ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

2161–2180 of 2,420 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome. 2: Treatment and future research.

Kantrowitz, F G, Farrar, D J, Locke, S E·Behavioral medicine (Washington, D.C.)·1995

This review article examines different ways to treat ME/CFS and outlines important directions for future research. The authors discuss various treatment approaches that have been studied and identify gaps in our current understanding of the condition. The paper emphasizes that while treatment options exist, more research is needed to find more effective therapies.

Sleep

E3 PreliminaryBehavioralPEM not requiredCase-Control

Chronic fatigue syndrome associated with a psychotic state resulting in multiple murders.

Ghahramani, M, Gooriah, V·The Bulletin of the American Academy of Psychiatry and the Law·1995

This case study describes a young man who developed severe fatigue and depression following infectious mononucleosis, and later experienced a serious mental health crisis involving psychosis and grandiose delusions. The case highlights how severe infections can sometimes lead to complex psychiatric symptoms that took considerable time to properly diagnose and treat with antipsychotic medications.

E3 PreliminaryPEM unclear

[The classification of Lyme borreliosis (Lyme disease)].

Lesniak, O M, Belikov, E S·Terapevticheskii arkhiv·1995

This paper proposes a new way to classify and organize Lyme disease based on when it starts (acute, subacute, or chronic), how widespread it is in the body, and whether certain tests are positive or negative. The authors also note that some people develop chronic fatigue syndrome or fibromyalgia after Lyme disease, and they include these complications in their classification system.

E3 PreliminaryMechanismPEM not requiredCase-Control

Electron-microscopic investigation of muscle mitochondria in chronic fatigue syndrome.

Plioplys, A V, Plioplys, S·Neuropsychobiology·1995

This study examined muscle tissue from CFS patients under a powerful microscope to look for damage to mitochondria (the energy-producing structures in cells). Researchers compared 15 CFS patients with 15 healthy people and found no visible structural differences in the mitochondria between the two groups, even though CFS causes severe fatigue and weakness.

Energy Metabolism

E3 PreliminaryReviewPEM unclearReview-Narrative

New pathogens, and diseases old and new. I) Afipia felis and Rochalimaea. II) Parvovirus B 19. III) herpesvirus 6.

Zannolli, R, Morgese, G·Panminerva medica·1995

This review examines three viruses (Afipia felis, Parvovirus B19, and Herpesvirus 6) that cause common childhood diseases like cat scratch disease and measles-like rashes. The authors note that these same viruses have been suggested as possible causes of chronic fatigue syndrome and other conditions, but proving this connection has been difficult because current tests cannot always tell whether someone has an active infection or just carries the virus from the past.

E3 PreliminaryReviewPEM unclearReview-Narrative

Fatigue brought on by malfunction of the central and peripheral nervous systems.

McComas, A J, Miller, R G, Gandevia, S C·Advances in experimental medicine and biology·1995

This review examines why people with nervous system disorders experience extreme tiredness and weakness. The authors looked at several conditions—including post-polio syndrome, multiple sclerosis, spinal cord injury, ALS, and ME/CFS—and found that damage to nerves can make muscles tire much more easily than normal. Lack of physical activity can make this problem worse over time.

E3 PreliminaryGuidelinePEM not requiredGuideline

Chronic fatigue syndrome. Committee for Science and Education, Medical Association of South Africa.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·1995

A group of South African medical experts created guidelines to help doctors recognize and treat chronic fatigue syndrome (CFS). The guidelines outline what symptoms and test results might help diagnose CFS, and suggest reasonable ways to manage the condition while keeping costs reasonable. However, the experts disagreed significantly about whether CFS is a real, distinct illness.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Sleep, neuroimmune and neuroendocrine functions in fibromyalgia and chronic fatigue syndrome.

