ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

3321–3340 of 6,188 studies

E2 ModerateCohortPEM not requiredCross-Sectional

The difference in patterns of motor and cognitive function in chronic fatigue syndrome and severe depressive illness.

Lawrie, S M, MacHale, S M, Cavanagh, J T et al.·Psychological medicine·2000

This study compared thinking and physical abilities in people with ME/CFS, people with depression, and healthy individuals. Researchers found that people with ME/CFS had worse memory and thinking skills than healthy people, but generally better than those with depression. Both ME/CFS and depression groups showed significant problems with muscle strength and motor control compared to healthy controls.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

The capnography head-up tilt test for evaluation of chronic fatigue syndrome.

Naschitz, J E, Rosner, I, Rozenbaum, M et al.·Seminars in arthritis and rheumatism·2000

This study tested whether a special tilt table test that measures blood pressure, heart rate, breathing, and carbon dioxide levels could help diagnose ME/CFS. Researchers compared 32 ME/CFS patients to 32 healthy people during this test. ME/CFS patients showed abnormal responses—like drops in blood pressure, increases in heart rate, faster breathing, and lower carbon dioxide levels—while healthy people did not, suggesting this test might help identify ME/CFS.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

How significant are primary sleep disorders and sleepiness in the chronic fatigue syndrome?

Le Bon, O, Fischler, B, Hoffmann, G et al.·Sleep research online : SRO·2000

This study looked at whether sleep problems might explain ME/CFS symptoms in 46 patients. Researchers found that many CFS patients did have sleep disorders like sleep apnea, but these sleep problems were not connected to how severe their CFS was or their other symptoms. Importantly, over half of the CFS patients had no sleep disorders at all, suggesting that ME/CFS is a distinct condition separate from typical sleep problems.

Sleep

E2 ModerateCohortPEM not requiredObservational

Magnesium status and parameters of the oxidant-antioxidant balance in patients with chronic fatigue: effects of supplementation with magnesium.

Manuel y Keenoy, B, Moorkens, G, Vertommen, J et al.·Journal of the American College of Nutrition·2000

This study looked at whether magnesium deficiency and oxidative stress (cellular damage from unstable molecules) are connected in people with chronic fatigue. Researchers tested 93 patients, about half of whom had CFS, and found that people lacking magnesium had lower antioxidant protection in their blood. When these patients took magnesium supplements, some improved antioxidant markers and vitamin E levels, suggesting magnesium may help protect cells from damage.

E2 ModerateBehavioralPEM not requiredCase-Control

The role of personality in the development and perpetuation of chronic fatigue syndrome.

White, C, Schweitzer, R·Journal of psychosomatic research·2000

This study compared personality traits between 44 people with ME/CFS and 44 healthy people without the illness. Researchers measured perfectionism (setting very high standards), self-esteem (how people value themselves), and emotional control. People with ME/CFS showed higher levels of perfectionism and lower self-esteem, but emotional control was similar between groups.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Chronic fatigue syndrome: a woman's dilemma.

Tuck, I, Wallace, D·Health care for women international·2000

This study looked at how ME/CFS affects women's lives by interviewing 22 women and surveying 42 others about their experiences. The researchers found that the illness significantly disrupts women's work, relationships, and how they see themselves. The study highlights that living with ME/CFS and managing its symptoms has a major impact on quality of life beyond just the medical aspects of the disease.

E2 ModerateCohortPEM not requiredCross-Sectional

Overlapping conditions among patients with chronic fatigue syndrome, fibromyalgia, and temporomandibular disorder.

Aaron, L A, Burke, M M, Buchwald, D·Archives of internal medicine·2000

This study found that ME/CFS, fibromyalgia, and temporomandibular disorder (TMD) often occur together in the same patients and share similar symptoms like pain, fatigue, and sleep problems. The researchers also discovered that patients with these conditions frequently experience other illnesses like irritable bowel syndrome and headaches—much more often than healthy people do. The study suggests these conditions may be connected in some way we don't yet fully understand.

Pain and SensitizationSleepCognitive Impairment

E2 ModerateBehavioralPEM not requiredCross-Sectional

The genetic aetiology of somatic distress.

Gillespie, N A, Zhu, G, Heath, A C et al.·Psychological medicine·2000

This study looked at whether the physical and mental exhaustion seen in chronic fatigue syndrome runs in families and whether it's genetically distinct from depression and anxiety. Researchers surveyed nearly 3,500 Australian twins and found that about one-third of the genetic factors affecting somatic distress (physical symptoms and fatigue) are unique to those symptoms and not shared with depression or anxiety, suggesting these are separate conditions with different causes.

