ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

2081–2100 of 2,420 studies

E3 PreliminaryCohortPEM unclearCross-Sectional

Demonstration of Borna disease virus RNA in peripheral blood mononuclear cells derived from Japanese patients with chronic fatigue syndrome.

Nakaya, T, Takahashi, H, Nakamura, Y et al.·FEBS letters·1996

Researchers tested blood cells from 25 Japanese patients with chronic fatigue syndrome (ME/CFS) to see if a virus called Borna disease virus (BDV) was present. They found evidence of BDV in 3 patients' blood cells and antibodies (immune markers) against BDV in 6 patients, suggesting about 32% of their study group may have been exposed to or infected with this virus. This finding raised the possibility that BDV might be connected to ME/CFS in Japanese patients.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

Possible relationship between chronic fatigue and postural tachycardia syndromes.

De Lorenzo, F, Hargreaves, J, Kakkar, V V·Clinical autonomic research : official journal of the Clinical Autonomic Research Society·1996

This study looked at five people with ME/CFS who experienced symptoms like dizziness, blurred vision, and heart palpitations when standing up. When these patients were tested while lying on a tilting table that slowly moved them upright, researchers found that their blood pressure dropped and heart rate increased significantly. This suggests that some ME/CFS patients may have a condition called postural tachycardia syndrome, which affects how the body manages blood pressure during position changes.

Autonomic Nervous System

E3 PreliminaryCohortPEM not requiredCase-Control

Severe stealth virus encephalopathy following chronic-fatigue-syndrome-like illness: clinical and histopathological features.

Martin, W J·Pathobiology : journal of immunopathology, molecular and cellular biology·1996

This study looked at three patients who started with symptoms similar to ME/CFS and then developed severe brain inflammation. Brain tissue samples showed signs of unusual viral infection with damaged cells, but without the typical immune response usually seen in brain infections. Two patients partially recovered over time, while one remained severely disabled for years.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Fibromyalgia syndrome: a review.

Reiffenberger, D H, Amundson, L H·American family physician·1996

Fibromyalgia syndrome is a chronic condition characterized by widespread pain, stiffness, and tender points in muscles and soft tissues, often accompanied by fatigue and sleep problems. It affects women more than men, typically starting around age 49. Treatment combines medication (like certain antidepressants), education, reassurance, and exercise to help manage symptoms.

Pain and SensitizationSleep

E3 PreliminaryBehavioralPEM not requiredCase-Control

Chronic fatigue syndrome and dieting disorders: diagnosis and management problems.

Griffiths, R A, Beumont, P J, Moore, G M et al.·The Australian and New Zealand journal of psychiatry·1996

This study looked at three patients who were diagnosed with ME/CFS but also had eating disorders (anorexia nervosa or bulimia nervosa). The doctors found that proper screening for eating disorders is important because patients and families may focus on the ME/CFS diagnosis and miss the eating disorder, which delays appropriate treatment. Early identification of both conditions together can help reduce serious health problems.

Diagnostics

E3 PreliminaryMechanismPEM not requiredMechanistic

Sensory characterization of somatic parietal tissues in humans with chronic fatigue syndrome.

Vecchiet, L, Montanari, G, Pizzigallo, E et al.·Neuroscience letters·1996

This study tested whether people with ME/CFS have increased pain sensitivity in their muscles compared to their skin. Researchers found that muscles were significantly more sensitive to pain in ME/CFS patients, while skin sensitivity was normal. They also discovered abnormal structures and damage in muscle cells from ME/CFS patients, including problems with mitochondria (the energy-producing parts of cells) and signs of degeneration.

Pain and Sensitization

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome--psychiatric aspects].

Lemke, M R·Fortschritte der Neurologie-Psychiatrie·1996

This editorial discusses how ME/CFS involves both physical symptoms and mental health aspects that need to be understood together. The authors explain that while doctors have focused heavily on physical symptoms, psychiatric factors—such as stress, sleep problems, and how the body's stress system works—play an important role in the syndrome. An effective approach to ME/CFS requires doctors from different specialties to work together.

SleepImmune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Development and application of HHV-6 antigen capture assay for the detection of HHV-6 infections.

Marsh, S, Kaplan, M, Asano, Y et al.·Journal of virological methods·1996

Researchers developed a new laboratory test to detect HHV-6, a common virus, in blood and body fluids. This test is faster, cheaper, and easier to use than older methods, and works reliably in clinical settings. They tested it on samples from healthy people, children with fever rashes, and patients with various conditions including chronic fatigue syndrome.

