ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

1281–1300 of 2,422 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

[What's about overactive lifestyle in fibromyalgia and chronic fatigue syndrome].

Masquelier, E, Scaillet, N, Luminet, O et al.·Revue medicale suisse·2011

This study explores how being very active and 'driven' in lifestyle might contribute to both fibromyalgia and chronic fatigue syndrome (ME/CFS). While these are different conditions, they share similar root causes and can be made worse by pushing too hard. The authors suggest that doctors need to take a whole-person approach—considering physical, mental, and social factors together—to help patients find better balance and cope with ongoing pain and activity.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Analysis of cerebrospinal fluid from chronic fatigue syndrome patients for multiple human ubiquitous viruses and xenotropic murine leukemia-related virus.

Schutzer, Steven E, Rounds, Megan A, Natelson, Benjamin H et al.·Annals of neurology·2011

Researchers tested cerebrospinal fluid (the fluid around the brain and spinal cord) from 43 ME/CFS patients to look for XMRV, a virus that some earlier studies suggested might be present in ME/CFS patients' blood. They also tested for several other common viruses. The study found none of these viruses in the cerebrospinal fluid, suggesting that if a virus is involved in ME/CFS, it may work differently than previously thought.

E3 PreliminaryBehavioralPEM unclearObservational

Factors influencing engagement of patients in a novel intervention for CFS/ME: a qualitative study.

Chew-Graham, Carolyn, Brooks, Joanna, Wearden, Alison et al.·Primary health care research & development·2011

This study asked 19 ME/CFS patients about their experiences with a new type of therapy called pragmatic rehabilitation. Researchers found that patients were more likely to stick with treatment if their doctor believed them, if they accepted their ME/CFS diagnosis, and if the treatment approach matched how they understood their own illness. When patients had very different ideas about what was causing their illness than what the therapy suggested, they were less likely to complete the treatment.

E3 PreliminaryCommentaryPEM unclearEditorial

Chronic fatigue syndrome--a neuroimmunological model.

Arnett, S V, Alleva, L M, Korossy-Horwood, R et al.·Medical hypotheses·2011

This review suggests that ME/CFS may develop when the body has trouble controlling infections early on, leading to long-term inflammation in the brain. The authors propose that this inflammatory process—involving both the immune system and the nervous system—could explain many ME/CFS symptoms and why more women are affected than men. They also suggest that anti-inflammatory treatments targeting a protein called TNF might help patients.

NeuroinflammationImmune System

E3 PreliminaryCommentaryPEM unclearEditorial

Diagnosis and management of fibromyalgia: how and why.

Hayhoe, Simon·Pain management·2011

Fibromyalgia is a condition causing widespread muscle pain, tiredness, and sleep problems that doctors still debate about. It shares some features with ME/CFS and may involve both physical changes in how the nervous system processes pain and psychological factors. Treatment typically includes certain antidepressants, anti-seizure medications, and talking therapy with gentle exercise, though most patients only get partial improvement.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

The common immunogenic etiology of chronic fatigue syndrome: from infections to vaccines via adjuvants to the ASIA syndrome.

Rosenblum, Hemda, Shoenfeld, Yehuda, Amital, Howard·Infectious disease clinics of North America·2011

ME/CFS is a long-lasting illness of extreme fatigue and other symptoms that often starts suddenly like a flu. This review examines several theories about what might cause ME/CFS, including infections, genetic factors, hormone problems, immune system dysfunction, and psychological stress. The authors discuss a newer condition called ASIA syndrome, which involves autoimmune reactions that may be triggered by vaccine adjuvants (ingredients added to vaccines to boost immune response).

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

XMRV Discovery and Prostate Cancer-Related Research.

Kang, David E, Lee, Michael C, Das Gupta, Jaydip et al.·Advances in virology·2011

This review discusses XMRV, a virus discovered in 2006 that researchers initially thought might be connected to both prostate cancer and ME/CFS. Scientists around the world have conducted studies to see if this virus is present in patients with these conditions, but results have been inconsistent. A major problem has been contamination in laboratories, where mouse-based materials and the virus itself were often present, making it difficult to know if the virus was really there or just a lab artifact.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Presence of murine leukemia virus (MLV)-related virus gene sequences in a commercial RT-PCR reagent.

Wolff, Dietmar, Gerritzen, Andreas·Clinical laboratory·2011

Researchers were trying to develop a test to detect a virus (MLV-related virus) that some studies claimed was found in ME/CFS patients. However, they discovered that their test was giving false positive results—meaning it was detecting the virus when it wasn't actually there. The problem came from contamination in a commercial reagent (a chemical kit) they were using, which helps explain why different research groups were getting different results.

