ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

521–540 of 2,420 studies

E3 PreliminaryCohortPEM unclearCross-Sectional

"it's a medical condition … you need to support as much as possible": a qualitative analysis of teachers' experiences of chronic fatigue syndrome / myalgic encephalomyelitis (CFS/ME).

Brigden, Amberly, Shaw, Alison, Crawley, Esther·BMC pediatrics·2021

This study asked 11 primary school teachers about their experiences supporting children aged 5-11 with ME/CFS in the classroom. Teachers described seeing significant fatigue and thinking problems in their students, along with variable symptoms like pain, headaches, and sensitivity to light or sound. Most teachers wanted to help and used practical strategies like rest breaks and modified activities, but said they needed more training and resources to understand ME/CFS better.

E3 PreliminaryMechanismPEM unclearMechanistic

The effect of IL-2 stimulation and treatment of TRPM3 on channel co-localisation with PIP2 and NK cell function in myalgic encephalomyelitis/chronic fatigue syndrome patients.

Eaton-Fitch, Natalie, Cabanas, Hélène, du Preez, Stanley et al.·Journal of translational medicine·2021

This study looked at immune cells called NK cells in ME/CFS patients and compared them to healthy people. The researchers focused on a protein channel called TRPM3 that helps control calcium levels in cells, which may be important for immune function. They found that this channel doesn't work properly in ME/CFS patients, but when cells were stimulated with a chemical called IL-2, the NK cells from ME/CFS patients could kill viruses and abnormal cells as effectively as healthy people's cells.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Broadband electrical impedance as a novel characterization of oxidative stress in single L6 skeletal muscle cells.

Ferguson, Caroline, Pini, Niccolo, Du, Xiaotian et al.·Analytica chimica acta·2021

This study tested whether a special electrical measurement could detect damage from oxidative stress (harmful chemical reactions) in muscle cells. Researchers treated rat muscle cells with hydrogen peroxide to create oxidative stress, then measured how these stressed cells behaved electrically compared to healthy cells. The stressed cells showed distinctly different electrical patterns, suggesting this technology might one day help diagnose ME/CFS by detecting oxidative stress in patients' muscle cells.

Biomarkers

E3 PreliminaryMechanismPEM not requiredMechanistic

Homeostatic disturbance of thermoregulatory functions in rats with chronic fatigue.

Li, Danxi, Hu, Di, Shigeta, Mika et al.·Neuroscience research·2021

Many ME/CFS patients report feeling feverish or chilled even when their body temperature is normal. This study used rats with chronic fatigue to understand what goes wrong with the body's temperature control system. Researchers found that in early fatigue, the body tried to raise its temperature to cope, but over time this system broke down and stopped working properly, which may explain why fatigue becomes long-lasting.

Autonomic Nervous System

E3 PreliminaryCohortPEM unclearObservational

Experiences of Living with Severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Strassheim, Victoria, Newton, Julia L, Collins, Tracy·Healthcare (Basel, Switzerland)·2021

This study listened to five people living with the most severe form of ME/CFS—those who are bedbound, housebound, or wheelchair-dependent—to understand what their daily lives are really like. By interviewing them and analyzing their stories, researchers found three main themes: how they experience living with the illness, the major challenges it creates, and how they try to manage their condition. This research helps doctors and scientists better understand the needs of the most severely affected patients.

Severe ME

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia and Associated Disorders: From Pain to Chronic Suffering, From Subjective Hypersensitivity to Hypersensitivity Syndrome.

Maugars, Yves, Berthelot, Jean-Marie, Le Goff, Benoit et al.·Frontiers in medicine·2021

This article reviews what scientists know about fibromyalgia as of 2020, including how it's diagnosed and why it happens. The authors explain that fibromyalgia involves the brain processing pain signals too intensely, and that people with fibromyalgia often experience many other symptoms like fatigue, sleep problems, and sensitivity to sounds, lights, and touch. They also discuss how fibromyalgia shares common features with other conditions like ME/CFS, all involving a heightened sensitivity to stimuli controlled by the central nervous system.

Sleep

E3 PreliminaryCohortPEM requiredCase-Control

Three Cases of Severe ME/CFS in Adults.

Williams, Leah R, Isaacson-Barash, Carol·Healthcare (Basel, Switzerland)·2021

This study describes the experiences of three adults living with ME/CFS at different severity levels—moderate, severe, and very severe. The researchers wanted to show how differently this illness affects people and how overwhelming it can be, especially for those who are housebound or bedbound. The study highlights what doctors and healthcare providers can do to better support patients with this complex condition.

Post-Exertional Malaise

E3 PreliminaryReviewPEM requiredReview-Narrative

COVID-19 and post-infectious myalgic encephalomyelitis/chronic fatigue syndrome: a narrative review.

