ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

1341–1360 of 2,423 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

Traditional chinese medicine for chronic fatigue syndrome.

Chen, Rui, Moriya, Junji, Yamakawa, Jun-Ichi et al.·Evidence-based complementary and alternative medicine : eCAM·2010

This review examines how traditional Chinese medicine (TCM) might help people with ME/CFS. The authors suggest that TCM treatments may reduce symptoms like fatigue, sleep problems, and brain fog, and may work by improving immune function and reducing oxidative stress. However, they note that current TCM research on ME/CFS has significant quality and consistency issues that need to be addressed.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Implications of forgiveness enhancement in patients with fibromyalgia and chronic fatigue syndrome.

Toussaint, Loren, Overvold-Ronningen, Mary, Vincent, Ann et al.·Journal of health care chaplaincy·2010

This review examines whether learning to forgive—others and ourselves—might help people with ME/CFS and fibromyalgia cope better with the anger, stress, fear, and depression that often come with these conditions. The authors suggest that forgiveness could be a helpful complementary approach, alongside other treatments, to reduce the emotional burden of living with these chronic illnesses. They propose a model to guide future research on how forgiveness might improve well-being in these patient populations.

E3 PreliminaryReviewPEM requiredReview-Narrative

Chronic fatigue syndrome: Harvey and Wessely's (bio)psychosocial model versus a bio(psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways.

Maes, Michael, Twisk, Frank N M·BMC medicine·2010

This study compares two different ways of understanding ME/CFS. One model suggests the illness is mainly caused by how the mind and behavior interact with the body, and proposes treatments like cognitive behavioral therapy and graded exercise. The other model focuses on biological problems like inflammation and oxidative stress in the body. The authors argue that the biological model better explains ME/CFS and that exercise-based treatments could actually make some patients worse.

Immune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredMechanistic

Activity in the hypothalamo-hypophyseal-adrenocortical system on experimental induction of chronic fatigue syndrome.

Fomicheva, E E, Filatenkova, T A, Rybakina, E G·Neuroscience and behavioral physiology·2010

This study used an experimental model to investigate how ME/CFS might affect the body's stress response system. Researchers gave animals a substance that mimics a viral infection to trigger CFS-like symptoms, then tested how well their stress hormone system worked. They found that the stress response system became impaired, with reduced ability to produce and respond to key stress hormones.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome and fibromyalgia: a status report in 2010.

Natelson, Benjamin H·MD advisor : a journal for New Jersey medical community·2010

This 2010 report by Dr. Benjamin Natelson reviews the current understanding of ME/CFS and fibromyalgia, two conditions that cause persistent fatigue and pain. The report summarizes what doctors and researchers knew at that time about how these conditions develop, how they affect the body, and how they are treated. It provides an overview of the scientific evidence available in 2010 to help explain why people with these conditions experience their symptoms.

Biomarkers

E3 PreliminaryCommentaryPEM not requiredEditorial

Xenotropic murine leukemia virus-related virus in chronic fatigue syndrome and prostate cancer.

Baraniuk, James N·Current allergy and asthma reports·2010

This study examined whether a virus called XMRV might be connected to ME/CFS. Researchers found this virus in about half to two-thirds of ME/CFS patients tested, compared to only about 4% of healthy people. The virus was able to spread from patient blood to laboratory cells, raising questions about whether it could be transmitted between people.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

EBV Chronic Infections.

Eligio, Pizzigallo, Delia, Racciatti, Valeria, Gorgoretti·Mediterranean journal of hematology and infectious diseases·2010

This review explores the connection between Epstein-Barr virus (EBV)—the virus that causes mononucleosis—and ME/CFS. While EBV can persist in the body and reactivate at times, it is not clear whether it directly causes chronic fatigue syndrome in most patients. The authors suggest that ME/CFS likely has multiple causes, including EBV in some people, other viruses in others, and non-infectious factors, but the underlying mechanism may involve inflammation and oxidative damage.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Distribution of xenotropic murine leukemia virus-related virus (XMRV) infection in chronic fatigue syndrome and prostate cancer.

