ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

2141–2160 of 2,422 studies

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Determination of observer-rated alpha activity during sleep.

Flanigan, M J, Morehouse, R L, Shapiro, C M·Sleep·1995

Many ME/CFS patients have been reported to show a particular brain wave pattern called 'alpha intrusion' during sleep, which may contribute to poor sleep quality. This study examined whether the way researchers measure brain waves during sleep affects whether they can detect this pattern. The researchers found that the type of electrode placement and reference point used significantly influenced whether alpha waves were observed, suggesting that previous findings about alpha intrusion in ME/CFS patients may depend heavily on the measurement method used.

Sleep

E3 PreliminaryReviewPEM unclearReview-Narrative

The pathogenesis of chronic pain and fatigue syndromes, with special reference to fibromyalgia.

Clauw, D J·Medical hypotheses·1995

This paper reviews what doctors and researchers knew in 1995 about fibromyalgia and similar conditions that cause chronic pain and tiredness. The authors noticed that fibromyalgia overlaps significantly with chronic fatigue syndrome, migraines, irritable bowel syndrome, and mood disorders, suggesting these conditions may share common underlying causes rather than being completely separate diseases.

SleepAutonomic Nervous System

E3 PreliminaryMechanismPEM not requiredMechanistic

Phylogenetic analysis of short enteroviral sequences from patients with chronic fatigue syndrome.

Galbraith, D N, Nairn, C, Clements, G B·The Journal of general virology·1995

Researchers looked for enterovirus genetic material in ME/CFS patients and compared it to viruses found in people with acute infections. Using genetic analysis, they found that most of the virus sequences from ME/CFS patients were novel and distinct from known enteroviruses. This suggests that some ME/CFS patients may have persistent enterovirus infections that are different from typical acute infections.

E3 PreliminaryCommentaryPEM unclearEditorial

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Goldenberg, D L·Current opinion in rheumatology·1995

This review article examines fibromyalgia, chronic fatigue syndrome, and related muscle pain conditions. Research using specialized magnetic imaging showed that muscle damage is not the main problem in fibromyalgia. Scientists are now focusing on how the brain and nervous system may be involved in these conditions, using new technologies to better understand what causes them.

E3 PreliminaryCohortPEM unclear

Chronic fatigue syndrome.

Krilov, L R·Pediatric annals·1995

This 1995 study examined chronic fatigue syndrome (ME/CFS) in children by comparing cases with controls. The research aimed to better understand how this condition affects young patients. As a case-control study, it looked at differences between children who had ME/CFS and those who didn't to identify important patterns.

E3 PreliminaryReviewPEM unclearReview-Narrative

Fatigue brought on by malfunction of the central and peripheral nervous systems.

McComas, A J, Miller, R G, Gandevia, S C·Advances in experimental medicine and biology·1995

This review examines why people with nervous system disorders experience extreme tiredness and weakness. The authors looked at several conditions—including post-polio syndrome, multiple sclerosis, spinal cord injury, ALS, and ME/CFS—and found that damage to nerves can make muscles tire much more easily than normal. Lack of physical activity can make this problem worse over time.

E3 PreliminaryTrialPEM not requiredRCT

Interferon alfa-2b versus no maintenance therapy during the plateau phase in multiple myeloma: a randomized study. Cooperative Study Group.

Westin, J, Rödjer, S, Turesson, I et al.·British journal of haematology·1995

This study tested whether a drug called interferon alfa-2b could help multiple myeloma patients (a type of blood cancer) stay in remission longer after their initial treatment. Patients who received interferon stayed in remission for about 14 months compared to 6 months for those who didn't, but both groups lived about the same length of time overall.

E3 PreliminaryGuidelinePEM not requiredGuideline

Chronic fatigue syndrome. Committee for Science and Education, Medical Association of South Africa.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·1995

A group of South African medical experts created guidelines to help doctors recognize and treat chronic fatigue syndrome (CFS). The guidelines outline what symptoms and test results might help diagnose CFS, and suggest reasonable ways to manage the condition while keeping costs reasonable. However, the experts disagreed significantly about whether CFS is a real, distinct illness.

Diagnostics

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Vestibular function test anomalies in patients with chronic fatigue syndrome.

