ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

1321–1340 of 2,422 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

The search for reliable biomarkers of disease in multiple chemical sensitivity and other environmental intolerances.

De Luca, Chiara, Raskovic, Desanka, Pacifico, Valeria et al.·International journal of environmental research and public health·2011

This review examines why some people develop severe reactions to chemicals, foods, and environmental exposures at levels that shouldn't cause harm. The authors argue these conditions—including ME/CFS, fibromyalgia, and multiple chemical sensitivity—are real biological disorders, not just psychological problems. They explore evidence that problems with how the body detoxifies and handles harmful substances, along with imbalances in antioxidant protection, may be key to understanding these diseases.

Energy Metabolism

E3 PreliminaryMechanismPEM not requiredMechanistic

Increased HDAC in association with decreased plasma cortisol in older adults with chronic fatigue syndrome.

Jason, Leonard, Sorenson, Matthew, Sebally, Kebba et al.·Brain, behavior, and immunity·2011

This study examined stress hormone systems in older adults with ME/CFS. Researchers found that people with ME/CFS had lower levels of cortisol (a stress hormone) but higher levels of an enzyme called HDAC and lower antioxidant protection. These findings suggest that the body's stress response system isn't working properly in ME/CFS, possibly due to increased cellular stress.

Endocrine Disruption

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Nucleic Acid, Antibody, and Virus Culture Methods to Detect Xenotropic MLV-Related Virus in Human Blood Samples.

Kearney, M F, Lee, K, Bagni, R K et al.·Advances in virology·2011

Researchers developed sensitive tests to detect a virus called XMRV in blood samples. They used their tests on blood and tissue samples from patients with prostate cancer, but did not find the virus in any of the blood samples they tested. This study shows that while their detection methods work well, XMRV was not present in the patients' blood.

E3 PreliminaryMechanismPEM not requiredMechanistic

Activity in the hypothalamo-hypophyseal-adrenocortical system on experimental induction of chronic fatigue syndrome.

Fomicheva, E E, Filatenkova, T A, Rybakina, E G·Neuroscience and behavioral physiology·2010

This study used an experimental model to investigate how ME/CFS might affect the body's stress response system. Researchers gave animals a substance that mimics a viral infection to trigger CFS-like symptoms, then tested how well their stress hormone system worked. They found that the stress response system became impaired, with reduced ability to produce and respond to key stress hormones.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Traditional chinese medicine for chronic fatigue syndrome.

Chen, Rui, Moriya, Junji, Yamakawa, Jun-Ichi et al.·Evidence-based complementary and alternative medicine : eCAM·2010

This review examines how traditional Chinese medicine (TCM) might help people with ME/CFS. The authors suggest that TCM treatments may reduce symptoms like fatigue, sleep problems, and brain fog, and may work by improving immune function and reducing oxidative stress. However, they note that current TCM research on ME/CFS has significant quality and consistency issues that need to be addressed.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Implications of forgiveness enhancement in patients with fibromyalgia and chronic fatigue syndrome.

Toussaint, Loren, Overvold-Ronningen, Mary, Vincent, Ann et al.·Journal of health care chaplaincy·2010

This review examines whether learning to forgive—others and ourselves—might help people with ME/CFS and fibromyalgia cope better with the anger, stress, fear, and depression that often come with these conditions. The authors suggest that forgiveness could be a helpful complementary approach, alongside other treatments, to reduce the emotional burden of living with these chronic illnesses. They propose a model to guide future research on how forgiveness might improve well-being in these patient populations.

E3 PreliminaryCohortPEM not requiredCase-Control

Endometriosis-associated Lyme disease.

Matalliotakis, I M, Cakmak, H, Ziogos, M D E et al.·Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology·2010

This study looked at whether Lyme disease (an infection from tick bites) appears more often in women with endometriosis (a painful condition affecting the uterus). Researchers reviewed medical records from 605 women over 6 years and found that 3 women had both endometriosis and Lyme disease. The study suggests that women with endometriosis may be more likely to develop autoimmune and inflammatory conditions, including Lyme disease.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[The HPA axis in the pathogenesis of chronic fatigue syndrome].

