ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

1541–1560 of 2,423 studies

E3 PreliminaryCohortPEM not requiredCase-Control

Normalization of the increased translocation of endotoxin from gram negative enterobacteria (leaky gut) is accompanied by a remission of chronic fatigue syndrome.

Maes, Michael, Coucke, Francis, Leunis, Jean-Claude·Neuro endocrinology letters·2007

This study describes a teenage girl with ME/CFS who had damage to her gut lining, allowing bacterial toxins to leak into her bloodstream. When she was treated with antioxidants, dietary changes to repair her gut, and immune support therapy, the leaky gut improved and her ME/CFS symptoms disappeared. The findings suggest that gut damage may play a role in some ME/CFS cases.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Odds ratio based multifactor-dimensionality reduction method for detecting gene-gene interactions.

Chung, Yujin, Lee, Seung Yeoun, Elston, Robert C et al.·Bioinformatics (Oxford, England)·2007

This study presents a new computational tool called OR MDR that helps scientists find combinations of genes that might increase the risk of developing diseases like ME/CFS. Unlike older methods that simply sort gene combinations into two groups (high-risk or low-risk), this new tool provides more detailed information about exactly how much each gene combination increases disease risk, including ranges of uncertainty around those estimates.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

[Identification and application of marker genes for differential diagnosis of chronic fatigue syndrome].

Kawai, Tomoko, Rokutan, Kazuhito·Nihon rinsho. Japanese journal of clinical medicine·2007

This study looked for genetic markers (differences in how genes are expressed) that could help doctors diagnose ME/CFS with a blood test. The researchers identified 9 genes that were expressed differently in ME/CFS patients compared to healthy people, and showed these genes could potentially be used to distinguish ME/CFS from other conditions.

Biomarkers

E3 PreliminaryMechanismPEM not requiredMechanistic

Lymphatic drainage of the neuraxis in chronic fatigue syndrome: a hypothetical model for the cranial rhythmic impulse.

Perrin, Raymond N·The Journal of the American Osteopathic Association·2007

This study proposes that ME/CFS may be connected to problems with how fluid drains from the brain and spinal cord. The author suggests that the cranial rhythmic impulse—a subtle body rhythm that practitioners can feel—reflects cerebrospinal fluid drainage and lymphatic system activity controlled by the nervous system. When this drainage process becomes disrupted, the author argues it could cause the fatigue and other symptoms of ME/CFS.

Neuroinflammation

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Gamma-aminobutyric acid--metabolism and its disorders].

Kowalski, Antoni, Rebas, Elzbieta, Zylińska, Ludmiła·Postepy biochemii·2007

Your brain uses a chemical messenger called GABA to calm nerve signals and prevent them from becoming overactive. When three key enzymes that control GABA levels don't work properly, it can cause various neurological problems including chronic fatigue syndrome, anxiety, seizures, and stiff-person syndrome. This article reviews what happens when GABA metabolism breaks down and how it affects the nervous system.

E3 PreliminaryCommentaryPEM unclearEditorial

Mitochondrial dysfunction and molecular pathways of disease.

Pieczenik, Steve R, Neustadt, John·Experimental and molecular pathology·2007

This article explains that many different diseases—including chronic fatigue syndrome—may share a common problem: damage to mitochondria, the energy-producing parts of our cells. When mitochondria don't work properly, they produce harmful molecules called reactive oxygen species that can further damage cells. The authors suggest that antioxidant treatments and specific urine tests might help doctors treat these conditions more effectively.

Energy Metabolism

E3 PreliminaryReviewPEM not requiredReview-Narrative

Mechanisms of cancer-related fatigue.

Ryan, Julie L, Carroll, Jennifer K, Ryan, Elizabeth P et al.·The oncologist·2007

Cancer-related fatigue is extreme tiredness that happens during and after cancer treatment and significantly impacts quality of life, but doctors don't fully understand why it occurs. This review examines several possible causes, including problems with brain chemicals, muscle metabolism, hormonal balance, sleep-wake cycles, and inflammation in the body. Understanding these mechanisms could help develop better treatments for this distressing symptom.

Energy Metabolism

E3 PreliminaryReviewPEM not requiredReview-Narrative

Current research priorities in chronic fatigue syndrome/myalgic encephalomyelitis: disease mechanisms, a diagnostic test and specific treatments.

