ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

1621–1640 of 2,423 studies

E3 PreliminaryCohortPEM not requiredObservational

Causes of death among patients with chronic fatigue syndrome.

Jason, Leonard A, Corradi, Karina, Gress, Sara et al.·Health care for women international·2006

This study looked at 166 people with ME/CFS who had passed away to understand what caused their deaths. The researchers found that heart failure, suicide, and cancer were the three leading causes, together accounting for nearly 60% of deaths. Notably, people with ME/CFS who died from cancer or suicide were much younger—in their late 30s to mid-40s—compared to people in the general population who died from these same causes.

E3 PreliminaryReviewPEM unclearReview-Narrative

Proton and 31-phosphorus neurospectroscopy in the study of membrane phospholipids and fatty acid intervention in schizophrenia, depression, chronic fatigue syndrome (myalgic encephalomyelitis) and dyslexia.

Puri, Basant K·International review of psychiatry (Abingdon, England)·2006

This study describes advanced brain imaging techniques that can measure specific chemicals in the brain without surgery. These techniques help researchers understand how the brain uses fats and other building blocks to maintain healthy cell membranes. The authors explain how these imaging methods could be applied to study brain chemistry in ME/CFS and other conditions.

Energy Metabolism

E3 PreliminaryReviewPEM not requiredReview-Narrative

Is human herpesvirus-6 a trigger for chronic fatigue syndrome?

Komaroff, Anthony L·Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2006

This study reviews evidence about whether a virus called human herpesvirus-6 (HHV-6) might cause ME/CFS. Researchers found that active HHV-6 infection appears more frequently in ME/CFS patients than in healthy people, and the virus may be connected to some of the nervous system and immune system problems seen in ME/CFS. However, not all ME/CFS patients test positive for active HHV-6, suggesting it may only trigger the illness in some people.

Immune System

E3 PreliminaryBehavioralPEM unclearCross-Sectional

Illness Beliefs in Chronic Fatigue Syndrome: A Study Involving Affected Adolescents and their Parents.

Richards, Jo, Chaplin, Robert, Starkey, Caroline et al.·Child and adolescent mental health·2006

This study asked 21 young people with ME/CFS and their parents about what they thought caused the illness and how they managed it. Most people believed the illness started from an infection, while fewer thought it was psychological. Many found that resting and reducing activity helped manage symptoms. The study highlights that doctors should listen carefully to what patients and families believe about ME/CFS before deciding on treatment.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Possible mechanisms of chronic fatigue syndrome in multiple sclerosis].

Kasatkin, D S, Spirin, N N·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2006

This review describes how fatigue in multiple sclerosis (MS) can happen in different ways: tiredness even at rest, exhaustion during activity, and fatigue linked to MS flare-ups. The authors explain that fatigue likely involves both brain-based and body-based mechanisms, and often occurs alongside depression and sleep problems, suggesting these conditions may share common biological causes related to brain chemicals like serotonin.

NeuroinflammationPost-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

[On the important role of Siguan points in treatment of chronic fatigue syndrome].

Wang, Jing-jing, Meng, Hong, Cui, Cheng-bin et al.·Zhongguo zhen jiu = Chinese acupuncture & moxibustion·2006

This study examined whether a traditional Chinese medicine acupuncture technique called Siguan points might help treat chronic fatigue syndrome (ME/CFS). The researchers reviewed existing literature on this acupuncture method and concluded that using Siguan points as the main treatment approach showed promise for improving ME/CFS symptoms.

Interventions

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Gene expression profile of empirically delineated classes of unexplained chronic fatigue.

Carmel, Liran, Efroni, Sol, White, Peter D et al.·Pharmacogenomics·2006

Researchers examined genes in blood samples from 111 women with unexplained chronic fatigue to see if different types of fatigue had different gene patterns. They used computer analysis to identify specific genes that were active or inactive in different fatigue groups. They found that certain genes were consistently different between fatigued and healthy people, while other genes only differed in specific fatigue subgroups.

Biomarkers

E3 PreliminaryReviewPEM unclearReview-Narrative

Cognitive dysfunction in fibromyalgia and chronic fatigue syndrome: new trends and future directions.

