ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

1901–1920 of 6,209 studies

E2 ModerateCohortPEM not requiredCross-Sectional

Cerebral blood flow and heart rate variability predict fatigue severity in patients with chronic fatigue syndrome.

Boissoneault, Jeff, Letzen, Janelle, Robinson, Michael et al.·Brain imaging and behavior·2019

This study looked at blood flow in the brain and heart rate patterns in women with ME/CFS compared to healthy women. The researchers found that women with ME/CFS who had better blood flow to the brain and more variable heart rates tended to have less severe fatigue. These findings suggest that how well the body's circulatory and nervous systems are working may be connected to how tired people with ME/CFS feel.

E2 ModerateCohortPEM unclearObservational

EBV-requisitioning physicians' guess on fatigue state 6 months after acute EBV infection.

Asprusten, Tarjei Tørre, Pedersen, Maria, Skovlund, Eva et al.·BMJ paediatrics open·2019

This study looked at whether doctors could predict which teenagers with mono (infectious mononucleosis caused by EBV) would develop long-lasting fatigue 6 months later. The researchers found that when doctors initially thought a patient would be 'likely fatigued' or 'unsurely fatigued,' those patients were more likely to actually develop fatigue compared to those predicted as 'not fatigued.' However, the doctors' predictions were only correct about two-thirds of the time.

E2 ModerateBehavioralPEM unclearCross-Sectional

HOW PSYCHIATRIC REFERRALS INFLUENCE STIGMATIZATION IN PATIENTS WITH MYALGIC ENCEPHALOMYELITIS AND CHRONIC FATIGUE SYNDROME: AN EXAMINATION OF AMERICAN AND BRITISH MODELS.

Terman, Julia M, Cotler, Joseph, Jason, Leonard A·Community psychology in global perspective·2019

This study looked at how ME/CFS patients feel when their doctors refer them to psychiatrists or psychologists. Researchers found that patients who received these referrals were more likely to feel stigmatized (judged or looked down upon) and to feel isolated from others. The experience was different in the United States and United Kingdom, suggesting that healthcare systems and culture play a role in how these referrals affect patients.

E2 ModerateCohortPEM not requiredCross-Sectional

Supervised machine learning to decipher the complex associations between neuro-immune biomarkers and quality of life in schizophrenia.

Kanchanatawan, Buranee, Sriswasdi, Sira, Maes, Michael·Metabolic brain disease·2019

This study looked at how chemical imbalances in the brain (called tryptophan breakdown products) and memory problems are connected to quality of life in people with schizophrenia. Researchers measured immune markers, cognitive function, and symptoms in 80 patients with schizophrenia and 40 healthy controls. They found that anxiety, fatigue-like symptoms, depression, and psychosis were the strongest predictors of lower quality of life, and these were linked to abnormal tryptophan metabolism and memory difficulties.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Evidence for similarity in symptoms and mechanism: The extra-pulmonary symptoms of severe asthma and the polysymptomatic presentation of fibromyalgia.

Hyland, Michael E, Lanario, Joseph W, Wei, Yinghui et al.·Immunity, inflammation and disease·2019

This study found that people with severe asthma report many symptoms beyond breathing problems—such as fatigue, pain, and digestive issues—that are very similar to symptoms seen in fibromyalgia and chronic fatigue syndrome. The researchers compared symptom patterns between asthma patients and people with various functional disorders, finding that asthma and fibromyalgia symptoms were 75% similar in type and pattern. This suggests these conditions may share common underlying mechanisms related to how the body's systems interact.

E2 ModerateCohortPEM unclearCross-Sectional

A new approach to find biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) by single-cell Raman micro-spectroscopy.

Xu, Jiabao, Potter, Michelle, Tomas, Cara et al.·The Analyst·2019

Researchers used a new scanning technology called Raman spectroscopy to look at individual cells from ME/CFS patients and healthy people. They found that cells from ME/CFS patients had higher levels of a protein building block called phenylalanine, similar to cells with broken energy-producing structures (mitochondria). Using computer learning, they could identify ME/CFS patient cells with 98% accuracy based on this signature.

Biomarkers

E2 ModerateBehavioralPEM not requiredObservational

Implementation of stepped care for patients with chronic fatigue syndrome in community-based mental health care: outcomes at post-treatment and long-term follow-up.

Janse, Anthonie, van Dam, Arno, Pijpers, Coby et al.·Behavioural and cognitive psychotherapy·2019

This study tested whether a step-by-step treatment program combining self-help materials and talk therapy (CBT) for ME/CFS could work well in regular mental health clinics, not just specialist centers. The treatment did help patients—their fatigue decreased and physical function improved—and these improvements lasted for years afterward. However, patients improved somewhat less in community clinics than they did in specialist ME/CFS centers.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Illness perceptions in adolescents with chronic fatigue syndrome and other physical health conditions: Application of the common sense model.