Kerr, J R, Christian, P, Hodgetts, A et al.·Journal of clinical pathology·2007

This review describes an organized effort by researchers to better understand ME/CFS by studying genes and immune system changes in patients' blood. The goal is to find biological markers that can reliably diagnose the illness and to test new treatments that might help. Researchers are using advanced technology to look at thousands of genes at once to find patterns specific to ME/CFS.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Advances in the treatment of multiple sclerosis?].

Tackenberg, B, Himmerich, H, Wellek, A et al.·MMW Fortschritte der Medizin·2007

This article reviews advances in treating multiple sclerosis (MS), a different neurological disease from ME/CFS. It discusses how MS treatment has improved with new diagnostic tools, early treatment approaches, and various medications. The article notes that MS patients often experience chronic fatigue, depression, and other symptoms that require separate treatment alongside MS-specific therapies.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Update in Hepatitis C virus associated extrahepatic manifestations].

Sène, D, Saadoun, D, Limal, N et al.·La Revue de medecine interne·2007

This review examines how hepatitis C virus (HCV) can affect parts of the body beyond the liver. The authors discuss various conditions linked to HCV infection, including chronic fatigue, dry mouth and eyes, diabetes, and certain blood cancers. They note that while these connections are documented, scientists still don't fully understand the mechanisms behind them.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia and overlapping disorders: the unifying concept of central sensitivity syndromes.

Yunus, Muhammad B·Seminars in arthritis and rheumatism·2007

This paper proposes that fibromyalgia, irritable bowel syndrome, chronic fatigue syndrome, and certain headaches may all share a common underlying problem: the nervous system becomes too sensitive to pain and other signals. Rather than being separate diseases, they might be related conditions caused by similar changes in how the brain and body communicate, combined with stress and emotional factors.

Pain and Sensitization

E3 PreliminaryMechanismPEM not requiredCross-Sectional

The association between experimental and clinical pain measures among persons with fibromyalgia and chronic fatigue syndrome.

Geisser, Michael E, Gracely, Richard H, Giesecke, Thorsten et al.·European journal of pain (London, England)·2007

Researchers tested whether laboratory pain tests (using heat and pressure) could predict the pain people with fibromyalgia and ME/CFS experience in daily life. They found that pressure-based tests were better predictors of real-world pain than heat tests, suggesting that pressure stimulation may be a more useful research tool for studying pain in these conditions.

Pain and Sensitization

E3 PreliminaryMechanismPEM not requiredObservational

[Sleep disturbance in chronic fatigue syndrome].

Kumano-go, Takayuki, Adachi, Hiroyoshi, Sugita, Yoshiro·Nihon rinsho. Japanese journal of clinical medicine·2007

This study looked at sleep problems in ME/CFS patients using a special laser device to measure blood flow patterns during sleep. The researchers found that different ME/CFS patients showed different types of abnormal sleep patterns, suggesting that ME/CFS may actually be several different conditions rather than one single illness. Sleep disturbances like insomnia, oversleeping, and irregular sleep-wake cycles are common in ME/CFS.

Sleep

E3 PreliminaryMechanismPEM not requiredObservational

[Chronic fatigue syndrome and herpesvirus reactivation].

Kondo, Kazuhiro·Nihon rinsho. Japanese journal of clinical medicine·2007

This study looked at whether two common viruses that hide dormant in our bodies (HHV-6 and HHV-7) wake up and become active during fatigue. Researchers found that healthy people shed more HHV-6 in their saliva when tired from work, but ME/CFS patients did not show this pattern. However, HHV-7 did increase in both groups, suggesting these viruses might be useful markers to measure fatigue objectively.

BiomarkersImmune System

E3 PreliminaryCohortPEM not requiredCase-Control

Resting muscle pain as the first clinical symptom in children carrying the MTTK A8344G mutation.

van de Glind, Gretha, de Vries, Maaike, Rodenburg, Richard et al.·European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society·2007

This study describes children in a family who carried a specific genetic mutation in their mitochondria (the energy-producing parts of cells) and presented with muscle pain as their first symptom. The researchers found that muscle pain combined with fatigue in children can sometimes be mistakenly labeled as fibromyalgia or chronic fatigue syndrome, when the real cause is actually a rare inherited mitochondrial disorder called MERRF syndrome.

Pain and Sensitization

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Antinuclear antibodies in patients with chronic fatigue syndrome].

