ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

1501–1520 of 2,422 studies

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Functional neuroimaging correlates of mental fatigue induced by cognition among chronic fatigue syndrome patients and controls.

Cook, Dane B, O'Connor, Patrick J, Lange, Gudrun et al.·NeuroImage·2007

This study used brain imaging to see how the brains of ME/CFS patients and healthy people respond during mentally tiring tasks. Researchers found that feelings of mental fatigue were linked to activity in specific brain regions during a difficult memory task, and that ME/CFS patients showed greater brain activity in these areas compared to healthy controls, even though they were doing the same task.

Cognitive Impairment

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Odds ratio based multifactor-dimensionality reduction method for detecting gene-gene interactions.

Chung, Yujin, Lee, Seung Yeoun, Elston, Robert C et al.·Bioinformatics (Oxford, England)·2007

This study presents a new computational tool called OR MDR that helps scientists find combinations of genes that might increase the risk of developing diseases like ME/CFS. Unlike older methods that simply sort gene combinations into two groups (high-risk or low-risk), this new tool provides more detailed information about exactly how much each gene combination increases disease risk, including ranges of uncertainty around those estimates.

E3 PreliminaryMechanismPEM not requiredMechanistic

Lymphatic drainage of the neuraxis in chronic fatigue syndrome: a hypothetical model for the cranial rhythmic impulse.

Perrin, Raymond N·The Journal of the American Osteopathic Association·2007

This study proposes that ME/CFS may be connected to problems with how fluid drains from the brain and spinal cord. The author suggests that the cranial rhythmic impulse—a subtle body rhythm that practitioners can feel—reflects cerebrospinal fluid drainage and lymphatic system activity controlled by the nervous system. When this drainage process becomes disrupted, the author argues it could cause the fatigue and other symptoms of ME/CFS.

Neuroinflammation

E3 PreliminaryMechanismPEM not requiredCross-Sectional

[Identification and application of marker genes for differential diagnosis of chronic fatigue syndrome].

Kawai, Tomoko, Rokutan, Kazuhito·Nihon rinsho. Japanese journal of clinical medicine·2007

This study looked for genetic markers (differences in how genes are expressed) that could help doctors diagnose ME/CFS with a blood test. The researchers identified 9 genes that were expressed differently in ME/CFS patients compared to healthy people, and showed these genes could potentially be used to distinguish ME/CFS from other conditions.

Biomarkers

E3 PreliminaryCommentaryPEM not requiredEditorial

On commonness and rarity of thyroid hormone resistance: a discussion based on mechanisms of reduced sensitivity in peripheral tissues.

Tjørve, E, Tjørve, K M C, Olsen, J O et al.·Medical hypotheses·2007

Your body's cells may not respond properly to thyroid hormone even when blood tests show normal thyroid levels. This resistance to thyroid hormone can develop from various causes including infections, medications, toxins, or the immune system attacking thyroid proteins. The authors suggest this acquired resistance might be more common than previously thought and could explain why some patients feel hypothyroid symptoms despite normal blood tests.

E3 PreliminaryCohortPEM not requiredCase-Control

[Chronic fatigue syndrome: from misunderstood illness to cause of job fitness management problem and of work total disability in a physiotherapist. Case report].

Belotti, L, Bigoni, F, Pezzoli, F et al.·Giornale italiano di medicina del lavoro ed ergonomia·2007

This study describes the case of a physiotherapist who developed ME/CFS and faced challenges staying in their job. The medical team had to evaluate whether the patient could continue working and eventually helped them obtain disability benefits. The case illustrates the real-world workplace challenges that people with ME/CFS encounter.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Enhanced feedback sensitivity to prednisolone in chronic fatigue syndrome.

Jerjes, Walid K, Taylor, Norman F, Wood, Peter J et al.·Psychoneuroendocrinology·2007

This study tested how the bodies of ME/CFS patients respond to a small dose of a steroid medication called prednisolone. Researchers found that people with ME/CFS showed a stronger suppression of cortisol (a stress hormone) after taking the medication compared to healthy controls, suggesting their bodies may be overly sensitive to this type of feedback signal from the steroid.

Endocrine Disruption

E3 PreliminaryReviewPEM not requiredReview-Narrative

Specific correlations between muscle oxidative stress and chronic fatigue syndrome: a working hypothesis.

