ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

2161–2180 of 2,423 studies

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue.

Smets, E M, Garssen, B, Bonke, B et al.·Journal of psychosomatic research·1995

Researchers created and tested a questionnaire called the Multidimensional Fatigue Inventory (MFI) to measure different types of fatigue people experience. The 20-question survey asks about general tiredness, physical exhaustion, mental tiredness, motivation, and activity levels. When they tested it with various groups—including people with chronic fatigue syndrome—the questionnaire worked well and reliably measured fatigue in all groups.

E3 PreliminaryCohortPEM requiredCase-Control

Is neurally mediated hypotension an unrecognised cause of chronic fatigue?

Rowe, P C, Bou-Holaigah, I, Kan, J S et al.·Lancet (London, England)·1995

This study looked at whether a condition called neurally mediated hypotension—where blood pressure drops suddenly when standing up—might be causing chronic fatigue in some patients. Researchers tested seven teenagers with severe fatigue using a tilt-table test (which gradually tilts the body upright) and found that all seven experienced significant drops in blood pressure. Four of these patients improved when treated with specific heart medications, suggesting this condition may contribute to some cases of ME/CFS.

Autonomic Nervous System

E3 PreliminaryTrialPEM not requiredRCT

Interferon alfa-2b versus no maintenance therapy during the plateau phase in multiple myeloma: a randomized study. Cooperative Study Group.

Westin, J, Rödjer, S, Turesson, I et al.·British journal of haematology·1995

This study tested whether a drug called interferon alfa-2b could help multiple myeloma patients (a type of blood cancer) stay in remission longer after their initial treatment. Patients who received interferon stayed in remission for about 14 months compared to 6 months for those who didn't, but both groups lived about the same length of time overall.

E3 PreliminaryMechanismPEM not requiredCase-Control

Electron-microscopic investigation of muscle mitochondria in chronic fatigue syndrome.

Plioplys, A V, Plioplys, S·Neuropsychobiology·1995

This study examined muscle tissue from CFS patients under a powerful microscope to look for damage to mitochondria (the energy-producing structures in cells). Researchers compared 15 CFS patients with 15 healthy people and found no visible structural differences in the mitochondria between the two groups, even though CFS causes severe fatigue and weakness.

Energy Metabolism

E3 PreliminaryCohortPEM not required

Neuroretinitis, aseptic meningitis, and lymphadenitis associated with Bartonella (Rochalimaea) henselae infection in immunocompetent patients and patients infected with human immunodeficiency virus type 1.

Wong, M T, Dolan, M J, Lattuada, C P et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1995

This study examined patients infected with Bartonella henselae, a bacteria spread by cat scratches and bites, which can cause lymph node swelling, eye inflammation, fever, and meningitis (brain membrane inflammation). Researchers found 23 patients with this infection, many of whom had been exposed to cats. Notably, one patient presented with a chronic fatigue syndrome-like illness, suggesting this bacterial infection might sometimes resemble ME/CFS symptoms.

E3 PreliminaryCohortPEM unclear

Chronic fatigue syndrome.

Krilov, L R·Pediatric annals·1995

This 1995 study examined chronic fatigue syndrome (ME/CFS) in children by comparing cases with controls. The research aimed to better understand how this condition affects young patients. As a case-control study, it looked at differences between children who had ME/CFS and those who didn't to identify important patterns.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Human herpesvirus-7 (HHV-7): current status.

Ablashi, D V, Berneman, Z N, Kramarsky, B et al.·Clinical and diagnostic virology·1995

This review article summarizes what scientists knew about human herpesvirus-7 (HHV-7) as of 1995, a newly discovered virus related to other common herpesviruses. HHV-7 was found in a chronic fatigue syndrome patient, along with healthy people, and is very common in the population (affecting over 85% of Americans). The virus has been linked to a few childhood rash illnesses and possibly some cases with liver involvement, but scientists had limited information about whether it causes ME/CFS.

