ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

1341–1360 of 2,422 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome and fibromyalgia: a status report in 2010.

Natelson, Benjamin H·MD advisor : a journal for New Jersey medical community·2010

This 2010 report by Dr. Benjamin Natelson reviews the current understanding of ME/CFS and fibromyalgia, two conditions that cause persistent fatigue and pain. The report summarizes what doctors and researchers knew at that time about how these conditions develop, how they affect the body, and how they are treated. It provides an overview of the scientific evidence available in 2010 to help explain why people with these conditions experience their symptoms.

Biomarkers

E3 PreliminaryMechanismPEM requiredMechanistic

Pain inhibition and postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: an experimental study.

Van Oosterwijck, J, Nijs, J, Meeus, M et al.·Journal of internal medicine·2010

This study compared how the body's pain-relief systems work in people with ME/CFS versus healthy people during exercise. Researchers found that after exercise, people with ME/CFS became more sensitive to pain (their pain thresholds decreased), while healthy people became less sensitive to pain. The ME/CFS group also experienced worsening symptoms after both types of exercise they tried.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM unclearObservational

Severity of symptom flare after moderate exercise is linked to cytokine activity in chronic fatigue syndrome.

White, Andrea T, Light, Alan R, Hughen, Ronald W et al.·Psychophysiology·2010

This study looked at why some people with ME/CFS feel much worse after exercise. Researchers measured immune chemicals in the blood before and after moderate exercise in people with ME/CFS and healthy controls. They found that patients who experienced severe symptom flare had increased levels of certain immune chemicals 8 hours after exercise, while those with mild flare or healthy people did not show this pattern.

Immune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredMechanistic

Protective effect of epigallocatechin gallate in murine water-immersion stress model of chronic fatigue syndrome.

Sachdeva, Anand Kamal, Kuhad, Anurag, Tiwari, Vinod et al.·Basic & clinical pharmacology & toxicology·2010

This study tested whether a compound from green tea called EGCG could help reduce fatigue in mice exposed to stress. Researchers induced fatigue-like symptoms in mice through daily forced swimming, then gave some mice EGCG supplements. The treatment appeared to reduce the mice's fatigue and also lowered harmful inflammation markers in their brains.

E3 PreliminaryCommentaryPEM not requiredEditorial

Xenotropic murine leukemia virus-related virus in chronic fatigue syndrome and prostate cancer.

Baraniuk, James N·Current allergy and asthma reports·2010

This study examined whether a virus called XMRV might be connected to ME/CFS. Researchers found this virus in about half to two-thirds of ME/CFS patients tested, compared to only about 4% of healthy people. The virus was able to spread from patient blood to laboratory cells, raising questions about whether it could be transmitted between people.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Readability of patient and health care professional targeted dietary supplement leaflets used for diabetes and chronic fatigue syndrome.

Clauson, Kevin A, Zeng-Treitler, Qing, Kandula, Sasikiran·Journal of alternative and complementary medicine (New York, N.Y.)·2010

This study examined whether instruction sheets about dietary supplements for diabetes and ME/CFS are written in a way that patients can easily understand. Researchers found that most of these leaflets are written at a college level (13th grade), far harder than the recommended 6th-grade level. This difficulty may make it harder for patients to understand important information and follow recommendations.

E3 PreliminaryReviewPEM unclearReview-Narrative

Distribution of xenotropic murine leukemia virus-related virus (XMRV) infection in chronic fatigue syndrome and prostate cancer.

Mikovits, Judy A, Huang, Ying, Pfost, Max A et al.·AIDS reviews·2010

Researchers tested blood samples from ME/CFS patients for a virus called XMRV using different detection methods. They found that simple DNA tests alone missed infections that were caught by more sensitive techniques. This study explains why different research teams got different results—the testing method matters a lot.

E3 PreliminaryCohortPEM not requiredCross-Sectional

A qualitative exploration of adolescents' experiences of chronic fatigue syndrome.

Jelbert, Rebecca, Stedmon, Jacqui, Stephens, Alison·Clinical child psychology and psychiatry·2010

This study talked to five teenagers who had recovered from ME/CFS about what the illness was like for them. Through interviews and careful analysis of their stories, researchers found that teens experienced five common themes: trying to understand their illness, feeling a sense of loss, noticing things that seemed to make it better or worse, dealing with difficult emotions, and eventually recovering. The teens' own voices highlight that there is still much we need to learn about how this illness affects young people.

