ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

641–660 of 2,422 studies

E3 PreliminaryMechanismPEM not requiredMechanistic

Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters.

Thakur, Vandana, Jamwal, Sumit, Kumar, Mandeep et al.·Neurotoxicity research·2020

Researchers studied a substance called hemin in mice to see if it could help with fatigue-like symptoms. Mice that were stressed for 21 days showed signs of exhaustion, weakness, and anxiety. When treated with hemin, these mice improved—they became more active, stronger, and less anxious. The improvements seemed to work through a specific pathway in the body related to an enzyme called HO-1.

Energy Metabolism

E3 PreliminaryMechanismPEM unclearCross-Sectional

Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations.

Mandarano, Alexandra H, Maya, Jessica, Giloteaux, Ludovic et al.·The Journal of clinical investigation·2020

This study looked at how immune cells (T cells) work differently in people with ME/CFS compared to healthy people. Researchers found that T cells from ME/CFS patients use energy less efficiently—they have trouble both producing energy at rest and responding when activated. These metabolic problems in immune cells may help explain why ME/CFS patients experience severe fatigue and other symptoms.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

Not what it seems to be: Depression versus periodic limb movement disorder.

Gupta, Ravi, Kundu, Kaustuv, Khayyam, Khwaja et al.·Indian journal of psychiatry·2020

This case report describes a patient who was initially diagnosed with depression and wasn't getting better with antidepressant medications. Doctors later realized he actually had a sleep disorder called periodic limb movement disorder (PLMD), where the legs move involuntarily during sleep. When treated with a medication called ropinirole, his symptoms improved significantly. This story highlights how sleep problems can look like depression or chronic fatigue, and getting the right diagnosis matters.

Sleep

E3 PreliminaryMechanismPEM not requiredMechanistic

Eradication of persistent coxsackievirus B infection from a pancreatic cell line with clinically used antiviral drugs.

Honkimaa, Anni, Sioofy-Khojine, Amir-Babak, Oikarinen, Sami et al.·Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2020

This study tested whether common antiviral medications could eliminate persistent coxsackievirus B infections in laboratory pancreatic cells. Researchers found that four drugs—Enviroxime, Fluoxetine, Hizentra (an immune protein), and Pleconaril—successfully cleared the virus from infected cells. The results suggest these medications might be worth testing in patients with chronic enterovirus infections.

E3 PreliminaryCohortPEM unclearCross-Sectional

Cerebral Blood Flow Is Reduced in Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients During Mild Orthostatic Stress Testing: An Exploratory Study at 20 Degrees of Head-Up Tilt Testing.

van Campen, C Linda M C, Rowe, Peter C, Visser, Frans C·Healthcare (Basel, Switzerland)·2020

This study looked at blood flow to the brain in 19 people with severe ME/CFS who have difficulty standing up (orthostatic intolerance). When patients tilted their heads up at a mild 20-degree angle for 15 minutes, blood flow to their brains dropped by an average of 27%. All 19 patients showed this abnormal reduction in brain blood flow, suggesting this shorter, gentler test could help diagnose the condition even in the most severely ill patients who cannot tolerate longer or more intense tests.

Autonomic Nervous System

E3 PreliminaryMechanismPEM requiredCross-Sectional

A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction.

Sweetman, Eiren, Kleffmann, Torsten, Edgar, Christina et al.·Journal of translational medicine·2020

Researchers examined immune cells from ME/CFS patients and compared them to healthy controls, looking at which proteins were present and in what amounts. They found that ME/CFS patients had different patterns of proteins, particularly ones involved in how cells produce energy (through structures called mitochondria). These findings suggest that people with ME/CFS may have problems with energy production in their cells, which could explain why fatigue and post-exertional malaise are core symptoms of the disease.

Post-Exertional Malaise

E3 PreliminaryCohortPEM unclearCase-Control

Severe ME in Children.

Speight, Nigel·Healthcare (Basel, Switzerland)·2020

This study looks at severe ME/CFS in children who are so sick they can barely leave their homes or beds. The doctor who wrote it shares real patient stories to show how the illness presents and how to manage it properly. The study highlights an important problem: many doctors don't recognize or diagnose ME/CFS, and there's very little information available about the most severely affected patients.

Severe ME

E3 PreliminaryPEM unclear

Is the efficacy of repetitive transcranial magnetic stimulation influenced by baseline severity of fatigue symptom in patients with myalgic encephalomyelitis.

Yang, De Gang, Gu, Rui, Kubo, Jin et al.·The International journal of neuroscience·2020

Researchers tested whether a brain stimulation treatment called repetitive transcranial magnetic stimulation (rTMS) could help ME/CFS patients with fatigue. They treated 22 patients with 6-8 sessions of rTMS and measured fatigue levels before and after treatment. The study found that rTMS improved fatigue symptoms in all patients, whether they started with severe or mild fatigue.

