ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

2161–2180 of 2,422 studies

Interferon alfa-2b versus no maintenance therapy during the plateau phase in multiple myeloma: a randomized study. Cooperative Study Group.

Westin, J, Rödjer, S, Turesson, I et al.·British journal of haematology·1995

This study tested whether a drug called interferon alfa-2b could help multiple myeloma patients (a type of blood cancer) stay in remission longer after their initial treatment. Patients who received interferon stayed in remission for about 14 months compared to 6 months for those who didn't, but both groups lived about the same length of time overall.

E3 PreliminaryCohortPEM not required

Neuroretinitis, aseptic meningitis, and lymphadenitis associated with Bartonella (Rochalimaea) henselae infection in immunocompetent patients and patients infected with human immunodeficiency virus type 1.

Wong, M T, Dolan, M J, Lattuada, C P et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1995

This study examined patients infected with Bartonella henselae, a bacteria spread by cat scratches and bites, which can cause lymph node swelling, eye inflammation, fever, and meningitis (brain membrane inflammation). Researchers found 23 patients with this infection, many of whom had been exposed to cats. Notably, one patient presented with a chronic fatigue syndrome-like illness, suggesting this bacterial infection might sometimes resemble ME/CFS symptoms.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue.

Smets, E M, Garssen, B, Bonke, B et al.·Journal of psychosomatic research·1995

Researchers created and tested a questionnaire called the Multidimensional Fatigue Inventory (MFI) to measure different types of fatigue people experience. The 20-question survey asks about general tiredness, physical exhaustion, mental tiredness, motivation, and activity levels. When they tested it with various groups—including people with chronic fatigue syndrome—the questionnaire worked well and reliably measured fatigue in all groups.

E3 PreliminaryCohortPEM unclear

Chronic fatigue syndrome.

Krilov, L R·Pediatric annals·1995

This 1995 study examined chronic fatigue syndrome (ME/CFS) in children by comparing cases with controls. The research aimed to better understand how this condition affects young patients. As a case-control study, it looked at differences between children who had ME/CFS and those who didn't to identify important patterns.

E3 PreliminaryReviewPEM unclearReview-Narrative

Sleep, neuroimmune and neuroendocrine functions in fibromyalgia and chronic fatigue syndrome.

Moldofsky, H·Advances in neuroimmunology·1995

This review examines how sleep problems, immune system dysfunction, and hormone imbalances may be connected in fibromyalgia and ME/CFS. The authors suggest that when the body's internal clock is disrupted, it can trigger a cascade of problems including poor sleep quality, pain, fatigue, and cognitive difficulties. They propose that studying these interconnected systems together—rather than separately—may help explain why these conditions are so disabling.

Immune System

E3 PreliminaryCohortPEM unclearCase-Control

Unusual pattern of mitochondrial DNA deletions in skeletal muscle of an adult human with chronic fatigue syndrome.

Zhang, C, Baumer, A, Mackay, I R et al.·Human molecular genetics·1995

This 1995 study examined muscle tissue from one adult patient with ME/CFS and found an unusual pattern of damaged mitochondrial DNA (the energy-producing structures in our cells). The researchers compared this patient's muscle cells to control samples and discovered deletions—missing pieces—in the mitochondrial DNA that weren't typically seen in healthy people. This finding suggested that energy production problems in muscle cells might contribute to the fatigue experienced by ME/CFS patients.

Energy Metabolism

E3 PreliminaryBehavioralPEM not required

'Repetitive strain injury': from Australia to the UK.

Reilly, P A·Journal of psychosomatic research·1995

In the 1980s, Australia experienced a widespread outbreak of upper limb pain that didn't fit standard medical diagnoses. The UK is now seeing a similar epidemic. This study examines whether the condition is truly caused by workplace activities or whether psychological and social factors play a larger role, similar to what happens in chronic fatigue syndrome.

Pain and Sensitization

E3 PreliminaryGuidelinePEM not requiredGuideline

Chronic fatigue syndrome. Committee for Science and Education, Medical Association of South Africa.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·1995

A group of South African medical experts created guidelines to help doctors recognize and treat chronic fatigue syndrome (CFS). The guidelines outline what symptoms and test results might help diagnose CFS, and suggest reasonable ways to manage the condition while keeping costs reasonable. However, the experts disagreed significantly about whether CFS is a real, distinct illness.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

[Clinical aspects and neurologic expert assessment in sequelae of whiplash injury to the cervical spine].

