ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

2101–2120 of 2,423 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

Causes of change in the health of populations: a biopsychosocial viewpoint.

Arnetz, B B·Social science & medicine (1982)·1996

This review article argues that our understanding of disease needs to include not just biological factors, but also psychological and social stressors. The authors suggest that modern work environments—with constant job changes, reorganizations, and high pressure—may be contributing to the rising rates of chronic illnesses like ME/CFS. They propose that the interaction between physical environment, chemical exposures, and stress together affect health in ways that traditional medical models don't fully explain.

E3 PreliminaryCohortPEM not requiredCase-Control

Riedel's thyroiditis: treatment with tamoxifen.

Few, J, Thompson, N W, Angelos, P et al.·Surgery·1996

Riedel's thyroiditis is a rare disease where fibrous tissue hardens in the thyroid gland, causing breathing problems, difficulty swallowing, and chronic fatigue. This small study found that four patients with this condition improved significantly when treated with a drug called tamoxifen, even though surgery and steroid medications had not worked well before.

E3 PreliminaryCohortPEM not requiredCase-Control

Possible relationship between chronic fatigue and postural tachycardia syndromes.

De Lorenzo, F, Hargreaves, J, Kakkar, V V·Clinical autonomic research : official journal of the Clinical Autonomic Research Society·1996

This study looked at five people with ME/CFS who experienced symptoms like dizziness, blurred vision, and heart palpitations when standing up. When these patients were tested while lying on a tilting table that slowly moved them upright, researchers found that their blood pressure dropped and heart rate increased significantly. This suggests that some ME/CFS patients may have a condition called postural tachycardia syndrome, which affects how the body manages blood pressure during position changes.

Autonomic Nervous System

E3 PreliminaryCohortPEM unclearCase-Control

A cluster of cases of chronic fatigue and chronic fatigue syndrome: clinical and immunologic studies.

Levine, P H, Dale, J K, Benson-Grigg, E et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1996

This study examined a group of people who developed chronic fatigue syndrome (ME/CFS), looking at their medical histories and immune system patterns to understand what might have caused their illness. Researchers compared patients with ME/CFS to control groups and measured various immune markers in their blood. The goal was to identify common features that might explain why these individuals became ill.

Immune System

E3 PreliminaryCommentaryPEM not requiredEditorial

Periodic limb movements of sleep and the restless legs syndrome.

Williams, D C·Virginia medical quarterly : VMQ·1996

This article examines periodic limb movements during sleep and restless legs syndrome, which are not diseases themselves but signs that something is disturbing the nervous system. The author suggests these conditions may be related to ME/CFS and other disorders, and that they arise from problems in a brainstem region that controls smooth sleep and wakefulness. Various treatments can help reduce symptoms and improve sleep quality.

Sleep

E3 PreliminaryCohortPEM unclearCross-Sectional

Demonstration of Borna disease virus RNA in peripheral blood mononuclear cells derived from Japanese patients with chronic fatigue syndrome.

Nakaya, T, Takahashi, H, Nakamura, Y et al.·FEBS letters·1996

Researchers tested blood cells from 25 Japanese patients with chronic fatigue syndrome (ME/CFS) to see if a virus called Borna disease virus (BDV) was present. They found evidence of BDV in 3 patients' blood cells and antibodies (immune markers) against BDV in 6 patients, suggesting about 32% of their study group may have been exposed to or infected with this virus. This finding raised the possibility that BDV might be connected to ME/CFS in Japanese patients.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

Use of anti HHV-6 transfer factor for the treatment of two patients with chronic fatigue syndrome (CFS). Two case reports.

Ablashi, D V, Levine, P H, De Vinci, C et al.·Biotherapy (Dordrecht, Netherlands)·1996

This small study tested whether a special immune treatment called transfer factor, designed to target HHV-6 (a virus that may be active in some ME/CFS patients), could help. Two ME/CFS patients with active HHV-6 infection received this treatment. One patient improved significantly and returned to normal activities within weeks, but the other patient saw no improvement. The results suggest this treatment might help control HHV-6 in some patients, but more research is needed.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Genetic instability and fragmentation of a stealth viral genome.

