ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

1541–1560 of 2,423 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Overview of chronic fatigue syndrome focusing on prevalence and diagnostic criteria].

Kuratsune, Hirohiko·Nihon rinsho. Japanese journal of clinical medicine·2007

This review examines ME/CFS as a real medical condition affecting the nervous system, immune system, and stress response. While researchers have found many different abnormalities in ME/CFS patients—including viral reactivation, immune problems, and chemical imbalances in the brain—no single cause has been identified in everyone with the condition. The authors suggest that ME/CFS likely results from a combination of genetic factors and life stress that disrupts how the body's immune and hormone systems work together.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Long-chain polyunsaturated fatty acids and the pathophysiology of myalgic encephalomyelitis (chronic fatigue syndrome).

Puri, B K·Journal of clinical pathology·2007

This study proposes that ME/CFS may be linked to persistent viral infections that interfere with how the body produces certain beneficial fatty acids called long-chain polyunsaturated fatty acids. These fatty acids are important for cell membranes and immune function. The researchers suggest that supplementing with specific oils like evening primrose oil and fish oil might help bypass this block and improve symptoms.

E3 PreliminaryReviewPEM unclearReview-Narrative

Infection and vaccination in chronic fatigue syndrome: myth or reality?

Appel, Shmuel, Chapman, Joab, Shoenfeld, Yehuda·Autoimmunity·2007

This review examines whether vaccinations might trigger ME/CFS, since infections can sometimes lead to the condition. The authors found some case reports of ME/CFS occurring after vaccination, but most studies did not find a reliable connection. A Canadian health organization concluded there is no strong evidence linking vaccinations to ME/CFS, though researchers agree more studies are needed.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Rehabilitation of decreased motor performance in patients with chronic fatigue syndrome: should we treat low effort capacity or reduced effort tolerance?

Van Houdenhove, B, Verheyen, L, Pardaens, K et al.·Clinical rehabilitation·2007

This paper proposes a new way to think about why people with ME/CFS have reduced physical ability. The authors suggest there may be two different problems: some patients may have low energy capacity (their bodies can't produce enough energy), while others may have reduced effort tolerance (their nervous system tells them to stop before their body actually reaches its limit). Understanding which problem a patient has could help doctors choose better treatments.

Post-Exertional Malaise

E3 PreliminaryCohortPEM not requiredCase-Control

Treatment of chronic fatigue and orthostatic intolerance with propranolol.

Wyller, Vegard Bruun, Thaulow, Erik, Amlie, Jan P·The Journal of pediatrics·2007

This study looked at a teenager with ME/CFS who also experienced dizziness and fainting when standing up (orthostatic intolerance). The doctors treated this teen with propranolol, a blood pressure medication that slows the heart rate. The case suggests that an overactive stress-response system in the nervous system might contribute to ME/CFS symptoms, and that a simple tilt test could help identify patients who might benefit from this type of treatment.

Autonomic Nervous System

E3 PreliminaryMechanismPEM not requiredMechanistic

Sense of effort during a fatiguing exercise protocol in chronic fatigue syndrome.

Wallman, Karen E, Sacco, Paul·Research in sports medicine (Print)·2007

This study asked whether people with ME/CFS feel more effort when doing physical tasks compared to healthy people. Researchers had both groups perform a repetitive arm exercise for 45 minutes while rating how hard it felt. People with ME/CFS reported significantly higher effort levels and produced more force than controls, even though the task was the same for everyone.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Antinuclear antibodies in patients with chronic fatigue syndrome].

Nishikai, Masahiko·Nihon rinsho. Japanese journal of clinical medicine·2007

This review examined whether people with ME/CFS have specific antibodies (immune proteins) that attack their own body cells. Researchers found that 15-25% of ME/CFS patients had these antibodies, but the patterns varied widely and were generally weak. A few new antibodies specific to ME/CFS were identified, with one type appearing in 13% of patients studied and linked to severe fatigue and concentration problems.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Cranial electrotherapy stimulation and fibromyalgia.

Gilula, Marshall F·Expert review of medical devices·2007

This review examines cranial electrotherapy stimulation (CES), a treatment that uses mild electrical stimulation applied to the head to help manage fibromyalgia pain and related symptoms. While CES is not a cure-all, research suggests it may help some fibromyalgia patients feel better. The review also discusses how fibromyalgia often occurs alongside other conditions like anxiety, depression, sleep problems, and fatigue—symptoms that overlap with ME/CFS.

