ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

1481–1500 of 2,420 studies

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Assessment of fibromyalgia & chronic fatigue syndrome: a new protocol designed to determine work capability--chronic pain abilities determination (CPAD).

Kelly, M, Gagne, R, Newman, J D et al.·Irish medical journal·2008

This study created a new testing system to help doctors objectively measure how much work someone with ME/CFS or fibromyalgia can do. The system combines patient interviews, standardized questionnaires about pain and fatigue, and several objective tests (including strength measurements, fitness tests, and cognitive assessments) to give a complete picture of someone's working abilities. The results are then compared to databases of normal working capacity to determine what kinds of work might be realistic.

E3 PreliminaryCohortPEM unclearCross-Sectional

Acute phase phospholipids related to the cardiolipin of mitochondria in the sera of patients with chronic fatigue syndrome (CFS), chronic Ciguatera fish poisoning (CCFP), and other diseases attributed to chemicals, Gulf War, and marine toxins.

Hokama, Yoshitsugi, Empey-Campora, Cara, Hara, Cynthia et al.·Journal of clinical laboratory analysis·2008

This study looked for specific molecules in the blood of ME/CFS patients that might be related to mitochondria (the energy-producing parts of cells). Researchers found that over 91% of ME/CFS patients had elevated levels of these molecules, similar to what was seen in people with other conditions linked to toxins. The study suggests these molecules might be a biological marker—like a sign—of ME/CFS, comparable to well-known inflammation markers in other diseases.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Identification of significant genes in genomics using Bayesian variable selection methods.

Lin, Eugene, Huang, Lung-Cheng·Advances and applications in bioinformatics and chemistry : AABC·2008

Researchers developed a new mathematical method to find which genes are most important in ME/CFS by sorting through large amounts of genetic data. Instead of looking at every gene equally, this approach helps identify a smaller group of genes that appear to have the strongest connection to the disease. This method could help scientists focus their research on the most promising genetic leads.

E3 PreliminaryCohortPEM not requiredCase-Control

Contact lens-related acanthamoeba keratitis in a patient with chronic fatigue syndrome.

Jhanji, Vishal, Beltz, Jacqueline, Vajpayee, Rasik B·Eye & contact lens·2008

This case report describes a man with ME/CFS who developed a serious eye infection from improper contact lens care. Because his ME/CFS made it difficult for him to maintain proper lens hygiene, bacteria-like organisms called Acanthamoeba infected his cornea (the clear front part of his eye). He eventually needed eye surgery to restore his vision after medical treatments alone did not work.

E3 PreliminaryReviewPEM unclearReview-Narrative

POTS versus deconditioning: the same or different?

Joyner, Michael J, Masuki, Shizue·Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2008

This review article compares POTS (a condition where heart rate and blood pressure drop abnormally when standing) with the physical deconditioning that happens after long bed rest or spaceflight. The authors suggest that both conditions may share similar causes and that carefully structured exercise training might help patients with POTS, ME/CFS, and fibromyalgia, while acknowledging the medical community must remain empathetic to patients with these complex conditions.

Autonomic Nervous System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Neuroactive steroids and fatigue severity in patients with primary biliary cirrhosis and hepatitis C.

Ahboucha, S, Butterworth, R F, Pomier-Layrargues, G et al.·Neurogastroenterology and motility·2008

This study looked at whether certain brain chemicals called neuroactive steroids might explain why people with liver disease feel extremely tired. Researchers measured these chemicals in patients with two types of liver disease and compared them to healthy people. They found that patients with liver disease had higher levels of these chemicals, and those with the most fatigue had the highest levels.

E3 PreliminaryPEM not required

Using multiple sources of knowledge to reach clinical understanding of chronic fatigue syndrome.

Chew-Graham, Carolyn A, Cahill, Greg, Dowrick, Christopher et al.·Annals of family medicine·2008

This study looked at how ME/CFS patients and their family doctors understand the illness and talk about it during medical visits. Researchers interviewed 24 patients and 14 doctors in England and found that both groups use general knowledge from society and media—not just medical training—to make sense of ME/CFS. When they talk together, both patients and doctors use scientific language to be heard and trusted, which can help them work together better.

E3 PreliminaryBehavioralPEM unclear

Association of chronic fatigue syndrome and acute psychotic episode: is it coincidental?

Kornreich, Charles, Szombat, Maya, Vandriette, Yun-Marie et al.·Primary care companion to the Journal of clinical psychiatry·2008

This study looked at whether ME/CFS and sudden onset of psychotic symptoms (like hallucinations or delusions) occur together by chance or if there might be a connection between them. The researchers examined case reports to explore whether patients with ME/CFS experienced psychotic episodes more often than would be expected. This small study helps raise awareness that mental health symptoms can sometimes accompany ME/CFS and deserve clinical attention.