Immune System

E3 PreliminaryCohortPEM not requiredCross-Sectional

["Prolonged" decay test and auditory brainstem responses in the clinical diagnosis of the chronic fatigue syndrome].

Neri, G, Bianchedi, M, Croce, A et al.·Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale·1996

This study tested whether two hearing-related tests could help diagnose ME/CFS. Researchers examined 21 people with suspected ME/CFS using specialized hearing tests that measure how the brainstem processes sound and how the ear muscles respond to loud noises. When both tests were combined, they correctly identified about 82% of people with ME/CFS, suggesting these tests might be useful diagnostic tools.

Biomarkers

E3 PreliminaryReviewPEM unclearReview-Narrative

[Pathogenicity of fungi in the intestines--current status of the discussion].

Scheurlen, M·Fortschritte der Medizin·1996

Some people believe that yeast infections in the gut, particularly from a fungus called Candida, might cause chronic fatigue syndrome and other long-term illnesses by producing harmful toxins. However, experts disagree about whether this theory is actually true. This editorial explains that while the idea is interesting, there isn't enough solid scientific evidence yet to prove it works or to recommend yeast-fighting treatments based on this theory alone.

Gut MicrobiomeImmune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Are echoviruses still orphans?

Hill, W M·British journal of biomedical science·1996

This review examines echoviruses, a family of common viruses that can cause outbreaks of illness around the world. The authors note that since polio has become rare, doctors have noticed more cases of non-polio enteroviruses (a related group of viruses) being linked to myalgic encephalomyelitis (ME) and post-viral fatigue syndrome. Different types of echoviruses tend to cause different patterns of illness in different populations.

E3 PreliminaryCohortPEM not requiredCase-Control

Epstein-Barr virus-related primary cutaneous amyloidosis. Successful treatment with acyclovir and interferon-alpha.

Drago, F, Ranieri, E, Pastorino, A et al.·The British journal of dermatology·1996

This case report describes a woman with ME/CFS who developed unusual skin lesions (brownish patches and bumps) on her chest and back for 10 years. Doctors found that the Epstein-Barr virus (EBV)—the virus that causes mononucleosis—was active in her skin and other body areas, and abnormal protein deposits were building up in her skin. When she was treated with antiviral medication (acyclovir) and a type of immune-boosting therapy (interferon-alpha), both her skin lesions and other symptoms improved significantly.

Immune System

E3 PreliminaryCommentaryPEM unclearCommentary

Missing the meaning and provoking resistance; a case of myalgic encephalomyelitis.

Butler, C, Rollnick, S·Family practice·1996

This study examines a conversation between a doctor and a patient who believed they had ME/CFS. Even though the doctor tried to listen carefully, they didn't fully understand what the diagnosis meant to the patient. The study shows that when doctors don't truly understand what patients mean by their diagnosis, it can damage trust and may slow recovery. The authors suggest that doctors should use reflective listening—repeating back what they hear—to make sure they really understand what patients are experiencing.

E3 PreliminaryCohortPEM not requiredCase-Control

Simian cytomegalovirus-related stealth virus isolated from the cerebrospinal fluid of a patient with bipolar psychosis and acute encephalopathy.

Martin, W J·Pathobiology : journal of immunopathology, molecular and cellular biology·1996

Researchers found an unusual virus in the spinal fluid of a patient with severe brain inflammation and psychiatric symptoms. This virus was similar to one previously found in a chronic fatigue syndrome patient. The study suggests that certain viruses might be responsible for various brain-related illnesses.

E3 PreliminaryMechanismPEM not requiredObservational

Investigation by polymerase chain reaction of enteroviral infection in patients with chronic fatigue syndrome.

McArdle, A, McArdle, F, Jackson, M J et al.·Clinical science (London, England : 1979)·1996

Researchers wanted to test whether a virus called enterovirus might be hiding in the muscles of people with ME/CFS and causing the fatigue and pain. They took muscle samples from 34 patients and looked carefully for signs of enteroviral infection, but found none. However, they did find that muscle tissue showed signs of reduced activity, including lower levels of the building blocks that muscle cells need to function properly.