Jenzer, G·Der Nervenarzt·1995

This review examined whiplash injuries to the neck and the long-term complications some patients develop, called chronic whiplash syndrome. The authors found that whiplash injuries can cause a complex mix of symptoms similar to those seen in chronic fatigue syndrome and fibromyalgia, making diagnosis challenging. Most people recover well from whiplash, though some experience prolonged difficulties.

Diagnostics

E3 PreliminaryMechanismPEM not requiredCase-Control

Electron-microscopic investigation of muscle mitochondria in chronic fatigue syndrome.

Plioplys, A V, Plioplys, S·Neuropsychobiology·1995

This study examined muscle tissue from CFS patients under a powerful microscope to look for damage to mitochondria (the energy-producing structures in cells). Researchers compared 15 CFS patients with 15 healthy people and found no visible structural differences in the mitochondria between the two groups, even though CFS causes severe fatigue and weakness.

Energy Metabolism

E3 PreliminaryReviewPEM not requiredReview-Narrative

Human herpesvirus-7 (HHV-7).

Ablashi, D V, Berneman, Z N, Kramarsky, B et al.·In vivo (Athens, Greece)·1994

This review examines Human herpesvirus-7 (HHV-7), a common virus that infects most people in the United States. HHV-7 was first discovered in 1990 and was found in a ME/CFS patient in 1992, raising early questions about whether it might be involved in the illness. However, researchers have not yet found clear evidence that HHV-7 causes any specific disease.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Human herpesvirus 6. General overview].

Tîrdei, G, Ruţă, S M, Popescu, A E·Revue roumaine de virologie (Bucharest, Romania : 1990)·1994

Human herpesvirus 6 (HHV6) is a common virus that infects most people before age three, usually causing no symptoms or only mild illness. Researchers have good understanding of how the virus works and spreads, but it remains unclear whether HHV6 plays a role in chronic fatigue syndrome and some other long-term illnesses. This review summarizes what we know and don't know about this virus.

Immune System

E3 PreliminaryMechanismPEM not requiredObservational

Cytokine production and fatigue in patients with chronic fatigue syndrome and healthy control subjects in response to exercise.

Lloyd, A, Gandevia, S, Brockman, A et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

Researchers asked whether a specific immune response causes the fatigue that ME/CFS patients experience after exercise. They had patients and healthy people do a 30-minute hand-grip exercise and checked their blood for immune chemicals (cytokines) before, during, and after exercise. Surprisingly, they found no changes in these immune chemicals in either group, and patients actually reported feeling less fatigued after the exercise—the opposite of what happens in real life.

Immune SystemPost-Exertional Malaise

E3 PreliminaryGuidelinePEM unclearGuideline

[Therapeutic guidelines in chronic fatigue syndrome].

Bertolín Guillén, J M, Bedate Villar, J·Actas luso-espanolas de neurologia, psiquiatria y ciencias afines·1994

This article reviews different treatment approaches for ME/CFS, which currently lacks a definitive cure. Researchers found that antidepressant medications—particularly amfebutamone and selective serotonin reuptake inhibitors—showed the most promise, while other medications (antivirals, immune boosters, anti-inflammatory drugs) had limited success. A combination of cognitive behavioral therapy and comprehensive psychiatric management tailored to each patient's needs also appeared helpful.

Interventions

E3 PreliminaryMechanismPEM unclearCross-Sectional

Effects of mild exercise on cytokines and cerebral blood flow in chronic fatigue syndrome patients.

Peterson, P K, Sirr, S A, Grammith, F C et al.·Clinical and diagnostic laboratory immunology·1994

Researchers tested whether light exercise (30 minutes of slow walking) would trigger abnormal immune and brain blood flow responses in ME/CFS patients compared to healthy people. They found that ME/CFS patients had higher levels of a specific immune protein (TGF-beta) both at rest and after exercise, and also showed changes in brain blood flow. These changes appeared larger in ME/CFS patients than in healthy controls, though the difference wasn't statistically significant.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

[A new virus: the human herpesvirus 6].

