Randomised, double-blind, placebo-controlled study of fluoxetine in chronic fatigue syndrome.
Vercoulen, J H, Swanink, C M, Zitman, F G et al.·Lancet (London, England)·1996
This study tested whether fluoxetine (an antidepressant medication) could help people with ME/CFS feel better. Researchers gave 96 patients either fluoxetine or a placebo for 8 weeks and measured changes in fatigue, mood, sleep, and physical activity. The medication did not improve any of these symptoms compared to placebo, whether or not patients were depressed.