ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

1501–1520 of 2,420 studies

E3 PreliminaryMechanismPEM not requiredMechanistic

Inclusion of the glucocorticoid receptor in a hypothalamic pituitary adrenal axis model reveals bistability.

Gupta, Shakti, Aslakson, Eric, Gurbaxani, Brian M et al.·Theoretical biology & medical modelling·2007

This study created a mathematical model of the body's stress-response system (the HPA axis) that helps explain why some people with chronic stress develop low cortisol levels. The model shows that when stress is repeated over a long time, the body can get 'stuck' in a low-cortisol state, similar to what happens in ME/CFS. The research suggests this happens because of how cortisol's receptor proteins build up and change how the stress system works.

E3 PreliminaryMechanismPEM not requiredObservational

[Sleep disturbance in chronic fatigue syndrome].

Kumano-go, Takayuki, Adachi, Hiroyoshi, Sugita, Yoshiro·Nihon rinsho. Japanese journal of clinical medicine·2007

This study looked at sleep problems in ME/CFS patients using a special laser device to measure blood flow patterns during sleep. The researchers found that different ME/CFS patients showed different types of abnormal sleep patterns, suggesting that ME/CFS may actually be several different conditions rather than one single illness. Sleep disturbances like insomnia, oversleeping, and irregular sleep-wake cycles are common in ME/CFS.

Sleep

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Odds ratio based multifactor-dimensionality reduction method for detecting gene-gene interactions.

Chung, Yujin, Lee, Seung Yeoun, Elston, Robert C et al.·Bioinformatics (Oxford, England)·2007

This study presents a new computational tool called OR MDR that helps scientists find combinations of genes that might increase the risk of developing diseases like ME/CFS. Unlike older methods that simply sort gene combinations into two groups (high-risk or low-risk), this new tool provides more detailed information about exactly how much each gene combination increases disease risk, including ranges of uncertainty around those estimates.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Autonomic function and child chronic fatigue syndrome].

Tanaka, Hidetaka·Nihon rinsho. Japanese journal of clinical medicine·2007

This review examined how the autonomic nervous system—the part of your nervous system that controls automatic functions like heart rate and blood pressure—might be involved in childhood ME/CFS. Researchers found that about one-third of children with ME/CFS had problems regulating their blood pressure and heart rate when standing up, a condition called orthostatic dysregulation. While some studies suggested increased sympathetic nervous system activity, the findings were not consistent across all research.

Autonomic Nervous System

E3 PreliminaryDiagnosticPEM not requiredCross-Sectional

[Spectroscopic diagnosis of chronic fatigue syndrome by multivariate analysis of visible and near-infrared spectra].

Sakudo, Akikazu, Kuratsune, Hirohiko, Hakariya, Yukiko et al.·Nihon rinsho. Japanese journal of clinical medicine·2007

Researchers tested whether a special light-based technology called visible and near-infrared spectroscopy could help diagnose ME/CFS by analyzing blood samples and skin. The technique uses different wavelengths of light to detect patterns that might differ between people with ME/CFS and healthy people. Early results showed the method could correctly identify about 70-80% of cases, suggesting this approach might one day offer a quick, non-invasive way to help diagnose the condition.

Biomarkers

E3 PreliminaryReviewPEM not requiredReview-Narrative

Current research priorities in chronic fatigue syndrome/myalgic encephalomyelitis: disease mechanisms, a diagnostic test and specific treatments.

Kerr, J R, Christian, P, Hodgetts, A et al.·Journal of clinical pathology·2007

This review describes an organized effort by researchers to better understand ME/CFS by studying genes and immune system changes in patients' blood. The goal is to find biological markers that can reliably diagnose the illness and to test new treatments that might help. Researchers are using advanced technology to look at thousands of genes at once to find patterns specific to ME/CFS.

Immune System

E3 PreliminaryMechanismPEM not requiredObservational

[Chronic fatigue syndrome and herpesvirus reactivation].

Kondo, Kazuhiro·Nihon rinsho. Japanese journal of clinical medicine·2007

This study looked at whether two common viruses that hide dormant in our bodies (HHV-6 and HHV-7) wake up and become active during fatigue. Researchers found that healthy people shed more HHV-6 in their saliva when tired from work, but ME/CFS patients did not show this pattern. However, HHV-7 did increase in both groups, suggesting these viruses might be useful markers to measure fatigue objectively.

BiomarkersImmune System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Enhanced feedback sensitivity to prednisolone in chronic fatigue syndrome.

