ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

1501–1520 of 2,423 studies

E3 PreliminaryMechanismPEM not requiredObservational

[Evaluation of fatigue by using acceleration plethysmography].

Yamaguti, Kouzi·Nihon rinsho. Japanese journal of clinical medicine·2007

Researchers tested a new device called acceleration plethysmography to measure fatigue in ME/CFS patients. This device tracks tiny blood vessel changes and nervous system activity in the fingertip. The study found that fatigue levels were connected to specific patterns in these measurements, suggesting this tool might help doctors objectively measure ME/CFS fatigue in the future.

Autonomic Nervous System

E3 PreliminaryBehavioralPEM not requiredCase-Control

Fibromylagia, chronic fatigue, and adult attention deficit hyperactivity disorder in the adult: a case study.

Young, Joel L, Redmond, Judith C·Psychopharmacology bulletin·2007

This study looked at patients who came to a psychiatry clinic with ADHD symptoms and also had unexplained tiredness and widespread pain—conditions similar to ME/CFS or fibromyalgia. When doctors treated the ADHD with medication, some patients noticed their fatigue and pain improved along with their attention problems. The researchers suggest this might mean these conditions involve how the brain processes information rather than problems in muscles and joints.

Cognitive Impairment

E3 PreliminaryCohortPEM not requiredCase-Control

Sympathomimetic amine therapy may improve refractory gastroparesis similar to its effect on chronic pelvic pain--case report.

Boimel, P, Check, J H, Katsoff, D·Clinical and experimental obstetrics & gynecology·2007

This case report describes one patient with ME/CFS who had severe stomach emptying problems (gastroparesis) that didn't respond to standard treatments. When she was given a stimulant medication called dextroamphetamine, her stomach symptoms improved significantly and stayed better for at least eight months. The authors suggest this type of medication might help some people with refractory gastroparesis, similar to how it may help other ME/CFS-related symptoms.

Autonomic Nervous System

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

An experimental study of the influence of individual participant characteristics on formal consensus development.

Carpenter, James, Hutchings, Andrew, Raine, Rosalind et al.·International journal of technology assessment in health care·2007

This study looked at how different types of doctors and healthcare workers rate whether psychological treatments are appropriate for ME/CFS and other chronic conditions. Researchers had 346 people in 20 groups review mental health treatments and rate how suitable they were, testing whether factors like the doctors' specialty, age, and sex changed their opinions.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Overview of chronic fatigue syndrome focusing on prevalence and diagnostic criteria].

Kuratsune, Hirohiko·Nihon rinsho. Japanese journal of clinical medicine·2007

This review examines ME/CFS as a real medical condition affecting the nervous system, immune system, and stress response. While researchers have found many different abnormalities in ME/CFS patients—including viral reactivation, immune problems, and chemical imbalances in the brain—no single cause has been identified in everyone with the condition. The authors suggest that ME/CFS likely results from a combination of genetic factors and life stress that disrupts how the body's immune and hormone systems work together.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Considerations for the treatment of chronic fatigue syndrome].

Murakami, Masato·Nihon rinsho. Japanese journal of clinical medicine·2007

This review examines how stress and emotional factors play a role in ME/CFS. The authors suggest that treating ME/CFS effectively requires addressing both the body and mind, not just physical symptoms. They discuss how antidepressants and certain herbal medicines may help reduce anxiety and depression, and emphasize that lifestyle changes and behavioral adjustments are important parts of recovery.

E3 PreliminaryCohortPEM not requiredCross-Sectional

Increased serum IgM antibodies directed against phosphatidyl inositol (Pi) in chronic fatigue syndrome (CFS) and major depression: evidence that an IgM-mediated immune response against Pi is one factor underpinning the comorbidity between both CFS and depression.

Maes, Michael, Mihaylova, Ivanka, Leunis, Jean-Claude·Neuro endocrinology letters·2007

This study found that people with ME/CFS and depression have higher levels of specific immune proteins (IgM antibodies) that attack a substance called phosphatidyl inositol in their blood compared to healthy people. These antibody levels were linked to fatigue and depression symptoms, suggesting that an abnormal immune response against this substance might contribute to both conditions.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia and overlapping disorders: the unifying concept of central sensitivity syndromes.

Yunus, Muhammad B·Seminars in arthritis and rheumatism·2007

This paper proposes that fibromyalgia, irritable bowel syndrome, chronic fatigue syndrome, and certain headaches may all share a common underlying problem: the nervous system becomes too sensitive to pain and other signals. Rather than being separate diseases, they might be related conditions caused by similar changes in how the brain and body communicate, combined with stress and emotional factors.