Ash-Bernal, R, Wall, C, Komaroff, A L et al.·Acta oto-laryngologica·1995

Many people with ME/CFS experience dizziness and balance problems, but doctors weren't sure where these problems originated in the body. This study tested the balance and inner ear function of 11 ME/CFS patients using specialized equipment and found several abnormalities—particularly difficulty with tests that rely heavily on the inner ear and brain working together. The pattern of results suggested the problem may be in how the brain processes balance signals rather than damage to the inner ear itself.

E3 PreliminaryBehavioralPEM not required

'Repetitive strain injury': from Australia to the UK.

Reilly, P A·Journal of psychosomatic research·1995

In the 1980s, Australia experienced a widespread outbreak of upper limb pain that didn't fit standard medical diagnoses. The UK is now seeing a similar epidemic. This study examines whether the condition is truly caused by workplace activities or whether psychological and social factors play a larger role, similar to what happens in chronic fatigue syndrome.

Pain and Sensitization

E3 PreliminaryMechanismPEM not requiredMechanistic

Acute encephalopathy induced in cats with a stealth virus isolated from a patient with chronic fatigue syndrome.

Martin, W J, Glass, R T·Pathobiology : journal of immunopathology, molecular and cellular biology·1995

Researchers isolated a virus from a ME/CFS patient and injected it into cats to see what would happen. The cats developed serious neurological illness, and examination of their brain tissue showed viral particles and cell damage. This suggests that a particular type of virus might play a role in ME/CFS-related brain symptoms.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Reversible and selective inhibitors of monoamine oxidase A in mental and other disorders.

Priest, R G, Gimbrett, R, Roberts, M et al.·Acta psychiatrica Scandinavica. Supplementum·1995

This review examines moclobemide and similar medications called RIMAs, which work by affecting brain chemicals involved in mood. The medication has proven effective for depression and is being tested in chronic fatigue syndrome (ME/CFS). Researchers note it may also help with anxiety, social phobia, and other conditions, with fewer side effects than older antidepressants.

E3 PreliminaryCohortPEM unclearCase-Control

Unusual pattern of mitochondrial DNA deletions in skeletal muscle of an adult human with chronic fatigue syndrome.

Zhang, C, Baumer, A, Mackay, I R et al.·Human molecular genetics·1995

This 1995 study examined muscle tissue from one adult patient with ME/CFS and found an unusual pattern of damaged mitochondrial DNA (the energy-producing structures in our cells). The researchers compared this patient's muscle cells to control samples and discovered deletions—missing pieces—in the mitochondrial DNA that weren't typically seen in healthy people. This finding suggested that energy production problems in muscle cells might contribute to the fatigue experienced by ME/CFS patients.

Energy Metabolism

E3 PreliminaryCohortPEM not required

Neuroretinitis, aseptic meningitis, and lymphadenitis associated with Bartonella (Rochalimaea) henselae infection in immunocompetent patients and patients infected with human immunodeficiency virus type 1.

Wong, M T, Dolan, M J, Lattuada, C P et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1995

This study examined patients infected with Bartonella henselae, a bacteria spread by cat scratches and bites, which can cause lymph node swelling, eye inflammation, fever, and meningitis (brain membrane inflammation). Researchers found 23 patients with this infection, many of whom had been exposed to cats. Notably, one patient presented with a chronic fatigue syndrome-like illness, suggesting this bacterial infection might sometimes resemble ME/CFS symptoms.

E3 PreliminaryCohortPEM not requiredCross-Sectional

[Auditory brain stem evoked potentials in the evaluation of chronic fatigue syndrome].

Bianchedi, M, Croce, A, Moretti, A et al.·Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale·1995

Researchers tested a special hearing test on people with ME/CFS to see if it could find differences in how their brainstem (the lower part of the brain) processes sound. They used two types of sound frequencies—slow and fast clicking sounds—while measuring brain electrical activity. The fast clicking test found unusual patterns in about 64% of people with confirmed ME/CFS, but not in people without ME/CFS, suggesting this test might help identify the condition.

E3 PreliminaryGuidelinePEM not requiredGuideline

Chronic fatigue syndrome: current perspectives on evaluation and management.

Hickie, I B, Lloyd, A R, Wakefield, D·The Medical journal of Australia·1995

This guideline helps doctors evaluate and treat ME/CFS by reviewing what we know about the condition. The authors found that while many medical and psychological factors can affect recovery, no single infection has been proven to cause ME/CFS. Treatment works best when doctors address all aspects of a patient's health—physical, mental, and social—rather than focusing on just one area.

