ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

2141–2160 of 2,420 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

Human herpesvirus-7 (HHV-7): current status.

Ablashi, D V, Berneman, Z N, Kramarsky, B et al.·Clinical and diagnostic virology·1995

This review article summarizes what scientists knew about human herpesvirus-7 (HHV-7) as of 1995, a newly discovered virus related to other common herpesviruses. HHV-7 was found in a chronic fatigue syndrome patient, along with healthy people, and is very common in the population (affecting over 85% of Americans). The virus has been linked to a few childhood rash illnesses and possibly some cases with liver involvement, but scientists had limited information about whether it causes ME/CFS.

Immune System

E3 PreliminaryCohortPEM unclearObservational

Cytomegalovirus and Epstein-Barr Virus Infection as a Cause of Chronic Fatigue Syndrome in Travelers to Tropical Countries.

Gascón, J, Marcos, T, Vidal, J et al.·Journal of travel medicine·1995

This study looked at whether two common viruses—cytomegalovirus (CMV) and Epstein-Barr virus (EBV)—might be responsible for causing ME/CFS in people who had traveled to tropical regions. The researchers observed a group of travelers and tracked whether those infected with these viruses developed chronic fatigue symptoms similar to ME/CFS.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue.

Smets, E M, Garssen, B, Bonke, B et al.·Journal of psychosomatic research·1995

Researchers created and tested a questionnaire called the Multidimensional Fatigue Inventory (MFI) to measure different types of fatigue people experience. The 20-question survey asks about general tiredness, physical exhaustion, mental tiredness, motivation, and activity levels. When they tested it with various groups—including people with chronic fatigue syndrome—the questionnaire worked well and reliably measured fatigue in all groups.

E3 PreliminaryTrialPEM not requiredRCT

Interferon alfa-2b versus no maintenance therapy during the plateau phase in multiple myeloma: a randomized study. Cooperative Study Group.

Westin, J, Rödjer, S, Turesson, I et al.·British journal of haematology·1995

This study tested whether a drug called interferon alfa-2b could help multiple myeloma patients (a type of blood cancer) stay in remission longer after their initial treatment. Patients who received interferon stayed in remission for about 14 months compared to 6 months for those who didn't, but both groups lived about the same length of time overall.

E3 PreliminaryBehavioralPEM not requiredCase-Control

Chronic fatigue syndrome associated with a psychotic state resulting in multiple murders.

Ghahramani, M, Gooriah, V·The Bulletin of the American Academy of Psychiatry and the Law·1995

This case study describes a young man who developed severe fatigue and depression following infectious mononucleosis, and later experienced a serious mental health crisis involving psychosis and grandiose delusions. The case highlights how severe infections can sometimes lead to complex psychiatric symptoms that took considerable time to properly diagnose and treat with antipsychotic medications.

E3 PreliminaryReviewPEM unclearReview-Narrative

The pathogenesis of chronic pain and fatigue syndromes, with special reference to fibromyalgia.

Clauw, D J·Medical hypotheses·1995

This paper reviews what doctors and researchers knew in 1995 about fibromyalgia and similar conditions that cause chronic pain and tiredness. The authors noticed that fibromyalgia overlaps significantly with chronic fatigue syndrome, migraines, irritable bowel syndrome, and mood disorders, suggesting these conditions may share common underlying causes rather than being completely separate diseases.

SleepAutonomic Nervous System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Corticotropin releasing hormone in the pathophysiology of melancholic and atypical depression and in the mechanism of action of antidepressant drugs.

Gold, P W, Licinio, J, Wong, M L et al.·Annals of the New York Academy of Sciences·1995

This research examines how the stress hormone system works differently in people with depression and chronic fatigue syndrome. The study found that while some people with depression have too much cortisol (a stress hormone), others—particularly those with fatigue-related conditions—may have too little activity in the part of the brain that normally triggers this hormone. This suggests that different types of depression and fatigue conditions might involve different problems with the body's stress response system.

Endocrine Disruption

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Vestibular function test anomalies in patients with chronic fatigue syndrome.

