ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

1041–1060 of 1,198 studies

E3 PreliminaryMechanismPEM not requiredObservational

The effect of brief exercise cessation on pain, fatigue, and mood symptom development in healthy, fit individuals.

Glass, Jennifer M, Lyden, Angela K, Petzke, Frank et al.·Journal of psychosomatic research·2004

This study looked at whether stopping exercise for just one week could trigger pain, fatigue, or mood problems in healthy people who exercise regularly. Researchers found that 8 out of 18 fit volunteers developed these symptoms after a week without exercise, and these people had weaker stress-response systems (measured by cortisol levels, immune cells, and heart rate patterns) at the start of the study. This suggests some healthy people may naturally have less active biological stress systems and may actually rely on regular exercise to keep their symptoms suppressed.

Autonomic Nervous SystemImmune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Is chronic fatigue syndrome an autoimmune disorder of endogenous neuropeptides, exogenous infection and molecular mimicry?

Staines, Donald R·Medical hypotheses·2004

This paper proposes that ME/CFS may develop when the immune system mistakenly attacks natural signaling chemicals in the body called vasoactive neuropeptides, which are crucial for nerve function, blood flow, temperature regulation, and immune balance. The author suggests this autoimmune attack could be triggered by infection, intense exercise, or occur on its own, and explains how damage to these chemicals could cause the main symptoms of ME/CFS including fatigue, muscle pain, brain fog, and chemical sensitivity.

Evidence Atlas

Evidence browser

The effect of brief exercise cessation on pain, fatigue, and mood symptom development in healthy, fit individuals.

Is chronic fatigue syndrome an autoimmune disorder of endogenous neuropeptides, exogenous infection and molecular mimicry?

Immunological anomalies and thrombocytopenia in 117 dogs and cats diagnosed with chronic fatigue syndrome (CFS).

Identification of novel expressed sequences, up-regulated in the leucocytes of chronic fatigue syndrome patients.

[Lessons from macrophagic myofasciitis: towards definition of a vaccine adjuvant-related syndrome].

Type I interferons induce proteins susceptible to act as thyroid receptor (TR) corepressors and to signal the TR for destruction by the proteasome: possible etiology for unexplained chronic fatigue.

Successful intravenous immunoglobulin therapy in 3 cases of parvovirus B19-associated chronic fatigue syndrome.

Cytokines in parvovirus B19 infection as an aid to understanding chronic fatigue syndrome.

The neurological significance of abnormal natural killer cell activity in chronic toxigenic mold exposures.

Theoretical accounts of Gulf War Syndrome: from environmental toxins to psychoneuroimmunology and neurodegeneration.

Chronic fatigue syndrome: probable pathogenesis and possible treatments.

[Role of pathological delayed-type hypersensitivity in chronic fatigue syndrome: importance of the evaluation of lymphocyte activation by flow cytometry and the measurement of urinary neopterin].

A computational analysis of Canale-Smith syndrome: chronic lymphadenopathy simulating malignant lymphoma.

Ribonuclease L proteolysis in peripheral blood mononuclear cells of chronic fatigue syndrome patients.

Connecting cytokines and brain: a review of current issues.

Cytokine responses to physical activity, with particular reference to IL-6: sources, actions, and clinical implications.

Using an interleukin-6 challenge to evaluate neuropsychological performance in chronic fatigue syndrome.

[Use of IVIG in secondary immunodeficiencies].

Structural and functional features of the 37-kDa 2-5A-dependent RNase L in chronic fatigue syndrome.

Peripheral blood mononuclear cell beta-endorphin concentration is decreased in chronic fatigue syndrome and fibromyalgia but not in depression: preliminary report.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research