Jerjes, Walid K, Taylor, Norman F, Wood, Peter J et al.·Psychoneuroendocrinology·2007

This study tested how the bodies of ME/CFS patients respond to a small dose of a steroid medication called prednisolone. Researchers found that people with ME/CFS showed a stronger suppression of cortisol (a stress hormone) after taking the medication compared to healthy controls, suggesting their bodies may be overly sensitive to this type of feedback signal from the steroid.

Endocrine Disruption

E3 PreliminaryCommentaryPEM unclearEditorial

Mitochondrial dysfunction and molecular pathways of disease.

Pieczenik, Steve R, Neustadt, John·Experimental and molecular pathology·2007

This article explains that many different diseases—including chronic fatigue syndrome—may share a common problem: damage to mitochondria, the energy-producing parts of our cells. When mitochondria don't work properly, they produce harmful molecules called reactive oxygen species that can further damage cells. The authors suggest that antioxidant treatments and specific urine tests might help doctors treat these conditions more effectively.

Energy Metabolism

E3 PreliminaryCohortPEM not requiredCase-Control

Normalization of the increased translocation of endotoxin from gram negative enterobacteria (leaky gut) is accompanied by a remission of chronic fatigue syndrome.

Maes, Michael, Coucke, Francis, Leunis, Jean-Claude·Neuro endocrinology letters·2007

This study describes a teenage girl with ME/CFS who had damage to her gut lining, allowing bacterial toxins to leak into her bloodstream. When she was treated with antioxidants, dietary changes to repair her gut, and immune support therapy, the leaky gut improved and her ME/CFS symptoms disappeared. The findings suggest that gut damage may play a role in some ME/CFS cases.

Immune System

E3 PreliminaryTrialPEM not requiredRCT

Effects of elevated plasma tryptophan on brain activation associated with the Stroop task.

Morgan, Rhian M, Parry, Allyson M M, Arida, Ricardo M et al.·Psychopharmacology·2007

This study looked at how a dietary supplement called tryptophan affects the brain's activity during mental tasks in people experiencing central fatigue (like in ME/CFS). Researchers used brain imaging to watch what happens when people take tryptophan versus a placebo while doing a challenging attention test. They found that tryptophan slowed down responses and changed brain activity patterns in several regions, particularly in areas related to awareness and processing information.

Cognitive Impairment

E3 PreliminaryMechanismPEM not requiredCross-Sectional

[Identification and application of marker genes for differential diagnosis of chronic fatigue syndrome].

Kawai, Tomoko, Rokutan, Kazuhito·Nihon rinsho. Japanese journal of clinical medicine·2007

This study looked for genetic markers (differences in how genes are expressed) that could help doctors diagnose ME/CFS with a blood test. The researchers identified 9 genes that were expressed differently in ME/CFS patients compared to healthy people, and showed these genes could potentially be used to distinguish ME/CFS from other conditions.

Biomarkers

E3 PreliminaryReviewPEM not requiredReview-Narrative

Vitamin d and rehabilitation: improving functional outcomes.

Shinchuk, Leonid M, Holick, Michael F·Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition·2007

Vitamin D deficiency is very common in people undergoing rehabilitation and can cause bone pain, muscle weakness, and poor balance. This review explains that maintaining healthy vitamin D levels (measured as 30–60 ng/mL in the blood) through sunlight exposure, diet, or supplements can help prevent fractures and improve muscle function. Because vitamin D deficiency can mimic or worsen symptoms of ME/CFS, fibromyalgia, and other conditions, doctors should check vitamin D levels in patients with these problems.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

The association between experimental and clinical pain measures among persons with fibromyalgia and chronic fatigue syndrome.

Geisser, Michael E, Gracely, Richard H, Giesecke, Thorsten et al.·European journal of pain (London, England)·2007

Researchers tested whether laboratory pain tests (using heat and pressure) could predict the pain people with fibromyalgia and ME/CFS experience in daily life. They found that pressure-based tests were better predictors of real-world pain than heat tests, suggesting that pressure stimulation may be a more useful research tool for studying pain in these conditions.

Pain and Sensitization

E3 PreliminaryBehavioralPEM not requiredCase-Control

Can homeopathy learn something from psychoanalysis?

Van Hootegem, H·Homeopathy : the journal of the Faculty of Homeopathy·2007

This study describes a single case of a 23-year-old woman with chronic fatigue syndrome treated with homeopathy combined with psychoanalytic principles. The author explores whether ideas from psychoanalysis—such as the importance of the therapeutic relationship, the role of dreams, and inherited family trauma—might help explain how homeopathic treatment works. The paper is theoretical rather than providing strong medical evidence.

E3 PreliminaryMechanismPEM not requiredMechanistic

Lymphatic drainage of the neuraxis in chronic fatigue syndrome: a hypothetical model for the cranial rhythmic impulse.

