ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

2281–2300 of 2,423 studies

E3 PreliminaryCohortPEM unclearCross-Sectional

[Symptoms, signs and laboratory findings in patients with chronic fatigue syndrome].

Kuratsune, H, Yamaguti, K, Hattori, H et al.·Nihon rinsho. Japanese journal of clinical medicine·1992

This study examined 59 patients with ME/CFS to identify common symptoms and laboratory abnormalities. The main findings were that patients experienced prolonged fatigue after exercise, headaches, sleep problems, and mild fevers. Researchers found that ME/CFS patients had low levels of a substance called acylcarnitine in their muscles, which may help explain why their bodies struggle to produce energy and why they experience muscle pain and worsening symptoms after activity.

BiomarkersPost-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome.

Calabrese, L, Danao, T, Camara, E et al.·American family physician·1992

ME/CFS is a condition where people experience severe, disabling tiredness that starts suddenly and lasts at least six months, often getting worse with physical activity. Patients often have fever, sore throat, and tender lymph nodes, along with sleep problems and muscle pain. Treatment focuses on education, support, gentle exercise, and managing individual symptoms like sleep issues and pain.

Immune System

E3 PreliminaryMechanismPEM not requiredObservational

Plasma and cerebrospinal fluid monoamine metabolism in patients with chronic fatigue syndrome: preliminary findings.

Demitrack, M A, Gold, P W, Dale, J K et al.·Biological psychiatry·1992

This study measured chemical messengers in the blood and spinal fluid of people with ME/CFS and compared them to healthy individuals. Researchers found that people with ME/CFS had lower levels of one chemical (MHPG, related to stress response) and higher levels of another (5-HIAA, related to mood regulation). These differences suggest ME/CFS may have biological markers that distinguish it from purely psychiatric conditions.

Endocrine Disruption

E3 PreliminaryReviewPEM unclearReview-Narrative

[What is the relation of human herpesvirus 6 to chronic fatigue syndrome?].

Bauermeister, C D, Wagner, C, Brede, H D·Medizinische Monatsschrift fur Pharmazeuten·1992

This 1992 study investigated whether a common virus called human herpesvirus 6 (HHV-6) might be connected to ME/CFS. Researchers examined the relationship between this virus and chronic fatigue syndrome symptoms. While early research suggested a possible link, this study represents early work in understanding whether HHV-6 plays a role in the disease.

E3 PreliminaryReviewPEM unclearReview-Narrative

The chronic fatigue syndrome: considerations relevant to children and adolescents.

Dale, J K, Straus, S E·Advances in pediatric infectious diseases·1992

This paper reviews how ME/CFS (chronic fatigue syndrome) presents differently in children and teenagers compared to adults. The authors discuss important clinical considerations for recognizing and understanding the condition in younger patients. The review highlights that children and adolescents with ME/CFS face unique challenges in diagnosis and management.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Viral infection and its causative role for chronic fatigue syndrome].

Okano, M·Nihon rinsho. Japanese journal of clinical medicine·1992

This review examines whether viral infections, particularly Epstein-Barr virus (EBV), cause ME/CFS. The author notes that ME/CFS shares symptoms with chronic EBV infection—including fatigue, swollen lymph nodes, and fever—but the connection remains unclear. The review also discusses a more severe condition called severe chronic active EBV infection and highlights that the true cause and best treatment for ME/CFS are still unknown.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome: a joint paediatric-psychiatric approach.

Vereker, M I·Archives of disease in childhood·1992

This 1992 paper discusses how ME/CFS (then called chronic fatigue syndrome) in children should be evaluated and treated by working together between pediatric doctors and mental health specialists. The authors suggest that understanding both the physical and emotional aspects of the illness is important for helping young patients.

E3 PreliminaryMechanismPEM unclearObservational

Skeletal muscle metabolism in the chronic fatigue syndrome. In vivo assessment by 31P nuclear magnetic resonance spectroscopy.

Wong, R, Lopaschuk, G, Zhu, G et al.·Chest·1992

This study used a special imaging technique (31P NMR spectroscopy) to examine how muscles use energy during exercise in people with ME/CFS compared to healthy volunteers. Patients with ME/CFS became exhausted much faster during exercise (about 8 minutes versus 11 minutes) and had lower levels of ATP, the main energy molecule muscles use. The patterns of energy use looked similar between groups, but happened much more quickly in the ME/CFS group.

Post-Exertional Malaise

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

[Diagnostic criteria for chronic fatigue syndrome by the CFS Study Group in Japan].

Kitani, T, Kuratsune, H, Yamaguchi, K·Nihon rinsho. Japanese journal of clinical medicine·1992

In 1992, Japanese researchers created new diagnostic guidelines to help doctors identify ME/CFS in their patients. These guidelines were based on earlier American standards but included some modifications, such as defining less severe cases and recognizing a form that develops after infections.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome. Recent advances in diagnosis and treatment.

Bell, D S·Postgraduate medicine·1992

ME/CFS typically starts suddenly with severe tiredness and flu-like symptoms that come and go over months or years. While blood tests sometimes show immune system changes, doctors diagnose ME/CFS mainly by recognizing the pattern of symptoms and ruling out other illnesses. Current treatment focuses on managing symptoms and helping patients cope with this long-lasting, disabling condition.

InterventionsDiagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome. A review from the general practice perspective.

Murdoch, J C·Australian family physician·1992

This 1992 review examines ME/CFS from the perspective of general practitioners (GPs) in Australia. The paper discusses how GPs can recognize, understand, and manage ME/CFS in their patients, highlighting the challenges of diagnosing a condition that doesn't show up on standard blood tests. It emphasizes that ME/CFS is a real medical condition deserving of proper clinical attention and patient support.