Martin, W J·Pathobiology : journal of immunopathology, molecular and cellular biology·1996

Researchers studied a virus found in a patient with chronic fatigue syndrome (ME/CFS) and discovered it has an unusual fragmented structure with many genetic errors. The virus appears to be related to cytomegalovirus but is much less organized, splitting into small pieces rather than staying intact. These genetic defects in the virus might actually help the body fight it off and recover from illness.

E3 PreliminaryCohortPEM not requiredObservational

[Multiple chemical sensitivity disorder in patients with neurotoxic illnesses].

Lohmann, K, Pröhl, A, Schwarz, E·Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany))·1996

This study looked at 466 people who had neurological symptoms from toxic chemical exposure and found that 136 of them also had Multiple Chemical Sensitivity (MCS)—a condition where people react strongly to low levels of chemicals. The researchers found that wood preservatives, solvents, and formaldehyde were common culprits, and people with MCS were more likely to have chronic fatigue symptoms and allergies than those without MCS.

Pain and Sensitization

E3 PreliminaryReviewPEM not requiredReview-Narrative

Research on cognitive complaints and cognitive functioning in patients with chronic fatigue syndrome (CFS): What conclusions can we draw?

Wearden, A J, Appleby, L·Journal of psychosomatic research·1996

People with ME/CFS often report problems with memory and concentration, but when researchers test their cognitive abilities in the lab, they don't find major deficits. This review suggests the gap between what patients experience and what tests show might be because lab tests don't measure 'real-world' thinking very well. In ME/CFS, everyday mental tasks may be using up so much energy that patients have less mental flexibility left over for other things.

Cognitive Impairment

E3 PreliminaryCohortPEM not requiredCase-Control

Severe stealth virus encephalopathy following chronic-fatigue-syndrome-like illness: clinical and histopathological features.

Martin, W J·Pathobiology : journal of immunopathology, molecular and cellular biology·1996

This study looked at three patients who started with symptoms similar to ME/CFS and then developed severe brain inflammation. Brain tissue samples showed signs of unusual viral infection with damaged cells, but without the typical immune response usually seen in brain infections. Two patients partially recovered over time, while one remained severely disabled for years.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Endocrinopathy in the differential diagnosis of chronic fatigue syndrome].

Sterzl, I, Zamrazil, V·Vnitrni lekarstvi·1996

This review discusses how disorders of the endocrine system (hormone-producing glands) can cause fatigue and other symptoms that overlap with ME/CFS, making them difficult to distinguish. The authors highlight that some patients initially thought to have ME/CFS actually have treatable hormone conditions, particularly autoimmune thyroid disease or other glandular disorders. They also explore how problems with the stress-hormone system (the hypothalamus-pituitary-adrenal axis) might play a role in both endocrine disease and ME/CFS.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome].

Rouillon, F, Delhommeau, L, Vinceneux, P·Presse medicale (Paris, France : 1983)·1996

This review examines chronic fatigue syndrome (CFS), a condition where people experience lasting, unexplained tiredness that interferes with daily life. The condition has been recognized for over a century under different names. Currently, doctors and researchers don't fully understand what causes CFS, though it may involve viral infections, immune system problems, or psychiatric factors. Most treatments tested so far have shown limited effectiveness.

Interventions

E3 PreliminaryReviewPEM unclearReview-Narrative

Are echoviruses still orphans?

Hill, W M·British journal of biomedical science·1996

This review examines echoviruses, a family of common viruses that can cause outbreaks of illness around the world. The authors note that since polio has become rare, doctors have noticed more cases of non-polio enteroviruses (a related group of viruses) being linked to myalgic encephalomyelitis (ME) and post-viral fatigue syndrome. Different types of echoviruses tend to cause different patterns of illness in different populations.

E3 PreliminaryCohortPEM not requiredCase-Control

Epstein-Barr virus-related primary cutaneous amyloidosis. Successful treatment with acyclovir and interferon-alpha.

Drago, F, Ranieri, E, Pastorino, A et al.·The British journal of dermatology·1996

This case report describes a woman with ME/CFS who developed unusual skin lesions (brownish patches and bumps) on her chest and back for 10 years. Doctors found that the Epstein-Barr virus (EBV)—the virus that causes mononucleosis—was active in her skin and other body areas, and abnormal protein deposits were building up in her skin. When she was treated with antiviral medication (acyclovir) and a type of immune-boosting therapy (interferon-alpha), both her skin lesions and other symptoms improved significantly.

