ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

1501–1520 of 2,423 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Update in Hepatitis C virus associated extrahepatic manifestations].

Sène, D, Saadoun, D, Limal, N et al.·La Revue de medecine interne·2007

This review examines how hepatitis C virus (HCV) can affect parts of the body beyond the liver. The authors discuss various conditions linked to HCV infection, including chronic fatigue, dry mouth and eyes, diabetes, and certain blood cancers. They note that while these connections are documented, scientists still don't fully understand the mechanisms behind them.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Advances in the treatment of multiple sclerosis?].

Tackenberg, B, Himmerich, H, Wellek, A et al.·MMW Fortschritte der Medizin·2007

This article reviews advances in treating multiple sclerosis (MS), a different neurological disease from ME/CFS. It discusses how MS treatment has improved with new diagnostic tools, early treatment approaches, and various medications. The article notes that MS patients often experience chronic fatigue, depression, and other symptoms that require separate treatment alongside MS-specific therapies.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Current research priorities in chronic fatigue syndrome/myalgic encephalomyelitis: disease mechanisms, a diagnostic test and specific treatments.

Kerr, J R, Christian, P, Hodgetts, A et al.·Journal of clinical pathology·2007

This review describes an organized effort by researchers to better understand ME/CFS by studying genes and immune system changes in patients' blood. The goal is to find biological markers that can reliably diagnose the illness and to test new treatments that might help. Researchers are using advanced technology to look at thousands of genes at once to find patterns specific to ME/CFS.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Gamma-aminobutyric acid--metabolism and its disorders].

Kowalski, Antoni, Rebas, Elzbieta, Zylińska, Ludmiła·Postepy biochemii·2007

Your brain uses a chemical messenger called GABA to calm nerve signals and prevent them from becoming overactive. When three key enzymes that control GABA levels don't work properly, it can cause various neurological problems including chronic fatigue syndrome, anxiety, seizures, and stiff-person syndrome. This article reviews what happens when GABA metabolism breaks down and how it affects the nervous system.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome and neurotransmitters].

Miwa, Soichi, Takikawa, Osamu·Nihon rinsho. Japanese journal of clinical medicine·2007

This review examines how chemical messengers in the brain called neurotransmitters may be disrupted in ME/CFS. The researchers found that ME/CFS patients may have problems with serotonin and glutamate signaling, possibly triggered by viral infections or genetic differences. These imbalances could help explain why ME/CFS causes such persistent exhaustion.

Energy MetabolismImmune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Cirrhotic cardiomyopathy].

Osipenko, M F, Bikbulatova, E A·Klinicheskaia meditsina·2007

This review examines how liver cirrhosis (severe liver disease) affects the heart. The study found that patients with cirrhosis develop heart problems including thickened heart walls and weakened heart function, especially during physical activity. These heart changes may contribute to fatigue and reduced ability to work, but importantly, these problems can improve significantly after a liver transplant.

Post-Exertional Malaise

E3 PreliminaryDiagnosticPEM not requiredCross-Sectional

[Spectroscopic diagnosis of chronic fatigue syndrome by multivariate analysis of visible and near-infrared spectra].

Sakudo, Akikazu, Kuratsune, Hirohiko, Hakariya, Yukiko et al.·Nihon rinsho. Japanese journal of clinical medicine·2007

Researchers tested whether a special light-based technology called visible and near-infrared spectroscopy could help diagnose ME/CFS by analyzing blood samples and skin. The technique uses different wavelengths of light to detect patterns that might differ between people with ME/CFS and healthy people. Early results showed the method could correctly identify about 70-80% of cases, suggesting this approach might one day offer a quick, non-invasive way to help diagnose the condition.

Biomarkers

E3 PreliminaryMechanismPEM not requiredCross-Sectional

[Identification and application of marker genes for differential diagnosis of chronic fatigue syndrome].

Kawai, Tomoko, Rokutan, Kazuhito·Nihon rinsho. Japanese journal of clinical medicine·2007

This study looked for genetic markers (differences in how genes are expressed) that could help doctors diagnose ME/CFS with a blood test. The researchers identified 9 genes that were expressed differently in ME/CFS patients compared to healthy people, and showed these genes could potentially be used to distinguish ME/CFS from other conditions.

Biomarkers

E3 PreliminaryMechanismPEM not requiredMechanistic

Lymphatic drainage of the neuraxis in chronic fatigue syndrome: a hypothetical model for the cranial rhythmic impulse.