Fulle, Stefania, Pietrangelo, Tiziana, Mancinelli, Rosa et al.·Journal of muscle research and cell motility·2007

This paper explores whether muscle damage from unstable molecules called free radicals might contribute to ME/CFS. The researchers reviewed existing evidence suggesting that muscles in ME/CFS patients may experience harmful oxidative stress—a chemical imbalance that damages cells. While this is a theoretical discussion rather than a new experiment, it proposes that understanding this muscle damage could help explain why ME/CFS causes such severe fatigue.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Vitamin d and rehabilitation: improving functional outcomes.

Shinchuk, Leonid M, Holick, Michael F·Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition·2007

Vitamin D deficiency is very common in people undergoing rehabilitation and can cause bone pain, muscle weakness, and poor balance. This review explains that maintaining healthy vitamin D levels (measured as 30–60 ng/mL in the blood) through sunlight exposure, diet, or supplements can help prevent fractures and improve muscle function. Because vitamin D deficiency can mimic or worsen symptoms of ME/CFS, fibromyalgia, and other conditions, doctors should check vitamin D levels in patients with these problems.

E3 PreliminaryCohortPEM not requiredCross-Sectional

Increased serum IgM antibodies directed against phosphatidyl inositol (Pi) in chronic fatigue syndrome (CFS) and major depression: evidence that an IgM-mediated immune response against Pi is one factor underpinning the comorbidity between both CFS and depression.

Maes, Michael, Mihaylova, Ivanka, Leunis, Jean-Claude·Neuro endocrinology letters·2007

This study found that people with ME/CFS and depression have higher levels of specific immune proteins (IgM antibodies) that attack a substance called phosphatidyl inositol in their blood compared to healthy people. These antibody levels were linked to fatigue and depression symptoms, suggesting that an abnormal immune response against this substance might contribute to both conditions.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

Normalization of the increased translocation of endotoxin from gram negative enterobacteria (leaky gut) is accompanied by a remission of chronic fatigue syndrome.

Maes, Michael, Coucke, Francis, Leunis, Jean-Claude·Neuro endocrinology letters·2007

This study describes a teenage girl with ME/CFS who had damage to her gut lining, allowing bacterial toxins to leak into her bloodstream. When she was treated with antioxidants, dietary changes to repair her gut, and immune support therapy, the leaky gut improved and her ME/CFS symptoms disappeared. The findings suggest that gut damage may play a role in some ME/CFS cases.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Possible mechanisms of the formation of chronic fatigue syndrome in the clinical picture of multiple sclerosis.

Kasatkin, D S, Spirin, N N·Neuroscience and behavioral physiology·2007

This study examined why people with multiple sclerosis (MS) often experience severe fatigue. The researchers identified different types of fatigue—exhaustion at rest, excessive tiredness after activity, and worsening fatigue during MS flare-ups—and explored how brain chemistry, hormones, immune system problems, and sleep issues might all contribute to this fatigue.

Sleep

E3 PreliminaryBehavioralPEM not requiredCase-Control

Can homeopathy learn something from psychoanalysis?

Van Hootegem, H·Homeopathy : the journal of the Faculty of Homeopathy·2007

This study describes a single case of a 23-year-old woman with chronic fatigue syndrome treated with homeopathy combined with psychoanalytic principles. The author explores whether ideas from psychoanalysis—such as the importance of the therapeutic relationship, the role of dreams, and inherited family trauma—might help explain how homeopathic treatment works. The paper is theoretical rather than providing strong medical evidence.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Gamma-aminobutyric acid--metabolism and its disorders].

Kowalski, Antoni, Rebas, Elzbieta, Zylińska, Ludmiła·Postepy biochemii·2007

Your brain uses a chemical messenger called GABA to calm nerve signals and prevent them from becoming overactive. When three key enzymes that control GABA levels don't work properly, it can cause various neurological problems including chronic fatigue syndrome, anxiety, seizures, and stiff-person syndrome. This article reviews what happens when GABA metabolism breaks down and how it affects the nervous system.

E3 PreliminaryCommentaryPEM unclearEditorial

Mitochondrial dysfunction and molecular pathways of disease.

Pieczenik, Steve R, Neustadt, John·Experimental and molecular pathology·2007

This article explains that many different diseases—including chronic fatigue syndrome—may share a common problem: damage to mitochondria, the energy-producing parts of our cells. When mitochondria don't work properly, they produce harmful molecules called reactive oxygen species that can further damage cells. The authors suggest that antioxidant treatments and specific urine tests might help doctors treat these conditions more effectively.

Energy Metabolism

E3 PreliminaryBehavioralPEM not requiredObservational

Orthostatic panic attacks among Vietnamese refugees.

