ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

521–540 of 2,423 studies

E3 PreliminaryBehavioralPEM unclearCross-Sectional

Qualitative study of the acceptability and feasibility of acceptance and commitment therapy for adolescents with chronic fatigue syndrome.

Clery, Philippa, Starbuck, Jennifer, Laffan, Amanda et al.·BMJ paediatrics open·2021

This study asked teenagers with ME/CFS who weren't getting better, along with their parents and doctors, what they thought about a therapy called Acceptance and Commitment Therapy (ACT). Everyone interviewed thought ACT sounded like a good option because it helps people focus on what matters to them while accepting difficult thoughts and feelings, rather than trying to fight them. Most teenagers were willing to try ACT, though they worried about being randomly assigned to different treatment groups in a future study.

E3 PreliminaryReviewPEM unclearReview-Narrative

The Impact of Severe ME/CFS on Student Learning and K-12 Educational Limitations.

Newton, Faith R·Healthcare (Basel, Switzerland)·2021

This article examines how severe ME/CFS affects children's ability to attend school and learn. Many severely ill children are confined to bed or home and cannot attend regular classes. The study suggests that schools are not providing adequate support for these students and proposes new educational approaches and resources that could help them continue learning despite their illness.

Severe ME

E3 PreliminaryMechanismPEM unclearMechanistic

The effect of IL-2 stimulation and treatment of TRPM3 on channel co-localisation with PIP2 and NK cell function in myalgic encephalomyelitis/chronic fatigue syndrome patients.

Eaton-Fitch, Natalie, Cabanas, Hélène, du Preez, Stanley et al.·Journal of translational medicine·2021

This study looked at immune cells called NK cells in ME/CFS patients and compared them to healthy people. The researchers focused on a protein channel called TRPM3 that helps control calcium levels in cells, which may be important for immune function. They found that this channel doesn't work properly in ME/CFS patients, but when cells were stimulated with a chemical called IL-2, the NK cells from ME/CFS patients could kill viruses and abnormal cells as effectively as healthy people's cells.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Broadband electrical impedance as a novel characterization of oxidative stress in single L6 skeletal muscle cells.

Ferguson, Caroline, Pini, Niccolo, Du, Xiaotian et al.·Analytica chimica acta·2021

This study tested whether a special electrical measurement could detect damage from oxidative stress (harmful chemical reactions) in muscle cells. Researchers treated rat muscle cells with hydrogen peroxide to create oxidative stress, then measured how these stressed cells behaved electrically compared to healthy cells. The stressed cells showed distinctly different electrical patterns, suggesting this technology might one day help diagnose ME/CFS by detecting oxidative stress in patients' muscle cells.

Biomarkers

E3 PreliminaryCohortPEM unclearCase-Control

Life-Threatening Malnutrition in Very Severe ME/CFS.

Baxter, Helen, Speight, Nigel, Weir, William·Healthcare (Basel, Switzerland)·2021

This study describes five patients with very severe ME/CFS who developed life-threatening malnutrition because doctors delayed providing tube feeding support. Some severely affected patients cannot eat or drink normally due to swallowing difficulties, severe stomach problems, or being too ill to feed themselves. The research shows that doctors sometimes mistakenly blamed psychological factors instead of recognizing nutrition problems as a direct result of the disease, leading to dangerous delays in life-saving treatment.

Severe ME

E3 PreliminaryCohortPEM unclearObservational

Experiences of Living with Severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Strassheim, Victoria, Newton, Julia L, Collins, Tracy·Healthcare (Basel, Switzerland)·2021

This study listened to five people living with the most severe form of ME/CFS—those who are bedbound, housebound, or wheelchair-dependent—to understand what their daily lives are really like. By interviewing them and analyzing their stories, researchers found three main themes: how they experience living with the illness, the major challenges it creates, and how they try to manage their condition. This research helps doctors and scientists better understand the needs of the most severely affected patients.

Severe ME

E3 PreliminaryMechanismPEM not requiredMechanistic

Inflammation plays a causal role in fatigue-like behavior induced by pelvic irradiation in mice.

Wolff, Brian S, Alshawi, Sarah A, Feng, Li Rebekah et al.·Brain, behavior, & immunity - health·2021

Researchers gave mice targeted radiation to the pelvis (similar to cancer treatment) and found that the mice became less active afterward—a fatigue-like behavior. They discovered that inflammation, particularly a protein called IL-6, plays a key role in causing this fatigue. When they reduced inflammation using a drug called minocycline or using mice genetically unable to trigger certain inflammatory pathways, the fatigue was reduced but not completely eliminated.

