ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

1561–1580 of 2,423 studies

E3 PreliminaryBehavioralPEM unclearCross-Sectional

An 'overwhelming illness': women's experiences of learning to live with chronic fatigue syndrome/myalgic encephalomyelitis.

Edwards, Catherine R, Thompson, Andrew R, Blair, Alan·Journal of health psychology·2007

This study interviewed eight women with ME/CFS about how they learned to cope with their illness. Many felt overwhelmed at first and frustrated when doctors didn't believe or help them. Over time, women found ways to manage by learning more about their condition, getting support from others, and taking charge of their own care, which helped them feel more in control.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Antinuclear antibodies in patients with chronic fatigue syndrome].

Nishikai, Masahiko·Nihon rinsho. Japanese journal of clinical medicine·2007

This review examined whether people with ME/CFS have specific antibodies (immune proteins) that attack their own body cells. Researchers found that 15-25% of ME/CFS patients had these antibodies, but the patterns varied widely and were generally weak. A few new antibodies specific to ME/CFS were identified, with one type appearing in 13% of patients studied and linked to severe fatigue and concentration problems.

Immune System

E3 PreliminaryBehavioralPEM not requiredObservational

Orthostatic panic attacks among Vietnamese refugees.

Hinton, Devon E, Hinton, Ladson, Tran, Minh et al.·Transcultural psychiatry·2007

This study looked at Vietnamese refugees who experienced panic attacks triggered by standing up quickly from a sitting or lying position (orthostatic dizziness). The researchers found that these panic attacks were common among this group and were often linked to trauma memories and cultural beliefs about health. The study suggests that doctors treating Vietnamese refugees should check for and treat these specific panic attacks as part of their care.

Autonomic Nervous System

E3 PreliminaryMechanismPEM not requiredObservational

[Chronic fatigue syndrome and herpesvirus reactivation].

Kondo, Kazuhiro·Nihon rinsho. Japanese journal of clinical medicine·2007

This study looked at whether two common viruses that hide dormant in our bodies (HHV-6 and HHV-7) wake up and become active during fatigue. Researchers found that healthy people shed more HHV-6 in their saliva when tired from work, but ME/CFS patients did not show this pattern. However, HHV-7 did increase in both groups, suggesting these viruses might be useful markers to measure fatigue objectively.

BiomarkersImmune System

E3 PreliminaryCohortPEM not requiredCase-Control

Treatment of chronic fatigue and orthostatic intolerance with propranolol.

Wyller, Vegard Bruun, Thaulow, Erik, Amlie, Jan P·The Journal of pediatrics·2007

This study looked at a teenager with ME/CFS who also experienced dizziness and fainting when standing up (orthostatic intolerance). The doctors treated this teen with propranolol, a blood pressure medication that slows the heart rate. The case suggests that an overactive stress-response system in the nervous system might contribute to ME/CFS symptoms, and that a simple tilt test could help identify patients who might benefit from this type of treatment.

Autonomic Nervous System

E3 PreliminaryCommentaryPEM not requiredEditorial

Drug residues store in the body following cessation of use: impacts on neuroendocrine balance and behavior--use of the Hubbard sauna regimen to remove toxins and restore health.

Cecchini, Marie, LoPresti, Vincent·Medical hypotheses·2007

This paper proposes that medications and drugs can accumulate in body fat over time and potentially cause long-term health problems even after someone stops taking them. The authors suggest that a treatment program involving exercise, sauna use, and vitamins might help remove these stored substances from the body and improve symptoms in conditions like ME/CFS.

Endocrine Disruption

E3 PreliminaryMechanismPEM not requiredMechanistic

Sense of effort during a fatiguing exercise protocol in chronic fatigue syndrome.

Wallman, Karen E, Sacco, Paul·Research in sports medicine (Print)·2007

This study asked whether people with ME/CFS feel more effort when doing physical tasks compared to healthy people. Researchers had both groups perform a repetitive arm exercise for 45 minutes while rating how hard it felt. People with ME/CFS reported significantly higher effort levels and produced more force than controls, even though the task was the same for everyone.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Infection and vaccination in chronic fatigue syndrome: myth or reality?

Appel, Shmuel, Chapman, Joab, Shoenfeld, Yehuda·Autoimmunity·2007

This review examines whether vaccinations might trigger ME/CFS, since infections can sometimes lead to the condition. The authors found some case reports of ME/CFS occurring after vaccination, but most studies did not find a reliable connection. A Canadian health organization concluded there is no strong evidence linking vaccinations to ME/CFS, though researchers agree more studies are needed.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Central sensitization: a biopsychosocial explanation for chronic widespread pain in patients with fibromyalgia and chronic fatigue syndrome.