Moldofsky, H·Advances in neuroimmunology·1995

This review examines how sleep problems, immune system dysfunction, and hormone imbalances may be connected in fibromyalgia and ME/CFS. The authors suggest that when the body's internal clock is disrupted, it can trigger a cascade of problems including poor sleep quality, pain, fatigue, and cognitive difficulties. They propose that studying these interconnected systems together—rather than separately—may help explain why these conditions are so disabling.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Professional and popular views of chronic fatigue syndrome.

MacLean, G, Wessely, S·BMJ (Clinical research ed.)·1994

This study looked at how ME/CFS was covered in different types of media between 1980 and 1994. Researchers found that scientific journals were skeptical about whether ME/CFS had physical causes, while newspapers and magazines tended to present it as a real medical illness. This difference in coverage may have confused the public and healthcare providers about what ME/CFS actually is.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Viral studies of chronic fatigue syndrome.

Levy, J A·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

This review explores whether viruses might cause ME/CFS. Researchers found that while many different viruses have been suspected, no single virus has been proven to be the cause. However, studies show that people with ME/CFS have immune system abnormalities—particularly problems with cells that fight infection—suggesting their body may be stuck in an overactive response to a virus they once had or still have.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Cognitive functioning of patients with chronic fatigue syndrome.

Johnson, S K, DeLuca, J, Fiedler, N et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

Many people with ME/CFS experience brain fog and difficulty thinking clearly, which can be just as disabling as physical symptoms. This review examined research on these cognitive problems and found that the issue may not be with memory itself, but rather with how the brain processes information—like a computer that struggles to handle incoming data quickly enough. Understanding this difference is important for developing better treatments and support strategies.

Cognitive Impairment

E3 PreliminaryPEM not required

Cytomegalovirus-related sequence in an atypical cytopathic virus repeatedly isolated from a patient with chronic fatigue syndrome.

Martin, W J, Zeng, L C, Ahmed, K et al.·The American journal of pathology·1994

Researchers found an unusual virus in a patient with chronic fatigue syndrome that looked similar to cytomegalovirus (CMV) under a microscope but behaved differently. The virus had genetic material that partially matched CMV, but it didn't react to standard tests for known viruses. This suggests it may be a previously unknown type of virus that can establish a long-term infection in humans.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Human herpesvirus 6. General overview].

Tîrdei, G, Ruţă, S M, Popescu, A E·Revue roumaine de virologie (Bucharest, Romania : 1990)·1994

Human herpesvirus 6 (HHV6) is a common virus that infects most people before age three, usually causing no symptoms or only mild illness. Researchers have good understanding of how the virus works and spreads, but it remains unclear whether HHV6 plays a role in chronic fatigue syndrome and some other long-term illnesses. This review summarizes what we know and don't know about this virus.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

Chronic fatigue: a peculiar evolution of eosinophilia myalgia syndrome following treatment with L-tryptophan in four Italian adolescents.

Priori, R, Conti, F, Luan, F L et al.·European journal of pediatrics·1994

This study describes four teenagers in Italy who developed severe, persistent fatigue after taking L-tryptophan supplements. Before the fatigue developed, they experienced eosinophilia myalgia syndrome (EMS)—a condition with high levels of certain white blood cells and severe muscle pain. The researchers found that these teenagers' symptoms looked very similar to chronic fatigue syndrome (ME/CFS).

E3 PreliminaryReviewPEM unclearReview-Narrative

Neurobiological aspects of the chronic fatigue syndrome.

Bearn, J, Wessely, S·European journal of clinical investigation·1994

This study looked at how the brain and nervous system may be involved in chronic fatigue syndrome (ME/CFS). Researchers examined the biological mechanisms that might explain why people with ME/CFS experience persistent tiredness and other symptoms. The review helps identify which parts of the nervous system could be affected in this condition.

Immune System

E3 PreliminaryGuidelinePEM unclearGuideline

[Therapeutic guidelines in chronic fatigue syndrome].

