Cognitive behaviour therapy for chronic fatigue syndrome: a multicentre randomised controlled trial.
Prins, J B, Bleijenberg, G, Bazelmans, E et al.·Lancet (London, England)·2001
This study tested whether cognitive behaviour therapy (CBT)—a type of talking therapy that focuses on thoughts and behaviours—helps people with ME/CFS. Researchers compared CBT with support groups and no treatment across three hospitals, following 278 patients for 14 months. CBT showed modest benefits for fatigue and daily functioning compared to the other groups, though only about one-third to one-half of patients experienced meaningful improvement.