Meeus, Mira, Nijs, Jo·Clinical rheumatology·2007

Many people with ME/CFS experience widespread pain in addition to fatigue, similar to fibromyalgia. This paper proposes that both conditions may be caused by 'central sensitization'—a problem where the nervous system becomes overly sensitive to pain signals. The authors review evidence suggesting this mechanism could explain ME/CFS pain, though more research is needed to confirm it.

Pain and Sensitization

E3 PreliminaryMechanismPEM not requiredObservational

[Evaluation of fatigue by using acceleration plethysmography].

Yamaguti, Kouzi·Nihon rinsho. Japanese journal of clinical medicine·2007

Researchers tested a new device called acceleration plethysmography to measure fatigue in ME/CFS patients. This device tracks tiny blood vessel changes and nervous system activity in the fingertip. The study found that fatigue levels were connected to specific patterns in these measurements, suggesting this tool might help doctors objectively measure ME/CFS fatigue in the future.

Autonomic Nervous System

E3 PreliminaryCohortPEM not requiredCase-Control

Resting muscle pain as the first clinical symptom in children carrying the MTTK A8344G mutation.

van de Glind, Gretha, de Vries, Maaike, Rodenburg, Richard et al.·European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society·2007

This study describes children in a family who carried a specific genetic mutation in their mitochondria (the energy-producing parts of cells) and presented with muscle pain as their first symptom. The researchers found that muscle pain combined with fatigue in children can sometimes be mistakenly labeled as fibromyalgia or chronic fatigue syndrome, when the real cause is actually a rare inherited mitochondrial disorder called MERRF syndrome.

Pain and Sensitization

E3 PreliminaryReviewPEM unclearReview-Narrative

[The chronic fatigue syndrome and its diagnosis in internal medicine].

Barbado Hernández, F J, Gómez Cerezo, J, López Rodríguez, M et al.·Anales de medicina interna (Madrid, Spain : 1984)·2006

This article reviews how chronic fatigue syndrome (ME/CFS) is diagnosed and understood within internal medicine practice. The authors discuss the clinical features, diagnostic criteria, and challenges that doctors face when identifying ME/CFS in patients. The paper helps physicians recognize and properly diagnose this condition in their everyday practice.

Diagnostics

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

CFSUM1 and CFSUM2 in urine from patients with chronic fatigue syndrome are methodological artefacts.

Chalmers, Ronald A, Jones, Mark G, Goodwin, C Stewart et al.·Clinica chimica acta; international journal of clinical chemistry·2006

An earlier study claimed to find two special markers in the urine of ME/CFS patients that could help diagnose the condition. This study re-examined those findings and discovered that these supposed markers were actually just artifacts—unintended byproducts created by the way the urine samples were prepared in the lab, not real biological differences between patients and healthy people.

Biomarkers

E3 PreliminaryCohortPEM not requiredObservational

Submaximal aerobic exercise with mechanical vibrations improves the functional status of patients with chronic fatigue syndrome.

Saggini, R, Vecchiet, J, Iezzi, S et al.·Europa medicophysica·2006

This small study tested whether a special exercise machine that combines gentle exercise with vibrations could help ME/CFS patients feel better. Ten patients did submaximal aerobic exercise using a Galileo 2000 device over six months. After the treatment, patients reported improvements in pain sensitivity, fatigue, and muscle strength compared to before they started.

E3 PreliminaryCohortPEM not requiredCross-Sectional

Reduced responsiveness is an essential feature of chronic fatigue syndrome: a fMRI study.

Tanaka, Masaaki, Sadato, Norihiro, Okada, Tomohisa et al.·BMC neurology·2006

Researchers used brain imaging to compare how the brains of ME/CFS patients and healthy people responded to sounds while doing a tiring visual task. They found that healthy people's brains stayed responsive to sounds during the task, but ME/CFS patients' brains showed reduced responses to sounds—and this reduction matched how fatigued the patients felt. This suggests that ME/CFS may involve the brain becoming less able to process information that isn't directly related to the main task at hand.

Cognitive Impairment

E3 PreliminaryCohortPEM unclearObservational

Quest, chaos and restitution: living with chronic fatigue syndrome/myalgic encephalomyelitis.