Immune System

E3 PreliminaryCohortPEM unclearCase-Control

Unusual pattern of mitochondrial DNA deletions in skeletal muscle of an adult human with chronic fatigue syndrome.

Zhang, C, Baumer, A, Mackay, I R et al.·Human molecular genetics·1995

This 1995 study examined muscle tissue from one adult patient with ME/CFS and found an unusual pattern of damaged mitochondrial DNA (the energy-producing structures in our cells). The researchers compared this patient's muscle cells to control samples and discovered deletions—missing pieces—in the mitochondrial DNA that weren't typically seen in healthy people. This finding suggested that energy production problems in muscle cells might contribute to the fatigue experienced by ME/CFS patients.

Energy Metabolism

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome. 2: Treatment and future research.

Kantrowitz, F G, Farrar, D J, Locke, S E·Behavioral medicine (Washington, D.C.)·1995

This review article examines different ways to treat ME/CFS and outlines important directions for future research. The authors discuss various treatment approaches that have been studied and identify gaps in our current understanding of the condition. The paper emphasizes that while treatment options exist, more research is needed to find more effective therapies.

Sleep

E3 PreliminaryReviewPEM unclearReview-Narrative

Neurasthenia, myalgic encephalitis or cryptogenic chronic fatigue syndrome?

Leitch, A G·QJM : monthly journal of the Association of Physicians·1995

This 1995 paper explores the history and naming of ME/CFS, comparing three different terms used to describe the condition: neurasthenia (an older term), myalgic encephalitis, and chronic fatigue syndrome. The author examines how the same illness has been called different names over time and in different places, which can create confusion about what the condition actually is.

Diagnostics

E3 PreliminaryBehavioralPEM not required

'Repetitive strain injury': from Australia to the UK.

Reilly, P A·Journal of psychosomatic research·1995

In the 1980s, Australia experienced a widespread outbreak of upper limb pain that didn't fit standard medical diagnoses. The UK is now seeing a similar epidemic. This study examines whether the condition is truly caused by workplace activities or whether psychological and social factors play a larger role, similar to what happens in chronic fatigue syndrome.

Pain and Sensitization

E3 PreliminaryCommentaryPEM not requiredEditorial

Chronic fatigue syndrome update. Findings now point to CNS involvement.

Bell, D S·Postgraduate medicine·1994

This review examines what causes ME/CFS and finds that common viruses like Epstein-Barr virus are likely not responsible. Instead, the evidence points to problems in the central nervous system—the brain and spinal cord—as a key factor in ME/CFS. Researchers found multiple abnormalities related to how the brain regulates hormones, processes chemicals, and controls blood flow, which may explain why patients experience fatigue and other symptoms.

Immune System

E3 PreliminaryBehavioralPEM unclearCase-Control

Chronic fatigue syndrome or affective disorder? Implications of the diagnosis on management.

Giannopoulou, Joanna, Marriott, Sarah·European child & adolescent psychiatry·1994

This case study describes a teenage boy who was initially thought to have post-viral fatigue syndrome (a condition similar to ME/CFS that follows infections) but was actually diagnosed with bipolar disorder, a mental health condition involving extreme mood swings. The doctors discuss how difficult it can be to tell the difference between these two conditions in young people, and how getting the diagnosis wrong can seriously affect their treatment and development.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Viral studies of chronic fatigue syndrome.

Ablashi, D V·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

This review article examines whether viruses play a role in causing ME/CFS by looking at existing research on viral infections in patients with this condition. The author analyzes studies investigating connections between various viruses and ME/CFS symptoms. The review helps summarize what scientists knew in 1994 about potential viral causes of the illness.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

MELISA-an in vitro tool for the study of metal allergy.

Stejskal, V D, Cederbrant, K, Lindvall, A et al.·Toxicology in vitro : an international journal published in association with BIBRA·1994

This study tested whether certain metals used in dental work and medical devices can trigger immune system reactions in people with chronic fatigue and mouth problems. Researchers used a laboratory test called MELISA to measure how immune cells from patients responded to metals like mercury, gold, and palladium. They found that people with symptoms had stronger immune reactions to these metals than healthy people without symptoms, suggesting a possible connection between metal exposure and their health problems.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome].

