ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

2081–2100 of 2,422 studies

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

Chronic fatigue syndrome: a qualitative investigation of patients' beliefs about the illness.

Clements, A, Sharpe, M, Simkin, S et al.·Journal of psychosomatic research·1997

This study interviewed 66 people with ME/CFS to understand what they believe causes their illness and how they think they can manage it. Most patients believed their illness was primarily physical, though over half also thought stress played a role. Patients felt they could control symptoms by reducing activity, but believed they could not influence the underlying disease itself.

E3 PreliminaryReviewPEM unclearReview-Narrative

Evidence that abnormalities of central neurohormonal systems are key to understanding fibromyalgia and chronic fatigue syndrome.

Crofford, L J, Demitrack, M A·Rheumatic diseases clinics of North America·1996

This study explores how stress-response systems in the brain and body may be broken in people with fibromyalgia and chronic fatigue syndrome (ME/CFS). Both conditions often start after stressful events and get worse during stressful times. The researchers found that the brain's main stress-management system—called the hypothalamic-pituitary-adrenal (HPA) axis—does not work normally in these patients, which could explain why their symptoms worsen with stress.

Endocrine Disruption

E3 PreliminaryCohortPEM not requiredCase-Control

Use of anti HHV-6 transfer factor for the treatment of two patients with chronic fatigue syndrome (CFS). Two case reports.

Ablashi, D V, Levine, P H, De Vinci, C et al.·Biotherapy (Dordrecht, Netherlands)·1996

This small study tested whether a special immune treatment called transfer factor, designed to target HHV-6 (a virus that may be active in some ME/CFS patients), could help. Two ME/CFS patients with active HHV-6 infection received this treatment. One patient improved significantly and returned to normal activities within weeks, but the other patient saw no improvement. The results suggest this treatment might help control HHV-6 in some patients, but more research is needed.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Endocrinopathy in the differential diagnosis of chronic fatigue syndrome].

Sterzl, I, Zamrazil, V·Vnitrni lekarstvi·1996

This review discusses how disorders of the endocrine system (hormone-producing glands) can cause fatigue and other symptoms that overlap with ME/CFS, making them difficult to distinguish. The authors highlight that some patients initially thought to have ME/CFS actually have treatable hormone conditions, particularly autoimmune thyroid disease or other glandular disorders. They also explore how problems with the stress-hormone system (the hypothalamus-pituitary-adrenal axis) might play a role in both endocrine disease and ME/CFS.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome. Definition, diagnostic measures and therapeutic possibilities].

Lieb, K, Dammann, G, Berger, M et al.·Der Nervenarzt·1996

ME/CFS is a disorder that causes persistent tiredness, but doctors cannot diagnose it with a simple blood test or scan. Instead, doctors use specific clinical criteria to identify the condition, while carefully ruling out other illnesses like depression or sleep problems that can look similar. Currently, there is no cure for ME/CFS, so treatment focuses on managing individual symptoms like poor sleep, pain, and mood changes with a combination of medical care and psychological support.

Pain and SensitizationSleepDiagnostics

E3 PreliminaryMechanismPEM unclearObservational

Influence of immediate hypersensitivity skin reactions on delayed reactions in patients with chronic fatigue syndrome.

Steinberg, P, Pheley, A, Peterson, P K·The Journal of allergy and clinical immunology·1996

This study looked at how immediate allergic skin reactions (like those that happen within minutes of allergen exposure) might affect delayed allergic reactions (which develop over hours or days) in people with ME/CFS. Researchers were investigating whether the immune system's early response to allergens could influence its later response in this patient population. Understanding these connections may help explain why some ME/CFS patients experience unusual or prolonged allergic reactions.

Immune System

E3 PreliminaryCohortPEM not requiredObservational

[Multiple chemical sensitivity disorder in patients with neurotoxic illnesses].

Lohmann, K, Pröhl, A, Schwarz, E·Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany))·1996

This study looked at 466 people who had neurological symptoms from toxic chemical exposure and found that 136 of them also had Multiple Chemical Sensitivity (MCS)—a condition where people react strongly to low levels of chemicals. The researchers found that wood preservatives, solvents, and formaldehyde were common culprits, and people with MCS were more likely to have chronic fatigue symptoms and allergies than those without MCS.