Pain and SensitizationSleep

E3 PreliminaryCommentaryPEM not requiredEditorial

Drug residues store in the body following cessation of use: impacts on neuroendocrine balance and behavior--use of the Hubbard sauna regimen to remove toxins and restore health.

Cecchini, Marie, LoPresti, Vincent·Medical hypotheses·2007

This paper proposes that medications and drugs can accumulate in body fat over time and potentially cause long-term health problems even after someone stops taking them. The authors suggest that a treatment program involving exercise, sauna use, and vitamins might help remove these stored substances from the body and improve symptoms in conditions like ME/CFS.

Endocrine Disruption

E3 PreliminaryMechanismPEM not requiredObservational

[Evaluation of fatigue by using acceleration plethysmography].

Yamaguti, Kouzi·Nihon rinsho. Japanese journal of clinical medicine·2007

Researchers tested a new device called acceleration plethysmography to measure fatigue in ME/CFS patients. This device tracks tiny blood vessel changes and nervous system activity in the fingertip. The study found that fatigue levels were connected to specific patterns in these measurements, suggesting this tool might help doctors objectively measure ME/CFS fatigue in the future.

Autonomic Nervous System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Childhood chronic fatigue syndrome].

Miike, Teruhisa·Nihon rinsho. Japanese journal of clinical medicine·2007

This review discusses chronic fatigue syndrome (CFS) in children and teenagers, a serious condition affecting 3-5% of young people. Children with CFS experience extreme tiredness, sleep problems, trouble learning and remembering, and immune system issues. While routine blood tests often look normal, special testing can reveal abnormalities in how their bodies handle energy, regulate temperature, and control hormones.

Immune System

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

Brief report: The accuracy of parents for the thoughts and feelings of their adolescent suffering from chronic fatigue: a preliminary study of empathy.

Vervoort, Tine, Crombez, Geert, Buysse, Ann et al.·Journal of pediatric psychology·2007

This study looked at whether parents of teenagers with ME/CFS could accurately understand what their child was thinking and feeling. Researchers found that parents were less able to understand their teenager's thoughts and feelings about ME/CFS itself compared to other life situations. Interestingly, teenagers thought their mothers understood them better than their fathers did, even though fathers were actually just as accurate in understanding them.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Cirrhotic cardiomyopathy].

Osipenko, M F, Bikbulatova, E A·Klinicheskaia meditsina·2007

This review examines how liver cirrhosis (severe liver disease) affects the heart. The study found that patients with cirrhosis develop heart problems including thickened heart walls and weakened heart function, especially during physical activity. These heart changes may contribute to fatigue and reduced ability to work, but importantly, these problems can improve significantly after a liver transplant.

Post-Exertional Malaise

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

The chronic fatigue syndrome: a comparative pathway analysis.

Emmert-Streib, Frank·Journal of computational biology : a journal of computational molecular cell biology·2007

This study developed a new method to find biological pathways that go wrong in ME/CFS, rather than just looking at individual genes. The researchers compared how biological systems work differently in sick versus healthy people using computer analysis of gene expression data. This approach helps scientists understand ME/CFS as a disease of interconnected biological processes.

E3 PreliminaryGuidelinePEM requiredGuideline

Definitions and aetiology of myalgic encephalomyelitis: how the Canadian consensus clinical definition of myalgic encephalomyelitis works.

Carruthers, B M·Journal of clinical pathology·2007

This article discusses how doctors should define and diagnose ME/CFS, emphasizing that clear, consistent definitions help doctors recognize the condition and understand how severely it affects individual patients. The authors argue that good clinical guidelines are essential so doctors can properly diagnose ME/CFS, predict how it will progress, and develop appropriate treatments. They stress that combining what doctors learn from individual patients with scientific research findings creates the best foundation for patient care.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Clinical features of chronic fatigue syndrome--symptoms].

Ban, Nobutaro, Saiki, Takuya, Ko, Gyoshin et al.·Nihon rinsho. Japanese journal of clinical medicine·2007

This review article summarizes the most common symptoms experienced by people with ME/CFS. The researchers identified and described the top 10 symptoms in detail, including severe fatigue, problems with memory and concentration, muscle pain, poor sleep, and headaches. Understanding these symptom patterns can help doctors recognize and diagnose ME/CFS more accurately.