E3 PreliminaryPEM unclear

Can exercise limits prevent post-exertional malaise in chronic fatigue syndrome? An uncontrolled clinical trial.

Nijs, Jo, Almond, Freya, De Becker, Pascale et al.·Clinical rehabilitation·2008

This study tested whether limiting both how hard and how long people with ME/CFS exercise could prevent post-exertional malaise (feeling much worse after activity). Twenty-four patients did a controlled walking test designed to stay within their personal limits. While tiredness improved within 24 hours, pain increased and didn't fully go away, and some patients reported their overall health got worse. The exercise limits helped prevent major health changes but didn't completely stop symptom flare-ups.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Diagnostic and treatment challenges of chronic fatigue syndrome: role of immediate-release methylphenidate.

Valdizán Usón, José Ramón, Idiazábal Alecha, María Angeles·Expert review of neurotherapeutics·2008

This study explores whether a medication called methylphenidate (commonly known as Ritalin) might help people with ME/CFS who experience brain fog, memory problems, and difficulty concentrating. The authors reviewed existing research, including one small study showing positive results, and discussed how this medication works in the brain to boost focus and thinking speed. They suggest methylphenidate could be a promising treatment option worth further investigation for ME/CFS patients.

Cognitive Impairment

E3 PreliminaryReviewPEM unclearReview-Narrative

The potential toxicity of artificial sweeteners.

Whitehouse, Christina R, Boullata, Joseph, McCauley, Linda A·AAOHN journal : official journal of the American Association of Occupational Health Nurses·2008

This article reviews what we know about artificial sweeteners—sugar substitutes used in diet drinks and other products. Scientists have debated whether these sweeteners are safe, and some have suggested links to various diseases including chronic fatigue syndrome, though the evidence is mixed. The authors provide an overview of different types of sweeteners, how they work in the body, and what research shows so far.

E3 PreliminaryReviewPEM unclearReview-Narrative

Hypothesis: the chaos and complexity theory may help our understanding of fibromyalgia and similar maladies.

Martinez-Lavin, Manuel, Infante, Oscar, Lerma, Claudia·Seminars in arthritis and rheumatism·2008

This article proposes a new way to understand fibromyalgia, ME/CFS, and similar conditions by applying complexity theory—the study of how complex systems work. Instead of looking for a single cause or structural damage, the authors suggest these illnesses result from the body's systems losing their ability to adapt flexibly to stress. This perspective could help explain why these conditions involve so many different symptoms affecting different body systems.

E3 PreliminaryPEM unclear

Individuals' experience of chronic fatigue syndrome/myalgic encephalomyelitis: an interpretative phenomenological analysis.

Arroll, Megan A, Senior, Victoria·Psychology & health·2008

This study asked eight people with ME/CFS to describe their personal experience of the illness through telephone interviews. Researchers found that patients experience their symptoms in complex ways, with fatigue, pain, and other problems affecting their daily lives in varying patterns. An important discovery was that receiving a diagnosis, while helpful, didn't necessarily make the journey easier—patients continued to struggle with understanding and managing their condition.

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

'That was my old life; it's almost like a past-life now': identity crisis, loss and adjustment amongst people living with Chronic Fatigue Syndrome.

Dickson, Adele, Knussen, Christina, Flowers, Paul·Psychology & health·2008

This study asked 14 people with ME/CFS about their personal experiences living with the condition. Participants described feeling a loss of identity and control over their lives, struggling with not being able to plan for the future, and feeling worthless. They also mentioned how disbelief from others made these feelings worse. The study found that learning to accept the illness and adapt to their new life helped people cope better.

E3 PreliminaryMechanismPEM unclearMechanistic

Differential heat shock protein responses to strenuous standardized exercise in chronic fatigue syndrome patients and matched healthy controls.

Thambirajah, Anita A, Sleigh, Kenna, Stiver, H Grant et al.·Clinical and investigative medicine. Medecine clinique et experimentale·2008

This study looked at special protective proteins called heat shock proteins (HSPs) in the blood cells of ME/CFS patients and healthy people before and after exercise. The researchers found that ME/CFS patients had higher levels of these proteins at rest, but their levels dropped after exercise and stayed low for a week. In contrast, healthy people's HSP levels stayed stable or increased after exercise. This difference suggests ME/CFS patients may have trouble recovering from physical stress.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM unclearMechanistic

Gene profiling of patients with chronic fatigue syndrome/myalgic encephalomyelitis.

