ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

1321–1340 of 2,420 studies

E3 PreliminaryMechanismPEM not requiredMechanistic

Infection, viral dissemination, and antibody responses of rhesus macaques exposed to the human gammaretrovirus XMRV.

Onlamoon, Nattawat, Das Gupta, Jaydip, Sharma, Prachi et al.·Journal of virology·2011

This study examined whether XMRV, a virus that had been proposed as a potential cause of chronic fatigue syndrome, could establish persistent infection in primates similar to humans. Researchers injected five macaques with XMRV and tracked the virus over 9 months, finding that it created a long-lasting infection that spread to multiple organs and tissues, even when it disappeared from the blood. The virus affected different cell types in different organs and triggered some immune responses, but these responses were weak and didn't effectively clear the infection.

Immune System

E3 PreliminaryCohortPEM unclearCross-Sectional

A discourse analytic study of ME/CFS (Chronic Fatigue Syndrome) sufferers' experiences of interactions with doctors.

Guise, Jennie, McVittie, Chris, McKinlay, Andy·Journal of health psychology·2010

This study looked at how ME/CFS patients describe their experiences when talking to doctors. Researchers analyzed conversations from an online support group and found that patients often feel their doctors don't listen to them or take their condition seriously. Interestingly, patients were careful about how they complained, trying to focus on practical issues rather than seeming like they were just complaining.

Diagnostics

E3 PreliminaryCommentaryPEM unclearEditorial

Chronic fatigue syndrome/myalgic encephalomyelitis: an update.

Capelli, E, Zola, R, Lorusso, L et al.·International journal of immunopathology and pharmacology·2010

ME/CFS is a serious illness of unknown cause that affects about 1 in every 100 people worldwide, with women affected six times more often than men. Most people develop it between ages 20-40, and symptoms typically last several years. While doctors don't yet have a cure, treatment focuses on managing individual symptoms to help patients improve their quality of life.

Immune System

E3 PreliminaryCohortPEM not requiredCross-Sectional

EEG findings in burnout patients.

van Luijtelaar, Gilles, Verbraak, Marc, van den Bunt, Martijn et al.·The Journal of neuropsychiatry and clinical neurosciences·2010

This study used brain wave recordings (EEG) to look for physical markers that could help identify burnout as a distinct condition. Researchers found that people with burnout showed different brain wave patterns compared to healthy people, including reduced activity in certain frequency bands. The findings suggest burnout may have measurable brain differences that set it apart from depression and chronic fatigue.

E3 PreliminaryCohortPEM unclearCross-Sectional

Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) in adults: a qualitative study of perspectives from professional practice.

Horton, Simon M C, Poland, Fiona, Kale, Swati et al.·BMC family practice·2010

This study spoke with six healthcare providers who were praised by ME/CFS patients for being helpful and understanding. The researchers asked these doctors and specialists what they thought worked best when treating ME/CFS. The key finding was that patients benefit most from doctors who truly listen, show respect, build trust, and recognize how serious and complex the condition is—rather than those who dismiss or minimize ME/CFS.

Diagnostics

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

The PRIME project: developing a patient evidence-base.

Staniszewska, Sophie, Crowe, Sally, Badenoch, Douglas et al.·Health expectations : an international journal of public participation in health care and health policy·2010

The PRIME project created a collection of stories and experiences from 40 people with ME/CFS to help researchers and doctors better understand what it's really like to live with this condition. Instead of just looking at test results and medical costs, this study captured patients' own descriptions of their symptoms, daily challenges, and how the illness affects their lives. The researchers organized all these personal experiences into themes that can be used to guide future ME/CFS research in ways that matter most to patients.

E3 PreliminaryMechanismPEM requiredMechanistic

Pain inhibition and postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: an experimental study.

Van Oosterwijck, J, Nijs, J, Meeus, M et al.·Journal of internal medicine·2010

This study compared how the body's pain-relief systems work in people with ME/CFS versus healthy people during exercise. Researchers found that after exercise, people with ME/CFS became more sensitive to pain (their pain thresholds decreased), while healthy people became less sensitive to pain. The ME/CFS group also experienced worsening symptoms after both types of exercise they tried.

Post-Exertional Malaise

E3 PreliminaryReviewPEM requiredReview-Narrative

Chronic fatigue syndrome: Harvey and Wessely's (bio)psychosocial model versus a bio(psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways.