E3 PreliminaryReviewPEM unclearReview-Narrative

XMRV, prostate cancer and chronic fatigue syndrome.

Kenyon, Julia C, Lever, Andrew M L·British medical bulletin·2011

A virus called XMRV was discovered in 2009 and researchers initially thought it might be linked to ME/CFS. However, studies from different countries could not confirm this connection, and many scientists now believe the virus was not actually present in patient samples but was instead introduced by accident during laboratory testing. While the virus can infect human cells in theory, it does not appear to be a significant cause of ME/CFS.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Blood pressure variability and closed-loop baroreflex assessment in adolescent chronic fatigue syndrome during supine rest and orthostatic stress.

Wyller, Vegard Bruun, Barbieri, Riccardo, Saul, J Philip·European journal of applied physiology·2011

This study looked at how the nervous system controls heart rate and blood pressure in teenagers with ME/CFS compared to healthy peers. Researchers found that teenagers with ME/CFS had less flexible blood pressure responses and their bodies shifted more toward 'fight or flight' nervous system activation when standing or experiencing mild stress, suggesting their autonomic nervous system (which controls these functions automatically) may not work as efficiently.

Autonomic Nervous System

E3 PreliminaryBehavioralPEM not requiredCase-Control

Pain neurophysiology education improves cognitions, pain thresholds, and movement performance in people with chronic whiplash: a pilot study.

Van Oosterwijck, Jessica, Nijs, Jo, Meeus, Mira et al.·Journal of rehabilitation research and development·2011

This small study tested whether teaching patients with chronic neck pain from whiplash about how pain works in the body could help them feel better. Six patients received this education, and researchers found that afterward, patients had less fear of movement, used healthier coping strategies, reported less disability, and could move their necks with less pain.

Pain and Sensitization

E3 PreliminaryMechanismPEM not requiredMechanistic

Hepatitis C virus enters human peripheral neuroblastoma cells - evidence for extra-hepatic cells sustaining hepatitis C virus penetration.

Bürgel, B, Friesland, M, Koch, A et al.·Journal of viral hepatitis·2011

This study investigated whether hepatitis C virus (HCV) can infect and replicate in nerve cells, since some HCV patients experience fatigue, depression, and memory problems. Researchers tested whether HCV could enter and survive in different types of brain and nerve cells in the laboratory. They found that HCV could enter one type of peripheral nerve cell, but could not replicate in any of the brain or nerve cell types tested.

Neuroinflammation

E3 PreliminaryMechanismPEM unclearMechanistic

The left half of the XMRV retrovirus is present in an endogenous retrovirus of NIH/3T3 Swiss mouse cells.

Mendoza, Ramon, Vaughan, Andrew E, Miller, A Dusty·Journal of virology·2011

Scientists searched for where XMRV (a virus once suspected in ME/CFS) might have originally come from by looking in mouse cells. They found a piece of XMRV in mouse DNA but not a complete virus. This discovery suggests XMRV has mouse origins and warns that lab contamination from mouse cells could create false positive results when testing for this virus.

E3 PreliminaryCohortPEM unclearCase-Control

Carcinoid tumour associated with enterovirus infection.

Chia, John, Chia, Andrew, El-Habbal, Rabiha·Journal of clinical pathology·2011

This study looked at two patients—one with ME/CFS and one with chronic abdominal pain—who had rare tumors called carcinoid tumors in their intestines. Researchers found traces of enterovirus (a common virus that infects the gut) inside these tumors using special staining techniques. The authors suggest this might indicate a link between chronic enterovirus infection and the development of these tumors, though much more research is needed to understand if this connection is real.

E3 PreliminaryMechanismPEM unclearMechanistic

XMRV: usage of receptors and potential co-receptors.

Setty, Mohan Kumar Haleyur Giri, Devadas, Krishnakumar, Ragupathy, Viswanath et al.·Virology journal·2011

Scientists studied how a virus called XMRV enters and infects human cells, particularly immune cells. They found that while this virus is known to use one main doorway (called XPR1) to get into cells, it can also use other doorways, including ones normally used by immune system molecules called chemokine receptors. This suggests the virus may be more flexible at infecting different types of cells than previously thought.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

No evidence of murine leukemia virus-related viruses in live attenuated human vaccines.