Pain and Sensitization

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

Hyperventilation in patients with chronic fatigue syndrome: the role of coping strategies.

Bogaerts, Katleen, Hubin, Morgane, Van Diest, Ilse et al.·Behaviour research and therapy·2007

This study looked at how people with ME/CFS breathe differently depending on how they mentally cope with their illness. Researchers found that when patients imagined resisting or fighting against their illness, their breathing changed in ways that made their symptoms worse. In contrast, when patients imagined accepting their illness, their breathing stayed more stable and symptoms improved. This suggests that our psychological response to ME/CFS may directly affect how our body breathes and which symptoms we experience.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Functional neuroimaging correlates of mental fatigue induced by cognition among chronic fatigue syndrome patients and controls.

Cook, Dane B, O'Connor, Patrick J, Lange, Gudrun et al.·NeuroImage·2007

This study used brain imaging to see how the brains of ME/CFS patients and healthy people respond during mentally tiring tasks. Researchers found that feelings of mental fatigue were linked to activity in specific brain regions during a difficult memory task, and that ME/CFS patients showed greater brain activity in these areas compared to healthy controls, even though they were doing the same task.

Cognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

Rehabilitation of decreased motor performance in patients with chronic fatigue syndrome: should we treat low effort capacity or reduced effort tolerance?

Van Houdenhove, B, Verheyen, L, Pardaens, K et al.·Clinical rehabilitation·2007

This paper proposes a new way to think about why people with ME/CFS have reduced physical ability. The authors suggest there may be two different problems: some patients may have low energy capacity (their bodies can't produce enough energy), while others may have reduced effort tolerance (their nervous system tells them to stop before their body actually reaches its limit). Understanding which problem a patient has could help doctors choose better treatments.

Post-Exertional Malaise

E3 PreliminaryCohortPEM not requiredCase-Control

[Chronic fatigue syndrome: from misunderstood illness to cause of job fitness management problem and of work total disability in a physiotherapist. Case report].

Belotti, L, Bigoni, F, Pezzoli, F et al.·Giornale italiano di medicina del lavoro ed ergonomia·2007

This study describes the case of a physiotherapist who developed ME/CFS and faced challenges staying in their job. The medical team had to evaluate whether the patient could continue working and eventually helped them obtain disability benefits. The case illustrates the real-world workplace challenges that people with ME/CFS encounter.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Vitamin d and rehabilitation: improving functional outcomes.

Shinchuk, Leonid M, Holick, Michael F·Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition·2007

Vitamin D deficiency is very common in people undergoing rehabilitation and can cause bone pain, muscle weakness, and poor balance. This review explains that maintaining healthy vitamin D levels (measured as 30–60 ng/mL in the blood) through sunlight exposure, diet, or supplements can help prevent fractures and improve muscle function. Because vitamin D deficiency can mimic or worsen symptoms of ME/CFS, fibromyalgia, and other conditions, doctors should check vitamin D levels in patients with these problems.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Fibromyalgia and chronic fatigue syndrome in children and adolescents].

Galanopoulos, Ng, Kampakis, Gp, Ladopoulou, Kf·Psychiatrike = Psychiatriki·2007

This review discusses fibromyalgia and chronic fatigue syndrome (ME/CFS) in children and teenagers, noting that both conditions are fairly common in this age group. Patients with these conditions experience widespread muscle pain, exhaustion, depression, headaches, and sleep problems that can significantly impact school, family life, and overall development. The authors emphasize that early diagnosis and treatment combining medication, physical therapy, and psychological support are important for helping young people manage these conditions.

Pain and SensitizationSleep

E3 PreliminaryCommentaryPEM not requiredEditorial

On commonness and rarity of thyroid hormone resistance: a discussion based on mechanisms of reduced sensitivity in peripheral tissues.

Tjørve, E, Tjørve, K M C, Olsen, J O et al.·Medical hypotheses·2007

Your body's cells may not respond properly to thyroid hormone even when blood tests show normal thyroid levels. This resistance to thyroid hormone can develop from various causes including infections, medications, toxins, or the immune system attacking thyroid proteins. The authors suggest this acquired resistance might be more common than previously thought and could explain why some patients feel hypothyroid symptoms despite normal blood tests.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[School phobia and childhood chronic fatigue syndrome (CCFS)].