Interventions

E3 PreliminaryMechanismPEM unclearMechanistic

Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Schreiner, Philipp, Harrer, Thomas, Scheibenbogen, Carmen et al.·ImmunoHorizons·2020

This study explores how a virus called HHV-6 might trigger ME/CFS by examining what happens inside cells when the virus reactivates. The researchers found that when HHV-6 wakes up, it causes cells to switch into a protective mode that fights other viruses but seriously damages the cell's power plants (mitochondria) and energy-making abilities. Importantly, blood serum from ME/CFS patients showed similar patterns, suggesting HHV-6 reactivation may play a role in the disease.

Energy Metabolism

E3 PreliminaryGuidelinePEM not requiredGuideline

International expert consensus on the management of allergic rhinitis (AR) aggravated by air pollutants: Impact of air pollution on patients with AR: Current knowledge and future strategies.

Naclerio, Robert, Ansotegui, Ignacio J, Bousquet, Jean et al.·The World Allergy Organization journal·2020

Allergic rhinitis (hay fever and similar nasal allergies) affects millions of people and becomes worse when air pollution is present. This expert consensus report reviews how air pollution—both indoors and outdoors—makes allergic rhinitis symptoms worse, and discusses the best ways to manage it. The main treatment involves following standard allergy guidelines and reducing exposure to pollutants, though more research is needed on which medicines work best for people dealing with both allergies and air pollution.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Antioxidant and immunomodulatory properties of Spilanthes oleracea with potential effect in chronic fatigue syndrome infirmity.

Nipate, Sonali S, Tiwari, Anand H·Journal of Ayurveda and integrative medicine·2020

This study tested whether an extract from Spilanthes oleracea (a plant used in traditional medicine) could help relieve fatigue symptoms in mice subjected to chronic stress. The researchers found that the plant extract reduced markers of cellular damage and improved physical performance in stressed mice, suggesting it may work by reducing harmful molecules called oxidative stress in the body.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Jerusalem artichoke (Helianthus tuberosus L.) as a medicinal plant and its natural products.

Sawicka, Barbara, Skiba, Dominika, Pszczółkowski, Piotr et al.·Cellular and molecular biology (Noisy-le-Grand, France)·2020

This review examined Jerusalem artichoke, a root vegetable, to understand its nutritional and health benefits. The researchers found that Jerusalem artichoke contains compounds that may help with blood sugar control, weight management, immune function, and several chronic conditions including chronic fatigue syndrome. However, this is a review of existing research rather than a new experiment testing these benefits in patients.

Energy MetabolismImmune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Mapping the Alterations of Glutamate Using Glu-Weighted CEST MRI in a Rat Model of Fatigue.

Li, Ruili, Dai, Zhuozhi, Hu, Di et al.·Frontiers in neurology·2020

Researchers used a special brain imaging technique to measure glutamate (a chemical messenger in the brain) in rats that were made fatigued through a 10-day stressful procedure. They found that fatigued rats had higher levels of glutamate in their brains compared to rested rats, and the fatigued rats moved around less. This suggests that too much glutamate in the brain might be involved in causing fatigue.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Development of a conceptual framework to underpin a health-related quality of life outcome measure in paediatric chronic fatigue syndrome/myalgic encephalopathy (CFS/ME): prioritisation through card ranking.

Parslow, Roxanne M, Anderson, Nina, Byrne, Danielle et al.·Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2020

Researchers asked young people with ME/CFS and their parents what aspects of their health and daily life matter most to them. Using a card-ranking game, 21 young people (ages 12-17) and their parents identified and discussed the outcomes that would be most important to improve. The study found that symptoms, tiredness, 'payback' (crashing after activity), and hobbies were ranked as most important by both groups, though young people prioritized school more and parents worried more about mood.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredMechanistic

An Adrenalectomy Mouse Model Reflecting Clinical Features for Chronic Fatigue Syndrome.

Lee, Jin-Seok, Jeon, Yoo-Jin, Park, Samuel-Young et al.·Biomolecules·2020

Researchers tested three different mouse models to find the best one for studying ME/CFS. They found that removing the adrenal glands (small organs that produce stress hormones) in mice created fatigue and pain symptoms most similar to ME/CFS, while other common models mainly produced depression-like behaviors. The adrenal-removed mice also showed specific brain changes involving inflammation and stress hormone pathways.

Neuroinflammation

E3 PreliminaryCohortPEM unclearObservational

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Organic Disease or Psychosomatic Illness? A Re-Examination of the Royal Free Epidemic of 1955.

Underhill, Rosemary, Baillod, Rosemarie·Medicina (Kaunas, Lithuania)·2020

This study examined a major ME/CFS outbreak that occurred at Royal Free Hospital in London in 1955, which forced the hospital to close for three months. Researchers interviewed 27 former staff members who experienced the outbreak and found their descriptions matched an infectious illness affecting the lymph nodes, muscles, and nervous system—not mass hysteria as some had claimed 15 years after the event. The study provides firsthand evidence that the 1955 epidemic was a real physical illness, not a psychological one.