Diagnostics

E3 PreliminaryMechanismPEM not requiredCross-Sectional

The disease associations of the antibody response against the Epstein-Barr virus transactivator protein ZEBRA can be separated into different epitopes.

Tedeschi, R, Foong, Y T, Cheng, H M et al.·The Journal of general virology·1995

This study looked at antibody patterns against a specific EBV protein called ZEBRA, which becomes active when the virus 'wakes up' from dormancy. Researchers found that different parts of this protein trigger antibodies in different diseases—some patterns were more common in people with nasopharyngeal cancer, others in people with infectious mononucleosis, and some in people with chronic fatigue syndrome. This suggests that the type of EBV reactivation may differ depending on the illness someone has.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Corticotropin releasing hormone in the pathophysiology of melancholic and atypical depression and in the mechanism of action of antidepressant drugs.

Gold, P W, Licinio, J, Wong, M L et al.·Annals of the New York Academy of Sciences·1995

This research examines how the stress hormone system works differently in people with depression and chronic fatigue syndrome. The study found that while some people with depression have too much cortisol (a stress hormone), others—particularly those with fatigue-related conditions—may have too little activity in the part of the brain that normally triggers this hormone. This suggests that different types of depression and fatigue conditions might involve different problems with the body's stress response system.

Endocrine Disruption

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome--a review of the literature].

Hamre, H J·Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·1995

ME/CFS is a real medical condition that causes extreme tiredness, low-grade fevers, sore throats, and pain in joints and muscles, often starting after a flu-like illness. Exercise makes symptoms significantly worse. While doctors don't yet have a single blood test to diagnose it, research shows patients may have problems with brain blood flow, immune system issues, and mitochondrial (cellular energy) abnormalities.

Immune SystemPost-Exertional Malaise

E3 PreliminaryCohortPEM not requiredCase-Control

Chronic active Epstein-Barr virus disease in a case of persistent polyclonal B-cell lymphocytosis.

Mitterer, M, Pescosta, N, Fend, F et al.·British journal of haematology·1995

This report describes one patient who had an unusual blood disorder involving too many B cells (immune cells) along with symptoms resembling chronic fatigue syndrome, including persistent tiredness and recurring skin rashes. Testing showed the patient had a chronic active Epstein-Barr virus (EBV) infection with the virus actively replicating in their blood cells. The researchers suggest that persistent EBV replication may play a role in developing this lymphoproliferative disorder.

Immune System

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Evidence browser

Determination of observer-rated alpha activity during sleep.

The pathogenesis of chronic pain and fatigue syndromes, with special reference to fibromyalgia.

Phylogenetic analysis of short enteroviral sequences from patients with chronic fatigue syndrome.

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Chronic fatigue syndrome.

Fatigue brought on by malfunction of the central and peripheral nervous systems.

Interferon alfa-2b versus no maintenance therapy during the plateau phase in multiple myeloma: a randomized study. Cooperative Study Group.

Chronic fatigue syndrome. Committee for Science and Education, Medical Association of South Africa.

Vestibular function test anomalies in patients with chronic fatigue syndrome.

'Repetitive strain injury': from Australia to the UK.

Acute encephalopathy induced in cats with a stealth virus isolated from a patient with chronic fatigue syndrome.

Reversible and selective inhibitors of monoamine oxidase A in mental and other disorders.

Unusual pattern of mitochondrial DNA deletions in skeletal muscle of an adult human with chronic fatigue syndrome.

Neuroretinitis, aseptic meningitis, and lymphadenitis associated with Bartonella (Rochalimaea) henselae infection in immunocompetent patients and patients infected with human immunodeficiency virus type 1.

[Auditory brain stem evoked potentials in the evaluation of chronic fatigue syndrome].

Chronic fatigue syndrome: current perspectives on evaluation and management.

The disease associations of the antibody response against the Epstein-Barr virus transactivator protein ZEBRA can be separated into different epitopes.

Corticotropin releasing hormone in the pathophysiology of melancholic and atypical depression and in the mechanism of action of antidepressant drugs.

[Chronic fatigue syndrome--a review of the literature].

Chronic active Epstein-Barr virus disease in a case of persistent polyclonal B-cell lymphocytosis.

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