Mikovits, Judy A, Huang, Ying, Pfost, Max A et al.·AIDS reviews·2010

Researchers tested blood samples from ME/CFS patients for a virus called XMRV using different detection methods. They found that simple DNA tests alone missed infections that were caught by more sensitive techniques. This study explains why different research teams got different results—the testing method matters a lot.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Contamination of human DNA samples with mouse DNA can lead to false detection of XMRV-like sequences.

Oakes, Brendan, Tai, Albert K, Cingöz, Oya et al.·Retrovirology·2010

Researchers tested blood samples from ME/CFS patients and healthy people for a virus called XMRV. They discovered that when using very sensitive testing methods, they were getting false positive results because mouse DNA was contaminating the samples, not because patients actually had the virus. This study shows why careful testing procedures are essential when looking for viruses in patient samples.

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome, fibromyalgia, and related illnesses: a clinical model of assessment and intervention.

Friedberg, Fred·Journal of clinical psychology·2010

This article reviews how doctors and mental health professionals can better assess and help people with ME/CFS, fibromyalgia, and related conditions. The authors present a practical framework using cognitive-behavioral approaches—strategies that address both thoughts and behaviors—to improve care for patients who often feel dismissed by the medical system. The goal is to help clinicians understand why these patients experience unusual physical symptoms and provide more effective support.

E3 PreliminaryReviewPEM unclearReview-Narrative

Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes.

Sperber, Ami D, Dekel, Roy·Journal of neurogastroenterology and motility·2010

Many people with irritable bowel syndrome (IBS) also experience other chronic conditions like fibromyalgia or chronic fatigue syndrome (ME/CFS). When patients have IBS plus another functional disorder, their symptoms tend to be worse, they report lower quality of life, and they miss more work. This suggests these conditions may share common underlying mechanisms rather than being completely separate diseases.

E3 PreliminaryReviewPEM unclearReview-Narrative

The human retrovirus XMRV in prostate cancer and chronic fatigue syndrome.

Silverman, Robert H, Nguyen, Carvell, Weight, Christopher J et al.·Nature reviews. Urology·2010

This review examines XMRV, a newly discovered virus that has been found in some people with prostate cancer and some with ME/CFS. Researchers have found the virus at very different rates in different studies (0-27% in prostate cancer, 0-67% in ME/CFS patients). While some antiviral drugs appear to block this virus, scientists still do not know whether XMRV actually causes either disease.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Readability of patient and health care professional targeted dietary supplement leaflets used for diabetes and chronic fatigue syndrome.

Clauson, Kevin A, Zeng-Treitler, Qing, Kandula, Sasikiran·Journal of alternative and complementary medicine (New York, N.Y.)·2010

This study examined whether instruction sheets about dietary supplements for diabetes and ME/CFS are written in a way that patients can easily understand. Researchers found that most of these leaflets are written at a college level (13th grade), far harder than the recommended 6th-grade level. This difficulty may make it harder for patients to understand important information and follow recommendations.

E3 PreliminaryReviewPEM unclearReview-Narrative

Gut inflammation in chronic fatigue syndrome.

Lakhan, Shaheen E, Kirchgessner, Annette·Nutrition & metabolism·2010

Many ME/CFS patients experience gut problems similar to irritable bowel syndrome. This review discusses how three interconnected gut issues—changes in the bacteria that live in your intestines, a weakened intestinal lining, and an altered immune response in the gut—may contribute to ME/CFS. The authors suggest that treatments like probiotics (beneficial bacteria) might help by restoring healthy gut bacteria and reducing inflammation.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Understanding chronic fatigue syndrome].

Rivera Redondo, Javier·Reumatologia clinica·2010

This article provides an overview of chronic fatigue syndrome (ME/CFS), explaining what the condition is and how it affects patients. The author discusses the main features of ME/CFS, including persistent exhaustion that doesn't improve with rest and other symptoms that can develop after infection or stress. The goal is to help readers understand this complex illness better.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Validation of ECG-derived sleep architecture and ventilation in sleep apnea and chronic fatigue syndrome.

Decker, Michael J, Eyal, Shulamit, Shinar, Zvika et al.·Sleep & breathing = Schlaf & Atmung·2010

Researchers tested a new computer method that analyzes heart rate patterns to measure sleep quality and breathing problems during sleep, comparing it to the traditional gold-standard method of manually reviewing sleep recordings. The new method worked very well for measuring overall sleep time, wake time, and most sleep stages, though it was less accurate at distinguishing between deep and light sleep. This could eventually allow easier and cheaper sleep testing for patients with ME/CFS who often have sleep problems.