Pain and SensitizationCognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

Current research priorities in chronic fatigue syndrome/myalgic encephalomyelitis: disease mechanisms, a diagnostic test and specific treatments.

Kerr, J R, Christian, P, Hodgetts, A et al.·Journal of clinical pathology·2007

This review describes an organized effort by researchers to better understand ME/CFS by studying genes and immune system changes in patients' blood. The goal is to find biological markers that can reliably diagnose the illness and to test new treatments that might help. Researchers are using advanced technology to look at thousands of genes at once to find patterns specific to ME/CFS.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

Successful use of a primary care practice-specialty collaboration in the care of an adolescent with chronic fatigue syndrome.

Kuo, Dennis Z, Cheng, Tina L, Rowe, Peter C·Pediatrics·2007

This case report describes how one teenager with ME/CFS improved significantly when their regular doctor and a specialized ME/CFS expert worked together as a team, even though they lived in different cities. By staying in regular contact through phone calls and emails and clearly dividing responsibilities, the two doctors were able to manage the teen's symptoms more effectively. The study suggests that this type of teamwork between primary care doctors and specialists can help young people with ME/CFS get better care.

Interventions

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

The thoughts and methods for clinical research on acupuncture treatment of chronic fatigue syndrome.

Yao, Renmin·Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan·2007

This paper presents acupuncture treatment guidelines for chronic fatigue syndrome (ME/CFS), focusing on how acupuncture might restore balance to the body's energy systems according to traditional Chinese medicine. The authors discuss important considerations like which patients are most suitable for treatment, which acupuncture points to use, and how to measure whether the treatment is working.

Interventions

E3 PreliminaryBehavioralPEM not requiredCase-Control

[Usefulness of growth chart in children and adolescents with chronic fatigue syndrome].

Oki, Junichi, Okubo, Jun·Nihon rinsho. Japanese journal of clinical medicine·2007

This small study looked at growth charts from three young people with chronic fatigue syndrome to see if the charts could help identify what triggered their illness. The researchers found that life events—like overexercise, family stress, or infection—appeared before symptoms like extreme tiredness, nausea, and sleep problems started. While growth charts alone cannot predict who will develop ME/CFS, they may help doctors spot important life changes that happened around the time symptoms began.

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

[Overview of chronic fatigue syndrome focusing on prevalence and diagnostic criteria].

Long-chain polyunsaturated fatty acids and the pathophysiology of myalgic encephalomyelitis (chronic fatigue syndrome).

Infection and vaccination in chronic fatigue syndrome: myth or reality?

Rehabilitation of decreased motor performance in patients with chronic fatigue syndrome: should we treat low effort capacity or reduced effort tolerance?

Treatment of chronic fatigue and orthostatic intolerance with propranolol.

Sense of effort during a fatiguing exercise protocol in chronic fatigue syndrome.

[Antinuclear antibodies in patients with chronic fatigue syndrome].

Cranial electrotherapy stimulation and fibromyalgia.

Drug residues store in the body following cessation of use: impacts on neuroendocrine balance and behavior--use of the Hubbard sauna regimen to remove toxins and restore health.

[Evaluation of fatigue by using acceleration plethysmography].

[Childhood chronic fatigue syndrome].

Brief report: The accuracy of parents for the thoughts and feelings of their adolescent suffering from chronic fatigue: a preliminary study of empathy.

[Cirrhotic cardiomyopathy].

The chronic fatigue syndrome: a comparative pathway analysis.

Definitions and aetiology of myalgic encephalomyelitis: how the Canadian consensus clinical definition of myalgic encephalomyelitis works.

[Clinical features of chronic fatigue syndrome--symptoms].

Current research priorities in chronic fatigue syndrome/myalgic encephalomyelitis: disease mechanisms, a diagnostic test and specific treatments.

Successful use of a primary care practice-specialty collaboration in the care of an adolescent with chronic fatigue syndrome.

The thoughts and methods for clinical research on acupuncture treatment of chronic fatigue syndrome.

[Usefulness of growth chart in children and adolescents with chronic fatigue syndrome].

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research