Haines, Cara, Loades, Maria, Davis, Cara·Clinical child psychology and psychiatry·2019

This study compared how teenagers with ME/CFS view their illness compared to teenagers with diabetes or arthritis. Teenagers with ME/CFS had very different beliefs about their condition—particularly about how much control they had over it, how long it would last, and how well they understood what was happening to them. The researchers suggest that helping teenagers with ME/CFS feel more in control and understand their condition better might help them cope better.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Cognitive and behavioral coping in people with Chronic fatigue syndrome: An exploratory study searching for intervention targets for depressive symptoms.

Kraaij, Vivian, Bik, Janneke, Garnefski, Nadia·Journal of health psychology·2019

This study looked at how 30 people with ME/CFS cope with depression by using different thinking and behavior strategies. The researchers found that the way people think about and reframe their problems has a bigger impact on depression than what they do. Focusing on positive aspects, looking at problems in a different light, and avoiding catastrophizing (imagining the worst) seemed to help the most.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredObservational

Sleep education in primary school prevents future school refusal behavior.

Maeda, Tsutomu, Oniki, Kentaro, Miike, Teruhisa·Pediatrics international : official journal of the Japan Pediatric Society·2019

This study tested whether teaching primary school children about healthy sleep habits could prevent school refusal (persistent avoidance of attending school) later on. Researchers in Japan had students track their sleep for 2 weeks, gave them feedback, and taught them and their parents about the importance of regular sleep schedules. After the program started, school refusal rates dropped dramatically—from 10% of graduates in 2007 to 0% by 2012.

Sleep

E2 ModerateCohortPEM not requiredObservational

How fair is our service? Evaluating access to specialist paediatric care.

Neale, Francesca K, Armstrong, Edward J, Cohen, Jonathan M et al.·Archives of disease in childhood·2019

This study looked at whether all children, regardless of their family's income level, had equal access to specialist hospital clinics in one UK hospital between 2007 and 2018. Researchers found that local outpatient clinics (like those for asthma and chronic fatigue syndrome) served children from all income levels fairly equally, but specialist tertiary clinics served more children from wealthier families. This suggests that some children may have better access to specialized care depending on where they live and their family's economic situation.

E2 ModerateCohortPEM not requiredCase-Control

MicroRNAs as Biomarkers of Pain Intensity in Patients With Chronic Fatigue Syndrome.

Al-Rawaf, Hadeel A, Alghadir, Ahmad H, Gabr, Sami A·Pain practice : the official journal of World Institute of Pain·2019

This study looked at tiny molecules called microRNAs in the blood of adolescents with ME/CFS to see if they could help explain why these patients experience pain. Researchers found that five specific microRNAs were lower in ME/CFS patients compared to healthy teens, and these changes were linked to higher levels of inflammatory chemicals that are known to cause pain. Interestingly, girls with ME/CFS had even lower microRNA levels and higher inflammation markers than boys with the condition.

BiomarkersImmune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Adolescent and parent factors related to fatigue in paediatric multiple sclerosis and chronic fatigue syndrome: A comparative study.

Carroll, Susan, Chalder, Trudie, Hemingway, Cheryl et al.·European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society·2019

This study compared teenagers with multiple sclerosis (MS) who experienced fatigue, teenagers with ME/CFS, and healthy teenagers to understand what factors contribute to severe fatigue. Researchers found that teenagers with MS who were fatigued and teenagers with ME/CFS had very similar patterns of fatigue and unhelpful thinking patterns about their symptoms, but teenagers with ME/CFS had normal brain function while those with MS had some cognitive difficulties. The study suggests that psychological approaches used successfully in ME/CFS might also help teenagers with MS who experience fatigue.

Cognitive Impairment

E2 ModerateCohortPEM not requiredLongitudinal

Increased risk of chronic fatigue syndrome in patients with inflammatory bowel disease: a population-based retrospective cohort study.

Tsai, Shin-Yi, Chen, Hsuan-Ju, Lio, Chon-Fu et al.·Journal of translational medicine·2019

This study found that people with inflammatory bowel disease (IBD) are more than twice as likely to develop ME/CFS compared to people without IBD. The researchers looked at medical records from Taiwan and followed patients over time to see who developed ME/CFS. The increased risk was especially high in men and older adults with IBD who didn't have other chronic conditions.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Cytokine profiles in patients with Q fever fatigue syndrome.

Raijmakers, Ruud P H, Koeken, Valerie A C M, Jansen, Anne F M et al.·The Journal of infection·2019

This study looked at inflammatory markers in people who developed prolonged fatigue after Q fever infection. Researchers compared blood samples from patients with Q fever fatigue syndrome, chronic fatigue syndrome patients, people who had Q fever but recovered, and healthy controls. They found that Q fever fatigue syndrome patients had higher levels of specific inflammation proteins, suggesting chronic inflammation may be driving their ongoing fatigue.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

Patients with Fibromyalgia and Chronic Fatigue Syndrome show increased hsCRP compared to healthy controls.