Sleep

E3 PreliminaryReviewPEM not requiredReview-Narrative

Short QT interval in clinical practice.

Bjerregaard, Preben, Nallapaneni, Hari, Gussak, Ihor·Journal of electrocardiology·2010

This review article discusses a heart rhythm pattern called a 'short QT interval' that doctors can see on heart electrical recordings (EKGs). The authors note that while this pattern is rare, it can sometimes be dangerous and increase the risk of sudden cardiac death. They found that short QT intervals have been reported in patients with ME/CFS, along with several other medical conditions, though we still don't fully understand what it means or how to best manage patients who have it.

E3 PreliminaryMechanismPEM unclearObservational

Severity of symptom flare after moderate exercise is linked to cytokine activity in chronic fatigue syndrome.

White, Andrea T, Light, Alan R, Hughen, Ronald W et al.·Psychophysiology·2010

This study looked at why some people with ME/CFS feel much worse after exercise. Researchers measured immune chemicals in the blood before and after moderate exercise in people with ME/CFS and healthy controls. They found that patients who experienced severe symptom flare had increased levels of certain immune chemicals 8 hours after exercise, while those with mild flare or healthy people did not show this pattern.

Immune SystemPost-Exertional Malaise

E3 PreliminaryCohortPEM unclearCross-Sectional

A discourse analytic study of ME/CFS (Chronic Fatigue Syndrome) sufferers' experiences of interactions with doctors.

Guise, Jennie, McVittie, Chris, McKinlay, Andy·Journal of health psychology·2010

This study looked at how ME/CFS patients describe their experiences when talking to doctors. Researchers analyzed conversations from an online support group and found that patients often feel their doctors don't listen to them or take their condition seriously. Interestingly, patients were careful about how they complained, trying to focus on practical issues rather than seeming like they were just complaining.

Diagnostics

E3 PreliminaryCohortPEM not requiredCross-Sectional

A qualitative exploration of adolescents' experiences of chronic fatigue syndrome.

Jelbert, Rebecca, Stedmon, Jacqui, Stephens, Alison·Clinical child psychology and psychiatry·2010

This study talked to five teenagers who had recovered from ME/CFS about what the illness was like for them. Through interviews and careful analysis of their stories, researchers found that teens experienced five common themes: trying to understand their illness, feeling a sense of loss, noticing things that seemed to make it better or worse, dealing with difficult emotions, and eventually recovering. The teens' own voices highlight that there is still much we need to learn about how this illness affects young people.

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Evidence browser

Traditional chinese medicine for chronic fatigue syndrome.

Implications of forgiveness enhancement in patients with fibromyalgia and chronic fatigue syndrome.

Chronic fatigue syndrome: Harvey and Wessely's (bio)psychosocial model versus a bio(psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways.

Activity in the hypothalamo-hypophyseal-adrenocortical system on experimental induction of chronic fatigue syndrome.

Chronic fatigue syndrome and fibromyalgia: a status report in 2010.

Xenotropic murine leukemia virus-related virus in chronic fatigue syndrome and prostate cancer.

EBV Chronic Infections.

Distribution of xenotropic murine leukemia virus-related virus (XMRV) infection in chronic fatigue syndrome and prostate cancer.

Contamination of human DNA samples with mouse DNA can lead to false detection of XMRV-like sequences.

Chronic fatigue syndrome, fibromyalgia, and related illnesses: a clinical model of assessment and intervention.

Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes.

The human retrovirus XMRV in prostate cancer and chronic fatigue syndrome.

Readability of patient and health care professional targeted dietary supplement leaflets used for diabetes and chronic fatigue syndrome.

Gut inflammation in chronic fatigue syndrome.

[Understanding chronic fatigue syndrome].

Validation of ECG-derived sleep architecture and ventilation in sleep apnea and chronic fatigue syndrome.

Short QT interval in clinical practice.

Severity of symptom flare after moderate exercise is linked to cytokine activity in chronic fatigue syndrome.

A discourse analytic study of ME/CFS (Chronic Fatigue Syndrome) sufferers' experiences of interactions with doctors.

A qualitative exploration of adolescents' experiences of chronic fatigue syndrome.

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