Glass, Jennifer M·Current rheumatology reports·2006

Many people with fibromyalgia and chronic fatigue syndrome report problems with memory and thinking clearly. When researchers tested these patients' cognitive abilities, they found real difficulties with memory and how quickly patients process information. Brain imaging studies showed that patients' brains work differently during thinking tasks, requiring more activation than expected.

Cognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

[The problem of fatigue in neurological disorders].

Kumor, Klaudiusz, Pierzchała, Krystyna·Wiadomosci lekarskie (Warsaw, Poland : 1960)·2006

Fatigue is an extremely common and often severely disabling symptom in many neurological disorders, affecting 40–90% of patients with conditions like multiple sclerosis, Parkinson's disease, and stroke. This review explains that fatigue is a real medical symptom that should be carefully distinguished from depression, weakness, and sleepiness, though these conditions often occur together. Currently, doctors assess fatigue mainly through patient questionnaires, and there is no clear biological test or proven cure—treatments focus on addressing the underlying disease and using behavioral and psychological approaches.

Diagnostics

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

High-resolution magnetic resonance imaging sinc-interpolation-based subvoxel registration and semi-automated quantitative lateral ventricular morphology employing threshold computation and binary image creation in the study of fatty acid interventions in schizophrenia, depression, chronic fatigue syndrome and Huntington's disease.

Puri, Basant K·International review of psychiatry (Abingdon, England)·2006

Researchers developed advanced brain imaging techniques to detect small structural changes in the brain over time by comparing multiple MRI scans with extremely high precision. They used these techniques to study whether a type of fish oil supplement (EPA) might affect brain structure in people with various conditions, including ME/CFS. This study focuses on the imaging methods themselves rather than reporting final results about whether the treatment worked.

E3 PreliminaryCommentaryPEM not requiredEditorial

Pain in patients with chronic fatigue syndrome: does nitric oxide trigger central sensitisation?

Nijs, Jo, Van de Velde, Bart, De Meirleir, Kenny·Medical hypotheses·2005

This study proposes a theory about why ME/CFS patients experience widespread pain. The researchers suggest that a molecule called nitric oxide may cause the central nervous system (the brain and spinal cord) to become overly sensitive, amplifying pain signals throughout the body. They propose that viral infections or other pathogens associated with ME/CFS may trigger this chain reaction, and that behaviors like catastrophizing or avoiding activity may either contribute to or result from this heightened sensitivity.

Neuroinflammation

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Improving the diagnostic criteria and procedures for chronic fatigue syndrome.

King, Caroline, Jason, Leonard A·Biological psychology·2005

Doctors have used different definitions to diagnose ME/CFS since 1988, but these definitions were never tested scientifically to see if they actually work well. This study compared 15 people with ME/CFS, 15 with depression, and 15 healthy people to find better ways to diagnose ME/CFS. The researchers found that adding new symptoms, measuring how severe symptoms are, and using specific tests could help doctors diagnose ME/CFS more accurately.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome. A brief review of functional disturbances and potential therapy.

Shephard, R J·The Journal of sports medicine and physical fitness·2005

This review examined what might cause ME/CFS and how to treat it. The authors found that many different factors have been suggested as causes—including overtraining, stress, hormonal problems, infections, and immune issues—but none consistently appears in all patients. They concluded that the best approach is to help patients gradually rebuild physical fitness through exercise, counseling, and encouragement, while avoiding the harmful cycle of doing less and becoming more deconditioned.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

[Significance of the chronic fatigue syndrome in rehabilitation medicine--status and perspectives].

Gutenbrunner, C, Linden, M, Gerdes, N et al.·Die Rehabilitation·2005

This paper discusses how chronic fatigue and exhaustion affect people undergoing rehabilitation for various medical conditions. The authors reviewed how fatigue is defined, how often it occurs in different patient groups (from 50-90% depending on the condition), and whether rehabilitation can help improve it. They suggest that fatigue symptoms do improve somewhat with rehabilitation, though some symptoms can remain.

E3 PreliminaryReviewPEM unclearReview-Narrative

A new view on hypocortisolism.

Fries, Eva, Hesse, Judith, Hellhammer, Juliane et al.·Psychoneuroendocrinology·2005

Some people with ME/CFS, fibromyalgia, and PTSD have abnormally low levels of cortisol, a stress hormone their body normally produces. This review suggests that this low cortisol may develop after the body's stress system works overtime for a long time. Interestingly, while low cortisol contributes to symptoms like fatigue, pain, and stress sensitivity, it may also provide some protective benefits to the body.

