ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

1521–1540 of 2,423 studies

E3 PreliminaryCohortPEM not requiredCase-Control

Resting muscle pain as the first clinical symptom in children carrying the MTTK A8344G mutation.

van de Glind, Gretha, de Vries, Maaike, Rodenburg, Richard et al.·European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society·2007

This study describes children in a family who carried a specific genetic mutation in their mitochondria (the energy-producing parts of cells) and presented with muscle pain as their first symptom. The researchers found that muscle pain combined with fatigue in children can sometimes be mistakenly labeled as fibromyalgia or chronic fatigue syndrome, when the real cause is actually a rare inherited mitochondrial disorder called MERRF syndrome.

Pain and Sensitization

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Overview of psychiatric therapy for chronic fatigue syndrome].

Yamadera, Wataru, Itoh, Hiroshi·Nihon rinsho. Japanese journal of clinical medicine·2007

This review examines how talking therapies, particularly cognitive behavioral therapy (CBT), can help people with ME/CFS. CBT focuses on identifying unhelpful thinking patterns and behaviors—like perfectionism, avoidance, and constantly searching for physical causes—that may be making fatigue worse. The approach involves keeping steady activity levels and making small, planned increases over time, rather than pushing hard and then collapsing.

E3 PreliminaryMechanismPEM not requiredObservational

[Sleep disturbance in chronic fatigue syndrome].

Kumano-go, Takayuki, Adachi, Hiroyoshi, Sugita, Yoshiro·Nihon rinsho. Japanese journal of clinical medicine·2007

This study looked at sleep problems in ME/CFS patients using a special laser device to measure blood flow patterns during sleep. The researchers found that different ME/CFS patients showed different types of abnormal sleep patterns, suggesting that ME/CFS may actually be several different conditions rather than one single illness. Sleep disturbances like insomnia, oversleeping, and irregular sleep-wake cycles are common in ME/CFS.

Sleep

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

An experimental study of the influence of individual participant characteristics on formal consensus development.

Carpenter, James, Hutchings, Andrew, Raine, Rosalind et al.·International journal of technology assessment in health care·2007

This study looked at how different types of doctors and healthcare workers rate whether psychological treatments are appropriate for ME/CFS and other chronic conditions. Researchers had 346 people in 20 groups review mental health treatments and rate how suitable they were, testing whether factors like the doctors' specialty, age, and sex changed their opinions.

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia and overlapping disorders: the unifying concept of central sensitivity syndromes.

Yunus, Muhammad B·Seminars in arthritis and rheumatism·2007

This paper proposes that fibromyalgia, irritable bowel syndrome, chronic fatigue syndrome, and certain headaches may all share a common underlying problem: the nervous system becomes too sensitive to pain and other signals. Rather than being separate diseases, they might be related conditions caused by similar changes in how the brain and body communicate, combined with stress and emotional factors.

Pain and Sensitization

E3 PreliminaryReviewPEM not requiredReview-Narrative

[School phobia and childhood chronic fatigue syndrome (CCFS)].

Tomoda, Akemi·Nihon rinsho. Japanese journal of clinical medicine·2007

This review examines childhood chronic fatigue syndrome (CCFS), a serious condition where children experience extreme tiredness that cannot be explained by other medical or mental health problems. Children with CCFS often struggle with memory and concentration, sleep problems, and symptoms related to their nervous system. The authors suggest that CCFS may involve changes in how the brain functions, which could explain why patients experience fatigue, thinking difficulties, and memory problems.

Autonomic Nervous SystemCognitive Impairment

E3 PreliminaryBehavioralPEM not requiredLongitudinal

Post concussion syndrome ebb and flow: longitudinal effects and management.

Rees, Roger J, Bellon, Michelle L·NeuroRehabilitation·2007

This study followed 20 adults who had lasting symptoms after a head injury (concussion) for an average of 3.35 years. Participants experienced fatigue, difficulty concentrating, mood changes, and sensitivity to noise. When they received counseling and therapy over two years, some symptoms like irritability improved, but many people still felt fundamentally changed and struggled with feelings of helplessness.

Cognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Autonomic function and child chronic fatigue syndrome].

Tanaka, Hidetaka·Nihon rinsho. Japanese journal of clinical medicine·2007

This review examined how the autonomic nervous system—the part of your nervous system that controls automatic functions like heart rate and blood pressure—might be involved in childhood ME/CFS. Researchers found that about one-third of children with ME/CFS had problems regulating their blood pressure and heart rate when standing up, a condition called orthostatic dysregulation. While some studies suggested increased sympathetic nervous system activity, the findings were not consistent across all research.

