ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2681–2700 of 6,209 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

New dimensions of abnormal illness behaviour derived from the Illness Behaviour Questionnaire.

Prior, Kirsty N, Bond, Malcolm J·Psychology & health·2010

Researchers tested a questionnaire that measures how people respond to and think about illness. They gave the questionnaire to 675 people, including 77 with ME/CFS, to see if it could identify different patterns of illness-related thoughts and behaviors. They found three main patterns: how much people affirm their illness, how concerned they are about their health, and their overall emotional state.

E2 ModerateCohortPEM not requiredObservational

Plasma IL-6, its soluble receptors and F2-isoprostanes at rest and during exercise in chronic fatigue syndrome.

Robinson, M, Gray, S R, Watson, M S et al.·Scandinavian journal of medicine & science in sports·2010

This study looked at specific markers of inflammation and oxidative stress (cellular damage) in people with ME/CFS compared to healthy individuals, both at rest and after exercise. Researchers found that a marker called F2-isoprostanes—which indicates oxidative stress—was consistently higher in ME/CFS patients. However, they did not find differences in inflammation markers like IL-6 between the two groups.

Immune SystemPost-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Microbial infections in eight genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis.

Zhang, Lihan, Gough, John, Christmas, David et al.·Journal of clinical pathology·2010

This study looked at blood samples from ME/CFS patients to identify different genetic subtypes based on how 88 genes were turned on or off. Researchers found that ME/CFS patients had distinct genetic patterns that were different from healthy people and those with depression. They also discovered that different viral infections—particularly Epstein-Barr virus and enterovirus—were linked to different genetic subtypes of ME/CFS.

Immune System

E2 ModerateCohortPEM not requiredObservational

Serological and virological investigation of the role of the herpesviruses EBV, CMV and HHV-6 in post-infective fatigue syndrome.

Cameron, Barbara, Flamand, Louis, Juwana, Hedy et al.·Journal of medical virology·2010

Researchers tested blood samples from ME/CFS patients and healthy controls to see whether three common herpesviruses (EBV, CMV, and HHV-6) were actively reactivating or causing ongoing infection. They found no evidence that these viruses were actively infected or reactivating in ME/CFS patients compared to controls who recovered normally from infection.

Immune System

E2 ModerateCohortPEM not requiredObservational

Absence of xenotropic murine leukemia virus-related virus in blood cells of men at risk for and infected with HIV.

Kunstman, Kevin J, Bhattacharya, Tanmoy, Flaherty, John et al.·AIDS (London, England)·2010

Researchers tested nearly 1,000 men for a virus called XMRV that had been found in some ME/CFS patients. They found no evidence of this virus in any of the men tested, even though the virus had been detected in a small percentage of healthy people from similar geographic areas. This suggests that if XMRV is linked to ME/CFS, it may only occur in certain populations.

E2 ModerateCohortPEM not requiredCase-Control

Nitric oxide metabolite production during exercise in chronic fatigue syndrome: a case-control study.

Suárez, Andrea, Guillamó, Elisabet, Roig, Teresa et al.·Journal of women's health (2002)·2010

This study looked at a chemical called nitric oxide in the blood of people with ME/CFS and healthy controls before and after exercise. Researchers found that people with ME/CFS had much higher levels of this chemical in their blood after exercise compared to healthy people. The findings suggest that measuring nitric oxide response to exercise might help doctors diagnose ME/CFS in the future.

Post-Exertional Malaise

E2 ModerateCohortPEM requiredCross-Sectional

Postexertional malaise in women with chronic fatigue syndrome.

VanNess, J Mark, Stevens, Staci R, Bateman, Lucinda et al.·Journal of women's health (2002)·2010

This study looked at how women with ME/CFS recover from exercise compared to healthy women. After a single exercise test, 85% of healthy women felt completely back to normal within 24 hours, but none of the women with ME/CFS did—in fact, most took much longer to recover, experiencing worsening fatigue, pain, cognitive problems, and other symptoms. This research confirms that postexertional malaise is a real and serious condition that makes recovery from physical activity dramatically different for people with ME/CFS.

Post-Exertional Malaise

E2 ModerateBehavioralPEM not requiredCross-Sectional

Interpersonal problems in alexithymia: A study in three primary care groups.

Vanheule, Stijn, Vandenbergen, Jan, Verhaeghe, Paul et al.·Psychology and psychotherapy·2010

This study looked at whether people with ME/CFS have difficulty recognizing and talking about their emotions (a condition called alexithymia), and whether this connects to how they interact with others. Researchers compared 52 ME/CFS patients with two other groups: 52 people with heart or autoimmune diseases, and 51 people with minor health problems. They found that ME/CFS patients and those with chronic diseases struggled more with identifying emotions and tended to have more distant or self-centered relationships compared to those with minor illnesses.