E3 PreliminaryReviewPEM unclearReview-Narrative

Endogenous retroviruses as potential hazards for vaccines.

Miyazawa, Takayuki·Biologicals : journal of the International Association of Biological Standardization·2010

This article reviews the concern that certain viruses called endogenous retroviruses (ERVs) may be present in animal cell lines used to make some vaccines. Scientists discovered a virus called XMRV in some patients with ME/CFS and prostate cancer. Because some vaccines are made using animal cells that naturally contain ERVs, there is a theoretical risk that these viruses could contaminate vaccines, though this has not been well studied.

E3 PreliminaryReviewPEM unclearReview-Narrative

The human retrovirus XMRV in prostate cancer and chronic fatigue syndrome.

Silverman, Robert H, Nguyen, Carvell, Weight, Christopher J et al.·Nature reviews. Urology·2010

This review examines XMRV, a newly discovered virus that has been found in some people with prostate cancer and some with ME/CFS. Researchers have found the virus at very different rates in different studies (0-27% in prostate cancer, 0-67% in ME/CFS patients). While some antiviral drugs appear to block this virus, scientists still do not know whether XMRV actually causes either disease.

Immune System

E3 PreliminaryCohortPEM not requiredCross-Sectional

EEG findings in burnout patients.

van Luijtelaar, Gilles, Verbraak, Marc, van den Bunt, Martijn et al.·The Journal of neuropsychiatry and clinical neurosciences·2010

This study used brain wave recordings (EEG) to look for physical markers that could help identify burnout as a distinct condition. Researchers found that people with burnout showed different brain wave patterns compared to healthy people, including reduced activity in certain frequency bands. The findings suggest burnout may have measurable brain differences that set it apart from depression and chronic fatigue.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Mouse DNA contamination in human tissue tested for XMRV.

Robinson, Mark J, Erlwein, Otto W, Kaye, Steve et al.·Retrovirology·2010

Researchers tested human prostate cancer tissue samples for a virus called XMRV that had been linked to both cancer and ME/CFS. They found that many samples were contaminated with mouse DNA, which can create false positive results. This study shows why it's crucial to carefully check for contamination when looking for viruses in human tissue samples.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Exploring the feasibility of establishing a disease-specific post-mortem tissue bank in the UK: a case study in ME/CFS.

Lacerda, Eliana M, Nacul, Luis, Pheby, Derek et al.·Journal of clinical pathology·2010

This study explored whether it would be possible and acceptable to create a tissue bank in the UK specifically for ME/CFS—a place where donated tissues from people with ME/CFS could be studied after death to better understand the disease. Researchers interviewed patients, held discussion groups, and consulted experts to find out what people thought about this idea. The findings show that both patients and experts believe such a tissue bank would be valuable and could work in practice, as long as certain concerns were properly addressed.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[The cerebralization of fatigue: an analysis of the cerebral hypothesis in the case of chronic fatigue syndrome].

Ortega, Francisco, Zorzanelli, Rafaela·Historia, ciencias, saude--Manguinhos·2010

This article examines how ME/CFS came to be understood as a brain-based illness rather than purely a physical one. The authors explore the history of how brain imaging and neuroscience research influenced medical thinking about ME/CFS, and how this shift reflected broader changes in how society views illness in general—increasingly looking to the brain as the primary source of disease.

E3 PreliminaryReviewPEM unclearReview-Narrative

Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes.

Sperber, Ami D, Dekel, Roy·Journal of neurogastroenterology and motility·2010

Many people with irritable bowel syndrome (IBS) also experience other chronic conditions like fibromyalgia or chronic fatigue syndrome (ME/CFS). When patients have IBS plus another functional disorder, their symptoms tend to be worse, they report lower quality of life, and they miss more work. This suggests these conditions may share common underlying mechanisms rather than being completely separate diseases.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Contamination of human DNA samples with mouse DNA can lead to false detection of XMRV-like sequences.

Oakes, Brendan, Tai, Albert K, Cingöz, Oya et al.·Retrovirology·2010

Researchers tested blood samples from ME/CFS patients and healthy people for a virus called XMRV. They discovered that when using very sensitive testing methods, they were getting false positive results because mouse DNA was contaminating the samples, not because patients actually had the virus. This study shows why careful testing procedures are essential when looking for viruses in patient samples.

