ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

3301–3320 of 6,209 studies

E2 ModerateCohortPEM not requiredCase-Control

Circadian rhythm of core body temperature in subjects with chronic fatigue syndrome.

Hamilos, D L, Nutter, D, Gershtenson, J et al.·Clinical physiology (Oxford, England)·2001

Researchers wanted to know if ME/CFS might be caused by broken internal body clocks, similar to jet lag. They measured core body temperature continuously in 10 ME/CFS patients and 10 healthy controls over 48 hours and analyzed the patterns. The body temperature rhythms in ME/CFS patients looked almost identical to healthy people, suggesting a disrupted body clock is unlikely to be the main cause of ME/CFS symptoms.

E2 ModerateCohortPEM not requiredCross-Sectional

Assessment of pentachlorophenol-exposed timber workers using a test-of-poisoning model.

Gorman, D, Monigatti, J, Glass, B et al.·International journal of occupational and environmental health·2001

This study looked at 62 former timber workers in New Zealand who were exposed to a toxic chemical called pentachlorophenol (PCP) during their jobs. Researchers found that some workers developed a cluster of symptoms including fever, headaches, breathing problems, and skin issues, while others developed a long-lasting fatigue that started while they were still working. However, the researchers concluded that these fatigue syndromes didn't clearly match what doctors expect from PCP poisoning, and many other factors could have caused the symptoms.

E2 ModerateCohortPEM not requiredCross-Sectional

Is physical deconditioning a perpetuating factor in chronic fatigue syndrome? A controlled study on maximal exercise performance and relations with fatigue, impairment and physical activity.

Bazelmans, E, Bleijenberg, G, Van Der Meer, J W et al.·Psychological medicine·2001

This study tested whether ME/CFS patients are in poor physical condition compared to healthy people, and whether being out of shape might be making their illness worse. Researchers had 20 ME/CFS patients and 20 healthy controls perform exercise tests while measuring heart rate, oxygen use, and other body functions. The study found no significant difference in physical fitness between the two groups, suggesting that poor fitness is not the main reason ME/CFS patients struggle with exercise.

Post-Exertional Malaise

E2 ModerateBehavioralPEM not requiredCross-Sectional

Psychological adjustment of adolescent girls with chronic fatigue syndrome.

van Middendorp, H, Geenen, R, Kuis, W et al.·Pediatrics·2001

This study looked at how 36 teenage girls with ME/CFS were coping emotionally and psychologically. The researchers found that most girls had experienced problems before getting sick, but they generally maintained healthy self-esteem and social skills despite their illness. However, the girls struggled with activities typical for teenagers, like sports and dating, and many kept their emotions bottled up rather than expressing them openly.

E2 ModerateCohortPEM not requiredCase-Control

Proton magnetic resonance spectroscopy and morphometry of the hippocampus in chronic fatigue syndrome.

Brooks, J C, Roberts, N, Whitehouse, G et al.·The British journal of radiology·2000

This study used brain imaging to examine a part of the brain called the hippocampus in people with ME/CFS and healthy controls. While the size of the hippocampus was normal in ME/CFS patients, a specific chemical marker called N-acetylaspartate was significantly lower in the right side of the hippocampus compared to healthy people. This suggests there may be subtle differences in how brain cells are functioning in ME/CFS, even when the brain structure looks normal.

E2 ModerateCohortPEM not requiredCross-Sectional

The capnography head-up tilt test for evaluation of chronic fatigue syndrome.

Naschitz, J E, Rosner, I, Rozenbaum, M et al.·Seminars in arthritis and rheumatism·2000

This study tested whether a special tilt table test that measures blood pressure, heart rate, breathing, and carbon dioxide levels could help diagnose ME/CFS. Researchers compared 32 ME/CFS patients to 32 healthy people during this test. ME/CFS patients showed abnormal responses—like drops in blood pressure, increases in heart rate, faster breathing, and lower carbon dioxide levels—while healthy people did not, suggesting this test might help identify ME/CFS.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Chronic fatigue syndrome: sociodemographic subtypes in a community-based sample.

Jason, L A, Taylor, R R, Kennedy, C L et al.·Evaluation & the health professions·2000

This study looked at people with ME/CFS living in Chicago to understand how their backgrounds affected their illness. Researchers found that women, people of color, and those unable to work experienced more severe symptoms, greater disability, and more emotional stress than men, white patients, and those who could still work. This suggests that social factors and circumstances may play a role in how badly ME/CFS affects different groups of people.

E2 ModerateCohortPEM not requiredCross-Sectional

Overlapping conditions among patients with chronic fatigue syndrome, fibromyalgia, and temporomandibular disorder.

