ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

1521–1540 of 2,420 studies

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

The thoughts and methods for clinical research on acupuncture treatment of chronic fatigue syndrome.

Yao, Renmin·Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan·2007

This paper presents acupuncture treatment guidelines for chronic fatigue syndrome (ME/CFS), focusing on how acupuncture might restore balance to the body's energy systems according to traditional Chinese medicine. The authors discuss important considerations like which patients are most suitable for treatment, which acupuncture points to use, and how to measure whether the treatment is working.

Interventions

E3 PreliminaryReviewPEM unclearReview-Narrative

Long-chain polyunsaturated fatty acids and the pathophysiology of myalgic encephalomyelitis (chronic fatigue syndrome).

Puri, B K·Journal of clinical pathology·2007

This study proposes that ME/CFS may be linked to persistent viral infections that interfere with how the body produces certain beneficial fatty acids called long-chain polyunsaturated fatty acids. These fatty acids are important for cell membranes and immune function. The researchers suggest that supplementing with specific oils like evening primrose oil and fish oil might help bypass this block and improve symptoms.

E3 PreliminaryReviewPEM unclearReview-Narrative

Violence, stress, and somatic syndromes.

Crofford, Leslie J·Trauma, violence & abuse·2007

This review article examines how experiences of violence and stress may trigger or worsen conditions like ME/CFS, fibromyalgia, and irritable bowel syndrome—illnesses that involve pain, exhaustion, mood changes, memory problems, and sleep issues. The authors explain that stress affects the brain and body's hormone and nervous system function, which may make people more vulnerable to developing these conditions. Understanding this connection could help us recognize how violence exposure affects long-term health.

Pain and SensitizationSleepCognitive Impairment

E3 PreliminaryReviewPEM unclearReview-Narrative

Myalgic encephalomyelitis: a review with emphasis on key findings in biomedical research.

Hooper, M·Journal of clinical pathology·2007

This review examines what scientific research has discovered about ME/CFS, a complex illness that affects multiple body systems and causes long-lasting tiredness, pain, and other symptoms. The authors discuss not only the medical findings but also how disagreements and differing opinions among doctors and scientists have affected research and care for ME/CFS patients. They emphasize that these broader debates have real consequences for patients seeking answers and proper treatment.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

[History of chronic fatigue syndrome].

Hashimoto, Nobuya·Nihon rinsho. Japanese journal of clinical medicine·2007

This article reviews the history of ME/CFS, showing that conditions with similar symptoms have existed for hundreds of years under different names like neurasthenia and myalgic encephalomyelitis. A major outbreak at Lake Tahoe in the 1980s brought modern attention to the disease, but doctors realized that not all patients with CFS symptoms actually had evidence of EBV infection, suggesting the disease is more complex than a simple viral cause. The authors explain how understanding this history can help develop better diagnostic guidelines for the condition.

Diagnostics

E3 PreliminaryCohortPEM unclearCross-Sectional

'What is it like to have ME?': the discursive construction of ME in computer-mediated communication and face-to-face interaction.

Guise, Jennifer, Widdicombe, Sue, McKinlay, Andy·Health (London, England : 1997)·2007

This study examined how people with ME/CFS describe their illness when talking online and face-to-face. Researchers analyzed conversations from 49 internet users and 7 people in support groups to understand how patients talk about their condition. They found that people consistently describe ME/CFS as serious, mysterious, and not caused by psychological factors—ways of talking that help them counter misconceptions and explain why their illness isn't their fault.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[School phobia and childhood chronic fatigue syndrome (CCFS)].

Tomoda, Akemi·Nihon rinsho. Japanese journal of clinical medicine·2007

This review examines childhood chronic fatigue syndrome (CCFS), a serious condition where children experience extreme tiredness that cannot be explained by other medical or mental health problems. Children with CCFS often struggle with memory and concentration, sleep problems, and symptoms related to their nervous system. The authors suggest that CCFS may involve changes in how the brain functions, which could explain why patients experience fatigue, thinking difficulties, and memory problems.

Autonomic Nervous SystemCognitive Impairment

E3 PreliminaryReviewPEM unclearReview-Narrative

[Fibromyalgia and chronic fatigue syndrome in children and adolescents].