Immune System

E3 PreliminaryMechanismPEM unclearObservational

Insights From Invasive Cardiopulmonary Exercise Testing of Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Joseph, Phillip, Arevalo, Carlo, Oliveira, Rudolf K F et al.·Chest·2021

This study used specialized heart and lung testing during exercise to understand why people with ME/CFS struggle with physical activity. Researchers found that ME/CFS patients had two different problems during exercise: some had reduced blood flow returning to the heart, while others couldn't efficiently extract oxygen from their blood. About 31% of patients also showed evidence of small nerve fiber damage in their skin biopsies.

Post-Exertional Malaise

E3 PreliminaryCohortPEM requiredCase-Control

Three Cases of Severe ME/CFS in Adults.

Williams, Leah R, Isaacson-Barash, Carol·Healthcare (Basel, Switzerland)·2021

This study describes the experiences of three adults living with ME/CFS at different severity levels—moderate, severe, and very severe. The researchers wanted to show how differently this illness affects people and how overwhelming it can be, especially for those who are housebound or bedbound. The study highlights what doctors and healthcare providers can do to better support patients with this complex condition.

Post-Exertional Malaise

E3 PreliminaryCohortPEM not requiredCase-Control

Chronic Fatigue Syndrome and Bone Marrow Defects of the Jaw - A Case Report on Additional Dental X-Ray Diagnostics with Ultrasound.

Lechner, Johann, Schick, Fabian·International medical case reports journal·2021

This case report describes a young man with ME/CFS who had headaches and tinnitus but no visible bone problems on standard X-rays. When doctors used ultrasound imaging, they found a suspicious area in his lower jawbone. Surgery revealed a fungal infection (aspergillosis) and inflamed tissue that standard X-rays had missed. This suggests that ultrasound might be a better tool for detecting hidden bone and jaw problems in some ME/CFS patients.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Current state about researches on selection of experimental indexs mechanisms of acupuncture underlying improvement of chronic fatigue syndrome].

Li, Yan-Hui, Ma, Qiao-Lin, Hu, Bin et al.·Zhen ci yan jiu = Acupuncture research·2021

This review examined research from the past 10 years on how acupuncture may help chronic fatigue syndrome by looking at four main body systems: immune function, stress hormones and brain chemistry, the body's ability to handle cellular damage, and cell signaling pathways. The researchers found evidence that acupuncture appears to work through multiple mechanisms rather than just one, potentially helping the body recover from CFS through different pathways.

Immune System

E3 PreliminaryPEM unclearRegistry-Resource

mapMECFS: a portal to enhance data discovery across biological disciplines and collaborative sites.

Mathur, Ravi, Carnes, Megan U, Harding, Alexander et al.·Journal of translational medicine·2021

Researchers created mapMECFS, an online database that brings together research information about ME/CFS from scientists around the world. Instead of having data scattered across different locations and websites, this portal allows researchers to easily find, share, and compare information about the disease in one place. This tool is designed to help scientists discover patterns and connections that might reveal new ways to diagnose and treat ME/CFS.

Biomarkers

E3 PreliminaryMechanismPEM unclearCross-Sectional

Chronic fatigue syndrome: Abnormally fast muscle fiber conduction in the membranes of motor units at low static force load.

Klaver-Krol, E G, Hermens, H J, Vermeulen, R C et al.·Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2021

Researchers used muscle sensors to measure how electrical signals travel through muscle fibers in people with ME/CFS, fibromyalgia, and healthy people during light strength exercises. They found that in ME/CFS patients, these electrical signals traveled unusually fast through muscle fibers as force increased, which didn't happen in the other groups. This suggests that muscle cells in ME/CFS may have a problem with how they work at the membrane level.

E3 PreliminaryMechanismPEM not requiredMechanistic

Oxidative stress caused by a dysregulated Wnt/β-catenin signalling pathway is involved in abnormal placenta formation in pregnant mice with chronic fatigue syndrome.

Zhao, Hai, Zhang, Jian, Qian, Ning et al.·Zygote (Cambridge, England)·2021

This study looked at how ME/CFS affects pregnancy in mice, focusing on how the placenta (which nourishes a developing baby) forms and functions. Researchers found that mice with CFS had more pregnancy complications, abnormal placentas, and increased cellular damage from oxidative stress (a harmful buildup of unstable molecules). The study suggests that two biological processes—oxidative stress and a disrupted cellular communication pathway called Wnt/β-catenin—may be responsible for these pregnancy problems.

E3 PreliminaryReviewPEM unclearReview-Narrative

Potential Implications of Mammalian Transient Receptor Potential Melastatin 7 in the Pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Review.

Du Preez, Stanley, Cabanas, Helene, Staines, Donald et al.·International journal of environmental research and public health·2021

This review examines a protein called TRPM7 that may play a role in ME/CFS. TRPM7 is an ion channel—a type of gateway that controls how calcium and other minerals move in and out of cells—and it appears to affect the nervous system, immune system, heart, and metabolism. The authors suggest that problems with TRPM7 could help explain some of the complex symptoms seen in ME/CFS, though this is still a developing area of research.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Split-Second Unlearning: Developing a Theory of Psychophysiological Dis-ease.

