ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

2081–2100 of 2,423 studies

E3 PreliminaryMechanismPEM unclearCross-Sectional

Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome.

Regland, B, Andersson, M, Abrahamsson, L et al.·Scandinavian journal of rheumatology·1997

Researchers tested the spinal fluid of 12 women who had both fibromyalgia and ME/CFS and found unusually high levels of a molecule called homocysteine in their brains and spinal cords. They also noticed that patients with lower vitamin B12 levels in their spinal fluid reported more severe fatigue. This suggests that a vitamin B12 deficiency might prevent the body from properly breaking down homocysteine, which could contribute to symptoms like exhaustion.

Energy Metabolism

E3 PreliminaryBehavioralPEM not requiredCase-Control

A body with chronic fatigue syndrome as a battleground for the fight to separate from the mother.

Simpson, M·The Journal of analytical psychology·1997

This study describes the therapy of one 20-year-old woman who experienced concentration and memory difficulties she attributed to ME/CFS. Through dream analysis and psychological exploration, a therapist found that her symptoms may have been connected to unresolved emotional conflicts with her mother. After working through these psychological issues in therapy, her symptoms improved.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Decreased postexercise facilitation of motor evoked potentials in patients with chronic fatigue syndrome or depression.

Samii, A, Wassermann, E M, Ikoma, K et al.·Neurology·1996

This study measured how the brain's motor cortex responds to exercise using magnetic stimulation in people with ME/CFS, depressed patients, and healthy controls. After exercise, healthy people showed a much stronger increase in brain activity (218%), while ME/CFS patients showed a weaker increase (126%), suggesting their brains may not respond as vigorously to physical exertion as they should.

Post-Exertional Malaise

E3 PreliminaryCohortPEM not requiredObservational

[Multiple chemical sensitivity disorder in patients with neurotoxic illnesses].

Lohmann, K, Pröhl, A, Schwarz, E·Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany))·1996

This study looked at 466 people who had neurological symptoms from toxic chemical exposure and found that 136 of them also had Multiple Chemical Sensitivity (MCS)—a condition where people react strongly to low levels of chemicals. The researchers found that wood preservatives, solvents, and formaldehyde were common culprits, and people with MCS were more likely to have chronic fatigue symptoms and allergies than those without MCS.

Pain and Sensitization

E3 PreliminaryReviewPEM not requiredReview-Narrative

Research on cognitive complaints and cognitive functioning in patients with chronic fatigue syndrome (CFS): What conclusions can we draw?

Wearden, A J, Appleby, L·Journal of psychosomatic research·1996

People with ME/CFS often report problems with memory and concentration, but when researchers test their cognitive abilities in the lab, they don't find major deficits. This review suggests the gap between what patients experience and what tests show might be because lab tests don't measure 'real-world' thinking very well. In ME/CFS, everyday mental tasks may be using up so much energy that patients have less mental flexibility left over for other things.

Cognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Endocrinopathy in the differential diagnosis of chronic fatigue syndrome].

Sterzl, I, Zamrazil, V·Vnitrni lekarstvi·1996

This review discusses how disorders of the endocrine system (hormone-producing glands) can cause fatigue and other symptoms that overlap with ME/CFS, making them difficult to distinguish. The authors highlight that some patients initially thought to have ME/CFS actually have treatable hormone conditions, particularly autoimmune thyroid disease or other glandular disorders. They also explore how problems with the stress-hormone system (the hypothalamus-pituitary-adrenal axis) might play a role in both endocrine disease and ME/CFS.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome. Definition, diagnostic measures and therapeutic possibilities].

Lieb, K, Dammann, G, Berger, M et al.·Der Nervenarzt·1996

ME/CFS is a disorder that causes persistent tiredness, but doctors cannot diagnose it with a simple blood test or scan. Instead, doctors use specific clinical criteria to identify the condition, while carefully ruling out other illnesses like depression or sleep problems that can look similar. Currently, there is no cure for ME/CFS, so treatment focuses on managing individual symptoms like poor sleep, pain, and mood changes with a combination of medical care and psychological support.