Energy Metabolism

E3 PreliminaryMechanismPEM not requiredObservational

Short-term night-shift working mimics the pituitary-adrenocortical dysfunction in chronic fatigue syndrome.

Leese, G, Chattington, P, Fraser, W et al.·The Journal of clinical endocrinology and metabolism·1996

This study found that nurses who worked night shifts for just 5 days showed abnormal stress hormone patterns similar to those seen in ME/CFS patients. Specifically, their bodies produced high levels of one stress hormone (ACTH) but low levels of another (cortisol) during night shifts. This suggests that disrupted sleep and routine alone may be enough to trigger the hormone imbalances characteristic of ME/CFS.

Sleep

E3 PreliminaryReviewPEM not requiredReview-Narrative

Neurobiology of chronic fatigue syndrome.

Gonzalez, M B, Cousins, J C, Doraiswamy, P M·Progress in neuro-psychopharmacology & biological psychiatry·1996

This review article examines what happens in the brain and nervous system of people with ME/CFS. Researchers found that ME/CFS involves real biological changes in the brain—not just fatigue—including problems with mood, thinking, and hormone regulation. The study suggests that ME/CFS is a neurological condition with measurable differences in brain function, rather than purely psychological.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Viral arthritis.

Schnitzer, T J, Penmetcha, M·Current opinion in rheumatology·1996

This review examines how viral infections can cause joint pain and arthritis. Researchers found that several viruses—including hepatitis C, parvovirus B19, and those in certain vaccines—may trigger arthritis in some people. Interestingly, the study noted a negative association between parvovirus B19 and chronic fatigue syndrome, suggesting these conditions may not be closely linked.

Immune System

E3 PreliminaryCommentaryPEM not requiredEditorial

The use of transfer factors in chronic fatigue syndrome: prospects and problems.

Levine, P H·Biotherapy (Dordrecht, Netherlands)·1996

ME/CFS often starts with a viral infection and some people have ongoing herpes virus activity. This article discusses transfer factors—a type of immune therapy—that might help fight these viruses and improve symptoms. The authors explain why we need better-designed studies to test if this treatment actually works.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome. Definition, diagnostic measures and therapeutic possibilities].

Lieb, K, Dammann, G, Berger, M et al.·Der Nervenarzt·1996

ME/CFS is a disorder that causes persistent tiredness, but doctors cannot diagnose it with a simple blood test or scan. Instead, doctors use specific clinical criteria to identify the condition, while carefully ruling out other illnesses like depression or sleep problems that can look similar. Currently, there is no cure for ME/CFS, so treatment focuses on managing individual symptoms like poor sleep, pain, and mood changes with a combination of medical care and psychological support.

Pain and SensitizationSleepDiagnostics

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Demonstration of Borna disease virus RNA in peripheral blood mononuclear cells derived from Japanese patients with chronic fatigue syndrome.

Possible relationship between chronic fatigue and postural tachycardia syndromes.

Severe stealth virus encephalopathy following chronic-fatigue-syndrome-like illness: clinical and histopathological features.

Fibromyalgia syndrome: a review.

Chronic fatigue syndrome and dieting disorders: diagnosis and management problems.

Sensory characterization of somatic parietal tissues in humans with chronic fatigue syndrome.

[Chronic fatigue syndrome--psychiatric aspects].

Development and application of HHV-6 antigen capture assay for the detection of HHV-6 infections.

["Prolonged" decay test and auditory brainstem responses in the clinical diagnosis of the chronic fatigue syndrome].

[Pathogenicity of fungi in the intestines--current status of the discussion].

Are echoviruses still orphans?

Epstein-Barr virus-related primary cutaneous amyloidosis. Successful treatment with acyclovir and interferon-alpha.

Missing the meaning and provoking resistance; a case of myalgic encephalomyelitis.

Simian cytomegalovirus-related stealth virus isolated from the cerebrospinal fluid of a patient with bipolar psychosis and acute encephalopathy.

Investigation by polymerase chain reaction of enteroviral infection in patients with chronic fatigue syndrome.

Short-term night-shift working mimics the pituitary-adrenocortical dysfunction in chronic fatigue syndrome.

Neurobiology of chronic fatigue syndrome.

Viral arthritis.

The use of transfer factors in chronic fatigue syndrome: prospects and problems.

[Chronic fatigue syndrome. Definition, diagnostic measures and therapeutic possibilities].

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