ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

3361–3380 of 6,209 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

The genetic aetiology of somatic distress.

Gillespie, N A, Zhu, G, Heath, A C et al.·Psychological medicine·2000

This study looked at whether the physical and mental exhaustion seen in chronic fatigue syndrome runs in families and whether it's genetically distinct from depression and anxiety. Researchers surveyed nearly 3,500 Australian twins and found that about one-third of the genetic factors affecting somatic distress (physical symptoms and fatigue) are unique to those symptoms and not shared with depression or anxiety, suggesting these are separate conditions with different causes.

E2 ModerateCohortPEM not requiredCross-Sectional

TNF-alpha and chronic fatigue syndrome.

Moss, R B, Mercandetti, A, Vojdani, A·Journal of clinical immunology·1999

This study looked at whether a molecule called TNF-alpha, which helps control inflammation in the body, is elevated in people with ME/CFS. Researchers compared blood levels of TNF-alpha in patients with ME/CFS to healthy people without the condition. They found that people with ME/CFS had significantly higher levels of TNF-alpha, suggesting that inflammation may play a role in the disease.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

Mercury and nickel allergy: risk factors in fatigue and autoimmunity.

Sterzl, Ivan, Procházková, Jarmila, Hrdá, Pavlína et al.·Neuro endocrinology letters·1999

This study tested whether allergies to metals like mercury (found in old dental fillings) and nickel might trigger fatigue and autoimmune problems in people with ME/CFS. Researchers compared three groups of tired patients with healthy controls and found that people with fatigue were more sensitive to these metals. When some patients had their mercury-containing fillings removed and replaced, their fatigue improved significantly.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Differences in adrenal steroid profile in chronic fatigue syndrome, in depression and in health.

Scott, L V, Salahuddin, F, Cooney, J et al.·Journal of affective disorders·1999

This study measured several hormones related to stress in people with ME/CFS, depression, and healthy individuals. Researchers found that people with ME/CFS had significantly lower levels of DHEA and DHEA-S (hormones produced by the adrenal glands) compared to healthy people, while cortisol levels were similar across all groups. This suggests ME/CFS may involve a different hormone pattern than depression, and DHEA could potentially help diagnose or treat ME/CFS.

Endocrine Disruption

E2 ModerateCohortPEM unclearCross-Sectional

Multiple mycoplasmal infections detected in blood of patients with chronic fatigue syndrome and/or fibromyalgia syndrome.

Nasralla, M, Haier, J, Nicolson, G L·European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·1999

Researchers tested blood samples from 91 patients with ME/CFS and/or fibromyalgia who already tested positive for mycoplasma bacteria. They found that most patients carried multiple types of mycoplasma—particularly Mycoplasma pneumoniae and Mycoplasma fermentans—and some patients had two or even three different mycoplasma species at the same time. Patients with multiple infections tended to have been sick longer, suggesting they may have picked up additional infections over time.

E2 ModerateCohortPEM not requiredCase-Control

Chronic fatigue syndrome in private practice psychiatry: family history of physical and mental health.

Endicott, N A·Journal of psychosomatic research·1999

This study looked at 45 psychiatric patients with ME/CFS and compared their family medical histories to two similar groups of psychiatric patients without ME/CFS. Researchers found that ME/CFS patients' parents tended to die younger and had more cancer, autoimmune disorders, and ME/CFS-like illnesses compared to the families of control patients. There were no significant differences in mental health conditions between the families.

E2 ModerateCohortPEM not requiredCross-Sectional

Absence of evidence of Borna disease virus infection in Swedish patients with Chronic Fatigue Syndrome.

Evengård, B, Briese, T, Lindh, G et al.·Journal of neurovirology·1999

Researchers tested whether a virus called Borna disease virus (BDV) might be causing ME/CFS in Swedish patients. They examined blood samples from 169 patients and 62 healthy controls using two different detection methods—one looking for antibodies (immune system markers) and another looking for viral genetic material. They found no evidence of BDV in any of the patient samples, suggesting this particular virus is not responsible for ME/CFS.

E2 ModerateCohortPEM not requiredCross-Sectional

Absence of Borrelia burgdorferi-specific immune complexes in chronic fatigue syndrome.