Kerr, Jonathan R·Current rheumatology reports·2008

Researchers used gene testing to look at which genes are turned on or off differently in people with ME/CFS compared to healthy people. They found 88 genes with different activity levels, mostly related to immune function and infection fighting. Importantly, they discovered that ME/CFS patients appear to fall into at least seven different subtypes based on their gene patterns, suggesting that ME/CFS may not be one single disease but rather several related conditions that might need different treatments.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Central sensitization: a biopsychosocial explanation for chronic widespread pain in patients with fibromyalgia and chronic fatigue syndrome.

Meeus, Mira, Nijs, Jo·Clinical rheumatology·2007

Many people with ME/CFS experience widespread pain in addition to fatigue, similar to fibromyalgia. This paper proposes that both conditions may be caused by 'central sensitization'—a problem where the nervous system becomes overly sensitive to pain signals. The authors review evidence suggesting this mechanism could explain ME/CFS pain, though more research is needed to confirm it.

Pain and Sensitization

E3 PreliminaryBehavioralPEM not requiredCase-Control

Fibromylagia, chronic fatigue, and adult attention deficit hyperactivity disorder in the adult: a case study.

Young, Joel L, Redmond, Judith C·Psychopharmacology bulletin·2007

This study looked at patients who came to a psychiatry clinic with ADHD symptoms and also had unexplained tiredness and widespread pain—conditions similar to ME/CFS or fibromyalgia. When doctors treated the ADHD with medication, some patients noticed their fatigue and pain improved along with their attention problems. The researchers suggest this might mean these conditions involve how the brain processes information rather than problems in muscles and joints.

Cognitive Impairment

E3 PreliminaryReviewPEM unclearReview-Narrative

Cranial electrotherapy stimulation and fibromyalgia.

Gilula, Marshall F·Expert review of medical devices·2007

This review examines cranial electrotherapy stimulation (CES), a treatment that uses mild electrical stimulation applied to the head to help manage fibromyalgia pain and related symptoms. While CES is not a cure-all, research suggests it may help some fibromyalgia patients feel better. The review also discusses how fibromyalgia often occurs alongside other conditions like anxiety, depression, sleep problems, and fatigue—symptoms that overlap with ME/CFS.

Pain and SensitizationSleep

E3 PreliminaryBehavioralPEM unclearCross-Sectional

An 'overwhelming illness': women's experiences of learning to live with chronic fatigue syndrome/myalgic encephalomyelitis.

Edwards, Catherine R, Thompson, Andrew R, Blair, Alan·Journal of health psychology·2007

This study interviewed eight women with ME/CFS about how they learned to cope with their illness. Many felt overwhelmed at first and frustrated when doctors didn't believe or help them. Over time, women found ways to manage by learning more about their condition, getting support from others, and taking charge of their own care, which helped them feel more in control.

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Assessment of fibromyalgia & chronic fatigue syndrome: a new protocol designed to determine work capability--chronic pain abilities determination (CPAD).

Acute phase phospholipids related to the cardiolipin of mitochondria in the sera of patients with chronic fatigue syndrome (CFS), chronic Ciguatera fish poisoning (CCFP), and other diseases attributed to chemicals, Gulf War, and marine toxins.

Identification of significant genes in genomics using Bayesian variable selection methods.

Contact lens-related acanthamoeba keratitis in a patient with chronic fatigue syndrome.

POTS versus deconditioning: the same or different?

Neuroactive steroids and fatigue severity in patients with primary biliary cirrhosis and hepatitis C.

Using multiple sources of knowledge to reach clinical understanding of chronic fatigue syndrome.

Association of chronic fatigue syndrome and acute psychotic episode: is it coincidental?

Can exercise limits prevent post-exertional malaise in chronic fatigue syndrome? An uncontrolled clinical trial.

Diagnostic and treatment challenges of chronic fatigue syndrome: role of immediate-release methylphenidate.

The potential toxicity of artificial sweeteners.

Hypothesis: the chaos and complexity theory may help our understanding of fibromyalgia and similar maladies.

Individuals' experience of chronic fatigue syndrome/myalgic encephalomyelitis: an interpretative phenomenological analysis.

'That was my old life; it's almost like a past-life now': identity crisis, loss and adjustment amongst people living with Chronic Fatigue Syndrome.

Differential heat shock protein responses to strenuous standardized exercise in chronic fatigue syndrome patients and matched healthy controls.

Gene profiling of patients with chronic fatigue syndrome/myalgic encephalomyelitis.

Central sensitization: a biopsychosocial explanation for chronic widespread pain in patients with fibromyalgia and chronic fatigue syndrome.

Fibromylagia, chronic fatigue, and adult attention deficit hyperactivity disorder in the adult: a case study.

Cranial electrotherapy stimulation and fibromyalgia.

An 'overwhelming illness': women's experiences of learning to live with chronic fatigue syndrome/myalgic encephalomyelitis.

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