Groven, Nina, Fors, Egil A, Reitan, Solveig Klæbo·Brain, behavior, and immunity·2019

This study measured inflammation markers in the blood of people with ME/CFS and fibromyalgia, compared to healthy people. Both patient groups had higher levels of a marker called hsCRP (a sign of inflammation) than healthy controls. The two conditions showed similar inflammation levels, suggesting they may share some biological similarities.

BiomarkersImmune System

E2 ModerateBehavioralPEM not requiredLongitudinal

Fatigue in Epstein-Barr virus infected adolescents and healthy controls: A prospective multifactorial association study.

Pedersen, Maria, Asprusten, Tarjei Tørre, Godang, Kristin et al.·Journal of psychosomatic research·2019

This study followed teenagers with acute Epstein-Barr virus (EBV) infection and compared them to healthy teenagers to understand what causes fatigue. Researchers measured 148 different factors including symptoms, quality of life, sleep, emotions, immune markers, and heart rate control at the start of infection and again six months later. They found that fatigue was consistently linked to sleep problems, negative emotions, and poor quality of life, but surprisingly, markers of active infection were not associated with how tired people felt.

SleepAutonomic Nervous System

E2 ModerateCohortPEM not requiredObservational

General theory of inflammation: patient self-administration of hydrocortisone safely achieves superior control of hydrocortisone-responding disorders by matching dosage with symptom intensity.

Irwin, John B, Baldwin, A L, Stenberg, Virgil I·Journal of inflammation research·2019

This study tested whether people with various chronic inflammatory conditions, including ME/CFS, could safely manage their own low-dose hydrocortisone treatment by adjusting it based on symptom flares. Over 2,000 participants achieved an average 76% improvement in symptoms while taking about 12 mg of hydrocortisone daily, and no serious side effects were reported.

Interventions

E2 ModerateCohortPEM unclearObservational

Unexplained exertional intolerance associated with impaired systemic oxygen extraction.

Melamed, Kathryn H, Santos, Mário, Oliveira, Rudolf K F et al.·European journal of applied physiology·2019

This study examined 313 patients with unexplained exercise intolerance using specialized heart and lung testing. Researchers found that about 12.5% of these patients have trouble exercising because their muscles cannot extract and use oxygen properly from the bloodstream, rather than having heart or lung problems. In these patients, the blood remained less acidic during exercise and had higher oxygen levels than expected, suggesting the muscles simply weren't using the available oxygen efficiently.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearCase-Control

Immunosignature Analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Günther, Oliver P, Gardy, Jennifer L, Stafford, Phillip et al.·Molecular neurobiology·2019

Researchers used a specialized test to examine antibodies (immune proteins) in the blood of people with ME/CFS and healthy controls. They found a pattern of 256 specific protein signatures in ME/CFS patients' blood that was different from healthy people. This suggests the immune system may be reacting to past infections in a way that could help doctors diagnose ME/CFS in the future.

Immune System

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Cerebral blood flow and heart rate variability predict fatigue severity in patients with chronic fatigue syndrome.

EBV-requisitioning physicians' guess on fatigue state 6 months after acute EBV infection.

HOW PSYCHIATRIC REFERRALS INFLUENCE STIGMATIZATION IN PATIENTS WITH MYALGIC ENCEPHALOMYELITIS AND CHRONIC FATIGUE SYNDROME: AN EXAMINATION OF AMERICAN AND BRITISH MODELS.

Supervised machine learning to decipher the complex associations between neuro-immune biomarkers and quality of life in schizophrenia.

Evidence for similarity in symptoms and mechanism: The extra-pulmonary symptoms of severe asthma and the polysymptomatic presentation of fibromyalgia.

A new approach to find biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) by single-cell Raman micro-spectroscopy.

Implementation of stepped care for patients with chronic fatigue syndrome in community-based mental health care: outcomes at post-treatment and long-term follow-up.

Illness perceptions in adolescents with chronic fatigue syndrome and other physical health conditions: Application of the common sense model.

Cognitive and behavioral coping in people with Chronic fatigue syndrome: An exploratory study searching for intervention targets for depressive symptoms.

Sleep education in primary school prevents future school refusal behavior.

How fair is our service? Evaluating access to specialist paediatric care.

MicroRNAs as Biomarkers of Pain Intensity in Patients With Chronic Fatigue Syndrome.

Adolescent and parent factors related to fatigue in paediatric multiple sclerosis and chronic fatigue syndrome: A comparative study.

Increased risk of chronic fatigue syndrome in patients with inflammatory bowel disease: a population-based retrospective cohort study.

Cytokine profiles in patients with Q fever fatigue syndrome.

Patients with Fibromyalgia and Chronic Fatigue Syndrome show increased hsCRP compared to healthy controls.

Fatigue in Epstein-Barr virus infected adolescents and healthy controls: A prospective multifactorial association study.

General theory of inflammation: patient self-administration of hydrocortisone safely achieves superior control of hydrocortisone-responding disorders by matching dosage with symptom intensity.

Unexplained exertional intolerance associated with impaired systemic oxygen extraction.

Immunosignature Analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

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