Autonomic Nervous System

E3 PreliminaryMechanismPEM not requiredMechanistic

Sense of effort during a fatiguing exercise protocol in chronic fatigue syndrome.

Wallman, Karen E, Sacco, Paul·Research in sports medicine (Print)·2007

This study asked whether people with ME/CFS feel more effort when doing physical tasks compared to healthy people. Researchers had both groups perform a repetitive arm exercise for 45 minutes while rating how hard it felt. People with ME/CFS reported significantly higher effort levels and produced more force than controls, even though the task was the same for everyone.

Post-Exertional Malaise

E3 PreliminaryPEM not required

[Chronic fatigue syndrome in a 15-year-old girl].

Díaz-Caneja Greciano, A, Rodríguez Sosa, J T, Aguilera Albesa, S et al.·Anales de pediatria (Barcelona, Spain : 2003)·2007

This report describes a 15-year-old girl diagnosed with ME/CFS (chronic fatigue syndrome), a condition that causes severe tiredness and lack of energy without an obvious physical cause. The doctors emphasize that ME/CFS should be considered when young people have chronic fatigue along with other symptoms but medical tests don't reveal why. Treatment focused on rehabilitation with cognitive behavioral therapy (talking therapy to address thoughts and behaviors) combined with a gradual, structured increase in activity levels.

Diagnostics

E3 PreliminaryDiagnosticPEM not requiredCross-Sectional

[Spectroscopic diagnosis of chronic fatigue syndrome by multivariate analysis of visible and near-infrared spectra].

Sakudo, Akikazu, Kuratsune, Hirohiko, Hakariya, Yukiko et al.·Nihon rinsho. Japanese journal of clinical medicine·2007

Researchers tested whether a special light-based technology called visible and near-infrared spectroscopy could help diagnose ME/CFS by analyzing blood samples and skin. The technique uses different wavelengths of light to detect patterns that might differ between people with ME/CFS and healthy people. Early results showed the method could correctly identify about 70-80% of cases, suggesting this approach might one day offer a quick, non-invasive way to help diagnose the condition.

Biomarkers

E3 PreliminaryBehavioralPEM not requiredCase-Control

[Usefulness of growth chart in children and adolescents with chronic fatigue syndrome].

Oki, Junichi, Okubo, Jun·Nihon rinsho. Japanese journal of clinical medicine·2007

This small study looked at growth charts from three young people with chronic fatigue syndrome to see if the charts could help identify what triggered their illness. The researchers found that life events—like overexercise, family stress, or infection—appeared before symptoms like extreme tiredness, nausea, and sleep problems started. While growth charts alone cannot predict who will develop ME/CFS, they may help doctors spot important life changes that happened around the time symptoms began.

E3 PreliminaryMechanismPEM not requiredObservational

[Evaluation of fatigue by using acceleration plethysmography].

Yamaguti, Kouzi·Nihon rinsho. Japanese journal of clinical medicine·2007

Researchers tested a new device called acceleration plethysmography to measure fatigue in ME/CFS patients. This device tracks tiny blood vessel changes and nervous system activity in the fingertip. The study found that fatigue levels were connected to specific patterns in these measurements, suggesting this tool might help doctors objectively measure ME/CFS fatigue in the future.

Autonomic Nervous System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Fibromyalgia and chronic fatigue syndrome in children and adolescents].

Galanopoulos, Ng, Kampakis, Gp, Ladopoulou, Kf·Psychiatrike = Psychiatriki·2007

This review discusses fibromyalgia and chronic fatigue syndrome (ME/CFS) in children and teenagers, noting that both conditions are fairly common in this age group. Patients with these conditions experience widespread muscle pain, exhaustion, depression, headaches, and sleep problems that can significantly impact school, family life, and overall development. The authors emphasize that early diagnosis and treatment combining medication, physical therapy, and psychological support are important for helping young people manage these conditions.

Pain and SensitizationSleep

E3 PreliminaryCohortPEM not requiredCase-Control

[A new treatment: thermal therapy for chronic fatigue syndrome].

Masuda, Akinori, Munemoto, Takao, Tei, Chuwa·Nihon rinsho. Japanese journal of clinical medicine·2007

Researchers tested far-infrared sauna therapy on 13 ME/CFS patients. Two patients experienced dramatic improvements in fatigue, pain, and fever, and were able to stop taking prednisolone and return to normal activities within 6 months. The remaining 11 patients also reported improvements in fatigue and pain, with additional benefits including relaxation and reduced depression symptoms.