Perrin, Raymond N·The Journal of the American Osteopathic Association·2007

This study proposes that ME/CFS may be connected to problems with how fluid drains from the brain and spinal cord. The author suggests that the cranial rhythmic impulse—a subtle body rhythm that practitioners can feel—reflects cerebrospinal fluid drainage and lymphatic system activity controlled by the nervous system. When this drainage process becomes disrupted, the author argues it could cause the fatigue and other symptoms of ME/CFS.

Neuroinflammation

E3 PreliminaryReviewPEM not requiredReview-Narrative

Specific correlations between muscle oxidative stress and chronic fatigue syndrome: a working hypothesis.

Fulle, Stefania, Pietrangelo, Tiziana, Mancinelli, Rosa et al.·Journal of muscle research and cell motility·2007

This paper explores whether muscle damage from unstable molecules called free radicals might contribute to ME/CFS. The researchers reviewed existing evidence suggesting that muscles in ME/CFS patients may experience harmful oxidative stress—a chemical imbalance that damages cells. While this is a theoretical discussion rather than a new experiment, it proposes that understanding this muscle damage could help explain why ME/CFS causes such severe fatigue.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Functional neuroimaging correlates of mental fatigue induced by cognition among chronic fatigue syndrome patients and controls.

Cook, Dane B, O'Connor, Patrick J, Lange, Gudrun et al.·NeuroImage·2007

This study used brain imaging to see how the brains of ME/CFS patients and healthy people respond during mentally tiring tasks. Researchers found that feelings of mental fatigue were linked to activity in specific brain regions during a difficult memory task, and that ME/CFS patients showed greater brain activity in these areas compared to healthy controls, even though they were doing the same task.

Cognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Overview of psychiatric therapy for chronic fatigue syndrome].

Yamadera, Wataru, Itoh, Hiroshi·Nihon rinsho. Japanese journal of clinical medicine·2007

This review examines how talking therapies, particularly cognitive behavioral therapy (CBT), can help people with ME/CFS. CBT focuses on identifying unhelpful thinking patterns and behaviors—like perfectionism, avoidance, and constantly searching for physical causes—that may be making fatigue worse. The approach involves keeping steady activity levels and making small, planned increases over time, rather than pushing hard and then collapsing.

E3 PreliminaryReviewPEM unclearReview-Narrative

Possible mechanisms of the formation of chronic fatigue syndrome in the clinical picture of multiple sclerosis.

Kasatkin, D S, Spirin, N N·Neuroscience and behavioral physiology·2007

This study examined why people with multiple sclerosis (MS) often experience severe fatigue. The researchers identified different types of fatigue—exhaustion at rest, excessive tiredness after activity, and worsening fatigue during MS flare-ups—and explored how brain chemistry, hormones, immune system problems, and sleep issues might all contribute to this fatigue.

Sleep

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Clinical features of chronic fatigue syndrome--symptoms].

Ban, Nobutaro, Saiki, Takuya, Ko, Gyoshin et al.·Nihon rinsho. Japanese journal of clinical medicine·2007

This review article summarizes the most common symptoms experienced by people with ME/CFS. The researchers identified and described the top 10 symptoms in detail, including severe fatigue, problems with memory and concentration, muscle pain, poor sleep, and headaches. Understanding these symptom patterns can help doctors recognize and diagnose ME/CFS more accurately.

Pain and SensitizationCognitive Impairment

E3 PreliminaryMechanismPEM not requiredCase-Control

The impact of a 4-hour sleep delay on slow wave activity in twins discordant for chronic fatigue syndrome.

Armitage, Roseanne, Landis, Carol, Hoffmann, Robert et al.·Sleep·2007

This study looked at how the brain's sleep patterns differ between people with ME/CFS and their healthy twins. Researchers kept twins awake 4 hours later than usual and then let them sleep normally. They found that people with ME/CFS showed weaker deep sleep activity when recovering from the sleep delay, suggesting their bodies may have trouble responding normally to sleep pressure.

Sleep

E3 PreliminaryPEM not required

[Chronic fatigue syndrome in a 15-year-old girl].