Galanopoulos, Ng, Kampakis, Gp, Ladopoulou, Kf·Psychiatrike = Psychiatriki·2007

This review discusses fibromyalgia and chronic fatigue syndrome (ME/CFS) in children and teenagers, noting that both conditions are fairly common in this age group. Patients with these conditions experience widespread muscle pain, exhaustion, depression, headaches, and sleep problems that can significantly impact school, family life, and overall development. The authors emphasize that early diagnosis and treatment combining medication, physical therapy, and psychological support are important for helping young people manage these conditions.

Pain and SensitizationSleep

E3 PreliminaryReviewPEM not requiredReview-Narrative

Rehabilitation of decreased motor performance in patients with chronic fatigue syndrome: should we treat low effort capacity or reduced effort tolerance?

Van Houdenhove, B, Verheyen, L, Pardaens, K et al.·Clinical rehabilitation·2007

This paper proposes a new way to think about why people with ME/CFS have reduced physical ability. The authors suggest there may be two different problems: some patients may have low energy capacity (their bodies can't produce enough energy), while others may have reduced effort tolerance (their nervous system tells them to stop before their body actually reaches its limit). Understanding which problem a patient has could help doctors choose better treatments.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Cranial electrotherapy stimulation and fibromyalgia.

Gilula, Marshall F·Expert review of medical devices·2007

This review examines cranial electrotherapy stimulation (CES), a treatment that uses mild electrical stimulation applied to the head to help manage fibromyalgia pain and related symptoms. While CES is not a cure-all, research suggests it may help some fibromyalgia patients feel better. The review also discusses how fibromyalgia often occurs alongside other conditions like anxiety, depression, sleep problems, and fatigue—symptoms that overlap with ME/CFS.

Pain and SensitizationSleep

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

Hyperventilation in patients with chronic fatigue syndrome: the role of coping strategies.

Bogaerts, Katleen, Hubin, Morgane, Van Diest, Ilse et al.·Behaviour research and therapy·2007

This study looked at how people with ME/CFS breathe differently depending on how they mentally cope with their illness. Researchers found that when patients imagined resisting or fighting against their illness, their breathing changed in ways that made their symptoms worse. In contrast, when patients imagined accepting their illness, their breathing stayed more stable and symptoms improved. This suggests that our psychological response to ME/CFS may directly affect how our body breathes and which symptoms we experience.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Overview of psychiatric therapy for chronic fatigue syndrome].

Yamadera, Wataru, Itoh, Hiroshi·Nihon rinsho. Japanese journal of clinical medicine·2007

This review examines how talking therapies, particularly cognitive behavioral therapy (CBT), can help people with ME/CFS. CBT focuses on identifying unhelpful thinking patterns and behaviors—like perfectionism, avoidance, and constantly searching for physical causes—that may be making fatigue worse. The approach involves keeping steady activity levels and making small, planned increases over time, rather than pushing hard and then collapsing.

E3 PreliminaryReviewPEM unclearReview-Narrative

Infection and vaccination in chronic fatigue syndrome: myth or reality?

Appel, Shmuel, Chapman, Joab, Shoenfeld, Yehuda·Autoimmunity·2007

This review examines whether vaccinations might trigger ME/CFS, since infections can sometimes lead to the condition. The authors found some case reports of ME/CFS occurring after vaccination, but most studies did not find a reliable connection. A Canadian health organization concluded there is no strong evidence linking vaccinations to ME/CFS, though researchers agree more studies are needed.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia and overlapping disorders: the unifying concept of central sensitivity syndromes.

Yunus, Muhammad B·Seminars in arthritis and rheumatism·2007

This paper proposes that fibromyalgia, irritable bowel syndrome, chronic fatigue syndrome, and certain headaches may all share a common underlying problem: the nervous system becomes too sensitive to pain and other signals. Rather than being separate diseases, they might be related conditions caused by similar changes in how the brain and body communicate, combined with stress and emotional factors.

Pain and Sensitization

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Antinuclear antibodies in patients with chronic fatigue syndrome].

Nishikai, Masahiko·Nihon rinsho. Japanese journal of clinical medicine·2007

This review examined whether people with ME/CFS have specific antibodies (immune proteins) that attack their own body cells. Researchers found that 15-25% of ME/CFS patients had these antibodies, but the patterns varied widely and were generally weak. A few new antibodies specific to ME/CFS were identified, with one type appearing in 13% of patients studied and linked to severe fatigue and concentration problems.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Overview of chronic fatigue syndrome focusing on prevalence and diagnostic criteria].