Maes, Michael, Twisk, Frank N M·BMC medicine·2010

This study compares two different ways of understanding ME/CFS. One model suggests the illness is mainly caused by how the mind and behavior interact with the body, and proposes treatments like cognitive behavioral therapy and graded exercise. The other model focuses on biological problems like inflammation and oxidative stress in the body. The authors argue that the biological model better explains ME/CFS and that exercise-based treatments could actually make some patients worse.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

The human retrovirus XMRV in prostate cancer and chronic fatigue syndrome.

Silverman, Robert H, Nguyen, Carvell, Weight, Christopher J et al.·Nature reviews. Urology·2010

This review examines XMRV, a newly discovered virus that has been found in some people with prostate cancer and some with ME/CFS. Researchers have found the virus at very different rates in different studies (0-27% in prostate cancer, 0-67% in ME/CFS patients). While some antiviral drugs appear to block this virus, scientists still do not know whether XMRV actually causes either disease.

Immune System

E3 PreliminaryCohortPEM not requiredCross-Sectional

A qualitative exploration of adolescents' experiences of chronic fatigue syndrome.

Jelbert, Rebecca, Stedmon, Jacqui, Stephens, Alison·Clinical child psychology and psychiatry·2010

This study talked to five teenagers who had recovered from ME/CFS about what the illness was like for them. Through interviews and careful analysis of their stories, researchers found that teens experienced five common themes: trying to understand their illness, feeling a sense of loss, noticing things that seemed to make it better or worse, dealing with difficult emotions, and eventually recovering. The teens' own voices highlight that there is still much we need to learn about how this illness affects young people.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[The cerebralization of fatigue: an analysis of the cerebral hypothesis in the case of chronic fatigue syndrome].

Ortega, Francisco, Zorzanelli, Rafaela·Historia, ciencias, saude--Manguinhos·2010

This article examines how ME/CFS came to be understood as a brain-based illness rather than purely a physical one. The authors explore the history of how brain imaging and neuroscience research influenced medical thinking about ME/CFS, and how this shift reflected broader changes in how society views illness in general—increasingly looking to the brain as the primary source of disease.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Contamination of human DNA samples with mouse DNA can lead to false detection of XMRV-like sequences.

Oakes, Brendan, Tai, Albert K, Cingöz, Oya et al.·Retrovirology·2010

Researchers tested blood samples from ME/CFS patients and healthy people for a virus called XMRV. They discovered that when using very sensitive testing methods, they were getting false positive results because mouse DNA was contaminating the samples, not because patients actually had the virus. This study shows why careful testing procedures are essential when looking for viruses in patient samples.

E3 PreliminaryCohortPEM not requiredCase-Control

Endometriosis-associated Lyme disease.

Matalliotakis, I M, Cakmak, H, Ziogos, M D E et al.·Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology·2010

This study looked at whether Lyme disease (an infection from tick bites) appears more often in women with endometriosis (a painful condition affecting the uterus). Researchers reviewed medical records from 605 women over 6 years and found that 3 women had both endometriosis and Lyme disease. The study suggests that women with endometriosis may be more likely to develop autoimmune and inflammatory conditions, including Lyme disease.

E3 PreliminaryReviewPEM not requiredReview-Narrative

A new hypothesis of chronic fatigue syndrome: co-conditioning theory.

Tanaka, Masaaki, Watanabe, Yasuyoshi·Medical hypotheses·2010

This article proposes a new theory about how ME/CFS might develop: repeated overwork or stress could train your body and brain to respond with fatigue and an urge to rest, similar to how habits form. The authors suggest that once this pattern becomes established, your body may continue producing fatigue even when you're no longer overworking. This theory could eventually lead to new ways of treating ME/CFS.

Post-Exertional Malaise

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Readability of patient and health care professional targeted dietary supplement leaflets used for diabetes and chronic fatigue syndrome.

Clauson, Kevin A, Zeng-Treitler, Qing, Kandula, Sasikiran·Journal of alternative and complementary medicine (New York, N.Y.)·2010

This study examined whether instruction sheets about dietary supplements for diabetes and ME/CFS are written in a way that patients can easily understand. Researchers found that most of these leaflets are written at a college level (13th grade), far harder than the recommended 6th-grade level. This difficulty may make it harder for patients to understand important information and follow recommendations.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Neuroendocrine and immune contributors to fatigue.