Endocrine Disruption

E3 PreliminaryCohortPEM not requiredCase-Control

Acupuncture in the treatment of post viral fatigue syndrome--a case report.

Mears, Tim·Acupuncture in medicine : journal of the British Medical Acupuncture Society·2005

This case report describes one patient with ME/CFS (chronic fatigue syndrome) who received electroacupuncture treatment. While the acupuncture did not cure the condition, the patient reported significant symptom improvement and was eventually able to return to work. This is one of the first published studies looking at how acupuncture might help ME/CFS patients.

Interventions

E3 PreliminaryReviewPEM not requiredReview-Narrative

Practitioner review: chronic fatigue syndrome in childhood.

Elena Garralda, M, Chalder, Trudie·Journal of child psychology and psychiatry, and allied disciplines·2005

This review examines how ME/CFS appears in children and teenagers and discusses the best ways to help them recover. The authors found that ME/CFS in young people is often triggered by infections and can be diagnosed using the same criteria as in adults. They recommend a family-based approach using cognitive behavior therapy and gradually increasing activity, which has shown promise in helping children regain function.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Characterization of virus isolates by particle-associated nucleic acid PCR.

Stang, Alexander, Korn, Klaus, Wildner, Oliver et al.·Journal of clinical microbiology·2005

Researchers developed a new laboratory method called PAN-PCR that can identify viruses in patient samples even when standard tests fail to detect them. This technique works by finding viral genetic material protected inside virus particles and then copying and analyzing it. As a test case, they used this method on a mouth sample from a ME/CFS patient and successfully identified herpes simplex virus type 1, which had been missed by conventional testing.

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome: it's tiring not knowing much--an in-depth review for occupational health professionals.

Glozier, N·Occupational medicine (Oxford, England)·2005

This is a detailed review article about ME/CFS written for occupational health professionals. The article examines what is known about ME/CFS, including how it affects people's ability to work, and highlights the significant gaps in our understanding of the condition. The main message is that ME/CFS remains poorly understood, which makes it difficult for doctors, employers, and patients to manage effectively.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Impairments of the 2-5A synthetase/RNase L pathway in chronic fatigue syndrome.

Nijs, Jo, De Meirleir, Kenny·In vivo (Athens, Greece)·2005

This study looks at a specific immune system pathway called the 2-5A synthetase/RNase L pathway that may be broken in ME/CFS patients. Researchers found that in ME/CFS, this pathway is overactive but also working improperly—it's being broken down into unusual pieces instead of functioning normally. This abnormal pathway appears connected to reduced natural killer cell function and problems with how cells die when they should.

Immune System

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Evidence browser

Causes of death among patients with chronic fatigue syndrome.

Proton and 31-phosphorus neurospectroscopy in the study of membrane phospholipids and fatty acid intervention in schizophrenia, depression, chronic fatigue syndrome (myalgic encephalomyelitis) and dyslexia.

Is human herpesvirus-6 a trigger for chronic fatigue syndrome?

Illness Beliefs in Chronic Fatigue Syndrome: A Study Involving Affected Adolescents and their Parents.

[Possible mechanisms of chronic fatigue syndrome in multiple sclerosis].

[On the important role of Siguan points in treatment of chronic fatigue syndrome].

Gene expression profile of empirically delineated classes of unexplained chronic fatigue.

Cognitive dysfunction in fibromyalgia and chronic fatigue syndrome: new trends and future directions.

[The problem of fatigue in neurological disorders].

Pain in patients with chronic fatigue syndrome: does nitric oxide trigger central sensitisation?

Improving the diagnostic criteria and procedures for chronic fatigue syndrome.

Chronic fatigue syndrome. A brief review of functional disturbances and potential therapy.

[Significance of the chronic fatigue syndrome in rehabilitation medicine--status and perspectives].

A new view on hypocortisolism.

Acupuncture in the treatment of post viral fatigue syndrome--a case report.

Practitioner review: chronic fatigue syndrome in childhood.

Characterization of virus isolates by particle-associated nucleic acid PCR.

Chronic fatigue syndrome: it's tiring not knowing much--an in-depth review for occupational health professionals.

Impairments of the 2-5A synthetase/RNase L pathway in chronic fatigue syndrome.

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