Hinton, Devon E, Hinton, Ladson, Tran, Minh et al.·Transcultural psychiatry·2007

This study looked at Vietnamese refugees who experienced panic attacks triggered by standing up quickly from a sitting or lying position (orthostatic dizziness). The researchers found that these panic attacks were common among this group and were often linked to trauma memories and cultural beliefs about health. The study suggests that doctors treating Vietnamese refugees should check for and treat these specific panic attacks as part of their care.

Autonomic Nervous System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

The chronic fatigue syndrome: a comparative pathway analysis.

Emmert-Streib, Frank·Journal of computational biology : a journal of computational molecular cell biology·2007

This study developed a new method to find biological pathways that go wrong in ME/CFS, rather than just looking at individual genes. The researchers compared how biological systems work differently in sick versus healthy people using computer analysis of gene expression data. This approach helps scientists understand ME/CFS as a disease of interconnected biological processes.

E3 PreliminaryMechanismPEM not requiredObservational

[Chronic fatigue syndrome and herpesvirus reactivation].

Kondo, Kazuhiro·Nihon rinsho. Japanese journal of clinical medicine·2007

This study looked at whether two common viruses that hide dormant in our bodies (HHV-6 and HHV-7) wake up and become active during fatigue. Researchers found that healthy people shed more HHV-6 in their saliva when tired from work, but ME/CFS patients did not show this pattern. However, HHV-7 did increase in both groups, suggesting these viruses might be useful markers to measure fatigue objectively.

BiomarkersImmune System

E3 PreliminaryBehavioralPEM unclearCross-Sectional

An 'overwhelming illness': women's experiences of learning to live with chronic fatigue syndrome/myalgic encephalomyelitis.

Edwards, Catherine R, Thompson, Andrew R, Blair, Alan·Journal of health psychology·2007

This study interviewed eight women with ME/CFS about how they learned to cope with their illness. Many felt overwhelmed at first and frustrated when doctors didn't believe or help them. Over time, women found ways to manage by learning more about their condition, getting support from others, and taking charge of their own care, which helped them feel more in control.

E3 PreliminaryBehavioralPEM not requiredCase-Control

[Usefulness of growth chart in children and adolescents with chronic fatigue syndrome].

Oki, Junichi, Okubo, Jun·Nihon rinsho. Japanese journal of clinical medicine·2007

This small study looked at growth charts from three young people with chronic fatigue syndrome to see if the charts could help identify what triggered their illness. The researchers found that life events—like overexercise, family stress, or infection—appeared before symptoms like extreme tiredness, nausea, and sleep problems started. While growth charts alone cannot predict who will develop ME/CFS, they may help doctors spot important life changes that happened around the time symptoms began.

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Functional neuroimaging correlates of mental fatigue induced by cognition among chronic fatigue syndrome patients and controls.

Odds ratio based multifactor-dimensionality reduction method for detecting gene-gene interactions.

Lymphatic drainage of the neuraxis in chronic fatigue syndrome: a hypothetical model for the cranial rhythmic impulse.

[Identification and application of marker genes for differential diagnosis of chronic fatigue syndrome].

On commonness and rarity of thyroid hormone resistance: a discussion based on mechanisms of reduced sensitivity in peripheral tissues.

[Chronic fatigue syndrome: from misunderstood illness to cause of job fitness management problem and of work total disability in a physiotherapist. Case report].

Enhanced feedback sensitivity to prednisolone in chronic fatigue syndrome.

Specific correlations between muscle oxidative stress and chronic fatigue syndrome: a working hypothesis.

Vitamin d and rehabilitation: improving functional outcomes.

Increased serum IgM antibodies directed against phosphatidyl inositol (Pi) in chronic fatigue syndrome (CFS) and major depression: evidence that an IgM-mediated immune response against Pi is one factor underpinning the comorbidity between both CFS and depression.

Normalization of the increased translocation of endotoxin from gram negative enterobacteria (leaky gut) is accompanied by a remission of chronic fatigue syndrome.

Possible mechanisms of the formation of chronic fatigue syndrome in the clinical picture of multiple sclerosis.

Can homeopathy learn something from psychoanalysis?

[Gamma-aminobutyric acid--metabolism and its disorders].

Mitochondrial dysfunction and molecular pathways of disease.

Orthostatic panic attacks among Vietnamese refugees.

The chronic fatigue syndrome: a comparative pathway analysis.

[Chronic fatigue syndrome and herpesvirus reactivation].

An 'overwhelming illness': women's experiences of learning to live with chronic fatigue syndrome/myalgic encephalomyelitis.

[Usefulness of growth chart in children and adolescents with chronic fatigue syndrome].

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