Hudson, Matt, Johnson, Mark I·Frontiers in psychology·2021

This study proposes that early emotional experiences—both traumatic and everyday—can create lasting patterns in how our bodies respond to stress. When we encounter triggers related to those memories, our body automatically activates a stress response even if the threat is no longer present. The researchers describe a new therapy approach where patients learn to observe their own automatic responses in the moment and gradually 'unlearn' the connection between the memory and the physical stress reaction.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Post-COVID-19 syndrome: epidemiology, diagnostic criteria and pathogenic mechanisms involved.

Carod-Artal, F J·Revista de neurologia·2021

Many people who have had COVID-19, even mild cases, don't fully recover and experience long-lasting symptoms for months afterward. This article reviews what we know about post-COVID-19 syndrome, including who gets it, what symptoms they have, and what might be causing it. Common symptoms include fatigue, breathing problems, difficulty concentrating, anxiety, and depression. The exact biological reasons why this happens are still unknown, though experts think abnormal immune and inflammatory responses may play a role.

DiagnosticsCognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

Post-Acute COVID-19 Syndrome and the cardiovascular system: What is known?

Dixit, Neal M, Churchill, Austin, Nsair, Ali et al.·American heart journal plus : cardiology research and practice·2021

Some people who have had COVID-19 develop long-lasting symptoms weeks or months later, including chest pain and heart palpitations (feeling your heart racing). This review examines what we know about how COVID-19 affects the heart during this long-COVID period. While the virus itself rarely causes direct heart damage, it can trigger several heart-related conditions that may explain why patients experience these symptoms.

E3 PreliminaryBehavioralPEM unclear

Is Cognitive Change Necessary to Alleviate Symptoms in Patients With Functional Somatic Syndrome?

Maroti, Daniel, Johansson, Robert·Frontiers in psychiatry·2021

This study examined whether changing how patients think about their symptoms (cognitive change) is necessary to improve symptoms in people with functional somatic syndromes like ME/CFS. The researchers explored the relationship between psychological thinking patterns and symptom improvement to understand better which approaches might help patients feel better.

Cognitive Impairment

E3 PreliminaryReviewPEM unclearReview-Narrative

Persistent Brainstem Dysfunction in Long-COVID: A Hypothesis.

Yong, Shin Jie·ACS chemical neuroscience·2021

This paper suggests that long-COVID symptoms may be caused by damage to the brainstem, a part of the brain that controls basic functions like breathing, heart rate, and digestion. The authors propose that the coronavirus may directly infect the brainstem or cause inflammation there, and because brain cells heal slowly, this damage could persist long after the initial infection. This theory could help explain why long-COVID patients experience lasting fatigue, breathing problems, and other widespread symptoms.

Neuroinflammation

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Evidence Atlas

Evidence browser

Qualitative study of the acceptability and feasibility of acceptance and commitment therapy for adolescents with chronic fatigue syndrome.

The Impact of Severe ME/CFS on Student Learning and K-12 Educational Limitations.

The effect of IL-2 stimulation and treatment of TRPM3 on channel co-localisation with PIP2 and NK cell function in myalgic encephalomyelitis/chronic fatigue syndrome patients.

Broadband electrical impedance as a novel characterization of oxidative stress in single L6 skeletal muscle cells.

Life-Threatening Malnutrition in Very Severe ME/CFS.

Experiences of Living with Severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Inflammation plays a causal role in fatigue-like behavior induced by pelvic irradiation in mice.

Insights From Invasive Cardiopulmonary Exercise Testing of Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Three Cases of Severe ME/CFS in Adults.

Chronic Fatigue Syndrome and Bone Marrow Defects of the Jaw - A Case Report on Additional Dental X-Ray Diagnostics with Ultrasound.

[Current state about researches on selection of experimental indexs mechanisms of acupuncture underlying improvement of chronic fatigue syndrome].

mapMECFS: a portal to enhance data discovery across biological disciplines and collaborative sites.

Chronic fatigue syndrome: Abnormally fast muscle fiber conduction in the membranes of motor units at low static force load.

Oxidative stress caused by a dysregulated Wnt/β-catenin signalling pathway is involved in abnormal placenta formation in pregnant mice with chronic fatigue syndrome.

Potential Implications of Mammalian Transient Receptor Potential Melastatin 7 in the Pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Review.

Split-Second Unlearning: Developing a Theory of Psychophysiological Dis-ease.

Post-COVID-19 syndrome: epidemiology, diagnostic criteria and pathogenic mechanisms involved.

Post-Acute COVID-19 Syndrome and the cardiovascular system: What is known?

Is Cognitive Change Necessary to Alleviate Symptoms in Patients With Functional Somatic Syndrome?

Persistent Brainstem Dysfunction in Long-COVID: A Hypothesis.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research