Díaz-Caneja Greciano, A, Rodríguez Sosa, J T, Aguilera Albesa, S et al.·Anales de pediatria (Barcelona, Spain : 2003)·2007

This report describes a 15-year-old girl diagnosed with ME/CFS (chronic fatigue syndrome), a condition that causes severe tiredness and lack of energy without an obvious physical cause. The doctors emphasize that ME/CFS should be considered when young people have chronic fatigue along with other symptoms but medical tests don't reveal why. Treatment focused on rehabilitation with cognitive behavioral therapy (talking therapy to address thoughts and behaviors) combined with a gradual, structured increase in activity levels.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Vitamin d and rehabilitation: improving functional outcomes.

Shinchuk, Leonid M, Holick, Michael F·Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition·2007

Vitamin D deficiency is very common in people undergoing rehabilitation and can cause bone pain, muscle weakness, and poor balance. This review explains that maintaining healthy vitamin D levels (measured as 30–60 ng/mL in the blood) through sunlight exposure, diet, or supplements can help prevent fractures and improve muscle function. Because vitamin D deficiency can mimic or worsen symptoms of ME/CFS, fibromyalgia, and other conditions, doctors should check vitamin D levels in patients with these problems.

E3 PreliminaryCohortPEM not requiredCase-Control

Successful use of a primary care practice-specialty collaboration in the care of an adolescent with chronic fatigue syndrome.

Kuo, Dennis Z, Cheng, Tina L, Rowe, Peter C·Pediatrics·2007

This case report describes how one teenager with ME/CFS improved significantly when their regular doctor and a specialized ME/CFS expert worked together as a team, even though they lived in different cities. By staying in regular contact through phone calls and emails and clearly dividing responsibilities, the two doctors were able to manage the teen's symptoms more effectively. The study suggests that this type of teamwork between primary care doctors and specialists can help young people with ME/CFS get better care.

Interventions

E3 PreliminaryCohortPEM not requiredCase-Control

[Chronic fatigue syndrome: from misunderstood illness to cause of job fitness management problem and of work total disability in a physiotherapist. Case report].

Belotti, L, Bigoni, F, Pezzoli, F et al.·Giornale italiano di medicina del lavoro ed ergonomia·2007

This study describes the case of a physiotherapist who developed ME/CFS and faced challenges staying in their job. The medical team had to evaluate whether the patient could continue working and eventually helped them obtain disability benefits. The case illustrates the real-world workplace challenges that people with ME/CFS encounter.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Considerations for the treatment of chronic fatigue syndrome].

Murakami, Masato·Nihon rinsho. Japanese journal of clinical medicine·2007

This review examines how stress and emotional factors play a role in ME/CFS. The authors suggest that treating ME/CFS effectively requires addressing both the body and mind, not just physical symptoms. They discuss how antidepressants and certain herbal medicines may help reduce anxiety and depression, and emphasize that lifestyle changes and behavioral adjustments are important parts of recovery.

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[Update in Hepatitis C virus associated extrahepatic manifestations].

[Advances in the treatment of multiple sclerosis?].

Current research priorities in chronic fatigue syndrome/myalgic encephalomyelitis: disease mechanisms, a diagnostic test and specific treatments.

[Gamma-aminobutyric acid--metabolism and its disorders].

[Chronic fatigue syndrome and neurotransmitters].

[Cirrhotic cardiomyopathy].

[Spectroscopic diagnosis of chronic fatigue syndrome by multivariate analysis of visible and near-infrared spectra].

[Identification and application of marker genes for differential diagnosis of chronic fatigue syndrome].

Lymphatic drainage of the neuraxis in chronic fatigue syndrome: a hypothetical model for the cranial rhythmic impulse.

Specific correlations between muscle oxidative stress and chronic fatigue syndrome: a working hypothesis.

Functional neuroimaging correlates of mental fatigue induced by cognition among chronic fatigue syndrome patients and controls.

[Overview of psychiatric therapy for chronic fatigue syndrome].

Possible mechanisms of the formation of chronic fatigue syndrome in the clinical picture of multiple sclerosis.

[Clinical features of chronic fatigue syndrome--symptoms].

The impact of a 4-hour sleep delay on slow wave activity in twins discordant for chronic fatigue syndrome.

[Chronic fatigue syndrome in a 15-year-old girl].

Vitamin d and rehabilitation: improving functional outcomes.

Successful use of a primary care practice-specialty collaboration in the care of an adolescent with chronic fatigue syndrome.

[Chronic fatigue syndrome: from misunderstood illness to cause of job fitness management problem and of work total disability in a physiotherapist. Case report].

[Considerations for the treatment of chronic fatigue syndrome].

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