Ash-Bernal, R, Wall, C, Komaroff, A L et al.·Acta oto-laryngologica·1995

Many people with ME/CFS experience dizziness and balance problems, but doctors weren't sure where these problems originated in the body. This study tested the balance and inner ear function of 11 ME/CFS patients using specialized equipment and found several abnormalities—particularly difficulty with tests that rely heavily on the inner ear and brain working together. The pattern of results suggested the problem may be in how the brain processes balance signals rather than damage to the inner ear itself.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Reversible and selective inhibitors of monoamine oxidase A in mental and other disorders.

Priest, R G, Gimbrett, R, Roberts, M et al.·Acta psychiatrica Scandinavica. Supplementum·1995

This review examines moclobemide and similar medications called RIMAs, which work by affecting brain chemicals involved in mood. The medication has proven effective for depression and is being tested in chronic fatigue syndrome (ME/CFS). Researchers note it may also help with anxiety, social phobia, and other conditions, with fewer side effects than older antidepressants.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome--a review of the literature].

Hamre, H J·Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·1995

ME/CFS is a real medical condition that causes extreme tiredness, low-grade fevers, sore throats, and pain in joints and muscles, often starting after a flu-like illness. Exercise makes symptoms significantly worse. While doctors don't yet have a single blood test to diagnose it, research shows patients may have problems with brain blood flow, immune system issues, and mitochondrial (cellular energy) abnormalities.

Immune SystemPost-Exertional Malaise

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Determination of observer-rated alpha activity during sleep.

Flanigan, M J, Morehouse, R L, Shapiro, C M·Sleep·1995

Many ME/CFS patients have been reported to show a particular brain wave pattern called 'alpha intrusion' during sleep, which may contribute to poor sleep quality. This study examined whether the way researchers measure brain waves during sleep affects whether they can detect this pattern. The researchers found that the type of electrode placement and reference point used significantly influenced whether alpha waves were observed, suggesting that previous findings about alpha intrusion in ME/CFS patients may depend heavily on the measurement method used.

Sleep

E3 PreliminaryMechanismPEM not requiredMechanistic

Phylogenetic analysis of short enteroviral sequences from patients with chronic fatigue syndrome.

Galbraith, D N, Nairn, C, Clements, G B·The Journal of general virology·1995

Researchers looked for enterovirus genetic material in ME/CFS patients and compared it to viruses found in people with acute infections. Using genetic analysis, they found that most of the virus sequences from ME/CFS patients were novel and distinct from known enteroviruses. This suggests that some ME/CFS patients may have persistent enterovirus infections that are different from typical acute infections.

E3 PreliminaryMechanismPEM not requiredCase-Control

Electron-microscopic investigation of muscle mitochondria in chronic fatigue syndrome.

Plioplys, A V, Plioplys, S·Neuropsychobiology·1995

This study examined muscle tissue from CFS patients under a powerful microscope to look for damage to mitochondria (the energy-producing structures in cells). Researchers compared 15 CFS patients with 15 healthy people and found no visible structural differences in the mitochondria between the two groups, even though CFS causes severe fatigue and weakness.

Energy Metabolism

E3 PreliminaryCohortPEM not requiredCross-Sectional

[Auditory brain stem evoked potentials in the evaluation of chronic fatigue syndrome].

Bianchedi, M, Croce, A, Moretti, A et al.·Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale·1995

Researchers tested a special hearing test on people with ME/CFS to see if it could find differences in how their brainstem (the lower part of the brain) processes sound. They used two types of sound frequencies—slow and fast clicking sounds—while measuring brain electrical activity. The fast clicking test found unusual patterns in about 64% of people with confirmed ME/CFS, but not in people without ME/CFS, suggesting this test might help identify the condition.

E3 PreliminaryCohortPEM not required

Neuroretinitis, aseptic meningitis, and lymphadenitis associated with Bartonella (Rochalimaea) henselae infection in immunocompetent patients and patients infected with human immunodeficiency virus type 1.

Wong, M T, Dolan, M J, Lattuada, C P et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1995

This study examined patients infected with Bartonella henselae, a bacteria spread by cat scratches and bites, which can cause lymph node swelling, eye inflammation, fever, and meningitis (brain membrane inflammation). Researchers found 23 patients with this infection, many of whom had been exposed to cats. Notably, one patient presented with a chronic fatigue syndrome-like illness, suggesting this bacterial infection might sometimes resemble ME/CFS symptoms.