Switzer, William M, Zheng, Haoqiang, Simmons, Graham et al.·PloS one·2011

Researchers tested 8 common vaccines to see if they contained XMRV or related viruses that had been previously linked to ME/CFS. They used sensitive tests including genetic sequencing to look for these viruses. None of the vaccines contained XMRV or the related viruses they were looking for, suggesting vaccines are not a source of these viruses in people.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Classifying medication use in clinical research.

Rizzo, Dorrie, Creti, Laura, Bailes, Sally et al.·Journal of primary care & community health·2011

Researchers created a simple system for organizing and grouping the medicines that patients take during medical studies. They tested this organizational method on patients with ME/CFS and sleep apnea to see if different groups of patients tend to take different combinations of medications. They found five main medicine categories, and importantly, the pattern of medicines taken by ME/CFS patients was quite different from sleep apnea patients, possibly reflecting different views about what causes these conditions.

E3 PreliminaryMechanismPEM not requiredMechanistic

Functional genomics of serotonin receptor 2A (HTR2A): interaction of polymorphism, methylation, expression and disease association.

Falkenberg, Virginia R, Gurbaxani, Brian M, Unger, Elizabeth R et al.·Neuromolecular medicine·2011

This study looked at how a specific genetic variation in the serotonin receptor 2A gene (HTR2A) affects how active this gene is in people with ME/CFS. The researchers found that this gene is turned up (overactive) in ME/CFS patients, and that this overactivity is influenced by both the genetic variant someone inherits and how stress hormones like cortisol affect the gene's activity. Think of it like a volume knob on a radio that can be turned up or down depending on your genes and stress levels.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Two sides of the same coin? On the history and phenomenology of chronic fatigue and burnout.

Leone, Stephanie S, Wessely, Simon, Huibers, Marcus J H et al.·Psychology & health·2011

This study compares burnout (exhaustion from work stress) and ME/CFS (chronic fatigue syndrome) by reviewing existing research and historical records. Though these conditions developed separately—burnout in psychology and CFS in medicine—they share many similar symptoms and appear to involve energy depletion. The authors found that while both conditions involve overload, need for rest, and affect similar types of people, they are often described differently depending on whether they're viewed through a psychological or medical lens.

E3 PreliminaryMechanismPEM not requiredMechanistic

Sleep and fatigue in mice infected with murine gammaherpesvirus 68.

Olivadoti, Melissa D, Weinberg, Jason B, Toth, Linda A et al.·Brain, behavior, and immunity·2011

Researchers infected mice with a virus similar to one that has been linked to chronic fatigue syndrome in humans. They found that infected mice showed fatigue-like symptoms (reduced activity, altered sleep and body temperature) during the first 1-2 weeks of infection. Notably, when these mice were given a bacterial toxin challenge a month later, they had much stronger and longer-lasting reactions than uninfected mice, suggesting that latent viral infection may make the body oversensitive to future immune challenges.

Immune System

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[What's about overactive lifestyle in fibromyalgia and chronic fatigue syndrome].

Analysis of cerebrospinal fluid from chronic fatigue syndrome patients for multiple human ubiquitous viruses and xenotropic murine leukemia-related virus.

Factors influencing engagement of patients in a novel intervention for CFS/ME: a qualitative study.

Chronic fatigue syndrome--a neuroimmunological model.

Diagnosis and management of fibromyalgia: how and why.

The common immunogenic etiology of chronic fatigue syndrome: from infections to vaccines via adjuvants to the ASIA syndrome.

XMRV Discovery and Prostate Cancer-Related Research.

Presence of murine leukemia virus (MLV)-related virus gene sequences in a commercial RT-PCR reagent.

XMRV, prostate cancer and chronic fatigue syndrome.

Blood pressure variability and closed-loop baroreflex assessment in adolescent chronic fatigue syndrome during supine rest and orthostatic stress.

Pain neurophysiology education improves cognitions, pain thresholds, and movement performance in people with chronic whiplash: a pilot study.

Hepatitis C virus enters human peripheral neuroblastoma cells - evidence for extra-hepatic cells sustaining hepatitis C virus penetration.

The left half of the XMRV retrovirus is present in an endogenous retrovirus of NIH/3T3 Swiss mouse cells.

Carcinoid tumour associated with enterovirus infection.

XMRV: usage of receptors and potential co-receptors.

No evidence of murine leukemia virus-related viruses in live attenuated human vaccines.

Classifying medication use in clinical research.

Functional genomics of serotonin receptor 2A (HTR2A): interaction of polymorphism, methylation, expression and disease association.

Two sides of the same coin? On the history and phenomenology of chronic fatigue and burnout.

Sleep and fatigue in mice infected with murine gammaherpesvirus 68.

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