs in their immune cells, which may explain why their immune systems don't work as well. These microRNA changes could be useful biomarkers—like a fingerprint—to help diagnose or understand ME/CFS.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Membrane fusion and cell entry of XMRV are pH-independent and modulated by the envelope glycoprotein's cytoplasmic tail.

Côté, Marceline, Zheng, Yi-Min, Liu, Shan-Lu·PloS one·2012

This study examined how XMRV, a virus once suspected to be linked to ME/CFS, enters human cells. Researchers found that XMRV enters cells differently than many other viruses—it doesn't require acidic conditions inside the cell. They also discovered that a small tail-like structure on the virus's outer coating controls whether the virus can fuse with and infect cells.

E3 PreliminaryCohortPEM not requiredCase-Control

Antibody to Epstein-Barr virus deoxyuridine triphosphate nucleotidohydrolase and deoxyribonucleotide polymerase in a chronic fatigue syndrome subset.

Lerner, A Martin, Ariza, Maria E, Williams, Marshall et al.·PloS one·2012

This study looked at a small group of ME/CFS patients to see if they had a specific pattern of antibodies (immune proteins) related to Epstein-Barr virus (EBV), a common virus that causes mono. The researchers found that most of these patients had high levels of antibodies against EBV proteins, and when they treated these patients with an antiviral medication for over a year, the patients improved. This suggests that EBV might be involved in ME/CFS for some patients, and a blood test might help identify them.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

The tale of xenotropic murine leukemia virus-related virus.

Groom, Harriet C T, Bishop, Kate N·The Journal of general virology·2012

In 2009, scientists announced they found a virus called XMRV in many ME/CFS patients, raising hopes for a breakthrough. However, when other researchers tried to repeat these findings, they couldn't find the virus in patient samples. By 2011, it became clear that the original samples were contaminated, meaning the virus had accidentally been introduced during testing rather than being present in patients naturally. This review explains how this scientific discovery turned out to be a false alarm.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Biomarkers of stress and fatigue].

Tanaka, Yoshihide·Nihon rinsho. Japanese journal of clinical medicine·2012

This paper reviews different ways to measure stress and fatigue in the body. Instead of just asking patients how stressed they feel, researchers are looking for physical markers—like stress hormones in saliva or hair—that show whether someone is experiencing chronic stress. The authors explain how chronic stress affects the nervous system, hormones, and immune system, and discuss which biological markers might be useful for understanding chronic fatigue syndrome.

BiomarkersImmune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Central sensitization as a component of post-deployment syndrome.

Lewis, Jeffrey D, Wassermann, Eric M, Chao, Wendy et al.·NeuroRehabilitation·2012

This study suggests that post-deployment syndrome—a condition affecting military veterans with chronic pain, fatigue, and memory problems—may develop through a process called central sensitization. Central sensitization means the nervous system becomes overly sensitive and amplifies pain signals. The researchers propose this happens because of changes in how the brain and spinal cord process information, and that stress and genes may increase the risk.

Pain and Sensitization

E3 PreliminaryReviewPEM unclearReview-Narrative

Loss of stress response as a consequence of viral infection: implications for disease and therapy.

Hooper, Philip L, Hightower, Lawrence E, Hooper, Paul L·Cell stress & chaperones·2012

This paper suggests that viral infections may damage the body's ability to handle stress at the cellular level, making tissues more vulnerable to injury. Rather than looking for one specific virus causing ME/CFS, the authors propose that ME/CFS might result from a general, nonspecific cellular damage response that occurs after many types of viral infections. Understanding this mechanism could open new treatment possibilities for conditions that have not responded well to existing therapies.

Immune System

E3 PreliminaryMechanismPEM unclearMechanistic

Intrinsic DNA synthesis fidelity of xenotropic murine leukemia virus-related virus reverse transcriptase.

Barrioluengo, Verónica, Wang, Yi, Le Grice, Stuart F J et al.·The FEBS journal·2012

This study examined how accurately a virus called XMRV copies its genetic material when it infects human cells. Researchers compared XMRV's copying accuracy to two other viruses (HIV and another mouse virus) by measuring how often mistakes happen during the copying process. The study found that XMRV makes copies with reasonable accuracy, though with a different pattern of errors than HIV.