E3 PreliminaryReviewPEM unclearReview-Narrative

The Interplay between Oxidative Stress, Exercise, and Pain in Health and Disease: Potential Role of Autonomic Regulation and Epigenetic Mechanisms.

Hendrix, Jolien, Nijs, Jo, Ickmans, Kelly et al.·Antioxidants (Basel, Switzerland)·2020

This review examines how physical activity, pain, and a harmful process called oxidative stress (cellular damage from unstable molecules) interact in both healthy people and those with chronic pain conditions. The authors found that the relationships between these three factors are complicated and depend on the type of exercise and which person is being studied. They suggest that the nervous system's automatic functions and changes in how genes are expressed may help explain why these connections work differently in different people.

Pain and SensitizationAutonomic Nervous System

E3 PreliminaryReviewPEM unclearReview-Narrative

Could Cognitive Behavioural Therapy Be an Effective Treatment for Long COVID and Post COVID-19 Fatigue Syndrome? Lessons from the Qure Study for Q-Fever Fatigue Syndrome.

Vink, Mark, Vink-Niese, Alexandra·Healthcare (Basel, Switzerland)·2020

This study looked at whether cognitive behavioural therapy (CBT)—a talk therapy that focuses on changing thought patterns—is effective for long COVID and post-COVID fatigue. The researchers re-examined a previous study on a similar condition called Q-fever fatigue syndrome and found serious problems with how that study was done. They concluded that CBT likely doesn't actually help people with these post-infection fatigue conditions feel better or become more able to do daily activities.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredMechanistic

Network Pharmacology to Uncover the Biological Basis of Spleen Qi Deficiency Syndrome and Herbal Treatment.

Wang, Xin, Wu, Min, Lai, Xinxing et al.·Oxidative medicine and cellular longevity·2020

This study used computer analysis and lab experiments to understand how traditional Chinese medicine views a condition called "spleen qi deficiency," which is linked to various diseases including chronic fatigue. Researchers found that this condition may involve problems with the immune system and how the body handles stress at the cellular level. They also identified which herbs traditionally used for this condition work by boosting immune cell activity.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Early Growth Response Gene Upregulation in Epstein-Barr Virus (EBV)-Associated Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Kerr, Jonathan·Biomolecules·2020

This study looked at specific genes called EGR genes that turn on in response to stress and infection. Researchers found that these genes were abnormally active in blood samples from some ME/CFS patients, and this activity matched up with signs of Epstein-Barr virus (EBV) reactivation. This suggests that in some people with ME/CFS, a dormant virus may be waking up and triggering an ongoing immune response.

Immune System

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Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters.

Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations.

Not what it seems to be: Depression versus periodic limb movement disorder.

Eradication of persistent coxsackievirus B infection from a pancreatic cell line with clinically used antiviral drugs.

Cerebral Blood Flow Is Reduced in Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients During Mild Orthostatic Stress Testing: An Exploratory Study at 20 Degrees of Head-Up Tilt Testing.

A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction.

Severe ME in Children.

Is the efficacy of repetitive transcranial magnetic stimulation influenced by baseline severity of fatigue symptom in patients with myalgic encephalomyelitis.

Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

International expert consensus on the management of allergic rhinitis (AR) aggravated by air pollutants: Impact of air pollution on patients with AR: Current knowledge and future strategies.

Antioxidant and immunomodulatory properties of Spilanthes oleracea with potential effect in chronic fatigue syndrome infirmity.

Jerusalem artichoke (Helianthus tuberosus L.) as a medicinal plant and its natural products.

Mapping the Alterations of Glutamate Using Glu-Weighted CEST MRI in a Rat Model of Fatigue.

Development of a conceptual framework to underpin a health-related quality of life outcome measure in paediatric chronic fatigue syndrome/myalgic encephalopathy (CFS/ME): prioritisation through card ranking.

An Adrenalectomy Mouse Model Reflecting Clinical Features for Chronic Fatigue Syndrome.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Organic Disease or Psychosomatic Illness? A Re-Examination of the Royal Free Epidemic of 1955.

The Interplay between Oxidative Stress, Exercise, and Pain in Health and Disease: Potential Role of Autonomic Regulation and Epigenetic Mechanisms.

Could Cognitive Behavioural Therapy Be an Effective Treatment for Long COVID and Post COVID-19 Fatigue Syndrome? Lessons from the Qure Study for Q-Fever Fatigue Syndrome.

Network Pharmacology to Uncover the Biological Basis of Spleen Qi Deficiency Syndrome and Herbal Treatment.

Early Growth Response Gene Upregulation in Epstein-Barr Virus (EBV)-Associated Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

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