Pain and SensitizationSleepDiagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Neuroimmune and neuropsychiatric aspects of chronic fatigue syndrome.

Krupp, L B, Pollina, D·Advances in neuroimmunology·1996

This review examined how the immune system and nervous system may both contribute to ME/CFS symptoms. The authors looked at evidence that ME/CFS involves both brain-based changes and immune system dysfunction, which could explain why patients experience fatigue, cognitive problems, and mood changes.

Immune System

E3 PreliminaryGuidelinePEM unclearGuideline

The chronic fatigue syndrome: a position paper.

Salit, I E·The Journal of rheumatology·1996

This is a position paper from a medical expert on chronic fatigue syndrome (ME/CFS) published in a rheumatology journal in 1996. Rather than presenting new research data, the author provides professional guidance and recommendations on how to understand and approach ME/CFS as a medical condition. This type of paper helps establish clinical standards and best practices for doctors treating patients with ME/CFS.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome].

Rouillon, F, Delhommeau, L, Vinceneux, P·Presse medicale (Paris, France : 1983)·1996

This review examines chronic fatigue syndrome (CFS), a condition where people experience lasting, unexplained tiredness that interferes with daily life. The condition has been recognized for over a century under different names. Currently, doctors and researchers don't fully understand what causes CFS, though it may involve viral infections, immune system problems, or psychiatric factors. Most treatments tested so far have shown limited effectiveness.

Interventions

E3 PreliminaryReviewPEM unclearReview-Narrative

Are echoviruses still orphans?

Hill, W M·British journal of biomedical science·1996

This review examines echoviruses, a family of common viruses that can cause outbreaks of illness around the world. The authors note that since polio has become rare, doctors have noticed more cases of non-polio enteroviruses (a related group of viruses) being linked to myalgic encephalomyelitis (ME) and post-viral fatigue syndrome. Different types of echoviruses tend to cause different patterns of illness in different populations.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Increased prolactin response to buspirone in chronic fatigue syndrome.

Sharpe, M, Clements, A, Hawton, K et al.·Journal of affective disorders·1996

Researchers gave a medication called buspirone to people with ME/CFS and healthy volunteers to see how their bodies would respond. People with ME/CFS had higher levels of a hormone called prolactin and experienced more nausea than the healthy group. This suggests that the brains of people with ME/CFS may process certain chemicals differently, particularly those involved in mood and nerve signaling.

Endocrine Disruption

E3 PreliminaryMechanismPEM not requiredObservational

Short-term night-shift working mimics the pituitary-adrenocortical dysfunction in chronic fatigue syndrome.

Leese, G, Chattington, P, Fraser, W et al.·The Journal of clinical endocrinology and metabolism·1996

This study found that nurses who worked night shifts for just 5 days showed abnormal stress hormone patterns similar to those seen in ME/CFS patients. Specifically, their bodies produced high levels of one stress hormone (ACTH) but low levels of another (cortisol) during night shifts. This suggests that disrupted sleep and routine alone may be enough to trigger the hormone imbalances characteristic of ME/CFS.

Sleep

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome.

Sharpe, M·The Psychiatric clinics of North America·1996

ME/CFS is a serious illness that causes extreme tiredness, difficulty concentrating, muscle pain, and other physical symptoms that doctors cannot fully explain with standard tests. This review explains that ME/CFS involves both real physical changes in the body and emotional or social factors that affect how someone experiences the illness. The best approach to treating ME/CFS is to carefully assess each person's unique situation rather than debating whether it's purely medical or psychiatric.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Fibromyalgia syndrome: a review.

Reiffenberger, D H, Amundson, L H·American family physician·1996

Fibromyalgia syndrome is a chronic condition characterized by widespread pain, stiffness, and tender points in muscles and soft tissues, often accompanied by fatigue and sleep problems. It affects women more than men, typically starting around age 49. Treatment combines medication (like certain antidepressants), education, reassurance, and exercise to help manage symptoms.