Schutzer, S E, Natelson, B H·Neurology·1999

This study tested whether people with ME/CFS have signs of Lyme disease infection in their blood. Researchers compared 39 ME/CFS patients to 40 healthy people using a specialized test that looks for Borrelia burgdorferi, the bacterium that causes Lyme disease. None of the patients or controls showed signs of this infection, suggesting that Lyme disease is not the hidden cause of ME/CFS in people without typical Lyme disease symptoms like the characteristic rash or joint problems.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

Vitamin B status in patients with chronic fatigue syndrome.

Heap, L C, Peters, T J, Wessely, S·Journal of the Royal Society of Medicine·1999

This study tested whether people with ME/CFS have lower levels of three B vitamins (B6, B2, and B1) compared to healthy people. Researchers measured how well these vitamins work in red blood cells from 12 ME/CFS patients and 18 healthy controls. They found that all three B vitamins appeared to be functioning less effectively in ME/CFS patients, suggesting a possible vitamin deficiency that might contribute to symptoms.

Energy Metabolism

E2 ModerateBehavioralPEM not requiredCross-Sectional

Personality and social attitudes in chronic fatigue syndrome.

Wood, B, Wessely, S·Journal of psychosomatic research·1999

This study compared personality traits and attitudes between people with ME/CFS and people with rheumatoid arthritis (RA) to see if ME/CFS patients have distinctive personality characteristics. Researchers found that ME/CFS patients and RA patients were actually quite similar in most personality measures, and the common stereotype that ME/CFS patients are perfectionists with negative views about psychiatry was not supported.

E2 ModerateCohortPEM not requiredCross-Sectional

Chronic fatigue syndrome: gender differences in the search for legitimacy.

Clarke, J N·The Australian and New Zealand journal of mental health nursing·1999

This study interviewed 59 people with ME/CFS (18 men and 41 women) about their experiences with the illness and how doctors treated them. While men and women described similar symptoms and the disease itself affected them in comparable ways, they experienced very different treatment from healthcare providers. The study suggests that gender plays an important role in how seriously doctors take ME/CFS patients and how they are believed.

E2 ModerateCohortPEM not requiredCase-Control

Chronic fatigue syndrome and nickel allergy.

Marcusson, J A, Lindh, G, Evengård, B·Contact dermatitis·1999

This study tested 50 patients with ME/CFS and 73 healthy people for allergic reactions to eight different metals. Researchers found that people with ME/CFS were more likely to be allergic to nickel—36% of ME/CFS patients had nickel allergies compared to only 19% of healthy people. This difference was especially pronounced in women with ME/CFS, where over half (52%) showed nickel allergy. The researchers suggest that nickel exposure might somehow trigger or contribute to ME/CFS in some people.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Domestic violence and sexual abuse in women physicians: associated medical, psychiatric, and professional difficulties.

Doyle, J P, Frank, E, Saltzman, L E et al.·Journal of women's health & gender-based medicine·1999

This study looked at how common domestic violence and sexual abuse are among women doctors and what health problems they experience afterward. Researchers surveyed over 4,500 women physicians and found that those who had experienced domestic violence or sexual abuse were more likely to report depression, substance abuse, and chronic fatigue syndrome. The study suggests these traumatic experiences can have lasting effects on doctors' physical and mental health.

E2 ModerateCohortPEM not requiredObservational

Approaches to coping with chronic fatigue syndrome (CFS).

Stark, F M, Sobetzko, H M·Zentralblatt fur Hygiene und Umweltmedizin = International journal of hygiene and environmental medicine·1999

This study looked at how people with ME/CFS can better manage their condition by following long-term care and support. The researchers observed a support group over time to understand what helps patients cope with this serious illness that causes extreme fatigue and reduces ability to work, study, and maintain social activities. They found that a personalized approach combining medical care from a regular doctor and participation in a support group was helpful for disease management.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Chronic fatigue syndrome, chronic fatigue, and psychiatric disorders: predictors of functional status in a national nursing sample.

Wagner-Raphael, Lynne I, Jason, Leonard A, Ferrari, Joseph R·Journal of occupational health psychology·1999

This study looked at nurses with severe tiredness to understand how fatigue affects their daily lives and well-being. Researchers found that as fatigue got worse, people had more trouble with physical activities, work tasks, social interactions, and overall quality of life. Nurses who had ME/CFS experienced greater difficulties than those with fatigue from other causes.

E2 ModerateBehavioralPEM not requiredCross-Sectional

[The chronic fatigue and neurasthenia in the student population].

