ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

1341–1360 of 2,420 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome, fibromyalgia, and related illnesses: a clinical model of assessment and intervention.

Friedberg, Fred·Journal of clinical psychology·2010

This article reviews how doctors and mental health professionals can better assess and help people with ME/CFS, fibromyalgia, and related conditions. The authors present a practical framework using cognitive-behavioral approaches—strategies that address both thoughts and behaviors—to improve care for patients who often feel dismissed by the medical system. The goal is to help clinicians understand why these patients experience unusual physical symptoms and provide more effective support.

E3 PreliminaryReviewPEM unclearReview-Narrative

Implications of forgiveness enhancement in patients with fibromyalgia and chronic fatigue syndrome.

Toussaint, Loren, Overvold-Ronningen, Mary, Vincent, Ann et al.·Journal of health care chaplaincy·2010

This review examines whether learning to forgive—others and ourselves—might help people with ME/CFS and fibromyalgia cope better with the anger, stress, fear, and depression that often come with these conditions. The authors suggest that forgiveness could be a helpful complementary approach, alongside other treatments, to reduce the emotional burden of living with these chronic illnesses. They propose a model to guide future research on how forgiveness might improve well-being in these patient populations.

E3 PreliminaryMechanismPEM not requiredObservational

Cytokines across the night in chronic fatigue syndrome with and without fibromyalgia.

Nakamura, Toru, Schwander, Stephan K, Donnelly, Robert et al.·Clinical and vaccine immunology : CVI·2010

Researchers studied immune signaling molecules called cytokines in people with ME/CFS and fibromyalgia while they slept in a lab, comparing them to healthy people. Instead of finding signs of excessive inflammation (which some theories predicted), they found slightly elevated levels of a calming immune molecule called interleukin-10. These small changes might help explain why many ME/CFS patients struggle with disrupted sleep.

Immune System

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Mouse DNA contamination in human tissue tested for XMRV.

Robinson, Mark J, Erlwein, Otto W, Kaye, Steve et al.·Retrovirology·2010

Researchers tested human prostate cancer tissue samples for a virus called XMRV that had been linked to both cancer and ME/CFS. They found that many samples were contaminated with mouse DNA, which can create false positive results. This study shows why it's crucial to carefully check for contamination when looking for viruses in human tissue samples.

E3 PreliminaryMechanismPEM not requiredMechanistic

Possible role of oxidative stress and immunological activation in mouse model of chronic fatigue syndrome and its attenuation by olive extract.

Gupta, Amit, Vij, Garima, Chopra, Kanwaljit·Journal of neuroimmunology·2010

Researchers used mice to study whether oxidative stress (chemical damage in cells) and immune activation play a role in ME/CFS-like symptoms. They found that mice treated with immune-triggering substances showed increased fatigue and pain sensitivity, along with signs of cellular damage. When given olive extract, these mice showed improvement in fatigue, pain, and markers of cellular damage.

Immune System

E3 PreliminaryMechanismPEM unclearCross-Sectional

Reduced pressure pain thresholds in response to exercise in chronic fatigue syndrome but not in chronic low back pain: an experimental study.

Meeus, Mira, Roussel, Nathalie A, Truijen, Steven et al.·Journal of rehabilitation medicine·2010

This study compared how people with ME/CFS, chronic back pain, and healthy people respond to exercise. Researchers found that people with ME/CFS have more sensitive pain responses than others, and importantly, their pain sensitivity got worse after light exercise—opposite to what happened in the other groups. This suggests ME/CFS involves different pain processing in the nervous system.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredMechanistic

Effects of exercise on behavior and peripheral blood lymphocyte apoptosis in a rat model of chronic fatigue syndrome.

Zou, Jun, Yuan, Jianqi, Lv, Shuang et al.·Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban·2010

Researchers created a rat model of ME/CFS using stress and shock, then tested whether exercise could help. Rats with the CFS-like condition showed decreased activity, memory problems, and abnormal immune cell death. When stressed rats were given access to a running wheel, their activity improved and their immune cell death decreased, suggesting exercise may help counteract some effects of the condition.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome.