E3 PreliminaryReviewPEM unclearReview-Narrative

Long-chain polyunsaturated fatty acids and the pathophysiology of myalgic encephalomyelitis (chronic fatigue syndrome).

Puri, B K·Journal of clinical pathology·2007

This study proposes that ME/CFS may be linked to persistent viral infections that interfere with how the body produces certain beneficial fatty acids called long-chain polyunsaturated fatty acids. These fatty acids are important for cell membranes and immune function. The researchers suggest that supplementing with specific oils like evening primrose oil and fish oil might help bypass this block and improve symptoms.

E3 PreliminaryReviewPEM unclearReview-Narrative

Central sensitization: a biopsychosocial explanation for chronic widespread pain in patients with fibromyalgia and chronic fatigue syndrome.

Meeus, Mira, Nijs, Jo·Clinical rheumatology·2007

Many people with ME/CFS experience widespread pain in addition to fatigue, similar to fibromyalgia. This paper proposes that both conditions may be caused by 'central sensitization'—a problem where the nervous system becomes overly sensitive to pain signals. The authors review evidence suggesting this mechanism could explain ME/CFS pain, though more research is needed to confirm it.

Pain and Sensitization

E3 PreliminaryCommentaryPEM not requiredEditorial

Drug residues store in the body following cessation of use: impacts on neuroendocrine balance and behavior--use of the Hubbard sauna regimen to remove toxins and restore health.

Cecchini, Marie, LoPresti, Vincent·Medical hypotheses·2007

This paper proposes that medications and drugs can accumulate in body fat over time and potentially cause long-term health problems even after someone stops taking them. The authors suggest that a treatment program involving exercise, sauna use, and vitamins might help remove these stored substances from the body and improve symptoms in conditions like ME/CFS.

Endocrine Disruption

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

The chronic fatigue syndrome: a comparative pathway analysis.

Emmert-Streib, Frank·Journal of computational biology : a journal of computational molecular cell biology·2007

This study developed a new method to find biological pathways that go wrong in ME/CFS, rather than just looking at individual genes. The researchers compared how biological systems work differently in sick versus healthy people using computer analysis of gene expression data. This approach helps scientists understand ME/CFS as a disease of interconnected biological processes.

E3 PreliminaryReviewPEM unclearReview-Narrative

Cranial electrotherapy stimulation and fibromyalgia.

Gilula, Marshall F·Expert review of medical devices·2007

This review examines cranial electrotherapy stimulation (CES), a treatment that uses mild electrical stimulation applied to the head to help manage fibromyalgia pain and related symptoms. While CES is not a cure-all, research suggests it may help some fibromyalgia patients feel better. The review also discusses how fibromyalgia often occurs alongside other conditions like anxiety, depression, sleep problems, and fatigue—symptoms that overlap with ME/CFS.

Pain and SensitizationSleep

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Resting muscle pain as the first clinical symptom in children carrying the MTTK A8344G mutation.

[Overview of psychiatric therapy for chronic fatigue syndrome].

[Sleep disturbance in chronic fatigue syndrome].

An experimental study of the influence of individual participant characteristics on formal consensus development.

Fibromyalgia and overlapping disorders: the unifying concept of central sensitivity syndromes.

[School phobia and childhood chronic fatigue syndrome (CCFS)].

Post concussion syndrome ebb and flow: longitudinal effects and management.

[Autonomic function and child chronic fatigue syndrome].

Sense of effort during a fatiguing exercise protocol in chronic fatigue syndrome.

[Chronic fatigue syndrome in a 15-year-old girl].

[Spectroscopic diagnosis of chronic fatigue syndrome by multivariate analysis of visible and near-infrared spectra].

[Usefulness of growth chart in children and adolescents with chronic fatigue syndrome].

[Evaluation of fatigue by using acceleration plethysmography].

[Fibromyalgia and chronic fatigue syndrome in children and adolescents].

[A new treatment: thermal therapy for chronic fatigue syndrome].

Long-chain polyunsaturated fatty acids and the pathophysiology of myalgic encephalomyelitis (chronic fatigue syndrome).

Central sensitization: a biopsychosocial explanation for chronic widespread pain in patients with fibromyalgia and chronic fatigue syndrome.

Drug residues store in the body following cessation of use: impacts on neuroendocrine balance and behavior--use of the Hubbard sauna regimen to remove toxins and restore health.

The chronic fatigue syndrome: a comparative pathway analysis.

Cranial electrotherapy stimulation and fibromyalgia.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research