Nishikai, Masahiko·Nihon rinsho. Japanese journal of clinical medicine·2007

This review examined whether people with ME/CFS have specific antibodies (immune proteins) that attack their own body cells. Researchers found that 15-25% of ME/CFS patients had these antibodies, but the patterns varied widely and were generally weak. A few new antibodies specific to ME/CFS were identified, with one type appearing in 13% of patients studied and linked to severe fatigue and concentration problems.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Cranial electrotherapy stimulation and fibromyalgia.

Gilula, Marshall F·Expert review of medical devices·2007

This review examines cranial electrotherapy stimulation (CES), a treatment that uses mild electrical stimulation applied to the head to help manage fibromyalgia pain and related symptoms. While CES is not a cure-all, research suggests it may help some fibromyalgia patients feel better. The review also discusses how fibromyalgia often occurs alongside other conditions like anxiety, depression, sleep problems, and fatigue—symptoms that overlap with ME/CFS.

Pain and SensitizationSleep

E3 PreliminaryReviewPEM unclearReview-Narrative

Infection and vaccination in chronic fatigue syndrome: myth or reality?

Appel, Shmuel, Chapman, Joab, Shoenfeld, Yehuda·Autoimmunity·2007

This review examines whether vaccinations might trigger ME/CFS, since infections can sometimes lead to the condition. The authors found some case reports of ME/CFS occurring after vaccination, but most studies did not find a reliable connection. A Canadian health organization concluded there is no strong evidence linking vaccinations to ME/CFS, though researchers agree more studies are needed.

Immune System

E3 PreliminaryBehavioralPEM unclearCross-Sectional

An 'overwhelming illness': women's experiences of learning to live with chronic fatigue syndrome/myalgic encephalomyelitis.

Edwards, Catherine R, Thompson, Andrew R, Blair, Alan·Journal of health psychology·2007

This study interviewed eight women with ME/CFS about how they learned to cope with their illness. Many felt overwhelmed at first and frustrated when doctors didn't believe or help them. Over time, women found ways to manage by learning more about their condition, getting support from others, and taking charge of their own care, which helped them feel more in control.

E3 PreliminaryMechanismPEM not requiredMechanistic

Sense of effort during a fatiguing exercise protocol in chronic fatigue syndrome.

Wallman, Karen E, Sacco, Paul·Research in sports medicine (Print)·2007

This study asked whether people with ME/CFS feel more effort when doing physical tasks compared to healthy people. Researchers had both groups perform a repetitive arm exercise for 45 minutes while rating how hard it felt. People with ME/CFS reported significantly higher effort levels and produced more force than controls, even though the task was the same for everyone.

Post-Exertional Malaise

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Normalization of the increased translocation of endotoxin from gram negative enterobacteria (leaky gut) is accompanied by a remission of chronic fatigue syndrome.

Odds ratio based multifactor-dimensionality reduction method for detecting gene-gene interactions.

[Identification and application of marker genes for differential diagnosis of chronic fatigue syndrome].

Lymphatic drainage of the neuraxis in chronic fatigue syndrome: a hypothetical model for the cranial rhythmic impulse.

[Gamma-aminobutyric acid--metabolism and its disorders].

Mitochondrial dysfunction and molecular pathways of disease.

Mechanisms of cancer-related fatigue.

Current research priorities in chronic fatigue syndrome/myalgic encephalomyelitis: disease mechanisms, a diagnostic test and specific treatments.

[Advances in the treatment of multiple sclerosis?].

[Update in Hepatitis C virus associated extrahepatic manifestations].

Fibromyalgia and overlapping disorders: the unifying concept of central sensitivity syndromes.

The association between experimental and clinical pain measures among persons with fibromyalgia and chronic fatigue syndrome.

[Sleep disturbance in chronic fatigue syndrome].

[Chronic fatigue syndrome and herpesvirus reactivation].

Resting muscle pain as the first clinical symptom in children carrying the MTTK A8344G mutation.

[Antinuclear antibodies in patients with chronic fatigue syndrome].

Cranial electrotherapy stimulation and fibromyalgia.

Infection and vaccination in chronic fatigue syndrome: myth or reality?

An 'overwhelming illness': women's experiences of learning to live with chronic fatigue syndrome/myalgic encephalomyelitis.

Sense of effort during a fatiguing exercise protocol in chronic fatigue syndrome.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research