Agut, H, Aubin, J T·La Revue du praticien·1994

Human herpesvirus 6 (HHV-6) is a virus discovered in 1986 that infects most people during childhood and stays in the body for life. It normally causes fever and rash in infants, but researchers have wondered whether it might play a role in chronic fatigue syndrome and other conditions, though this connection remains unclear. Some antiviral medications like ganciclovir appear to work against HHV-6 in laboratory tests.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

MELISA-an in vitro tool for the study of metal allergy.

Stejskal, V D, Cederbrant, K, Lindvall, A et al.·Toxicology in vitro : an international journal published in association with BIBRA·1994

This study tested whether certain metals used in dental work and medical devices can trigger immune system reactions in people with chronic fatigue and mouth problems. Researchers used a laboratory test called MELISA to measure how immune cells from patients responded to metals like mercury, gold, and palladium. They found that people with symptoms had stronger immune reactions to these metals than healthy people without symptoms, suggesting a possible connection between metal exposure and their health problems.

Immune System

E3 PreliminaryCommentaryPEM not requiredEditorial

Chronic fatigue syndrome update. Findings now point to CNS involvement.

Bell, D S·Postgraduate medicine·1994

This review examines what causes ME/CFS and finds that common viruses like Epstein-Barr virus are likely not responsible. Instead, the evidence points to problems in the central nervous system—the brain and spinal cord—as a key factor in ME/CFS. Researchers found multiple abnormalities related to how the brain regulates hormones, processes chemicals, and controls blood flow, which may explain why patients experience fatigue and other symptoms.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Stealth viruses as neuropathogens.

Martin, W J·CAP today·1994

This article suggests that certain stealth viruses may damage the nervous system and contribute to various brain-related conditions, including ME/CFS. The authors note that diseases like ME/CFS, fibromyalgia, depression, and autism share overlapping symptoms—such as pain, mood changes, and cognitive problems—which may reflect a common underlying problem in how the brain responds to different triggers.

Neuroinflammation

E3 PreliminaryCohortPEM not requiredCase-Control

Chronic fatigue: a peculiar evolution of eosinophilia myalgia syndrome following treatment with L-tryptophan in four Italian adolescents.

Priori, R, Conti, F, Luan, F L et al.·European journal of pediatrics·1994

This study describes four teenagers in Italy who developed severe, persistent fatigue after taking L-tryptophan supplements. Before the fatigue developed, they experienced eosinophilia myalgia syndrome (EMS)—a condition with high levels of certain white blood cells and severe muscle pain. The researchers found that these teenagers' symptoms looked very similar to chronic fatigue syndrome (ME/CFS).

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Interferon alfa-2b versus no maintenance therapy during the plateau phase in multiple myeloma: a randomized study. Cooperative Study Group.

Neuroretinitis, aseptic meningitis, and lymphadenitis associated with Bartonella (Rochalimaea) henselae infection in immunocompetent patients and patients infected with human immunodeficiency virus type 1.

The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue.

Chronic fatigue syndrome.

Sleep, neuroimmune and neuroendocrine functions in fibromyalgia and chronic fatigue syndrome.

Unusual pattern of mitochondrial DNA deletions in skeletal muscle of an adult human with chronic fatigue syndrome.

'Repetitive strain injury': from Australia to the UK.

Chronic fatigue syndrome. Committee for Science and Education, Medical Association of South Africa.

[Clinical aspects and neurologic expert assessment in sequelae of whiplash injury to the cervical spine].

Electron-microscopic investigation of muscle mitochondria in chronic fatigue syndrome.

Human herpesvirus-7 (HHV-7).

[Human herpesvirus 6. General overview].

Cytokine production and fatigue in patients with chronic fatigue syndrome and healthy control subjects in response to exercise.

[Therapeutic guidelines in chronic fatigue syndrome].

Effects of mild exercise on cytokines and cerebral blood flow in chronic fatigue syndrome patients.

[A new virus: the human herpesvirus 6].

MELISA-an in vitro tool for the study of metal allergy.

Chronic fatigue syndrome update. Findings now point to CNS involvement.

Stealth viruses as neuropathogens.

Chronic fatigue: a peculiar evolution of eosinophilia myalgia syndrome following treatment with L-tryptophan in four Italian adolescents.

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