Pain and Sensitization

E3 PreliminaryReviewPEM unclearReview-Narrative

Infectious agents and immunological disturbances in relation to chronic fatigue syndrome.

Tripathy, B K, Agarwal, A K, Sangla, K S et al.·The Journal of the Association of Physicians of India·1996

This review article examines the connection between infections and immune system problems in ME/CFS. The authors looked at existing research to understand whether certain germs or viruses might trigger the condition, and how the immune system behaves differently in people with ME/CFS compared to healthy individuals.

Immune System

E3 PreliminaryMechanismPEM not requiredObservational

Short-term night-shift working mimics the pituitary-adrenocortical dysfunction in chronic fatigue syndrome.

Leese, G, Chattington, P, Fraser, W et al.·The Journal of clinical endocrinology and metabolism·1996

This study found that nurses who worked night shifts for just 5 days showed abnormal stress hormone patterns similar to those seen in ME/CFS patients. Specifically, their bodies produced high levels of one stress hormone (ACTH) but low levels of another (cortisol) during night shifts. This suggests that disrupted sleep and routine alone may be enough to trigger the hormone imbalances characteristic of ME/CFS.

Sleep

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome: a stress disorder?

Cleare, A J, Wessely, S C·British journal of hospital medicine·1996

This paper explores whether ME/CFS might be connected to stress and how the body responds to stress. The authors examine the evidence around the relationship between stress responses and ME/CFS symptoms, considering whether stress-related factors play a role in the condition's development or persistence.

Endocrine Disruption

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Autoantibodies to nuclear envelope antigens in chronic fatigue syndrome.

Konstantinov, K, von Mikecz, A, Buchwald, D et al.·The Journal of clinical investigation·1996

Researchers found that about half of ME/CFS patients had antibodies (immune proteins) in their blood that attack a protein called lamin B1 found in the nucleus of cells. This suggests that ME/CFS may involve the immune system mistakenly attacking the body's own cells. This discovery provides evidence that autoimmunity—when the body's defense system malfunctions—may play a role in ME/CFS.

Immune System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Increased prolactin response to buspirone in chronic fatigue syndrome.

Sharpe, M, Clements, A, Hawton, K et al.·Journal of affective disorders·1996

Researchers gave a medication called buspirone to people with ME/CFS and healthy volunteers to see how their bodies would respond. People with ME/CFS had higher levels of a hormone called prolactin and experienced more nausea than the healthy group. This suggests that the brains of people with ME/CFS may process certain chemicals differently, particularly those involved in mood and nerve signaling.

Endocrine Disruption

E3 PreliminaryReviewPEM unclearReview-Narrative

Neuroimmune and neuropsychiatric aspects of chronic fatigue syndrome.

Krupp, L B, Pollina, D·Advances in neuroimmunology·1996

This review examined how the immune system and nervous system may both contribute to ME/CFS symptoms. The authors looked at evidence that ME/CFS involves both brain-based changes and immune system dysfunction, which could explain why patients experience fatigue, cognitive problems, and mood changes.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

Riedel's thyroiditis: treatment with tamoxifen.

Few, J, Thompson, N W, Angelos, P et al.·Surgery·1996

Riedel's thyroiditis is a rare disease where fibrous tissue hardens in the thyroid gland, causing breathing problems, difficulty swallowing, and chronic fatigue. This small study found that four patients with this condition improved significantly when treated with a drug called tamoxifen, even though surgery and steroid medications had not worked well before.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Fibromyalgia syndrome and chronic fatigue syndrome. Similarities and differences].

Hoffmann, A, Linder, R, Kröger, B et al.·Deutsche medizinische Wochenschrift (1946)·1996

This study compared fibromyalgia syndrome and chronic fatigue syndrome (ME/CFS) to understand how they are similar and how they differ. Researchers examined patients with both conditions to identify shared symptoms and unique characteristics that could help doctors better recognize and distinguish between them.