Whitehead, Lisa Claire·Social science & medicine (1982)·2006

This study looked at how 17 people with ME/CFS describe their illness and make sense of it. Researchers found that people often go through different ways of telling their story: first trying to get back to normal (restitution), then feeling overwhelmed by chaos, and eventually finding new meaning in their lives (quest narrative). Understanding these patterns helps explain how people cope with a long-term illness that's hard to diagnose and often misunderstood.

E3 PreliminaryReviewPEM unclearReview-Narrative

Highlights from 5th International Conference on HHV-6 and -7.

Komaroff, Anthony L, Jacobson, Steven, Ablashi, Dharam V et al.·Herpes : the journal of the IHMF·2006

Scientists at an international conference discussed new tests to detect two common viruses (HHV-6 and HHV-7) in the body and whether they might trigger nervous system diseases. These viruses can infect brain cells, and researchers think they may play a role in conditions like chronic fatigue syndrome, along with multiple sclerosis and other neurological problems. Better tests are being developed to tell if someone has an active infection or just carries the virus dormant.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Immunological dysfunction, vaccination and Gulf War illness.

Peakman, Mark, Skowera, Ania, Hotopf, Matthew·Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2006

This study investigated whether vaccines given to soldiers during the Gulf War might have caused Gulf War illness, a condition similar to ME/CFS. Researchers looked at both epidemiological data (patterns of illness across groups) and immune system studies from veterans. They found a weak link between multiple vaccines and illness, but could not find evidence that vaccines changed the immune system in a way that would explain the illness.

Immune System

E3 PreliminaryDiagnosticPEM unclearCross-Sectional

The validity of an empirical delineation of heterogeneity in chronic unexplained fatigue.

Aslakson, Eric, Vollmer-Conna, Uté, White, Peter D·Pharmacogenomics·2006

Researchers used statistical methods to identify distinct groups among people with chronic unexplained fatigue, including those with ME/CFS. They tested whether these groups were real and consistent by running their analysis multiple ways. They found that the groups they identified were valid and matched well with established ME/CFS diagnostic criteria, suggesting that ME/CFS is not one single condition but rather several related conditions with potentially different underlying causes.

Diagnostics

E3 PreliminaryPEM unclear

The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study.

Teitelbaum, Jacob E, Johnson, Clarence, St Cyr, John·Journal of alternative and complementary medicine (New York, N.Y.)·2006

Researchers gave 41 patients with ME/CFS or fibromyalgia a natural sugar called D-ribose to see if it could help their symptoms. Two-thirds of patients reported feeling noticeably better, with improvements in energy, sleep, mental clarity, pain, and overall well-being. The supplement was well-tolerated with no serious side effects reported.

Energy Metabolism

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An 'overwhelming illness': women's experiences of learning to live with chronic fatigue syndrome/myalgic encephalomyelitis.

[Antinuclear antibodies in patients with chronic fatigue syndrome].

Orthostatic panic attacks among Vietnamese refugees.

[Chronic fatigue syndrome and herpesvirus reactivation].

Treatment of chronic fatigue and orthostatic intolerance with propranolol.

Drug residues store in the body following cessation of use: impacts on neuroendocrine balance and behavior--use of the Hubbard sauna regimen to remove toxins and restore health.

Sense of effort during a fatiguing exercise protocol in chronic fatigue syndrome.

Infection and vaccination in chronic fatigue syndrome: myth or reality?

Central sensitization: a biopsychosocial explanation for chronic widespread pain in patients with fibromyalgia and chronic fatigue syndrome.

[Evaluation of fatigue by using acceleration plethysmography].

Resting muscle pain as the first clinical symptom in children carrying the MTTK A8344G mutation.

[The chronic fatigue syndrome and its diagnosis in internal medicine].

CFSUM1 and CFSUM2 in urine from patients with chronic fatigue syndrome are methodological artefacts.

Submaximal aerobic exercise with mechanical vibrations improves the functional status of patients with chronic fatigue syndrome.

Reduced responsiveness is an essential feature of chronic fatigue syndrome: a fMRI study.

Quest, chaos and restitution: living with chronic fatigue syndrome/myalgic encephalomyelitis.

Highlights from 5th International Conference on HHV-6 and -7.

Immunological dysfunction, vaccination and Gulf War illness.

The validity of an empirical delineation of heterogeneity in chronic unexplained fatigue.

The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study.

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