ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

1281–1300 of 2,420 studies

E3 PreliminaryBehavioralPEM unclearObservational

Factors influencing engagement of patients in a novel intervention for CFS/ME: a qualitative study.

Chew-Graham, Carolyn, Brooks, Joanna, Wearden, Alison et al.·Primary health care research & development·2011

This study asked 19 ME/CFS patients about their experiences with a new type of therapy called pragmatic rehabilitation. Researchers found that patients were more likely to stick with treatment if their doctor believed them, if they accepted their ME/CFS diagnosis, and if the treatment approach matched how they understood their own illness. When patients had very different ideas about what was causing their illness than what the therapy suggested, they were less likely to complete the treatment.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Irritable bowel syndrome and other functional gastrointestinal disorders.

Şimşek, Ilkay·Journal of clinical gastroenterology·2011

This review examines irritable bowel syndrome (IBS) and related digestive disorders that cause symptoms like abnormal gut movement and pain sensitivity. The authors found that many people with these conditions also have other illnesses, including ME/CFS and fibromyalgia, suggesting shared underlying causes. Changes in gut bacteria and immune system activity may play an important role in these overlapping conditions.

Immune System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Analysis of cerebrospinal fluid from chronic fatigue syndrome patients for multiple human ubiquitous viruses and xenotropic murine leukemia-related virus.

Schutzer, Steven E, Rounds, Megan A, Natelson, Benjamin H et al.·Annals of neurology·2011

Researchers tested cerebrospinal fluid (the fluid around the brain and spinal cord) from 43 ME/CFS patients to look for XMRV, a virus that some earlier studies suggested might be present in ME/CFS patients' blood. They also tested for several other common viruses. The study found none of these viruses in the cerebrospinal fluid, suggesting that if a virus is involved in ME/CFS, it may work differently than previously thought.

E3 PreliminaryReviewPEM unclearReview-Narrative

XMRV Discovery and Prostate Cancer-Related Research.

Kang, David E, Lee, Michael C, Das Gupta, Jaydip et al.·Advances in virology·2011

This review discusses XMRV, a virus discovered in 2006 that researchers initially thought might be connected to both prostate cancer and ME/CFS. Scientists around the world have conducted studies to see if this virus is present in patients with these conditions, but results have been inconsistent. A major problem has been contamination in laboratories, where mouse-based materials and the virus itself were often present, making it difficult to know if the virus was really there or just a lab artifact.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Nucleic Acid, Antibody, and Virus Culture Methods to Detect Xenotropic MLV-Related Virus in Human Blood Samples.

Kearney, M F, Lee, K, Bagni, R K et al.·Advances in virology·2011

Researchers developed sensitive tests to detect a virus called XMRV in blood samples. They used their tests on blood and tissue samples from patients with prostate cancer, but did not find the virus in any of the blood samples they tested. This study shows that while their detection methods work well, XMRV was not present in the patients' blood.

E3 PreliminaryMechanismPEM not requiredMechanistic

Recombinant origin of the retrovirus XMRV.

Paprotka, Tobias, Delviks-Frankenberry, Krista A, Cingöz, Oya et al.·Science (New York, N.Y.)·2011

Scientists studied a virus called XMRV that had been reported in some ME/CFS patients. They traced where this virus actually came from by examining cancer cell lines and tumors that had been grown in mice. They found that XMRV didn't exist in the original tumor but was created when two similar mouse viruses accidentally combined during laboratory handling. This suggests that when XMRV appeared in patient samples, it likely came from contamination during testing rather than being a real cause of ME/CFS.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Testing strategies for detection of xenotropic murine leukemia virus-related virus infection.

Tang, Shixing, Hewlett, Indira K·Advances in virology·2011

Researchers examined different laboratory methods to detect XMRV, a virus that was suspected to be linked to both prostate cancer and ME/CFS. Since this virus was discovered in 2006, scientists developed various tests to find it in patient samples, but these tests had not been properly validated or compared. The study highlights that careful testing is needed to avoid false results caused by mouse DNA contamination in samples.

E3 PreliminaryReviewPEM not requiredReview-Narrative

The common immunogenic etiology of chronic fatigue syndrome: from infections to vaccines via adjuvants to the ASIA syndrome.

Rosenblum, Hemda, Shoenfeld, Yehuda, Amital, Howard·Infectious disease clinics of North America·2011

ME/CFS is a long-lasting illness of extreme fatigue and other symptoms that often starts suddenly like a flu. This review examines several theories about what might cause ME/CFS, including infections, genetic factors, hormone problems, immune system dysfunction, and psychological stress. The authors discuss a newer condition called ASIA syndrome, which involves autoimmune reactions that may be triggered by vaccine adjuvants (ingredients added to vaccines to boost immune response).