Pain and SensitizationSleep

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Autoantibodies to nuclear envelope antigens in chronic fatigue syndrome.

Konstantinov, K, von Mikecz, A, Buchwald, D et al.·The Journal of clinical investigation·1996

Researchers found that about half of ME/CFS patients had antibodies (immune proteins) in their blood that attack a protein called lamin B1 found in the nucleus of cells. This suggests that ME/CFS may involve the immune system mistakenly attacking the body's own cells. This discovery provides evidence that autoimmunity—when the body's defense system malfunctions—may play a role in ME/CFS.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Neurobiology of chronic fatigue syndrome.

Gonzalez, M B, Cousins, J C, Doraiswamy, P M·Progress in neuro-psychopharmacology & biological psychiatry·1996

This review article examines what happens in the brain and nervous system of people with ME/CFS. Researchers found that ME/CFS involves real biological changes in the brain—not just fatigue—including problems with mood, thinking, and hormone regulation. The study suggests that ME/CFS is a neurological condition with measurable differences in brain function, rather than purely psychological.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports.

Wiebe, E·Canadian family physician Medecin de famille canadien·1996

This study looked at two individual ME/CFS patients to see which treatments might help them personally. One patient tried high-dose vitamin B12 injections but they didn't help. Another patient tried a medication called nimodipine and found it worked very well for them. The doctors used a special testing method called N of 1 trials, where treatments are tested in one person at a time to see what actually helps that specific individual.

Interventions

E3 PreliminaryMechanismPEM not requiredMechanistic

Genetic instability and fragmentation of a stealth viral genome.

Martin, W J·Pathobiology : journal of immunopathology, molecular and cellular biology·1996

Researchers studied a virus found in a patient with chronic fatigue syndrome (ME/CFS) and discovered it has an unusual fragmented structure with many genetic errors. The virus appears to be related to cytomegalovirus but is much less organized, splitting into small pieces rather than staying intact. These genetic defects in the virus might actually help the body fight it off and recover from illness.

E3 PreliminaryCommentaryPEM not requiredEditorial

The use of transfer factors in chronic fatigue syndrome: prospects and problems.

Levine, P H·Biotherapy (Dordrecht, Netherlands)·1996

ME/CFS often starts with a viral infection and some people have ongoing herpes virus activity. This article discusses transfer factors—a type of immune therapy—that might help fight these viruses and improve symptoms. The authors explain why we need better-designed studies to test if this treatment actually works.

Immune System

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Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome.

A body with chronic fatigue syndrome as a battleground for the fight to separate from the mother.

Decreased postexercise facilitation of motor evoked potentials in patients with chronic fatigue syndrome or depression.

[Multiple chemical sensitivity disorder in patients with neurotoxic illnesses].

Research on cognitive complaints and cognitive functioning in patients with chronic fatigue syndrome (CFS): What conclusions can we draw?

[Endocrinopathy in the differential diagnosis of chronic fatigue syndrome].

[Chronic fatigue syndrome. Definition, diagnostic measures and therapeutic possibilities].

Neuroimmune and neuropsychiatric aspects of chronic fatigue syndrome.

The chronic fatigue syndrome: a position paper.

[Chronic fatigue syndrome].

Are echoviruses still orphans?

Increased prolactin response to buspirone in chronic fatigue syndrome.

Short-term night-shift working mimics the pituitary-adrenocortical dysfunction in chronic fatigue syndrome.

Chronic fatigue syndrome.

Fibromyalgia syndrome: a review.

Autoantibodies to nuclear envelope antigens in chronic fatigue syndrome.

Neurobiology of chronic fatigue syndrome.

N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports.

Genetic instability and fragmentation of a stealth viral genome.

The use of transfer factors in chronic fatigue syndrome: prospects and problems.

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