Silverman, Marni N, Heim, Christine M, Nater, Urs M et al.·PM & R : the journal of injury, function, and rehabilitation·2010

This review explores how three body systems—the stress response system, the nervous system, and the immune system—may work together to cause the overwhelming tiredness experienced in ME/CFS. The researchers found that people with chronic fatigue often have an underactive stress-response system, an overactive fight-or-flight response, and immune system imbalances. Understanding how these systems interact may help explain why rest alone doesn't always resolve the fatigue.

Autonomic Nervous SystemImmune System

E3 PreliminaryMechanismPEM unclearMechanistic

Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors.

Groom, Harriet C T, Yap, Melvyn W, Galão, Rui Pedro et al.·Proceedings of the National Academy of Sciences of the United States of America·2010

Scientists studied a virus called XMRV that had been linked to ME/CFS to understand how it survives in human cells. They discovered that the body's natural antiviral defense proteins can block this virus, but XMRV does not appear to have developed ways to escape these defenses like some other viruses do. This finding helps researchers understand which cells XMRV can infect and how to design better laboratory studies of this virus.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[The chronic asthenia syndrome: a clinical approach].

Young, Pablo, Finn, Bárbara C, Bruetman, Julio et al.·Medicina·2010

Fatigue is one of the most common reasons people visit doctors, affecting about 30% of patients. This article explains how doctors should think about different types of fatigue—including chronic fatigue syndrome (ME/CFS), which affects 0.2–0.7% of people. The authors emphasize that finding and treating the underlying cause is the best approach, though about 20% of patients never get a clear diagnosis.

Diagnostics

E3 PreliminaryMechanismPEM unclearObservational

Severity of symptom flare after moderate exercise is linked to cytokine activity in chronic fatigue syndrome.

White, Andrea T, Light, Alan R, Hughen, Ronald W et al.·Psychophysiology·2010

This study looked at why some people with ME/CFS feel much worse after exercise. Researchers measured immune chemicals in the blood before and after moderate exercise in people with ME/CFS and healthy controls. They found that patients who experienced severe symptom flare had increased levels of certain immune chemicals 8 hours after exercise, while those with mild flare or healthy people did not show this pattern.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes.

Sperber, Ami D, Dekel, Roy·Journal of neurogastroenterology and motility·2010

Many people with irritable bowel syndrome (IBS) also experience other chronic conditions like fibromyalgia or chronic fatigue syndrome (ME/CFS). When patients have IBS plus another functional disorder, their symptoms tend to be worse, they report lower quality of life, and they miss more work. This suggests these conditions may share common underlying mechanisms rather than being completely separate diseases.

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Infection, viral dissemination, and antibody responses of rhesus macaques exposed to the human gammaretrovirus XMRV.

A discourse analytic study of ME/CFS (Chronic Fatigue Syndrome) sufferers' experiences of interactions with doctors.

Chronic fatigue syndrome/myalgic encephalomyelitis: an update.

EEG findings in burnout patients.

Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) in adults: a qualitative study of perspectives from professional practice.

The PRIME project: developing a patient evidence-base.

Pain inhibition and postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: an experimental study.

Chronic fatigue syndrome: Harvey and Wessely's (bio)psychosocial model versus a bio(psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways.

The human retrovirus XMRV in prostate cancer and chronic fatigue syndrome.

A qualitative exploration of adolescents' experiences of chronic fatigue syndrome.

[The cerebralization of fatigue: an analysis of the cerebral hypothesis in the case of chronic fatigue syndrome].

Contamination of human DNA samples with mouse DNA can lead to false detection of XMRV-like sequences.

Endometriosis-associated Lyme disease.

A new hypothesis of chronic fatigue syndrome: co-conditioning theory.

Readability of patient and health care professional targeted dietary supplement leaflets used for diabetes and chronic fatigue syndrome.

Neuroendocrine and immune contributors to fatigue.

Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors.

[The chronic asthenia syndrome: a clinical approach].

Severity of symptom flare after moderate exercise is linked to cytokine activity in chronic fatigue syndrome.

Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes.

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