Mojarro Práxedes MD, Benjumea Pino P·Actas espanolas de psiquiatria·1999

This study looked at fatigue in 277 medical students to see how common chronic fatigue syndrome (CFS) and a related condition called neurasthenia actually are. The researchers found that while over one-third of students reported fatigue, very few met the strict criteria for CFS (less than 1%), and a small number met criteria for neurasthenia (about 3%). The study also found that students with fatigue were more likely to have depression symptoms, though it's unclear whether depression causes fatigue or results from it.

Cognitive Impairment

E2 ModerateCohortPEM not requiredObservational

Human herpesviruses in chronic fatigue syndrome.

Wallace, H L, Natelson, B, Gause, W et al.·Clinical and diagnostic laboratory immunology·1999

Researchers tested whether common viruses (HHV6, HHV7, Epstein-Barr virus, and cytomegalovirus) are more active or present in people with ME/CFS compared to healthy people. They examined blood samples from ME/CFS patients and matched healthy controls, looking for both the viruses themselves and antibodies (immune markers) against these viruses. They found no significant differences between the two groups, suggesting these particular viruses may not be a primary driver of ME/CFS.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Orthostatic intolerance in adolescent chronic fatigue syndrome.

Stewart, J M, Gewitz, M H, Weldon, A et al.·Pediatrics·1999

This study looked at how the bodies of adolescents with ME/CFS respond when they stand up or tilt upright. Researchers found that nearly all ME/CFS patients showed significant problems with this response, including rapid heart rate, blood pressure drops, and symptoms like dizziness and fainting. These problems were much more common in ME/CFS patients than in healthy teenagers or those with simple fainting disorders.

Autonomic Nervous System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Psychiatric adjustment in adolescents with a history of chronic fatigue syndrome.

Garralda, E, Rangel, L, Levin, M et al.·Journal of the American Academy of Child and Adolescent Psychiatry·1999

This study looked at mental health in teenagers who had ME/CFS, comparing them to healthy peers. Researchers found that teenagers with a history of ME/CFS were more likely to experience anxiety and depression, had more emotional symptoms, and felt worse about themselves—especially regarding how they fit in socially. Interestingly, those who had recovered from ME/CFS actually showed more anxiety disorders than those still experiencing active illness.

E2 ModerateCohortPEM not requiredCross-Sectional

Cardiovascular response during head-up tilt in chronic fatigue syndrome.

LaManca, J J, Peckerman, A, Walker, J et al.·Clinical physiology (Oxford, England)·1999

This study tested how the hearts of ME/CFS patients respond to positional changes using a tilt table test, where participants lie flat then are gradually tilted upward for 45 minutes. While ME/CFS patients showed different baseline heart rates and heart pumping patterns compared to healthy controls, the overall frequency of fainting-like responses was similar between the two groups.

Autonomic Nervous System

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Evidence browser

The genetic aetiology of somatic distress.

TNF-alpha and chronic fatigue syndrome.

Mercury and nickel allergy: risk factors in fatigue and autoimmunity.

Differences in adrenal steroid profile in chronic fatigue syndrome, in depression and in health.

Multiple mycoplasmal infections detected in blood of patients with chronic fatigue syndrome and/or fibromyalgia syndrome.

Chronic fatigue syndrome in private practice psychiatry: family history of physical and mental health.

Absence of evidence of Borna disease virus infection in Swedish patients with Chronic Fatigue Syndrome.

Absence of Borrelia burgdorferi-specific immune complexes in chronic fatigue syndrome.

Vitamin B status in patients with chronic fatigue syndrome.

Personality and social attitudes in chronic fatigue syndrome.

Chronic fatigue syndrome: gender differences in the search for legitimacy.

Chronic fatigue syndrome and nickel allergy.

Domestic violence and sexual abuse in women physicians: associated medical, psychiatric, and professional difficulties.

Approaches to coping with chronic fatigue syndrome (CFS).

Chronic fatigue syndrome, chronic fatigue, and psychiatric disorders: predictors of functional status in a national nursing sample.

[The chronic fatigue and neurasthenia in the student population].

Human herpesviruses in chronic fatigue syndrome.

Orthostatic intolerance in adolescent chronic fatigue syndrome.

Psychiatric adjustment in adolescents with a history of chronic fatigue syndrome.

Cardiovascular response during head-up tilt in chronic fatigue syndrome.

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