Immune System

E3 PreliminaryMechanismPEM unclear

Analysis of XMRV integration sites from human prostate cancer tissues suggests PCR contamination rather than genuine human infection.

Garson, Jeremy A, Kellam, Paul, Towers, Greg J·Retrovirology·2011

This study examined whether XMRV, a virus previously claimed to be found in ME/CFS patients, was actually present in human tissue samples. Researchers found that some of the viral DNA sequences reported as coming from patients were actually identical to sequences from viruses grown in a laboratory dish in the same lab, suggesting the samples were contaminated during testing rather than representing real human infection.

E3 PreliminaryMechanismPEM not requiredMechanistic

Epigallocatechin gallate ameliorates behavioral and biochemical deficits in rat model of load-induced chronic fatigue syndrome.

Sachdeva, Anand Kamal, Kuhad, Anurag, Chopra, Kanwaljit·Brain research bulletin·2011

Researchers gave rats a substance called EGCG (found in green tea) to see if it could help with fatigue caused by physical and mental stress. The rats that received EGCG showed improvements in tiredness, concentration, and pain compared to rats that didn't receive it, suggesting this compound might have potential as a treatment for ME/CFS.

E3 PreliminaryMechanismPEM not requiredMechanistic

A Chinese herbal decoction, Danggui Buxue Tang, improves chronic fatigue syndrome induced by food restriction and forced swimming in rats.

Liu, Ya, Zhang, Hai-Gang, Li, Xiao-Hui·Phytotherapy research : PTR·2011

Researchers tested a traditional Chinese herbal mixture called Danggui Buxue Tang on rats engineered to have chronic fatigue-like symptoms. Rats treated with the herb showed improvements in body weight, physical endurance, and markers of immune function, suggesting the herbal mixture might help reduce fatigue by calming overactive immune responses.

Immune System

E3 PreliminaryCommentaryPEM unclearEditorial

Chronic fatigue syndrome--a neuroimmunological model.

Arnett, S V, Alleva, L M, Korossy-Horwood, R et al.·Medical hypotheses·2011

This review suggests that ME/CFS may develop when the body has trouble controlling infections early on, leading to long-term inflammation in the brain. The authors propose that this inflammatory process—involving both the immune system and the nervous system—could explain many ME/CFS symptoms and why more women are affected than men. They also suggest that anti-inflammatory treatments targeting a protein called TNF might help patients.

NeuroinflammationImmune System

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Detection of murine leukemia virus or mouse DNA in commercial RT-PCR reagents and human DNAs.

Zheng, HaoQiang, Jia, Hongwei, Shankar, Anupama et al.·PloS one·2011

Scientists tested commercial laboratory reagents and DNA samples commonly used in medical research and found that many contained mouse virus sequences (MLV). These contaminations appear to come from the manufacturing process and could produce false-positive test results if not properly identified. This discovery is important because earlier ME/CFS studies reporting MLV detection may have been affected by these contaminated supplies rather than finding a real virus in patients.

E3 PreliminaryReviewPEM unclearReview-Narrative

XMRV, prostate cancer and chronic fatigue syndrome.

Kenyon, Julia C, Lever, Andrew M L·British medical bulletin·2011

A virus called XMRV was discovered in 2009 and researchers initially thought it might be linked to ME/CFS. However, studies from different countries could not confirm this connection, and many scientists now believe the virus was not actually present in patient samples but was instead introduced by accident during laboratory testing. While the virus can infect human cells in theory, it does not appear to be a significant cause of ME/CFS.

E3 PreliminaryCohortPEM unclearCase-Control

Carcinoid tumour associated with enterovirus infection.

Chia, John, Chia, Andrew, El-Habbal, Rabiha·Journal of clinical pathology·2011

This study looked at two patients—one with ME/CFS and one with chronic abdominal pain—who had rare tumors called carcinoid tumors in their intestines. Researchers found traces of enterovirus (a common virus that infects the gut) inside these tumors using special staining techniques. The authors suggest this might indicate a link between chronic enterovirus infection and the development of these tumors, though much more research is needed to understand if this connection is real.

E3 PreliminaryBehavioralPEM unclearCross-Sectional

Finding the right balance of physical activity: a focus group study about experiences among patients with chronic fatigue syndrome.

Larun, Lillebeth, Malterud, Kirsti·Patient education and counseling·2011

This study asked ME/CFS patients about their experiences with physical activity to understand when exercise helped and when it caused problems. The researchers found that patients weren't against activity itself, but what mattered most was having a choice in the type and intensity of exercise, being able to adjust it to their own needs, and having support from healthcare providers. When activity was forced or not personalized, it often led to setbacks and made patients feel they had lost control of their bodies.