Aaron, L A, Burke, M M, Buchwald, D·Archives of internal medicine·2000

This study found that ME/CFS, fibromyalgia, and temporomandibular disorder (TMD) often occur together in the same patients and share similar symptoms like pain, fatigue, and sleep problems. The researchers also discovered that patients with these conditions frequently experience other illnesses like irritable bowel syndrome and headaches—much more often than healthy people do. The study suggests these conditions may be connected in some way we don't yet fully understand.

Pain and SensitizationSleepCognitive Impairment

E2 ModerateCohortPEM not requiredObservational

Identifying physical activity patterns in chronic fatigue syndrome using actigraphic assessment.

van der Werf, S P, Prins, J B, Vercoulen, J H et al.·Journal of psychosomatic research·2000

Researchers used a motion-tracking device to measure physical activity patterns in 277 ME/CFS patients over 12 days and compared them to 47 healthy people. Patients with ME/CFS showed less intense bursts of activity, shorter activity periods, and longer rest times afterward. About one-fourth of patients were identified as 'pervasively passive'—meaning they had very low activity levels throughout the entire study period.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredObservational

Chronic fatigue syndrome beginning suddenly occurs seasonally over the year.

Zhang, Q W, Natelson, B H, Ottenweller, J E et al.·Chronobiology international·2000

This study looked at 69 people with severe ME/CFS who all experienced a sudden onset of illness, with symptoms like sore throat, extreme fatigue, and body aches developing within 2 days. Researchers found that these sudden onsets happened much more often during winter months (November through January) and least often in spring (April through May). This pattern suggests that ME/CFS may be triggered by an infectious agent rather than being purely psychological.

E2 ModerateCohortPEM not requiredCase-Control

Integrity of the growth hormone/insulin-like growth factor system is maintained in patients with chronic fatigue syndrome.

Cleare, A J, Sookdeo, S S, Jones, J et al.·The Journal of clinical endocrinology and metabolism·2000

This study investigated whether people with ME/CFS have problems with growth hormone (GH), a chemical in the body that affects energy and metabolism. Researchers compared 37 ME/CFS patients to 37 healthy controls by measuring various growth hormone-related substances in their blood and urine, and tested how their bodies responded to specific hormone challenges. They found no significant differences between the two groups, suggesting that ME/CFS is not caused by growth hormone deficiency.

Energy Metabolism

E2 ModerateCohortPEM unclearObservational

[Relationship between fatigue in multiple sclerosis and the chronic fatigue syndrome].

Grimaud, J·Revue neurologique·2000

This study examined whether the severe tiredness experienced by people with multiple sclerosis (MS) is similar to the fatigue seen in ME/CFS. The research looked at how fatigue presents differently in these two conditions and whether they share common features. Understanding these similarities and differences can help doctors better recognize and treat fatigue in both diseases.

E2 ModerateCohortPEM not requiredLongitudinal

Longitudinal analysis of symptoms reported by patients with chronic fatigue syndrome.

Nisenbaum, R, Jones, A, Jones, J et al.·Annals of epidemiology·2000

This study followed 74 ME/CFS patients over two years to track how their symptoms changed over time. Researchers found that symptoms fluctuated throughout the illness, but most symptoms stayed about the same whether someone had been sick for 1 year or 20 years. The only exception was stomach pain, which became more common as illness duration increased.

E2 ModerateCohortPEM not requiredCross-Sectional

How significant are primary sleep disorders and sleepiness in the chronic fatigue syndrome?

Le Bon, O, Fischler, B, Hoffmann, G et al.·Sleep research online : SRO·2000

This study looked at whether sleep problems might explain ME/CFS symptoms in 46 patients. Researchers found that many CFS patients did have sleep disorders like sleep apnea, but these sleep problems were not connected to how severe their CFS was or their other symptoms. Importantly, over half of the CFS patients had no sleep disorders at all, suggesting that ME/CFS is a distinct condition separate from typical sleep problems.

Sleep

E2 ModerateBehavioralPEM not requiredCross-Sectional

Chronic fatigue syndrome: a woman's dilemma.

Tuck, I, Wallace, D·Health care for women international·2000

This study looked at how ME/CFS affects women's lives by interviewing 22 women and surveying 42 others about their experiences. The researchers found that the illness significantly disrupts women's work, relationships, and how they see themselves. The study highlights that living with ME/CFS and managing its symptoms has a major impact on quality of life beyond just the medical aspects of the disease.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Attributions in chronic fatigue syndrome and fibromyalgia syndrome in tertiary care.