E2 ModerateCohortPEM not requiredCase-Control

Detailed analysis of health status of Q fever patients 1 year after the first Dutch outbreak: a case-control study.

Limonard, G J M, Peters, J B, Nabuurs-Franssen, M H et al.·QJM : monthly journal of the Association of Physicians·2010

This study looked at people who had Q fever (a bacterial infection) during an outbreak in the Netherlands and checked how they were doing about a year later. Compared to people who never had Q fever, the infected patients reported significantly more fatigue, symptoms, and problems with daily functioning. About half of the Q fever patients experienced severe fatigue, which is notably higher than in the comparison group.

E2 ModerateCohortPEM not requiredCross-Sectional

Orthostatic symptoms predict functional capacity in chronic fatigue syndrome: implications for management.

Costigan, A, Elliott, C, McDonald, C et al.·QJM : monthly journal of the Association of Physicians·2010

This study found that ME/CFS patients have much greater difficulty with daily activities compared to healthy people. Among ME/CFS patients, those who experience dizziness or lightheadedness when standing up (orthostatic symptoms) had the most trouble with physical functioning. The researchers suggest that treating these standing-related symptoms might help patients do more in their daily lives.

Autonomic Nervous SystemCognitive Impairment

E2 ModerateCohortPEM not requiredCase-Control

Postinfectious fatigue in adolescents and physical activity.

Huang, Yue, Katz, Ben Z, Mears, Cynthia et al.·Archives of pediatrics & adolescent medicine·2010

This study followed 301 teenagers with infectious mononucleosis (mono) for 2 years, comparing those who developed chronic fatigue syndrome (CFS) with those who recovered normally. Adolescents with post-infection CFS reported much more severe fatigue and needed more daytime sleep than their peers, even though their overall activity levels looked similar on paper. The key finding suggests that teenagers with CFS after mono may be forcing themselves to stay active like their friends, but at a significant physical cost in terms of exhaustion and sleep needs.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearCross-Sectional

PCR and serology find no association between xenotropic murine leukemia virus-related virus (XMRV) and autism.

Satterfield, Brent C, Garcia, Rebecca A, Gurrieri, Fiorella et al.·Molecular autism·2010

This study tested whether a virus called XMRV is present in children with autism, particularly those born to mothers with ME/CFS. Researchers used blood tests and antibody checks on over 400 participants and found no evidence that XMRV is linked to autism. This helps clarify that despite earlier media suggestions, this particular virus does not appear to contribute to autism development.

E2 ModerateCohortPEM not requiredCross-Sectional

Interstitial cystitis/painful bladder syndrome and associated medical conditions with an emphasis on irritable bowel syndrome, fibromyalgia and chronic fatigue syndrome.

Nickel, J Curtis, Tripp, Dean A, Pontari, Michel et al.·The Journal of urology·2010

This study looked at how often bladder pain syndrome occurs alongside other conditions like irritable bowel syndrome, fibromyalgia, and ME/CFS. Researchers found that people with bladder pain syndrome were much more likely to have these other conditions compared to healthy controls. Importantly, people who had multiple overlapping conditions experienced worse pain, sleep problems, depression, and lower quality of life than those with just one condition.

Pain and SensitizationSleep

E2 ModerateCohortPEM not requiredCase-Control

Biomarkers in chronic fatigue syndrome: evaluation of natural killer cell function and dipeptidyl peptidase IV/CD26.

Fletcher, Mary A, Zeng, Xiao R, Maher, Kevin et al.·PloS one·2010

This study tested whether two immune system markers could reliably identify ME/CFS patients. Researchers measured natural killer (NK) cell function—a type of immune cell that fights infections—and CD26, a protein found on immune cells. They found that ME/CFS patients had lower NK cell function and different patterns of CD26 compared to healthy people, suggesting these markers could potentially help diagnose the condition.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Plasma cytokine profiles in females with irritable bowel syndrome and extra-intestinal co-morbidity.

Scully, Paul, McKernan, Declan P, Keohane, John et al.·The American journal of gastroenterology·2010

This study looked at inflammation markers in the blood of women with irritable bowel syndrome (IBS), particularly those who also had fibromyalgia, premenstrual symptoms, or chronic fatigue syndrome. Researchers found that women with IBS plus these extra conditions had higher levels of four inflammation-related substances (IL-1β, IL-6, IL-8, and TNFα) compared to healthy women, while those with IBS alone had elevated levels of two of these markers.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

The Newcastle NHS Chronic Fatigue Syndrome Service: not all fatigue is the same.

