Search and filter 6,166 studies by evidence level, diagnostic criteria, PEM status, and research domain. Each entry links to the original source.
Studies sorted by evidence level, then year. Browse by topic instead →
Evidence level (E0–E3) reflects study type and replication, not methodological quality. A weak systematic review still sits at E0. How evidence levels work →
201–214 of 214 studies
Delbanco, T L, Daley, J, Hartman, E E·JAMA·1998
This study describes the medical journey of one woman with ME/CFS over the course of a year, documenting how her symptoms changed and how different treatments affected her condition. The researchers tracked her experiences to provide insight into what living with ME/CFS is like over time and what approaches doctors tried to help her.
Gregg, V H·Journal of the Royal Society of Medicine·1997
This study examined whether hypnosis might help people with ME/CFS. Researchers compared people with ME/CFS who received hypnosis treatment to those who did not. The study provides early information about whether this type of mind-body treatment might be beneficial for managing symptoms.
Houde, S C, Kampfe-Leacher, R·The Nurse practitioner·1997
This article explains what ME/CFS is and how doctors can recognize it. The main challenge is that ME/CFS doesn't show up on standard tests, so doctors need to rule out other conditions first. Treatment works best when it's tailored to each person's specific symptoms and needs.
Wiebe, E·Canadian family physician Medecin de famille canadien·1996
This study looked at two individual ME/CFS patients to see which treatments might help them personally. One patient tried high-dose vitamin B12 injections but they didn't help. Another patient tried a medication called nimodipine and found it worked very well for them. The doctors used a special testing method called N of 1 trials, where treatments are tested in one person at a time to see what actually helps that specific individual.
Rouillon, F, Delhommeau, L, Vinceneux, P·Presse medicale (Paris, France : 1983)·1996
This review examines chronic fatigue syndrome (CFS), a condition where people experience lasting, unexplained tiredness that interferes with daily life. The condition has been recognized for over a century under different names. Currently, doctors and researchers don't fully understand what causes CFS, though it may involve viral infections, immune system problems, or psychiatric factors. Most treatments tested so far have shown limited effectiveness.
Bertolín Guillén, J M, Bedate Villar, J·Actas luso-espanolas de neurologia, psiquiatria y ciencias afines·1994
This article reviews different treatment approaches for ME/CFS, which currently lacks a definitive cure. Researchers found that antidepressant medications—particularly amfebutamone and selective serotonin reuptake inhibitors—showed the most promise, while other medications (antivirals, immune boosters, anti-inflammatory drugs) had limited success. A combination of cognitive behavioral therapy and comprehensive psychiatric management tailored to each patient's needs also appeared helpful.
Young, A·Journal of holistic nursing : official journal of the American Holistic Nurses' Association·1993
This study looked at Amma Therapy, a hands-on healing practice, as a possible way to help people with ME/CFS who feel frustrated with traditional medical care. The researcher examined how this holistic approach might benefit patients with chronic fatigue. The study suggests that some people with ME/CFS may find relief through this alternative therapy.
Bell, D S·Postgraduate medicine·1992
ME/CFS typically starts suddenly with severe tiredness and flu-like symptoms that come and go over months or years. While blood tests sometimes show immune system changes, doctors diagnose ME/CFS mainly by recognizing the pattern of symptoms and ruling out other illnesses. Current treatment focuses on managing symptoms and helping patients cope with this long-lasting, disabling condition.
Goodnick, P J, Sandoval, R, Brickman, A et al.·Biological psychiatry·1992
This study tested whether bupropion, an antidepressant medication, could help ME/CFS patients who didn't benefit from or couldn't tolerate fluoxetine (another antidepressant). Nine patients took 300 mg of bupropion daily for 8 weeks and showed significant improvement in depression symptoms. The researchers also found that bupropion appeared to affect certain brain chemicals and immune markers in ways that correlated with symptom improvement.
Leyton, E, Pross, H·Canadian family physician Medecin de famille canadien·1992
This study tested whether herbal and homeopathic treatments could help six ME/CFS patients feel better. Researchers tracked symptoms and measured blood markers before and after treatment. The treatments did not produce any measurable improvements in symptoms or immune function.
Gerow, G, Poierier, M B, Alt, R·Journal of manipulative and physiological therapeutics·1992
This study describes a 36-year-old woman who came to her doctor with severe fatigue and symptoms that looked like an immune system problem, but was eventually diagnosed with ME/CFS instead. The doctors used specific criteria to confirm the diagnosis. The patient reported feeling somewhat better after receiving chiropractic treatment, though this was only one person's experience.
Butler, S, Chalder, T, Ron, M et al.·Journal of neurology, neurosurgery, and psychiatry·1991
This study tested whether cognitive behaviour therapy (CBT)—a type of talk therapy focusing on thoughts and behaviors—could help 50 ME/CFS patients who had been sick for an average of five years. Patients received therapy aimed at identifying unhelpful beliefs about their symptoms and gradually returning to activities. The therapy led to meaningful improvements in fatigue, overall functioning, and mood, though some patients refused treatment.
Gracious, B, Wisner, K L·Biological psychiatry·1991
This study tested whether a medication called nortriptyline (an older type of antidepressant) could help one person with ME/CFS. The researchers gave the patient either the medication or a placebo (inactive pill) without telling them which was which, and tracked how they felt. This type of single-patient study can provide useful information, but it only shows what happened with one individual and cannot prove the treatment works for everyone with ME/CFS.
Wachsmuth, J R, MacMillan, H L·Clinical pediatrics·1991
This study describes the case of a teenager with chronic fatigue syndrome (ME/CFS) who received treatment. The doctors documented how the patient was evaluated and what approach was used to help manage their symptoms. This single case report provides an early clinical example of treating ME/CFS in young patients.
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Thematic groupings by clinical question or research area.
PET imaging and other studies providing evidence for brain inflammation in ME/CFS.
NeurologyMetabolomics and mitochondrial function studies revealing energy metabolism disruption.
MetabolismStudies identifying potential biological markers for ME/CFS diagnosis and stratification.
Biomarker