Immune System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Increased prolactin response to buspirone in chronic fatigue syndrome.

Sharpe, M, Clements, A, Hawton, K et al.·Journal of affective disorders·1996

Researchers gave a medication called buspirone to people with ME/CFS and healthy volunteers to see how their bodies would respond. People with ME/CFS had higher levels of a hormone called prolactin and experienced more nausea than the healthy group. This suggests that the brains of people with ME/CFS may process certain chemicals differently, particularly those involved in mood and nerve signaling.

Endocrine Disruption

E3 PreliminaryMechanismPEM not requiredObservational

Short-term night-shift working mimics the pituitary-adrenocortical dysfunction in chronic fatigue syndrome.

Leese, G, Chattington, P, Fraser, W et al.·The Journal of clinical endocrinology and metabolism·1996

This study found that nurses who worked night shifts for just 5 days showed abnormal stress hormone patterns similar to those seen in ME/CFS patients. Specifically, their bodies produced high levels of one stress hormone (ACTH) but low levels of another (cortisol) during night shifts. This suggests that disrupted sleep and routine alone may be enough to trigger the hormone imbalances characteristic of ME/CFS.

Sleep

E3 PreliminaryCommentaryPEM unclearCommentary

Missing the meaning and provoking resistance; a case of myalgic encephalomyelitis.

Butler, C, Rollnick, S·Family practice·1996

This study examines a conversation between a doctor and a patient who believed they had ME/CFS. Even though the doctor tried to listen carefully, they didn't fully understand what the diagnosis meant to the patient. The study shows that when doctors don't truly understand what patients mean by their diagnosis, it can damage trust and may slow recovery. The authors suggest that doctors should use reflective listening—repeating back what they hear—to make sure they really understand what patients are experiencing.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Fibromyalgia syndrome: a review.

Reiffenberger, D H, Amundson, L H·American family physician·1996

Fibromyalgia syndrome is a chronic condition characterized by widespread pain, stiffness, and tender points in muscles and soft tissues, often accompanied by fatigue and sleep problems. It affects women more than men, typically starting around age 49. Treatment combines medication (like certain antidepressants), education, reassurance, and exercise to help manage symptoms.

Pain and SensitizationSleep

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome: a stress disorder?

Cleare, A J, Wessely, S C·British journal of hospital medicine·1996

This paper explores whether ME/CFS might be connected to stress and how the body responds to stress. The authors examine the evidence around the relationship between stress responses and ME/CFS symptoms, considering whether stress-related factors play a role in the condition's development or persistence.

Endocrine Disruption

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Causes of change in the health of populations: a biopsychosocial viewpoint.

Riedel's thyroiditis: treatment with tamoxifen.

Possible relationship between chronic fatigue and postural tachycardia syndromes.

A cluster of cases of chronic fatigue and chronic fatigue syndrome: clinical and immunologic studies.

Periodic limb movements of sleep and the restless legs syndrome.

Demonstration of Borna disease virus RNA in peripheral blood mononuclear cells derived from Japanese patients with chronic fatigue syndrome.

Use of anti HHV-6 transfer factor for the treatment of two patients with chronic fatigue syndrome (CFS). Two case reports.

Genetic instability and fragmentation of a stealth viral genome.

[Multiple chemical sensitivity disorder in patients with neurotoxic illnesses].

Research on cognitive complaints and cognitive functioning in patients with chronic fatigue syndrome (CFS): What conclusions can we draw?

Severe stealth virus encephalopathy following chronic-fatigue-syndrome-like illness: clinical and histopathological features.

[Endocrinopathy in the differential diagnosis of chronic fatigue syndrome].

[Chronic fatigue syndrome].

Are echoviruses still orphans?

Epstein-Barr virus-related primary cutaneous amyloidosis. Successful treatment with acyclovir and interferon-alpha.

Increased prolactin response to buspirone in chronic fatigue syndrome.

Short-term night-shift working mimics the pituitary-adrenocortical dysfunction in chronic fatigue syndrome.

Missing the meaning and provoking resistance; a case of myalgic encephalomyelitis.

Fibromyalgia syndrome: a review.

Chronic fatigue syndrome: a stress disorder?

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research