E3 PreliminaryCommentaryPEM unclearEditorial

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Goldenberg, D L·Current opinion in rheumatology·1995

This review article examines fibromyalgia, chronic fatigue syndrome, and related muscle pain conditions. Research using specialized magnetic imaging showed that muscle damage is not the main problem in fibromyalgia. Scientists are now focusing on how the brain and nervous system may be involved in these conditions, using new technologies to better understand what causes them.

E3 PreliminaryCohortPEM not requiredCase-Control

Chronic active Epstein-Barr virus disease in a case of persistent polyclonal B-cell lymphocytosis.

Mitterer, M, Pescosta, N, Fend, F et al.·British journal of haematology·1995

This report describes one patient who had an unusual blood disorder involving too many B cells (immune cells) along with symptoms resembling chronic fatigue syndrome, including persistent tiredness and recurring skin rashes. Testing showed the patient had a chronic active Epstein-Barr virus (EBV) infection with the virus actively replicating in their blood cells. The researchers suggest that persistent EBV replication may play a role in developing this lymphoproliferative disorder.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Clinical aspects and neurologic expert assessment in sequelae of whiplash injury to the cervical spine].

Jenzer, G·Der Nervenarzt·1995

This review examined whiplash injuries to the neck and the long-term complications some patients develop, called chronic whiplash syndrome. The authors found that whiplash injuries can cause a complex mix of symptoms similar to those seen in chronic fatigue syndrome and fibromyalgia, making diagnosis challenging. Most people recover well from whiplash, though some experience prolonged difficulties.

Diagnostics

E3 PreliminaryMechanismPEM not requiredMechanistic

African green monkey origin of the atypical cytopathic 'stealth virus' isolated from a patient with chronic fatigue syndrome.

Martin, W J, Ahmed, K N, Zeng, L C et al.·Clinical and diagnostic virology·1995

Researchers found a virus in a chronic fatigue syndrome patient that resembled cytomegalovirus but had unusual characteristics. By comparing the virus's genetic code to known viruses in databases, they discovered it was most similar to a virus found in African green monkeys, suggesting this may be its original source.

E3 PreliminaryBehavioralPEM not requiredObservational

Chronic fatigue syndrome: a cognitive approach.

Surawy, C, Hackmann, A, Hawton, K et al.·Behaviour research and therapy·1995

This study looked at what ME/CFS patients were thinking and believing about their symptoms, and how these thoughts might play a role in the condition. Researchers listened to patients' own descriptions of their fatigue and the thoughts that came with it, then tested whether a talking therapy called cognitive behavioural therapy (CBT) could help. The study suggests that the way patients think about their symptoms might be part of what keeps them sick.

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Evidence browser

Human herpesvirus-7 (HHV-7): current status.

Cytomegalovirus and Epstein-Barr Virus Infection as a Cause of Chronic Fatigue Syndrome in Travelers to Tropical Countries.

The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue.

Interferon alfa-2b versus no maintenance therapy during the plateau phase in multiple myeloma: a randomized study. Cooperative Study Group.

Chronic fatigue syndrome associated with a psychotic state resulting in multiple murders.

The pathogenesis of chronic pain and fatigue syndromes, with special reference to fibromyalgia.

Corticotropin releasing hormone in the pathophysiology of melancholic and atypical depression and in the mechanism of action of antidepressant drugs.

Vestibular function test anomalies in patients with chronic fatigue syndrome.

Reversible and selective inhibitors of monoamine oxidase A in mental and other disorders.

[Chronic fatigue syndrome--a review of the literature].

Determination of observer-rated alpha activity during sleep.

Phylogenetic analysis of short enteroviral sequences from patients with chronic fatigue syndrome.

Electron-microscopic investigation of muscle mitochondria in chronic fatigue syndrome.

[Auditory brain stem evoked potentials in the evaluation of chronic fatigue syndrome].

Neuroretinitis, aseptic meningitis, and lymphadenitis associated with Bartonella (Rochalimaea) henselae infection in immunocompetent patients and patients infected with human immunodeficiency virus type 1.

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Chronic active Epstein-Barr virus disease in a case of persistent polyclonal B-cell lymphocytosis.

[Clinical aspects and neurologic expert assessment in sequelae of whiplash injury to the cervical spine].

African green monkey origin of the atypical cytopathic 'stealth virus' isolated from a patient with chronic fatigue syndrome.

Chronic fatigue syndrome: a cognitive approach.

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