E2 ModerateCohortPEM not requiredCross-Sectional

Chronic fatigue syndrome, fibromyalgia, and multiple chemical sensitivities in a community-based sample of persons with chronic fatigue syndrome-like symptoms.

Jason, L A, Taylor, R R, Kennedy, C L·Psychosomatic medicine·2000

This study looked at how often people with ME/CFS (chronic fatigue syndrome) also have fibromyalgia or chemical sensitivities, and how these conditions affect daily functioning. Researchers interviewed nearly 19,000 people in Chicago and then examined those with CFS-like symptoms in more detail. They found that people with multiple conditions experienced worse fatigue and disability than those with just one condition.

E2 ModerateCohortPEM not requiredLongitudinal

Longitudinal analysis of symptoms reported by patients with chronic fatigue syndrome.

Nisenbaum, R, Jones, A, Jones, J et al.·Annals of epidemiology·2000

This study followed 74 ME/CFS patients over two years to track how their symptoms changed over time. Researchers found that symptoms fluctuated throughout the illness, but most symptoms stayed about the same whether someone had been sick for 1 year or 20 years. The only exception was stomach pain, which became more common as illness duration increased.

E2 ModerateCohortPEM not requiredCase-Control

Human herpesviruses 6 and 7 in chronic fatigue syndrome: a case-control study.

Reeves, W C, Stamey, F R, Black, J B et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2000

Researchers tested whether three common viruses (HHV-6A, HHV-6B, and HHV-7) might be linked to ME/CFS. They compared blood samples from 26 ME/CFS patients with 52 healthy people and looked for signs of active or dormant virus infection. The study found no meaningful differences between the two groups, suggesting these particular viruses are not associated with ME/CFS.

E2 ModerateCohortPEM not requiredCase-Control

Salivary gland changes in chronic fatigue syndrome: a case-controlled preliminary histologic study.

Woo, S B, Schacterle, R S, Komaroff, A L et al.·Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics·2000

Researchers examined tiny salivary glands in the lips of 11 ME/CFS patients and compared them to healthy controls. They found that ME/CFS patients had various changes in these glands, including swelling, scarring, and immune cell infiltration. Most notably, ME/CFS patients had significantly more mast cells (immune cells) in their salivary glands than controls, suggesting these glands may be damaged in ME/CFS.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Use of alternative treatments by chronic fatigue syndrome discordant twins.

Afari, N, Eisenberg, DM, Herrell, R et al.·Integrative medicine : integrating conventional and alternative medicine·2000

This study looked at how often people with ME/CFS use alternative treatments compared to their identical twins who don't have the illness. Researchers surveyed 63 twin pairs and found that 91% of people with ME/CFS had tried at least one alternative therapy (such as herbs, vitamins, massage, or meditation), compared to 71% of their healthy twins. While many people found these treatments helpful, most didn't tell their doctors they were using them.

E2 ModerateCohortPEM not requiredCross-Sectional

Odor perception: multiple chemical sensitivities, chronic fatigue, and asthma.

Caccappolo, E, Kipen, H, Kelly-McNeil, K et al.·Journal of occupational and environmental medicine·2000

This study tested whether people with chemical sensitivities, chronic fatigue, and asthma have unusually sensitive noses. Researchers measured how well different groups could smell odors and identify them. While people with chemical sensitivities didn't actually detect odors at lower levels than others, they did report feeling more physical symptoms and found certain smells more unpleasant than other groups did.

Pain and Sensitization

E2 ModerateCohortPEM unclearCase-Control

Dysautonomia in chronic fatigue syndrome vs. fibromyalgia.

Rosner, I, Rozenbaum, M, Naschitz, J E et al.·The Israel Medical Association journal : IMAJ·2000

This study compared how the nervous systems of people with ME/CFS and fibromyalgia function differently, focusing on dysautonomia—problems with the automatic nervous system that controls heart rate, blood pressure, and other body functions. Researchers used a case-control design to examine whether these two conditions show distinct patterns of autonomic dysfunction. The findings help clarify whether ME/CFS and fibromyalgia are separate conditions with different underlying nervous system problems.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Chronic fatigue syndrome: occupation, medical utilization, and subtypes in a community-based sample.