Neerinckx, E, Van Houdenhove, B, Lysens, R et al.·The Journal of rheumatology·2000

This study looked at what 192 patients with ME/CFS, fibromyalgia, or chronic pain believed was causing their illness. Most patients thought their condition had both physical causes (like a virus or chemical imbalance) and emotional causes (like stress). The researchers found that patients' beliefs about what caused their illness were quite varied, and these beliefs did not differ much based on their specific diagnosis.

E2 ModerateDiagnosticPEM not requiredCross-Sectional

Fatigue rating scales: an empirical comparison.

Taylor, R R, Jason, L A, Torres, A·Psychological medicine·2000

This study compared two popular questionnaires that doctors use to measure fatigue in ME/CFS patients: the Fatigue Scale and the Fatigue Severity Scale. Researchers tested both tools on people with varying levels of fatigue, including those with ME/CFS-like symptoms and healthy people. The study found that while both tools are useful, the Fatigue Severity Scale better captures how fatigue affects daily functioning and quality of life in people with ME/CFS.

E2 ModerateCohortPEM not requiredCase-Control

Human herpesviruses 6 and 7 in chronic fatigue syndrome: a case-control study.

Reeves, W C, Stamey, F R, Black, J B et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2000

Researchers tested whether three common viruses (HHV-6A, HHV-6B, and HHV-7) might be linked to ME/CFS. They compared blood samples from 26 ME/CFS patients with 52 healthy people and looked for signs of active or dormant virus infection. The study found no meaningful differences between the two groups, suggesting these particular viruses are not associated with ME/CFS.

E2 ModerateCohortPEM not requiredLongitudinal

The course of severe chronic fatigue syndrome in childhood.

Rangel, L, Garralda, M E, Levin, M et al.·Journal of the Royal Society of Medicine·2000

This study followed 25 children with severe chronic fatigue syndrome for about 3.5 years after their illness began. Most children (two-thirds) eventually recovered and returned to normal activities, though the illness caused serious problems during its worst phases, including extended time out of school. The researchers found that children who had a clear physical trigger for their illness, started feeling sick in the autumn, or came from higher-income families were more likely to recover.

E2 ModerateCohortPEM not requiredCross-Sectional

Diagnosis of psychiatric disorder in clinical evaluation of chronic fatigue syndrome.

Deale, A, Wessely, S·Journal of the Royal Society of Medicine·2000

This study looked at how often ME/CFS patients are incorrectly diagnosed with psychiatric conditions like depression. Researchers found that about two-thirds of patients who had been labeled with a psychiatric diagnosis actually didn't have one, while about one-third of patients without a psychiatric diagnosis did have a treatable mental health condition. The study shows that distinguishing between ME/CFS and psychiatric disorders can be difficult, and doctors need better tools and training to get the diagnosis right.

Diagnostics

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Circadian rhythm of core body temperature in subjects with chronic fatigue syndrome.

Assessment of pentachlorophenol-exposed timber workers using a test-of-poisoning model.

Is physical deconditioning a perpetuating factor in chronic fatigue syndrome? A controlled study on maximal exercise performance and relations with fatigue, impairment and physical activity.

Psychological adjustment of adolescent girls with chronic fatigue syndrome.

Proton magnetic resonance spectroscopy and morphometry of the hippocampus in chronic fatigue syndrome.

The capnography head-up tilt test for evaluation of chronic fatigue syndrome.

Chronic fatigue syndrome: sociodemographic subtypes in a community-based sample.

Overlapping conditions among patients with chronic fatigue syndrome, fibromyalgia, and temporomandibular disorder.

Identifying physical activity patterns in chronic fatigue syndrome using actigraphic assessment.

Chronic fatigue syndrome beginning suddenly occurs seasonally over the year.

Integrity of the growth hormone/insulin-like growth factor system is maintained in patients with chronic fatigue syndrome.

[Relationship between fatigue in multiple sclerosis and the chronic fatigue syndrome].

Longitudinal analysis of symptoms reported by patients with chronic fatigue syndrome.

How significant are primary sleep disorders and sleepiness in the chronic fatigue syndrome?

Chronic fatigue syndrome: a woman's dilemma.

Attributions in chronic fatigue syndrome and fibromyalgia syndrome in tertiary care.

Fatigue rating scales: an empirical comparison.

Human herpesviruses 6 and 7 in chronic fatigue syndrome: a case-control study.

The course of severe chronic fatigue syndrome in childhood.

Diagnosis of psychiatric disorder in clinical evaluation of chronic fatigue syndrome.

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