E3 PreliminaryCohortPEM not required

Chronic fatigue syndrome after Giardia enteritis: clinical characteristics, disability and long-term sickness absence.

Naess, Halvor, Nyland, Morten, Hausken, Trygve et al.·BMC gastroenterology·2012

After a water contamination outbreak in Norway caused a bacterial infection (giardiasis), some patients developed long-lasting severe fatigue similar to ME/CFS. This study looked at 58 patients who met the official diagnostic criteria for CFS following this infection. Most patients reported their condition was getting worse over time, and all of them had to take extended time off work or school due to their fatigue and reduced ability to function.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Multi-source synthesis of data to inform health policy.

Pedersen, Vibe Hjelholt, Dagenais, Pierre, Lehoux, Pascale·International journal of technology assessment in health care·2011

This study developed a new way to combine information from published research with direct interviews from ME/CFS patients in Quebec. Researchers reviewed 31 published studies about the emotional and social challenges of ME/CFS, then interviewed 17 patients to see if their experiences matched the research and to identify needs that hadn't been studied before. The study found that patients felt their condition wasn't recognized by doctors and doctors, and suggested policy changes to better support ME/CFS patients.

E3 PreliminaryCohortPEM unclearCross-Sectional

Patients' hopes and expectations of a specialist chronic fatigue syndrome/ME service: a qualitative study.

McDermott, C, Lynch, J, Leydon, G M·Family practice·2011

This study asked 20 newly referred ME/CFS patients what they hoped to gain from visiting a specialist service. Patients most wanted a clear diagnosis, better understanding of their illness, practical guidance on managing it, and hope for the future. Most patients felt uncertain about ME/CFS and wanted more information earlier in their illness journey, rather than waiting to see a specialist.

Diagnostics

E3 PreliminaryMechanismPEM not requiredMechanistic

Polysaccharide of radix pseudostellariae improves chronic fatigue syndrome induced by poly I:C in mice.

Sheng, Rong, Xu, Xianxiang, Tang, Qin et al.·Evidence-based complementary and alternative medicine : eCAM·2011

Researchers tested whether a natural plant compound called polysaccharide from Radix Pseudostellariae (PRP) could help mice recover from fatigue-like symptoms. They found that mice given PRP before being exposed to a virus-like trigger showed less fatigue and better recovery of normal immune and stress hormone function compared to untreated mice.

Immune System

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

PCR master mixes harbour murine DNA sequences. Caveat emptor!

Tuke, Philip W, Tettmar, Kate I, Tamuri, Asif et al.·PloS one·2011

This study found that the laboratory chemicals used to detect viruses in blood samples may themselves contain mouse virus DNA, which can contaminate test results. When researchers tested water samples (with no actual virus present) using common laboratory kits, they still found mouse virus sequences—the same sequences that had been previously reported in ME/CFS patients. This suggests that previous findings of these viruses in ME/CFS patients may have been false positives caused by contaminated testing materials rather than actual infections.

E3 PreliminaryReviewPEM unclearReview-Narrative

Structural integration, an alternative method of manual therapy and sensorimotor education.

Jacobson, Eric·Journal of alternative and complementary medicine (New York, N.Y.)·2011

Structural Integration (SI) is a hands-on therapy that focuses on improving how your body moves and holds itself, rather than treating specific symptoms. This review looked at what we know about how SI might work—such as making muscles and connective tissues more flexible and improving how your nervous system processes movement and stress—and found that small studies have reported improvements in pain, movement, balance, and well-being in some conditions including chronic fatigue.

Pain and Sensitization

E3 PreliminaryReviewPEM unclearReview-Narrative

Evidence and controversies on the role of XMRV in prostate cancer and chronic fatigue syndrome.

Menéndez-Arias, Luis·Reviews in medical virology·2011

Researchers discovered a virus called XMRV in some people with prostate cancer and ME/CFS, which generated significant interest. However, other studies have not been able to confirm this finding, leaving uncertainty about whether XMRV actually causes disease in humans. This review examines what we know and don't know about XMRV's role in these conditions.

E3 PreliminaryReviewPEM unclearReview-Narrative

Systemic nickel hypersensitivity and diet: myth or reality?