Perrin, Raymond N·The Journal of the American Osteopathic Association·2007

This study proposes that ME/CFS may be connected to problems with how fluid drains from the brain and spinal cord. The author suggests that the cranial rhythmic impulse—a subtle body rhythm that practitioners can feel—reflects cerebrospinal fluid drainage and lymphatic system activity controlled by the nervous system. When this drainage process becomes disrupted, the author argues it could cause the fatigue and other symptoms of ME/CFS.

Neuroinflammation

E3 PreliminaryPEM unclear

Chronic fatigue syndrome after Q fever.

Ledina, Dragan, Bradarić, Nikola, Milas, Ivo et al.·Medical science monitor : international medical journal of experimental and clinical research·2007

Q fever is an infection caused by bacteria that can spread from animals to people. While most people recover from acute Q fever, a few develop chronic fatigue that looks like ME/CFS. This report describes three patients who developed post-Q-fever fatigue syndrome and were treated with antibiotics, with mixed results—two improved but one did not.

E3 PreliminaryCohortPEM not requiredCase-Control

Treatment of chronic fatigue and orthostatic intolerance with propranolol.

Wyller, Vegard Bruun, Thaulow, Erik, Amlie, Jan P·The Journal of pediatrics·2007

This study looked at a teenager with ME/CFS who also experienced dizziness and fainting when standing up (orthostatic intolerance). The doctors treated this teen with propranolol, a blood pressure medication that slows the heart rate. The case suggests that an overactive stress-response system in the nervous system might contribute to ME/CFS symptoms, and that a simple tilt test could help identify patients who might benefit from this type of treatment.

Autonomic Nervous System

E3 PreliminaryReviewPEM unclearReview-Narrative

Long-chain polyunsaturated fatty acids and the pathophysiology of myalgic encephalomyelitis (chronic fatigue syndrome).

Puri, B K·Journal of clinical pathology·2007

This study proposes that ME/CFS may be linked to persistent viral infections that interfere with how the body produces certain beneficial fatty acids called long-chain polyunsaturated fatty acids. These fatty acids are important for cell membranes and immune function. The researchers suggest that supplementing with specific oils like evening primrose oil and fish oil might help bypass this block and improve symptoms.

E3 PreliminaryReviewPEM unclearReview-Narrative

Myalgic encephalomyelitis: a review with emphasis on key findings in biomedical research.

Hooper, M·Journal of clinical pathology·2007

This review examines what scientific research has discovered about ME/CFS, a complex illness that affects multiple body systems and causes long-lasting tiredness, pain, and other symptoms. The authors discuss not only the medical findings but also how disagreements and differing opinions among doctors and scientists have affected research and care for ME/CFS patients. They emphasize that these broader debates have real consequences for patients seeking answers and proper treatment.

Diagnostics

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Evidence browser

Inclusion of the glucocorticoid receptor in a hypothalamic pituitary adrenal axis model reveals bistability.

[Sleep disturbance in chronic fatigue syndrome].

Odds ratio based multifactor-dimensionality reduction method for detecting gene-gene interactions.

[Autonomic function and child chronic fatigue syndrome].

[Spectroscopic diagnosis of chronic fatigue syndrome by multivariate analysis of visible and near-infrared spectra].

Current research priorities in chronic fatigue syndrome/myalgic encephalomyelitis: disease mechanisms, a diagnostic test and specific treatments.

[Chronic fatigue syndrome and herpesvirus reactivation].

Enhanced feedback sensitivity to prednisolone in chronic fatigue syndrome.

Mitochondrial dysfunction and molecular pathways of disease.

Normalization of the increased translocation of endotoxin from gram negative enterobacteria (leaky gut) is accompanied by a remission of chronic fatigue syndrome.

Effects of elevated plasma tryptophan on brain activation associated with the Stroop task.

[Identification and application of marker genes for differential diagnosis of chronic fatigue syndrome].

Vitamin d and rehabilitation: improving functional outcomes.

The association between experimental and clinical pain measures among persons with fibromyalgia and chronic fatigue syndrome.

Can homeopathy learn something from psychoanalysis?

Lymphatic drainage of the neuraxis in chronic fatigue syndrome: a hypothetical model for the cranial rhythmic impulse.

Chronic fatigue syndrome after Q fever.

Treatment of chronic fatigue and orthostatic intolerance with propranolol.

Long-chain polyunsaturated fatty acids and the pathophysiology of myalgic encephalomyelitis (chronic fatigue syndrome).

Myalgic encephalomyelitis: a review with emphasis on key findings in biomedical research.

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Metabolism & Mitochondria

Biomarkers

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