E3 PreliminaryGuidelinePEM unclearGuideline

The chronic fatigue syndrome: a position paper.

Salit, I E·The Journal of rheumatology·1996

This is a position paper from a medical expert on chronic fatigue syndrome (ME/CFS) published in a rheumatology journal in 1996. Rather than presenting new research data, the author provides professional guidance and recommendations on how to understand and approach ME/CFS as a medical condition. This type of paper helps establish clinical standards and best practices for doctors treating patients with ME/CFS.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Are echoviruses still orphans?

Hill, W M·British journal of biomedical science·1996

This review examines echoviruses, a family of common viruses that can cause outbreaks of illness around the world. The authors note that since polio has become rare, doctors have noticed more cases of non-polio enteroviruses (a related group of viruses) being linked to myalgic encephalomyelitis (ME) and post-viral fatigue syndrome. Different types of echoviruses tend to cause different patterns of illness in different populations.

E3 PreliminaryCommentaryPEM not requiredEditorial

Periodic limb movements of sleep and the restless legs syndrome.

Williams, D C·Virginia medical quarterly : VMQ·1996

This article examines periodic limb movements during sleep and restless legs syndrome, which are not diseases themselves but signs that something is disturbing the nervous system. The author suggests these conditions may be related to ME/CFS and other disorders, and that they arise from problems in a brainstem region that controls smooth sleep and wakefulness. Various treatments can help reduce symptoms and improve sleep quality.

Sleep

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Decreased postexercise facilitation of motor evoked potentials in patients with chronic fatigue syndrome or depression.

Samii, A, Wassermann, E M, Ikoma, K et al.·Neurology·1996

This study measured how the brain's motor cortex responds to exercise using magnetic stimulation in people with ME/CFS, depressed patients, and healthy controls. After exercise, healthy people showed a much stronger increase in brain activity (218%), while ME/CFS patients showed a weaker increase (126%), suggesting their brains may not respond as vigorously to physical exertion as they should.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Fibromyalgia syndrome: a review.

Reiffenberger, D H, Amundson, L H·American family physician·1996

Fibromyalgia syndrome is a chronic condition characterized by widespread pain, stiffness, and tender points in muscles and soft tissues, often accompanied by fatigue and sleep problems. It affects women more than men, typically starting around age 49. Treatment combines medication (like certain antidepressants), education, reassurance, and exercise to help manage symptoms.

Pain and SensitizationSleep

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Chronic fatigue syndrome: a qualitative investigation of patients' beliefs about the illness.

Evidence that abnormalities of central neurohormonal systems are key to understanding fibromyalgia and chronic fatigue syndrome.

Use of anti HHV-6 transfer factor for the treatment of two patients with chronic fatigue syndrome (CFS). Two case reports.

[Endocrinopathy in the differential diagnosis of chronic fatigue syndrome].

[Chronic fatigue syndrome. Definition, diagnostic measures and therapeutic possibilities].

Influence of immediate hypersensitivity skin reactions on delayed reactions in patients with chronic fatigue syndrome.

[Multiple chemical sensitivity disorder in patients with neurotoxic illnesses].

Infectious agents and immunological disturbances in relation to chronic fatigue syndrome.

Short-term night-shift working mimics the pituitary-adrenocortical dysfunction in chronic fatigue syndrome.

Chronic fatigue syndrome: a stress disorder?

Autoantibodies to nuclear envelope antigens in chronic fatigue syndrome.

Increased prolactin response to buspirone in chronic fatigue syndrome.

Neuroimmune and neuropsychiatric aspects of chronic fatigue syndrome.

Riedel's thyroiditis: treatment with tamoxifen.

[Fibromyalgia syndrome and chronic fatigue syndrome. Similarities and differences].

The chronic fatigue syndrome: a position paper.

Are echoviruses still orphans?

Periodic limb movements of sleep and the restless legs syndrome.

Decreased postexercise facilitation of motor evoked potentials in patients with chronic fatigue syndrome or depression.

Fibromyalgia syndrome: a review.

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