E3 PreliminaryCohortPEM unclearCross-Sectional

Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) in adults: a qualitative study of perspectives from professional practice.

Horton, Simon M C, Poland, Fiona, Kale, Swati et al.·BMC family practice·2010

This study spoke with six healthcare providers who were praised by ME/CFS patients for being helpful and understanding. The researchers asked these doctors and specialists what they thought worked best when treating ME/CFS. The key finding was that patients benefit most from doctors who truly listen, show respect, build trust, and recognize how serious and complex the condition is—rather than those who dismiss or minimize ME/CFS.

Diagnostics

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Validation of ECG-derived sleep architecture and ventilation in sleep apnea and chronic fatigue syndrome.

Decker, Michael J, Eyal, Shulamit, Shinar, Zvika et al.·Sleep & breathing = Schlaf & Atmung·2010

Researchers tested a new computer method that analyzes heart rate patterns to measure sleep quality and breathing problems during sleep, comparing it to the traditional gold-standard method of manually reviewing sleep recordings. The new method worked very well for measuring overall sleep time, wake time, and most sleep stages, though it was less accurate at distinguishing between deep and light sleep. This could eventually allow easier and cheaper sleep testing for patients with ME/CFS who often have sleep problems.

Sleep

E3 PreliminaryCohortPEM unclearCase-Control

Acute enterovirus infection followed by myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and viral persistence.

Chia, J, Chia, A, Voeller, M et al.·Journal of clinical pathology·2010

This study tracked patients who had acute enterovirus infections (common viral illnesses) and then developed ME/CFS symptoms. Researchers found that in three patients, the virus persisted in their stomach tissue years after the initial infection. This suggests that some ME/CFS cases may be triggered by enterovirus infections that don't fully clear from the body.

E3 PreliminaryReviewPEM requiredReview-Narrative

Chronic fatigue syndrome: Harvey and Wessely's (bio)psychosocial model versus a bio(psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways.

Maes, Michael, Twisk, Frank N M·BMC medicine·2010

This study compares two different ways of understanding ME/CFS. One model suggests the illness is mainly caused by how the mind and behavior interact with the body, and proposes treatments like cognitive behavioral therapy and graded exercise. The other model focuses on biological problems like inflammation and oxidative stress in the body. The authors argue that the biological model better explains ME/CFS and that exercise-based treatments could actually make some patients worse.

Immune SystemPost-Exertional Malaise

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Evidence Atlas

Evidence browser

Chronic fatigue syndrome and fibromyalgia: a status report in 2010.

Pain inhibition and postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: an experimental study.

Severity of symptom flare after moderate exercise is linked to cytokine activity in chronic fatigue syndrome.

Protective effect of epigallocatechin gallate in murine water-immersion stress model of chronic fatigue syndrome.

Xenotropic murine leukemia virus-related virus in chronic fatigue syndrome and prostate cancer.

Readability of patient and health care professional targeted dietary supplement leaflets used for diabetes and chronic fatigue syndrome.

Distribution of xenotropic murine leukemia virus-related virus (XMRV) infection in chronic fatigue syndrome and prostate cancer.

A qualitative exploration of adolescents' experiences of chronic fatigue syndrome.

Endogenous retroviruses as potential hazards for vaccines.

The human retrovirus XMRV in prostate cancer and chronic fatigue syndrome.

EEG findings in burnout patients.

Mouse DNA contamination in human tissue tested for XMRV.

Exploring the feasibility of establishing a disease-specific post-mortem tissue bank in the UK: a case study in ME/CFS.

[The cerebralization of fatigue: an analysis of the cerebral hypothesis in the case of chronic fatigue syndrome].

Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes.

Contamination of human DNA samples with mouse DNA can lead to false detection of XMRV-like sequences.

Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) in adults: a qualitative study of perspectives from professional practice.

Validation of ECG-derived sleep architecture and ventilation in sleep apnea and chronic fatigue syndrome.

Acute enterovirus infection followed by myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and viral persistence.

Chronic fatigue syndrome: Harvey and Wessely's (bio)psychosocial model versus a bio(psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways.

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