Poenaru, Sonia, Abdallah, Sara J, Corrales-Medina, Vicente et al.·Therapeutic advances in infectious disease·2021

Some people who recover from COVID-19 continue experiencing prolonged symptoms like fatigue, difficulty breathing, and brain fog for months afterward. These lingering symptoms are remarkably similar to ME/CFS, a chronic illness characterized by severe fatigue that worsens with activity. While COVID-19 could potentially trigger ME/CFS in some people, researchers currently don't have enough evidence to confirm this connection.

Severe MEPost-Exertional Malaise

E3 PreliminaryBehavioralPEM unclearCross-Sectional

Qualitative study of the acceptability and feasibility of acceptance and commitment therapy for adolescents with chronic fatigue syndrome.

Clery, Philippa, Starbuck, Jennifer, Laffan, Amanda et al.·BMJ paediatrics open·2021

This study asked teenagers with ME/CFS who weren't getting better, along with their parents and doctors, what they thought about a therapy called Acceptance and Commitment Therapy (ACT). Everyone interviewed thought ACT sounded like a good option because it helps people focus on what matters to them while accepting difficult thoughts and feelings, rather than trying to fight them. Most teenagers were willing to try ACT, though they worried about being randomly assigned to different treatment groups in a future study.

E3 PreliminaryCohortPEM unclearCase-Control

Life-Threatening Malnutrition in Very Severe ME/CFS.

Baxter, Helen, Speight, Nigel, Weir, William·Healthcare (Basel, Switzerland)·2021

This study describes five patients with very severe ME/CFS who developed life-threatening malnutrition because doctors delayed providing tube feeding support. Some severely affected patients cannot eat or drink normally due to swallowing difficulties, severe stomach problems, or being too ill to feed themselves. The research shows that doctors sometimes mistakenly blamed psychological factors instead of recognizing nutrition problems as a direct result of the disease, leading to dangerous delays in life-saving treatment.

Severe ME

E3 PreliminaryReviewPEM not requiredReview-Narrative

Photobiomodulation and Sports: Results of a Narrative Review.

Ailioaie, Laura Marinela, Litscher, Gerhard·Life (Basel, Switzerland)·2021

This review looked at studies on photobiomodulation (PBM)—a treatment using light to help cells work better—and how it might help athletes recover faster and perform better. The researchers found that in about 25 human studies, PBM appeared helpful for reducing fatigue and supporting recovery, though some studies didn't show clear benefits. The authors suggest that with better devices and clearer protocols, PBM could potentially help people dealing with exhaustion and physical stress.

E3 PreliminaryDiagnosticPEM requiredMethods-Paper

The development of an instrument to assess post-exertional malaise in patients with myalgic encephalomyelitis and chronic fatigue syndrome.

Jason, Leonard A, Holtzman, Carly S, Sunnquist, Madison et al.·Journal of health psychology·2021

This study created a new questionnaire called the DePaul Post-Exertional Malaise Questionnaire to measure post-exertional malaise (PEM)—the worsening of symptoms that happens after physical or mental activity in ME/CFS patients. Researchers worked with hundreds of patients to develop questions that accurately capture what PEM feels like. Early testing showed the questionnaire works well and connects meaningfully with how much physical activity patients can do.

Post-Exertional Malaise

E3 PreliminaryPEM unclearRegistry-Resource

mapMECFS: a portal to enhance data discovery across biological disciplines and collaborative sites.

Mathur, Ravi, Carnes, Megan U, Harding, Alexander et al.·Journal of translational medicine·2021

Researchers created mapMECFS, an online database that brings together research information about ME/CFS from scientists around the world. Instead of having data scattered across different locations and websites, this portal allows researchers to easily find, share, and compare information about the disease in one place. This tool is designed to help scientists discover patterns and connections that might reveal new ways to diagnose and treat ME/CFS.

Biomarkers

E3 PreliminaryCohortPEM not requiredCase-Control

Chronic Fatigue Syndrome and Bone Marrow Defects of the Jaw - A Case Report on Additional Dental X-Ray Diagnostics with Ultrasound.

Lechner, Johann, Schick, Fabian·International medical case reports journal·2021

This case report describes a young man with ME/CFS who had headaches and tinnitus but no visible bone problems on standard X-rays. When doctors used ultrasound imaging, they found a suspicious area in his lower jawbone. Surgery revealed a fungal infection (aspergillosis) and inflamed tissue that standard X-rays had missed. This suggests that ultrasound might be a better tool for detecting hidden bone and jaw problems in some ME/CFS patients.

E3 PreliminaryMechanismPEM unclearObservational

Insights From Invasive Cardiopulmonary Exercise Testing of Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Joseph, Phillip, Arevalo, Carlo, Oliveira, Rudolf K F et al.·Chest·2021

This study used specialized heart and lung testing during exercise to understand why people with ME/CFS struggle with physical activity. Researchers found that ME/CFS patients had two different problems during exercise: some had reduced blood flow returning to the heart, while others couldn't efficiently extract oxygen from their blood. About 31% of patients also showed evidence of small nerve fiber damage in their skin biopsies.