Mikovits, Judy A, Lombardi, Vincent C, Pfost, Max A et al.·Virulence·2010

This 2010 study reported finding a virus called XMRV in blood samples from over 75% of people with ME/CFS using multiple detection methods. The researchers emphasized that different laboratory techniques found the virus at different rates, with some methods being much more sensitive than others. The findings were controversial because other research groups had difficulty reproducing these results.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Endogenous retroviruses as potential hazards for vaccines.

Miyazawa, Takayuki·Biologicals : journal of the International Association of Biological Standardization·2010

This article reviews the concern that certain viruses called endogenous retroviruses (ERVs) may be present in animal cell lines used to make some vaccines. Scientists discovered a virus called XMRV in some patients with ME/CFS and prostate cancer. Because some vaccines are made using animal cells that naturally contain ERVs, there is a theoretical risk that these viruses could contaminate vaccines, though this has not been well studied.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome and an approach to its treatment].

Akarachkova, E S·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2010

This is a review article discussing chronic fatigue syndrome (ME/CFS) and treatment approaches. The authors examine what is known about the condition and offer clinical guidance on how to manage it. While not a new research study, it provides a medical perspective on understanding and treating this complex illness.

Interventions

E3 PreliminaryReviewPEM unclearReview-Narrative

Distribution of xenotropic murine leukemia virus-related virus (XMRV) infection in chronic fatigue syndrome and prostate cancer.

Mikovits, Judy A, Huang, Ying, Pfost, Max A et al.·AIDS reviews·2010

Researchers tested blood samples from ME/CFS patients for a virus called XMRV using different detection methods. They found that simple DNA tests alone missed infections that were caught by more sensitive techniques. This study explains why different research teams got different results—the testing method matters a lot.

E3 PreliminaryReviewPEM not requiredReview-Narrative

EBV Chronic Infections.

Eligio, Pizzigallo, Delia, Racciatti, Valeria, Gorgoretti·Mediterranean journal of hematology and infectious diseases·2010

This review explores the connection between Epstein-Barr virus (EBV)—the virus that causes mononucleosis—and ME/CFS. While EBV can persist in the body and reactivate at times, it is not clear whether it directly causes chronic fatigue syndrome in most patients. The authors suggest that ME/CFS likely has multiple causes, including EBV in some people, other viruses in others, and non-infectious factors, but the underlying mechanism may involve inflammation and oxidative damage.

Immune System

E3 PreliminaryCohortPEM unclearCase-Control

Acute enterovirus infection followed by myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and viral persistence.

Chia, J, Chia, A, Voeller, M et al.·Journal of clinical pathology·2010

This study tracked patients who had acute enterovirus infections (common viral illnesses) and then developed ME/CFS symptoms. Researchers found that in three patients, the virus persisted in their stomach tissue years after the initial infection. This suggests that some ME/CFS cases may be triggered by enterovirus infections that don't fully clear from the body.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Exploring the feasibility of establishing a disease-specific post-mortem tissue bank in the UK: a case study in ME/CFS.

Lacerda, Eliana M, Nacul, Luis, Pheby, Derek et al.·Journal of clinical pathology·2010

This study explored whether it would be possible and acceptable to create a tissue bank in the UK specifically for ME/CFS—a place where donated tissues from people with ME/CFS could be studied after death to better understand the disease. Researchers interviewed patients, held discussion groups, and consulted experts to find out what people thought about this idea. The findings show that both patients and experts believe such a tissue bank would be valuable and could work in practice, as long as certain concerns were properly addressed.

E3 PreliminaryCommentaryPEM unclearEditorial

Of Mice and Men: On the Origin of XMRV.

van der Kuyl, Antoinette Cornelia, Cornelissen, Marion, Berkhout, Ben·Frontiers in microbiology·2010

This study examines XMRV, a virus that was found in some ME/CFS patients but whose existence remains hotly debated in the scientific community. The authors suggest that XMRV may have entered humans through contamination in medical products like vaccines that were made using mouse cells. They explore how this virus, which is very similar to viruses naturally found in mice, could have crossed into humans.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Traditional chinese medicine for chronic fatigue syndrome.