Tomoda, Akemi·Nihon rinsho. Japanese journal of clinical medicine·2007

This review examines childhood chronic fatigue syndrome (CCFS), a serious condition where children experience extreme tiredness that cannot be explained by other medical or mental health problems. Children with CCFS often struggle with memory and concentration, sleep problems, and symptoms related to their nervous system. The authors suggest that CCFS may involve changes in how the brain functions, which could explain why patients experience fatigue, thinking difficulties, and memory problems.

Autonomic Nervous SystemCognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: inflammation, immune function, and neuroendocrine interactions.

Klimas, Nancy G, Koneru, Anne O'Brien·Current rheumatology reports·2007

Researchers studied what causes ME/CFS by looking at genes, immune cells, and hormones in patients. They found that how severe someone's initial viral infection was predicted whether fatigue would last long-term, and that people with ongoing ME/CFS show signs of reactivated viruses and problems with energy-producing structures in their cells. The immune system dysfunction they observed involved specialized infection-fighting cells not working properly.

Immune System

E3 PreliminaryGuidelinePEM not requiredGuideline

[Overview of medical treatment and management of chronic fatigue syndrome].

Yoshihara, Kazufumi, Kubo, Chiharu·Nihon rinsho. Japanese journal of clinical medicine·2007

This paper presents a comprehensive approach to treating ME/CFS that combines different types of therapies tailored to individual patients. The main treatments discussed include structured exercise programs (done gradually), lifestyle changes, and sometimes medications or mental health support when needed. The authors emphasize that doctors should carefully monitor patients throughout treatment and adjust their plan based on how well it's working.

E3 PreliminaryBehavioralPEM not requiredLongitudinal

Post concussion syndrome ebb and flow: longitudinal effects and management.

Rees, Roger J, Bellon, Michelle L·NeuroRehabilitation·2007

This study followed 20 adults who had lasting symptoms after a head injury (concussion) for an average of 3.35 years. Participants experienced fatigue, difficulty concentrating, mood changes, and sensitivity to noise. When they received counseling and therapy over two years, some symptoms like irritability improved, but many people still felt fundamentally changed and struggled with feelings of helplessness.

Cognitive Impairment

E3 PreliminaryReviewPEM unclearReview-Narrative

Violence, stress, and somatic syndromes.

Crofford, Leslie J·Trauma, violence & abuse·2007

This review article examines how experiences of violence and stress may trigger or worsen conditions like ME/CFS, fibromyalgia, and irritable bowel syndrome—illnesses that involve pain, exhaustion, mood changes, memory problems, and sleep issues. The authors explain that stress affects the brain and body's hormone and nervous system function, which may make people more vulnerable to developing these conditions. Understanding this connection could help us recognize how violence exposure affects long-term health.

Pain and SensitizationSleepCognitive Impairment

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[Evaluation of fatigue by using acceleration plethysmography].

Fibromylagia, chronic fatigue, and adult attention deficit hyperactivity disorder in the adult: a case study.

Sympathomimetic amine therapy may improve refractory gastroparesis similar to its effect on chronic pelvic pain--case report.

An experimental study of the influence of individual participant characteristics on formal consensus development.

[Overview of chronic fatigue syndrome focusing on prevalence and diagnostic criteria].

[Considerations for the treatment of chronic fatigue syndrome].

Increased serum IgM antibodies directed against phosphatidyl inositol (Pi) in chronic fatigue syndrome (CFS) and major depression: evidence that an IgM-mediated immune response against Pi is one factor underpinning the comorbidity between both CFS and depression.

Fibromyalgia and overlapping disorders: the unifying concept of central sensitivity syndromes.

Hyperventilation in patients with chronic fatigue syndrome: the role of coping strategies.

Functional neuroimaging correlates of mental fatigue induced by cognition among chronic fatigue syndrome patients and controls.

Rehabilitation of decreased motor performance in patients with chronic fatigue syndrome: should we treat low effort capacity or reduced effort tolerance?

[Chronic fatigue syndrome: from misunderstood illness to cause of job fitness management problem and of work total disability in a physiotherapist. Case report].

Vitamin d and rehabilitation: improving functional outcomes.

[Fibromyalgia and chronic fatigue syndrome in children and adolescents].

On commonness and rarity of thyroid hormone resistance: a discussion based on mechanisms of reduced sensitivity in peripheral tissues.

[School phobia and childhood chronic fatigue syndrome (CCFS)].

Chronic fatigue syndrome: inflammation, immune function, and neuroendocrine interactions.

[Overview of medical treatment and management of chronic fatigue syndrome].

Post concussion syndrome ebb and flow: longitudinal effects and management.

Violence, stress, and somatic syndromes.

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