Diagnostics

E3 PreliminaryCohortPEM unclearObservational

[Chronic fatigue syndrome--51 cases in the Jikei University School of Medicine].

Hashimoto, N, Kuraishi, Y, Yokose, T et al.·Nihon rinsho. Japanese journal of clinical medicine·1992

This study identified 51 patients with ME/CFS diagnosed using official CDC criteria between 1991 and 1992. Most patients were women in their 20s–30s who had been seen by many doctors before receiving a correct diagnosis. Standard blood tests did not reveal abnormal findings, though some immune markers were mildly abnormal. About 57% of patients showed general improvement, and doctors used various medications to manage severe symptoms.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Therapy of chronic fatigue syndrome].

Uchida, A·Nihon rinsho. Japanese journal of clinical medicine·1992

This review examined different treatment options for ME/CFS by looking at past clinical studies. Researchers found that while most treatments tested didn't work well, a few showed promise—including intravenous immunoglobulin therapy, magnesium supplements, and treatments designed to boost natural killer cells (immune cells that help fight infection). The authors suggest that immune system problems may play a role in ME/CFS, and fixing these problems might help patients feel better.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome.

Buchwald, D, Garrity, D, Pascualy, R et al.·Toxicology and industrial health·1992

This is a review article that examines what was known about chronic fatigue syndrome in the early 1990s. The authors looked at existing research to summarize the characteristics, possible causes, and impacts of this condition. This paper helped establish an early framework for understanding ME/CFS as a medical condition worthy of scientific investigation.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Search for retrovirus in the chronic fatigue syndrome.

Gow, J W, Simpson, K, Schliephake, A et al.·Journal of clinical pathology·1992

Researchers tested blood and muscle tissue from 30 ME/CFS patients to see if a virus called a retrovirus might be causing the illness. They used sensitive laboratory techniques to look for viral genetic material. They found no evidence that retroviruses were present in any of the patients tested, suggesting that this particular type of virus is not responsible for ME/CFS.

E3 PreliminaryBehavioralPEM unclear

Effective treatment for an adolescent with chronic fatigue syndrome.

Wachsmuth, J R, MacMillan, H L·Clinical pediatrics·1991

This study describes the case of a teenager with chronic fatigue syndrome (ME/CFS) who received treatment. The doctors documented how the patient was evaluated and what approach was used to help manage their symptoms. This single case report provides an early clinical example of treating ME/CFS in young patients.

Interventions

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Muscle performance, voluntary activation, twitch properties and perceived effort in normal subjects and patients with the chronic fatigue syndrome.

Lloyd, A R, Gandevia, S C, Hales, J P·Brain : a journal of neurology·1991

Researchers tested whether ME/CFS patients have weak muscles or lack motivation during exercise compared to healthy people. They measured muscle strength and effort in both groups while performing repetitive arm exercises for 45 minutes. Both groups showed similar muscle performance and reported similar levels of effort, suggesting that muscle weakness or poor motivation are not the primary causes of fatigue in ME/CFS.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Issues and problems in the conduct of epidemiologic research on chronic fatigue syndrome.

Grufferman, S·Reviews of infectious diseases·1991

This paper discusses how scientists should study ME/CFS using epidemiology—a research method that looks at how diseases spread through populations. The authors outline the main problems researchers face when studying ME/CFS, such as unclear diagnostic criteria and limited understanding of the condition, and suggest practical solutions. They emphasize that case-control studies (comparing people who have ME/CFS with similar people who don't) should be a priority for understanding what causes the illness.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Human herpesvirus-6 (HHV-6) (short review).

Ablashi, D V, Salahuddin, S Z, Josephs, S F et al.·In vivo (Athens, Greece)·1991

This review examines Human Herpesvirus-6 (HHV-6), a common virus that most people carry. The virus can reactivate in people with certain illnesses, including ME/CFS. The study found that people with ME/CFS sometimes have higher levels of antibodies to HHV-6, suggesting the virus may be active in their bodies.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

The chronic fatigue syndrome.

Shafran, S D·The American journal of medicine·1991

ME/CFS is a serious condition causing extreme fatigue lasting at least 6 months that doctors cannot fully explain. While most patients report getting sick before their fatigue started, researchers have not found proof that any specific infection causes ME/CFS. The condition mainly affects people aged 20-50, with more women than men affected.

Immune System

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Evidence browser

[Symptoms, signs and laboratory findings in patients with chronic fatigue syndrome].

Chronic fatigue syndrome.

Plasma and cerebrospinal fluid monoamine metabolism in patients with chronic fatigue syndrome: preliminary findings.

[What is the relation of human herpesvirus 6 to chronic fatigue syndrome?].

The chronic fatigue syndrome: considerations relevant to children and adolescents.

[Viral infection and its causative role for chronic fatigue syndrome].

Chronic fatigue syndrome: a joint paediatric-psychiatric approach.

Skeletal muscle metabolism in the chronic fatigue syndrome. In vivo assessment by 31P nuclear magnetic resonance spectroscopy.

[Diagnostic criteria for chronic fatigue syndrome by the CFS Study Group in Japan].

Chronic fatigue syndrome. Recent advances in diagnosis and treatment.

Chronic fatigue syndrome. A review from the general practice perspective.

[Chronic fatigue syndrome--51 cases in the Jikei University School of Medicine].

[Therapy of chronic fatigue syndrome].

Chronic fatigue syndrome.

Search for retrovirus in the chronic fatigue syndrome.

Effective treatment for an adolescent with chronic fatigue syndrome.

Muscle performance, voluntary activation, twitch properties and perceived effort in normal subjects and patients with the chronic fatigue syndrome.

Issues and problems in the conduct of epidemiologic research on chronic fatigue syndrome.

Human herpesvirus-6 (HHV-6) (short review).

The chronic fatigue syndrome.

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