Ursini, F, Succurro, E, Grembiale, A et al.·La Clinica terapeutica·2010

This review examines whether problems with the HPA axis—a system in your brain and body that manages stress and energy—might explain ME/CFS symptoms. The HPA axis controls cortisol and other hormones that help your body respond to stress and maintain energy levels. This article summarizes what scientists have found so far about whether HPA axis dysfunction could be a key cause of ME/CFS.

Endocrine Disruption

E3 PreliminaryReviewPEM not requiredReview-Narrative

[The chronic asthenia syndrome: a clinical approach].

Young, Pablo, Finn, Bárbara C, Bruetman, Julio et al.·Medicina·2010

Fatigue is one of the most common reasons people visit doctors, affecting about 30% of patients. This article explains how doctors should think about different types of fatigue—including chronic fatigue syndrome (ME/CFS), which affects 0.2–0.7% of people. The authors emphasize that finding and treating the underlying cause is the best approach, though about 20% of patients never get a clear diagnosis.

Diagnostics

E3 PreliminaryMechanismPEM not requiredMechanistic

Possible role of oxidative stress and immunological activation in mouse model of chronic fatigue syndrome and its attenuation by olive extract.

Gupta, Amit, Vij, Garima, Chopra, Kanwaljit·Journal of neuroimmunology·2010

Researchers used mice to study whether oxidative stress (chemical damage in cells) and immune activation play a role in ME/CFS-like symptoms. They found that mice treated with immune-triggering substances showed increased fatigue and pain sensitivity, along with signs of cellular damage. When given olive extract, these mice showed improvement in fatigue, pain, and markers of cellular damage.

Immune System

E3 PreliminaryMechanismPEM unclearCross-Sectional

Reduced pressure pain thresholds in response to exercise in chronic fatigue syndrome but not in chronic low back pain: an experimental study.

Meeus, Mira, Roussel, Nathalie A, Truijen, Steven et al.·Journal of rehabilitation medicine·2010

This study compared how people with ME/CFS, chronic back pain, and healthy people respond to exercise. Researchers found that people with ME/CFS have more sensitive pain responses than others, and importantly, their pain sensitivity got worse after light exercise—opposite to what happened in the other groups. This suggests ME/CFS involves different pain processing in the nervous system.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

[Understanding chronic fatigue syndrome].

Rivera Redondo, Javier·Reumatologia clinica·2010

This article provides an overview of chronic fatigue syndrome (ME/CFS), explaining what the condition is and how it affects patients. The author discusses the main features of ME/CFS, including persistent exhaustion that doesn't improve with rest and other symptoms that can develop after infection or stress. The goal is to help readers understand this complex illness better.

E3 PreliminaryMechanismPEM unclearMechanistic

Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors.

Groom, Harriet C T, Yap, Melvyn W, Galão, Rui Pedro et al.·Proceedings of the National Academy of Sciences of the United States of America·2010

Scientists studied a virus called XMRV that had been linked to ME/CFS to understand how it survives in human cells. They discovered that the body's natural antiviral defense proteins can block this virus, but XMRV does not appear to have developed ways to escape these defenses like some other viruses do. This finding helps researchers understand which cells XMRV can infect and how to design better laboratory studies of this virus.

Immune System

E3 PreliminaryCohortPEM unclearCross-Sectional

A discourse analytic study of ME/CFS (Chronic Fatigue Syndrome) sufferers' experiences of interactions with doctors.

Guise, Jennie, McVittie, Chris, McKinlay, Andy·Journal of health psychology·2010

This study looked at how ME/CFS patients describe their experiences when talking to doctors. Researchers analyzed conversations from an online support group and found that patients often feel their doctors don't listen to them or take their condition seriously. Interestingly, patients were careful about how they complained, trying to focus on practical issues rather than seeming like they were just complaining.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome and an approach to its treatment].

Akarachkova, E S·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2010

This is a review article discussing chronic fatigue syndrome (ME/CFS) and treatment approaches. The authors examine what is known about the condition and offer clinical guidance on how to manage it. While not a new research study, it provides a medical perspective on understanding and treating this complex illness.

Interventions

E3 PreliminaryReviewPEM not requiredReview-Narrative

Short QT interval in clinical practice.