Chen, Rui, Moriya, Junji, Yamakawa, Jun-Ichi et al.·Evidence-based complementary and alternative medicine : eCAM·2010

This review examines how traditional Chinese medicine (TCM) might help people with ME/CFS. The authors suggest that TCM treatments may reduce symptoms like fatigue, sleep problems, and brain fog, and may work by improving immune function and reducing oxidative stress. However, they note that current TCM research on ME/CFS has significant quality and consistency issues that need to be addressed.

Immune System

E3 PreliminaryCommentaryPEM not requiredEditorial

Xenotropic murine leukemia virus-related virus in chronic fatigue syndrome and prostate cancer.

Baraniuk, James N·Current allergy and asthma reports·2010

This study examined whether a virus called XMRV might be connected to ME/CFS. Researchers found this virus in about half to two-thirds of ME/CFS patients tested, compared to only about 4% of healthy people. The virus was able to spread from patient blood to laboratory cells, raising questions about whether it could be transmitted between people.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Gut inflammation in chronic fatigue syndrome.

Lakhan, Shaheen E, Kirchgessner, Annette·Nutrition & metabolism·2010

Many ME/CFS patients experience gut problems similar to irritable bowel syndrome. This review discusses how three interconnected gut issues—changes in the bacteria that live in your intestines, a weakened intestinal lining, and an altered immune response in the gut—may contribute to ME/CFS. The authors suggest that treatments like probiotics (beneficial bacteria) might help by restoring healthy gut bacteria and reducing inflammation.

Immune System

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Validation of ECG-derived sleep architecture and ventilation in sleep apnea and chronic fatigue syndrome.

Decker, Michael J, Eyal, Shulamit, Shinar, Zvika et al.·Sleep & breathing = Schlaf & Atmung·2010

Researchers tested a new computer method that analyzes heart rate patterns to measure sleep quality and breathing problems during sleep, comparing it to the traditional gold-standard method of manually reviewing sleep recordings. The new method worked very well for measuring overall sleep time, wake time, and most sleep stages, though it was less accurate at distinguishing between deep and light sleep. This could eventually allow easier and cheaper sleep testing for patients with ME/CFS who often have sleep problems.

Sleep

E3 PreliminaryReviewPEM unclearReview-Narrative

What is fatigue? Pathological and nonpathological fatigue.

Jason, Leonard A, Evans, Meredyth, Brown, Molly et al.·PM & R : the journal of injury, function, and rehabilitation·2010

This article explores what fatigue really is and how doctors can tell the difference between normal tiredness and the severe, disabling fatigue that comes with illnesses like ME/CFS. Fatigue is common in many diseases and conditions, but researchers have had difficulty measuring it consistently and understanding why it happens. The authors review the scientific literature to help clarify these important questions.

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Chronic fatigue syndrome, fibromyalgia, and related illnesses: a clinical model of assessment and intervention.

Implications of forgiveness enhancement in patients with fibromyalgia and chronic fatigue syndrome.

Cytokines across the night in chronic fatigue syndrome with and without fibromyalgia.

Mouse DNA contamination in human tissue tested for XMRV.

Possible role of oxidative stress and immunological activation in mouse model of chronic fatigue syndrome and its attenuation by olive extract.

Reduced pressure pain thresholds in response to exercise in chronic fatigue syndrome but not in chronic low back pain: an experimental study.

Effects of exercise on behavior and peripheral blood lymphocyte apoptosis in a rat model of chronic fatigue syndrome.

Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome.

Endogenous retroviruses as potential hazards for vaccines.

[Chronic fatigue syndrome and an approach to its treatment].

Distribution of xenotropic murine leukemia virus-related virus (XMRV) infection in chronic fatigue syndrome and prostate cancer.

EBV Chronic Infections.

Acute enterovirus infection followed by myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and viral persistence.

Exploring the feasibility of establishing a disease-specific post-mortem tissue bank in the UK: a case study in ME/CFS.

Of Mice and Men: On the Origin of XMRV.

Traditional chinese medicine for chronic fatigue syndrome.

Xenotropic murine leukemia virus-related virus in chronic fatigue syndrome and prostate cancer.

Gut inflammation in chronic fatigue syndrome.

Validation of ECG-derived sleep architecture and ventilation in sleep apnea and chronic fatigue syndrome.

What is fatigue? Pathological and nonpathological fatigue.

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