Sternon, J, Decaux, G, Hoffmann, G·Revue medicale de Bruxelles·1994

This paper describes how doctors can diagnose ME/CFS using specific criteria and discusses what might cause the condition. The authors note that viral infections may trigger ME/CFS, and that anxiety or depression can make symptoms worse. Importantly, they found that some patients improve on their own after a few years, though most don't respond well to available treatments.

SleepDiagnostics

E3 PreliminaryMechanismPEM not requiredObservational

Cytokine production and fatigue in patients with chronic fatigue syndrome and healthy control subjects in response to exercise.

Lloyd, A, Gandevia, S, Brockman, A et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

Researchers asked whether a specific immune response causes the fatigue that ME/CFS patients experience after exercise. They had patients and healthy people do a 30-minute hand-grip exercise and checked their blood for immune chemicals (cytokines) before, during, and after exercise. Surprisingly, they found no changes in these immune chemicals in either group, and patients actually reported feeling less fatigued after the exercise—the opposite of what happens in real life.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: a diagnostic challenge for the laboratory.

Lanham, R J·Clinical laboratory science : journal of the American Society for Medical Technology·1994

This review examined what we know about ME/CFS, a condition characterized by extreme tiredness, pain, and thinking difficulties that come and go in cycles. While researchers don't yet know what causes ME/CFS, studies show that people with this condition often have unusual immune system test results. Currently, there is no single blood test or marker that can definitively diagnose ME/CFS, so doctors treat symptoms based on what each patient experiences.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

[A new virus: the human herpesvirus 6].

Agut, H, Aubin, J T·La Revue du praticien·1994

Human herpesvirus 6 (HHV-6) is a virus discovered in 1986 that infects most people during childhood and stays in the body for life. It normally causes fever and rash in infants, but researchers have wondered whether it might play a role in chronic fatigue syndrome and other conditions, though this connection remains unclear. Some antiviral medications like ganciclovir appear to work against HHV-6 in laboratory tests.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Stealth viruses as neuropathogens.

Martin, W J·CAP today·1994

This article suggests that certain stealth viruses may damage the nervous system and contribute to various brain-related conditions, including ME/CFS. The authors note that diseases like ME/CFS, fibromyalgia, depression, and autism share overlapping symptoms—such as pain, mood changes, and cognitive problems—which may reflect a common underlying problem in how the brain responds to different triggers.

Neuroinflammation

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Evidence browser

The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue.

Is neurally mediated hypotension an unrecognised cause of chronic fatigue?

Interferon alfa-2b versus no maintenance therapy during the plateau phase in multiple myeloma: a randomized study. Cooperative Study Group.

Electron-microscopic investigation of muscle mitochondria in chronic fatigue syndrome.

Neuroretinitis, aseptic meningitis, and lymphadenitis associated with Bartonella (Rochalimaea) henselae infection in immunocompetent patients and patients infected with human immunodeficiency virus type 1.

Chronic fatigue syndrome.

Human herpesvirus-7 (HHV-7): current status.

Unusual pattern of mitochondrial DNA deletions in skeletal muscle of an adult human with chronic fatigue syndrome.

Chronic fatigue syndrome. 2: Treatment and future research.

Neurasthenia, myalgic encephalitis or cryptogenic chronic fatigue syndrome?

'Repetitive strain injury': from Australia to the UK.

Chronic fatigue syndrome update. Findings now point to CNS involvement.

Chronic fatigue syndrome or affective disorder? Implications of the diagnosis on management.

Viral studies of chronic fatigue syndrome.

MELISA-an in vitro tool for the study of metal allergy.

[Chronic fatigue syndrome].

Cytokine production and fatigue in patients with chronic fatigue syndrome and healthy control subjects in response to exercise.

Chronic fatigue syndrome: a diagnostic challenge for the laboratory.

[A new virus: the human herpesvirus 6].

Stealth viruses as neuropathogens.

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