Bertolín Guillén, J M, Bedate Villar, J·Actas luso-espanolas de neurologia, psiquiatria y ciencias afines·1994

This article reviews different treatment approaches for ME/CFS, which currently lacks a definitive cure. Researchers found that antidepressant medications—particularly amfebutamone and selective serotonin reuptake inhibitors—showed the most promise, while other medications (antivirals, immune boosters, anti-inflammatory drugs) had limited success. A combination of cognitive behavioral therapy and comprehensive psychiatric management tailored to each patient's needs also appeared helpful.

Interventions

E3 PreliminaryCommentaryPEM not requiredEditorial

Chronic fatigue syndrome update. Findings now point to CNS involvement.

Bell, D S·Postgraduate medicine·1994

This review examines what causes ME/CFS and finds that common viruses like Epstein-Barr virus are likely not responsible. Instead, the evidence points to problems in the central nervous system—the brain and spinal cord—as a key factor in ME/CFS. Researchers found multiple abnormalities related to how the brain regulates hormones, processes chemicals, and controls blood flow, which may explain why patients experience fatigue and other symptoms.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[A new virus: the human herpesvirus 6].

Agut, H, Aubin, J T·La Revue du praticien·1994

Human herpesvirus 6 (HHV-6) is a virus discovered in 1986 that infects most people during childhood and stays in the body for life. It normally causes fever and rash in infants, but researchers have wondered whether it might play a role in chronic fatigue syndrome and other conditions, though this connection remains unclear. Some antiviral medications like ganciclovir appear to work against HHV-6 in laboratory tests.

Immune System

E3 PreliminaryCommentaryPEM not requiredEditorial

Some preliminary thoughts on the potential contribution of epidemiology to the question of multiple chemical sensitivity.

Neutra, R R·Public health reviews·1994

This paper proposes using epidemiology—the study of disease patterns in populations—to better understand multiple chemical sensitivity (MCS), a condition where people report severe reactions to small amounts of chemicals. The author suggests that epidemiology could help clarify whether MCS is a genuine environmental disease or a condition primarily driven by psychological factors, similar to how epidemiology helped solve the mystery of AIDS and Chronic Fatigue Syndrome.

E3 PreliminaryCommentaryPEM unclearCommentary

Coming to terms with ME.

Hoad, A·Health visitor·1994

This article shares the personal story of Anne Hoad, a former health visitor who was diagnosed with ME in her mid-50s. She describes how difficult it was to accept the severe limitations ME placed on her life and how little understanding exists about this debilitating condition. Her account highlights common misconceptions about ME and the emotional challenge of coming to terms with a chronic illness that is poorly recognized by society.

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Chronic fatigue syndrome. 2: Treatment and future research.

Chronic fatigue syndrome associated with a psychotic state resulting in multiple murders.

[The classification of Lyme borreliosis (Lyme disease)].

Electron-microscopic investigation of muscle mitochondria in chronic fatigue syndrome.

New pathogens, and diseases old and new. I) Afipia felis and Rochalimaea. II) Parvovirus B 19. III) herpesvirus 6.

Fatigue brought on by malfunction of the central and peripheral nervous systems.

Chronic fatigue syndrome. Committee for Science and Education, Medical Association of South Africa.

Sleep, neuroimmune and neuroendocrine functions in fibromyalgia and chronic fatigue syndrome.

Professional and popular views of chronic fatigue syndrome.

Viral studies of chronic fatigue syndrome.

Cognitive functioning of patients with chronic fatigue syndrome.

Cytomegalovirus-related sequence in an atypical cytopathic virus repeatedly isolated from a patient with chronic fatigue syndrome.

[Human herpesvirus 6. General overview].

Chronic fatigue: a peculiar evolution of eosinophilia myalgia syndrome following treatment with L-tryptophan in four Italian adolescents.

Neurobiological aspects of the chronic fatigue syndrome.

[Therapeutic guidelines in chronic fatigue syndrome].

Chronic fatigue syndrome update. Findings now point to CNS involvement.

[A new virus: the human herpesvirus 6].

Some preliminary thoughts on the potential contribution of epidemiology to the question of multiple chemical sensitivity.

Coming to terms with ME.

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