Bjerregaard, Preben, Nallapaneni, Hari, Gussak, Ihor·Journal of electrocardiology·2010

This review article discusses a heart rhythm pattern called a 'short QT interval' that doctors can see on heart electrical recordings (EKGs). The authors note that while this pattern is rare, it can sometimes be dangerous and increase the risk of sudden cardiac death. They found that short QT intervals have been reported in patients with ME/CFS, along with several other medical conditions, though we still don't fully understand what it means or how to best manage patients who have it.

E3 PreliminaryCohortPEM not requiredCross-Sectional

Frequency and content analysis of chronic fatigue syndrome in medical text books.

Jason, Leonard A, Paavola, Erin, Porter, Nicole et al.·Australian journal of primary health·2010

This study looked at how much information about ME/CFS appears in medical textbooks that doctors and medical students use for training. Researchers found that while about 4 out of 10 textbooks mentioned ME/CFS at all, the information took up less than 0.1% of the total pages. Compared to other diseases like multiple sclerosis that are actually rarer, ME/CFS received much less coverage in these important educational materials.

E3 PreliminaryReviewPEM unclearReview-Narrative

Gut inflammation in chronic fatigue syndrome.

Lakhan, Shaheen E, Kirchgessner, Annette·Nutrition & metabolism·2010

Many ME/CFS patients experience gut problems similar to irritable bowel syndrome. This review discusses how three interconnected gut issues—changes in the bacteria that live in your intestines, a weakened intestinal lining, and an altered immune response in the gut—may contribute to ME/CFS. The authors suggest that treatments like probiotics (beneficial bacteria) might help by restoring healthy gut bacteria and reducing inflammation.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome.

Mikovits, Judy A, Lombardi, Vincent C, Pfost, Max A et al.·Virulence·2010

This 2010 study reported finding a virus called XMRV in blood samples from over 75% of people with ME/CFS using multiple detection methods. The researchers emphasized that different laboratory techniques found the virus at different rates, with some methods being much more sensitive than others. The findings were controversial because other research groups had difficulty reproducing these results.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

EBV Chronic Infections.

Eligio, Pizzigallo, Delia, Racciatti, Valeria, Gorgoretti·Mediterranean journal of hematology and infectious diseases·2010

This review explores the connection between Epstein-Barr virus (EBV)—the virus that causes mononucleosis—and ME/CFS. While EBV can persist in the body and reactivate at times, it is not clear whether it directly causes chronic fatigue syndrome in most patients. The authors suggest that ME/CFS likely has multiple causes, including EBV in some people, other viruses in others, and non-infectious factors, but the underlying mechanism may involve inflammation and oxidative damage.

Immune System

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Evidence browser

The search for reliable biomarkers of disease in multiple chemical sensitivity and other environmental intolerances.

Increased HDAC in association with decreased plasma cortisol in older adults with chronic fatigue syndrome.

Nucleic Acid, Antibody, and Virus Culture Methods to Detect Xenotropic MLV-Related Virus in Human Blood Samples.

Activity in the hypothalamo-hypophyseal-adrenocortical system on experimental induction of chronic fatigue syndrome.

Traditional chinese medicine for chronic fatigue syndrome.

Implications of forgiveness enhancement in patients with fibromyalgia and chronic fatigue syndrome.

Endometriosis-associated Lyme disease.

[The HPA axis in the pathogenesis of chronic fatigue syndrome].

[The chronic asthenia syndrome: a clinical approach].

Possible role of oxidative stress and immunological activation in mouse model of chronic fatigue syndrome and its attenuation by olive extract.

Reduced pressure pain thresholds in response to exercise in chronic fatigue syndrome but not in chronic low back pain: an experimental study.

[Understanding chronic fatigue syndrome].

Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors.

A discourse analytic study of ME/CFS (Chronic Fatigue Syndrome) sufferers' experiences of interactions with doctors.

[Chronic fatigue syndrome and an approach to its treatment].

Short QT interval in clinical practice.

Frequency and content analysis of chronic fatigue syndrome in medical text books.

Gut inflammation in chronic fatigue syndrome.

Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome.

EBV Chronic Infections.

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