Post-Exertional Malaise

E3 PreliminaryGuidelinePEM requiredGuideline

Caring for the Patient with Severe or Very Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Montoya, Jose G, Dowell, Theresa G, Mooney, Amy E et al.·Healthcare (Basel, Switzerland)·2021

This guide focuses on caring for people with severe ME/CFS who struggle to leave their homes or beds. The authors explain that these patients often can't visit doctors' offices and doctors frequently don't have good information about how to help them. The guide provides practical recommendations for diagnosis, assessment, and treatment options, including using telemedicine and working closely with patients and caregivers to provide better care.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

[Intestinal flora and neurological disorders].

Tang, Qianqian, Cao, Lihua·Sheng wu gong cheng xue bao = Chinese journal of biotechnology·2021

Your gut bacteria (microbiome) communicate with your brain through multiple pathways, including immune signals and nerve connections. When this gut-brain communication goes wrong, it may contribute to various neurological conditions, including chronic fatigue syndrome. This review summarizes what scientists know about how imbalanced gut bacteria might affect the nervous system and cause disease.

Neuroinflammation

E3 PreliminaryReviewPEM not requiredReview-Narrative

The Health-Promoting Properties and Clinical Applications of Rice Bran Arabinoxylan Modified with Shiitake Mushroom Enzyme-A Narrative Review.

Ooi, Soo Liang, Pak, Sok Cheon, Micalos, Peter S et al.·Molecules (Basel, Switzerland)·2021

This review examines a supplement called RBAC, made from rice bran processed with shiitake mushroom enzyme, which may have immune-boosting and anti-inflammatory effects. The authors found evidence that RBAC might help with several conditions including cancer, HIV, diabetes, irritable bowel syndrome, liver disease, and possibly chronic fatigue syndrome and the common cold. The supplement appears safe at typical doses of 2-3 grams per day, but more research is needed to confirm its benefits.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Lessons From Heat Stroke for Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Stanculescu, Dominic, Sepúlveda, Nuno, Lim, Chin Leong et al.·Frontiers in neurology·2021

This study compares how the body breaks down during heat stroke with what happens in ME/CFS. Both conditions involve similar problems: inflammation, damage to the gut lining that allows harmful substances into the bloodstream, blood clotting issues, and problems with how cells produce energy. By understanding heat stroke better, researchers hope to find new ways to treat ME/CFS.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Current state about researches on selection of experimental indexs mechanisms of acupuncture underlying improvement of chronic fatigue syndrome].

Li, Yan-Hui, Ma, Qiao-Lin, Hu, Bin et al.·Zhen ci yan jiu = Acupuncture research·2021

This review examined research from the past 10 years on how acupuncture may help chronic fatigue syndrome by looking at four main body systems: immune function, stress hormones and brain chemistry, the body's ability to handle cellular damage, and cell signaling pathways. The researchers found evidence that acupuncture appears to work through multiple mechanisms rather than just one, potentially helping the body recover from CFS through different pathways.

Immune System

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Evidence browser

"it's a medical condition … you need to support as much as possible": a qualitative analysis of teachers' experiences of chronic fatigue syndrome / myalgic encephalomyelitis (CFS/ME).

The effect of IL-2 stimulation and treatment of TRPM3 on channel co-localisation with PIP2 and NK cell function in myalgic encephalomyelitis/chronic fatigue syndrome patients.

Broadband electrical impedance as a novel characterization of oxidative stress in single L6 skeletal muscle cells.

Homeostatic disturbance of thermoregulatory functions in rats with chronic fatigue.

Experiences of Living with Severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Fibromyalgia and Associated Disorders: From Pain to Chronic Suffering, From Subjective Hypersensitivity to Hypersensitivity Syndrome.

Three Cases of Severe ME/CFS in Adults.

COVID-19 and post-infectious myalgic encephalomyelitis/chronic fatigue syndrome: a narrative review.

Qualitative study of the acceptability and feasibility of acceptance and commitment therapy for adolescents with chronic fatigue syndrome.

Life-Threatening Malnutrition in Very Severe ME/CFS.

Photobiomodulation and Sports: Results of a Narrative Review.

The development of an instrument to assess post-exertional malaise in patients with myalgic encephalomyelitis and chronic fatigue syndrome.

mapMECFS: a portal to enhance data discovery across biological disciplines and collaborative sites.

Chronic Fatigue Syndrome and Bone Marrow Defects of the Jaw - A Case Report on Additional Dental X-Ray Diagnostics with Ultrasound.

Insights From Invasive Cardiopulmonary Exercise Testing of Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Caring for the Patient with Severe or Very Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

[Intestinal flora and neurological disorders].

The Health-Promoting Properties and Clinical Applications of Rice Bran Arabinoxylan Modified with Shiitake Mushroom Enzyme-A Narrative Review.

Lessons From Heat Stroke for Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

[Current state about researches on selection of experimental indexs mechanisms of acupuncture underlying improvement of chronic fatigue syndrome].

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research