Kuratsune, Hirohiko·Nihon rinsho. Japanese journal of clinical medicine·2007

This review examines ME/CFS as a real medical condition affecting the nervous system, immune system, and stress response. While researchers have found many different abnormalities in ME/CFS patients—including viral reactivation, immune problems, and chemical imbalances in the brain—no single cause has been identified in everyone with the condition. The authors suggest that ME/CFS likely results from a combination of genetic factors and life stress that disrupts how the body's immune and hormone systems work together.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

The chronic fatigue syndrome: a comparative pathway analysis.

Emmert-Streib, Frank·Journal of computational biology : a journal of computational molecular cell biology·2007

This study developed a new method to find biological pathways that go wrong in ME/CFS, rather than just looking at individual genes. The researchers compared how biological systems work differently in sick versus healthy people using computer analysis of gene expression data. This approach helps scientists understand ME/CFS as a disease of interconnected biological processes.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Childhood chronic fatigue syndrome].

Miike, Teruhisa·Nihon rinsho. Japanese journal of clinical medicine·2007

This review discusses chronic fatigue syndrome (CFS) in children and teenagers, a serious condition affecting 3-5% of young people. Children with CFS experience extreme tiredness, sleep problems, trouble learning and remembering, and immune system issues. While routine blood tests often look normal, special testing can reveal abnormalities in how their bodies handle energy, regulate temperature, and control hormones.

Immune System

E3 PreliminaryMechanismPEM not requiredCase-Control

The impact of a 4-hour sleep delay on slow wave activity in twins discordant for chronic fatigue syndrome.

Armitage, Roseanne, Landis, Carol, Hoffmann, Robert et al.·Sleep·2007

This study looked at how the brain's sleep patterns differ between people with ME/CFS and their healthy twins. Researchers kept twins awake 4 hours later than usual and then let them sleep normally. They found that people with ME/CFS showed weaker deep sleep activity when recovering from the sleep delay, suggesting their bodies may have trouble responding normally to sleep pressure.

Sleep

E3 PreliminaryBehavioralPEM not requiredCase-Control

Fibromylagia, chronic fatigue, and adult attention deficit hyperactivity disorder in the adult: a case study.

Young, Joel L, Redmond, Judith C·Psychopharmacology bulletin·2007

This study looked at patients who came to a psychiatry clinic with ADHD symptoms and also had unexplained tiredness and widespread pain—conditions similar to ME/CFS or fibromyalgia. When doctors treated the ADHD with medication, some patients noticed their fatigue and pain improved along with their attention problems. The researchers suggest this might mean these conditions involve how the brain processes information rather than problems in muscles and joints.

Cognitive Impairment

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Evidence browser

The thoughts and methods for clinical research on acupuncture treatment of chronic fatigue syndrome.

Long-chain polyunsaturated fatty acids and the pathophysiology of myalgic encephalomyelitis (chronic fatigue syndrome).

Violence, stress, and somatic syndromes.

Myalgic encephalomyelitis: a review with emphasis on key findings in biomedical research.

[History of chronic fatigue syndrome].

'What is it like to have ME?': the discursive construction of ME in computer-mediated communication and face-to-face interaction.

[School phobia and childhood chronic fatigue syndrome (CCFS)].

[Fibromyalgia and chronic fatigue syndrome in children and adolescents].

Rehabilitation of decreased motor performance in patients with chronic fatigue syndrome: should we treat low effort capacity or reduced effort tolerance?

Cranial electrotherapy stimulation and fibromyalgia.

Hyperventilation in patients with chronic fatigue syndrome: the role of coping strategies.

[Overview of psychiatric therapy for chronic fatigue syndrome].

Infection and vaccination in chronic fatigue syndrome: myth or reality?

Fibromyalgia and overlapping disorders: the unifying concept of central sensitivity syndromes.

[Antinuclear antibodies in patients with chronic fatigue syndrome].

[Overview of chronic fatigue syndrome focusing on prevalence and diagnostic criteria].

The chronic fatigue syndrome: a comparative pathway analysis.

[Childhood chronic fatigue syndrome].

The impact of a 4-hour sleep delay on slow wave activity in twins discordant for chronic fatigue syndrome.

Fibromylagia, chronic fatigue, and adult attention deficit hyperactivity disorder in the adult: a case study.

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