Jason, L A, Taylor, R R, Kennedy, C L et al.·The Journal of nervous and mental disease·2000

This study looked at people with ME/CFS living in the Chicago community to understand how the condition affects their work, healthcare use, and daily life. Researchers randomly surveyed over 18,000 people, identified those with ME/CFS symptoms, and had doctors confirm their diagnosis. They found that people with ME/CFS differed significantly from each other in how sick they were, when their illness started, and whether a stressful event triggered it.

E2 ModerateCohortPEM not requiredLongitudinal

The course of severe chronic fatigue syndrome in childhood.

Rangel, L, Garralda, M E, Levin, M et al.·Journal of the Royal Society of Medicine·2000

This study followed 25 children with severe chronic fatigue syndrome for about 3.5 years after their illness began. Most children (two-thirds) eventually recovered and returned to normal activities, though the illness caused serious problems during its worst phases, including extended time out of school. The researchers found that children who had a clear physical trigger for their illness, started feeling sick in the autumn, or came from higher-income families were more likely to recover.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Psychiatric morbidity and illness experience of primary care patients with chronic fatigue in Hong Kong.

Lee, S, Yu, H, Wing, Y et al.·The American journal of psychiatry·2000

This study looked at 100 people in Hong Kong who had severe tiredness lasting at least 6 months to understand how common mental health conditions like depression and anxiety were in this group. Researchers found that over half of these patients had experienced depression or anxiety at some point in their lives, and about a quarter had these conditions at the time of the study. Interestingly, patients' main complaints were often pain, sleep problems, and worry—not just fatigue—and most believed their illness started from stressful life events.

E2 ModerateCohortPEM not requiredCase-Control

Strength and physiological response to exercise in patients with chronic fatigue syndrome.

Fulcher, K Y, White, P D·Journal of neurology, neurosurgery, and psychiatry·2000

This study compared muscle strength and exercise capacity in people with ME/CFS to healthy sedentary people and people with depression. Researchers found that ME/CFS patients were weaker and could not exercise as long, even though they were as physically deconditioned as the sedentary controls. After exercise therapy, patients improved—mainly by having lower heart rate responses during activity—suggesting that rebuilding physical fitness can help restore function.

E2 ModerateCohortPEM not requiredCross-Sectional

General practitioners' beliefs, attitudes and reported actions towards chronic fatigue syndrome.

Steven, I D, McGrath, B, Qureshi, F et al.·Australian family physician·2000

This study surveyed Australian doctors about what they think and do regarding ME/CFS. Most doctors who diagnose ME/CFS agreed on six key symptoms, including long-lasting fatigue that doesn't improve with rest and exhaustion after minor activity. However, nearly one-third of doctors didn't believe ME/CFS was a real condition and thought depression was the actual cause instead.

Diagnostics

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The difference in patterns of motor and cognitive function in chronic fatigue syndrome and severe depressive illness.

The capnography head-up tilt test for evaluation of chronic fatigue syndrome.

How significant are primary sleep disorders and sleepiness in the chronic fatigue syndrome?

Magnesium status and parameters of the oxidant-antioxidant balance in patients with chronic fatigue: effects of supplementation with magnesium.

The role of personality in the development and perpetuation of chronic fatigue syndrome.

Chronic fatigue syndrome: a woman's dilemma.

Overlapping conditions among patients with chronic fatigue syndrome, fibromyalgia, and temporomandibular disorder.

The genetic aetiology of somatic distress.

Chronic fatigue syndrome, fibromyalgia, and multiple chemical sensitivities in a community-based sample of persons with chronic fatigue syndrome-like symptoms.

Longitudinal analysis of symptoms reported by patients with chronic fatigue syndrome.

Human herpesviruses 6 and 7 in chronic fatigue syndrome: a case-control study.

Salivary gland changes in chronic fatigue syndrome: a case-controlled preliminary histologic study.

Use of alternative treatments by chronic fatigue syndrome discordant twins.

Odor perception: multiple chemical sensitivities, chronic fatigue, and asthma.

Dysautonomia in chronic fatigue syndrome vs. fibromyalgia.

Chronic fatigue syndrome: occupation, medical utilization, and subtypes in a community-based sample.

The course of severe chronic fatigue syndrome in childhood.

Psychiatric morbidity and illness experience of primary care patients with chronic fatigue in Hong Kong.

Strength and physiological response to exercise in patients with chronic fatigue syndrome.

General practitioners' beliefs, attitudes and reported actions towards chronic fatigue syndrome.

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