Newton, J L, Mabillard, H, Scott, A et al.·The journal of the Royal College of Physicians of Edinburgh·2010

This study looked at patients referred to a specialist fatigue clinic in Newcastle, England to see how many actually had ME/CFS versus other conditions causing tiredness. The researchers found that 60% of referred patients were diagnosed with ME/CFS, while the remaining 40% had other causes of fatigue—most commonly tiredness from other chronic illnesses, sleep problems, or mental health conditions. This suggests many people with fatigue don't fit ME/CFS criteria but still need help managing their symptoms.

Diagnostics

E2 ModerateCohortPEM not requiredObservational

Postinfectious and chronic fatigue syndromes: clinical experience from a tertiary-referral centre in Norway.

Naess, Halvor, Sundal, Endre, Myhr, Kjell-Morten et al.·In vivo (Athens, Greece)·2010

This study looked at 873 ME/CFS patients in Norway to see whether their illness started after an infection. About 77% of patients reported having an infection before their fatigue began. Patients who had an infection at the start were more likely to have a sudden onset of fatigue and to show some improvement by the time they were seen at the clinic, compared to those without an infection.

E2 ModerateCohortPEM not requiredCase-Control

Chronic fatigue syndrome is associated with metabolic syndrome: results from a case-control study in Georgia.

Maloney, Elizabeth M, Boneva, Roumiana S, Lin, Jin-Mann S et al.·Metabolism: clinical and experimental·2010

This study found that people with ME/CFS are twice as likely to have metabolic syndrome—a cluster of conditions including high blood pressure, high blood sugar, excess belly fat, and abnormal cholesterol levels—compared to healthy people. The more metabolic factors someone had, the worse their fatigue tended to be. This suggests that metabolic problems may be connected to ME/CFS severity.

Energy Metabolism

E2 ModerateBehavioralPEM not requiredCross-Sectional

Personality and perfectionism in chronic fatigue syndrome: a closer look.

Deary, Vincent, Chalder, Trudie·Psychology & health·2010

This study compared personality traits in 27 women with ME/CFS to 30 healthy women. People with ME/CFS scored higher on neuroticism (tendency to experience negative emotions) and unhealthy perfectionism (setting unrealistic standards and being self-critical). Interestingly, the combination of these traits appeared to be particularly problematic in the fatigued group, suggesting that personality patterns that might seem positive in healthy people can sometimes be harmful when someone has ME/CFS.

E2 ModerateCohortPEM not requiredCase-Control

Failure to detect Xenotropic murine leukaemia virus-related virus in Chinese patients with chronic fatigue syndrome.

Hong, Ping, Li, Jinming, Li, Yongzhe·Virology journal·2010

Researchers tested 65 people with ME/CFS and 85 healthy controls to see if a virus called XMRV might cause ME/CFS. Using sensitive laboratory tests, they found no evidence of XMRV in any of the study participants' blood cells. This study suggests XMRV is not associated with ME/CFS in Chinese patients.

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Evidence browser

New dimensions of abnormal illness behaviour derived from the Illness Behaviour Questionnaire.

Plasma IL-6, its soluble receptors and F2-isoprostanes at rest and during exercise in chronic fatigue syndrome.

Microbial infections in eight genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis.

Serological and virological investigation of the role of the herpesviruses EBV, CMV and HHV-6 in post-infective fatigue syndrome.

Absence of xenotropic murine leukemia virus-related virus in blood cells of men at risk for and infected with HIV.

Nitric oxide metabolite production during exercise in chronic fatigue syndrome: a case-control study.

Postexertional malaise in women with chronic fatigue syndrome.

Interpersonal problems in alexithymia: A study in three primary care groups.

Detailed analysis of health status of Q fever patients 1 year after the first Dutch outbreak: a case-control study.

Orthostatic symptoms predict functional capacity in chronic fatigue syndrome: implications for management.

Postinfectious fatigue in adolescents and physical activity.

PCR and serology find no association between xenotropic murine leukemia virus-related virus (XMRV) and autism.

Interstitial cystitis/painful bladder syndrome and associated medical conditions with an emphasis on irritable bowel syndrome, fibromyalgia and chronic fatigue syndrome.

Biomarkers in chronic fatigue syndrome: evaluation of natural killer cell function and dipeptidyl peptidase IV/CD26.

Plasma cytokine profiles in females with irritable bowel syndrome and extra-intestinal co-morbidity.

The Newcastle NHS Chronic Fatigue Syndrome Service: not all fatigue is the same.

Postinfectious and chronic fatigue syndromes: clinical experience from a tertiary-referral centre in Norway.

Chronic fatigue syndrome is associated with metabolic syndrome: results from a case-control study in Georgia.

Personality and perfectionism in chronic fatigue syndrome: a closer look.

Failure to detect Xenotropic murine leukaemia virus-related virus in Chinese patients with chronic fatigue syndrome.

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