Post-Exertional Malaise

E3 PreliminaryCohortPEM not required

Decades of delayed diagnosis in 4 levodopa-responsive young-onset monogenetic parkinsonism patients.

Ling, Helen, Braschinsky, Mark, Taba, Pille et al.·Movement disorders : official journal of the Movement Disorder Society·2011

This study describes four young patients who were initially misdiagnosed with psychological movement disorders or chronic fatigue syndrome, but actually had a genetic form of Parkinson's disease. Their misdiagnosis lasted 10 to 23 years before the correct diagnosis was made. Once they received the correct treatment with levodopa medication, they all improved significantly, showing that the right diagnosis and treatment can make a major difference.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Two sides of the same coin? On the history and phenomenology of chronic fatigue and burnout.

Leone, Stephanie S, Wessely, Simon, Huibers, Marcus J H et al.·Psychology & health·2011

This study compares burnout (exhaustion from work stress) and ME/CFS (chronic fatigue syndrome) by reviewing existing research and historical records. Though these conditions developed separately—burnout in psychology and CFS in medicine—they share many similar symptoms and appear to involve energy depletion. The authors found that while both conditions involve overload, need for rest, and affect similar types of people, they are often described differently depending on whether they're viewed through a psychological or medical lens.

E3 PreliminaryMechanismPEM unclearMechanistic

Phylogenetic analysis of murine leukemia virus sequences from longitudinally sampled chronic fatigue syndrome patients suggests PCR contamination rather than viral evolution.

Katzourakis, Aris, Hué, Stéphane, Kellam, Paul et al.·Journal of virology·2011

This study examined whether a virus called XMRV, found in some ME/CFS patients' samples over 15 years apart, could have naturally evolved within patients' bodies. Using genetic analysis, the researchers found that the virus sequences were actually different types of mouse viruses, not the same virus changing over time. This suggests the virus detections were likely due to laboratory contamination rather than evidence of an actual persistent infection.

E3 PreliminaryMechanismPEM not requiredMechanistic

Hepatitis C virus enters human peripheral neuroblastoma cells - evidence for extra-hepatic cells sustaining hepatitis C virus penetration.

Bürgel, B, Friesland, M, Koch, A et al.·Journal of viral hepatitis·2011

This study investigated whether hepatitis C virus (HCV) can infect and replicate in nerve cells, since some HCV patients experience fatigue, depression, and memory problems. Researchers tested whether HCV could enter and survive in different types of brain and nerve cells in the laboratory. They found that HCV could enter one type of peripheral nerve cell, but could not replicate in any of the brain or nerve cell types tested.

Neuroinflammation

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Factors influencing engagement of patients in a novel intervention for CFS/ME: a qualitative study.

Irritable bowel syndrome and other functional gastrointestinal disorders.

Analysis of cerebrospinal fluid from chronic fatigue syndrome patients for multiple human ubiquitous viruses and xenotropic murine leukemia-related virus.

XMRV Discovery and Prostate Cancer-Related Research.

Nucleic Acid, Antibody, and Virus Culture Methods to Detect Xenotropic MLV-Related Virus in Human Blood Samples.

Recombinant origin of the retrovirus XMRV.

Testing strategies for detection of xenotropic murine leukemia virus-related virus infection.

The common immunogenic etiology of chronic fatigue syndrome: from infections to vaccines via adjuvants to the ASIA syndrome.

Analysis of XMRV integration sites from human prostate cancer tissues suggests PCR contamination rather than genuine human infection.

Epigallocatechin gallate ameliorates behavioral and biochemical deficits in rat model of load-induced chronic fatigue syndrome.

A Chinese herbal decoction, Danggui Buxue Tang, improves chronic fatigue syndrome induced by food restriction and forced swimming in rats.

Chronic fatigue syndrome--a neuroimmunological model.

Detection of murine leukemia virus or mouse DNA in commercial RT-PCR reagents and human DNAs.

XMRV, prostate cancer and chronic fatigue syndrome.

Carcinoid tumour associated with enterovirus infection.

Finding the right balance of physical activity: a focus group study about experiences among patients with chronic fatigue syndrome.

Decades of delayed diagnosis in 4 levodopa-responsive young-onset monogenetic parkinsonism patients.

Two sides of the same coin? On the history and phenomenology of chronic fatigue and burnout.

Phylogenetic analysis of murine leukemia virus sequences from longitudinally sampled chronic fatigue syndrome patients suggests PCR contamination rather than viral evolution.

Hepatitis C virus enters human peripheral neuroblastoma cells - evidence for extra-hepatic cells sustaining hepatitis C virus penetration.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research