Pizzutelli, S·European annals of allergy and clinical immunology·2011

This review examines whether eating foods containing nickel causes widespread symptoms in people with nickel allergies. While nickel allergies from skin contact are well-established, the evidence that eating nickel-containing foods causes systemic symptoms—like fatigue, digestive problems, or neurological issues—is unclear and unproven. The authors conclude that current scientific evidence is not strong enough to recommend low-nickel diets as a treatment.

E3 PreliminaryReviewPEM unclearReview-Narrative

How to care for patients with chronic fatigue syndrome/ME.

McGough, Amanda·Nursing times·2011

This article provides practical guidance for nurses and healthcare professionals on how to care for patients with ME/CFS. It focuses on managing symptoms, supporting patients through their illness, and improving the quality of care these patients receive in clinical settings.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Fatigue and chronic fatigue in the elderly: definitions, diagnoses, and treatments.

Morelli, Vincent·Clinics in geriatric medicine·2011

This review article helps doctors understand fatigue in older adults by explaining three types: fatigue that comes on recently, fatigue that lasts a long time, and chronic fatigue syndrome. The article discusses how doctors can evaluate fatigue and offers both medication and non-medication treatments like exercise, vitamins, diet changes, and behavioral strategies.

Diagnostics

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Identification of Phosphoglycerate Kinase 1 (PGK1) as a reference gene for quantitative gene expression measurements in human blood RNA.

Falkenberg, Virginia R, Whistler, Toni, Murray, Janna' R et al.·BMC research notes·2011

Researchers studying ME/CFS need reliable ways to measure gene activity in blood samples. This study found that a gene called PGK1 is a stable and reliable 'reference point' for comparing gene measurements across different blood collection methods and sample types. Using a single stable reference gene like PGK1 makes it easier for scientists to get accurate, comparable results when searching for blood-based biomarkers of ME/CFS.

Biomarkers

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Regulatory T-cells: modern approaches to optimization of their numbers].

Pukhal'skiĭ, A L, Shmarina, G V, Aleshkin, V A·Vestnik Rossiiskoi akademii meditsinskikh nauk·2011

Your body has special immune cells called regulatory T-cells (Tregs) that normally help control inflammation and keep your immune system balanced. This article explains how long-term stress and aging can disrupt this balance—either causing too many Tregs to build up or too few to develop properly. The authors suggest that when Tregs become imbalanced, it may contribute to conditions like chronic fatigue syndrome, while also affecting allergy and cancer risk.

Immune System

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Evidence browser

Cytotoxic lymphocyte microRNAs as prospective biomarkers for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Membrane fusion and cell entry of XMRV are pH-independent and modulated by the envelope glycoprotein's cytoplasmic tail.

Antibody to Epstein-Barr virus deoxyuridine triphosphate nucleotidohydrolase and deoxyribonucleotide polymerase in a chronic fatigue syndrome subset.

The tale of xenotropic murine leukemia virus-related virus.

[Biomarkers of stress and fatigue].

Central sensitization as a component of post-deployment syndrome.

Loss of stress response as a consequence of viral infection: implications for disease and therapy.

Intrinsic DNA synthesis fidelity of xenotropic murine leukemia virus-related virus reverse transcriptase.

Chronic fatigue syndrome after Giardia enteritis: clinical characteristics, disability and long-term sickness absence.

Multi-source synthesis of data to inform health policy.

Patients' hopes and expectations of a specialist chronic fatigue syndrome/ME service: a qualitative study.

Polysaccharide of radix pseudostellariae improves chronic fatigue syndrome induced by poly I:C in mice.

PCR master mixes harbour murine DNA sequences. Caveat emptor!

Structural integration, an alternative method of manual therapy and sensorimotor education.

Evidence and controversies on the role of XMRV in prostate cancer and chronic fatigue syndrome.

Systemic nickel hypersensitivity and diet: myth or reality?

How to care for patients with chronic fatigue syndrome/ME.

Fatigue and chronic fatigue in the elderly: definitions, diagnoses, and treatments.

Identification of Phosphoglycerate Kinase 1 (PGK1) as a reference gene for quantitative gene expression measurements in human blood RNA.

[Regulatory T-cells: modern approaches to optimization of their numbers].

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