ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

3401–3420 of 6,161 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

Correlations among Epworth Sleepiness Scale scores, multiple sleep latency tests and psychological symptoms.

Olson, L G, Cole, M F, Ambrogetti, A·Journal of sleep research·1998

This study looked at whether a simple questionnaire about daytime sleepiness (the Epworth Sleepiness Scale) actually measures the same thing as a more complex sleep test that measures how quickly people fall asleep. The researchers found that these two tests don't measure the same thing—the questionnaire is influenced by mood and psychological symptoms, while the objective sleep test is not.

Sleep

E2 ModerateCohortPEM not requiredCase-Control

Yersinia enterocolitica and the chronic fatigue syndrome.

Swanink, C M, Stolk-Engelaar, V M, van der Meer, J W et al.·The Journal of infection·1998

This study looked for signs that a bacterium called Yersinia enterocolitica might cause ME/CFS by testing blood samples from 88 ME/CFS patients and 77 healthy people. Researchers found that antibodies (immune markers) to this bacterium were equally common in both groups, suggesting this particular infection is unlikely to be a major cause of ME/CFS.

Immune System

E2 ModerateBehavioralPEM not requiredObservational

A naturalistic study of the chronic fatigue syndrome among women in primary care.

Saltzstein, B J, Wyshak, G, Hubbuch, J T et al.·General hospital psychiatry·1998

This study interviewed 15 women with ME/CFS about their experiences and what helped them cope with the illness. Researchers found that 60% of the women reported improvement or recovery. Having strong support from family and friends, a supportive doctor who believed in the diagnosis, and lower depression symptoms were associated with better outcomes.

E2 ModerateCohortPEM unclearCross-Sectional

Secretion of growth hormone in patients with chronic fatigue syndrome.

Berwaerts, J, Moorkens, G, Abs, R·Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society·1998

This study looked at growth hormone levels in people with ME/CFS, because low growth hormone has been seen in related conditions like fibromyalgia. Researchers tested 20 ME/CFS patients and compared them to healthy controls, measuring growth hormone in different ways. They found that ME/CFS patients had lower levels of a growth hormone marker (IGF-I) and tended to produce less growth hormone at night, though other growth hormone tests were similar between groups.

Endocrine Disruption

E2 ModerateBehavioralPEM not requiredCross-Sectional

Coping and adaptive outcome in chronic fatigue syndrome: importance of illness cognitions.

Heijmans, M J·Journal of psychosomatic research·1998

This study looked at how 98 ME/CFS patients' beliefs about their illness affected how they coped with it and their quality of life. The researchers found that patients who believed their illness was serious, couldn't be controlled, and couldn't be cured tended to cope passively and experienced worse physical functioning, social problems, and mental health issues. Importantly, these beliefs about the illness itself were stronger predictors of these outcomes than the coping strategies people used.

E2 ModerateBehavioralPEM not requiredLongitudinal

Longitudinal changes associated with improvement in chronic fatigue patients.

Russo, J, Katon, W, Clark, M et al.·Journal of psychosomatic research·1998

Researchers followed people with chronic fatigue for 2.5 years to see what changes were linked to getting better. They found that improvements in mood, reduction in psychiatric symptoms, and disappearance of physical examination findings were connected to people feeling less fatigued, functioning better, and returning to work. People who either never had chronic fatigue syndrome or only had it at the start of the study showed the most improvement.

E2 ModerateCohortPEM not requiredObservational

Incidence, risk and prognosis of acute and chronic fatigue syndromes and psychiatric disorders after glandular fever.

White, P D, Thomas, J M, Amess, J et al.·The British journal of psychiatry : the journal of mental science·1998

This study followed 250 people who had either glandular fever (caused by Epstein-Barr virus) or a common cold to see how many developed long-lasting fatigue. Nearly half of those with glandular fever experienced severe tiredness immediately after infection, compared to only one-fifth with a common cold. About 9-22% of people with glandular fever developed chronic fatigue syndrome within six months, suggesting that this infection may trigger ME/CFS in some patients.

E2 ModerateCohortPEM not requiredObservational

Alteration of spatial-temporal parameters of gait in Chronic Fatigue Syndrome patients.

Saggini, R, Pizzigallo, E, Vecchiet, J et al.·Journal of the neurological sciences·1998

This study looked at how people with ME/CFS walk compared to healthy people. Researchers used specialized movement analysis tools to measure walking patterns in 12 patients and found clear differences in how smoothly and symmetrically they walked. Interestingly, these walking problems appeared right from the start of walking, not after fatigue set in, suggesting the issue may be related to how the brain controls movement rather than muscle tiredness.

E2 ModerateCohortPEM not requiredCross-Sectional

The epidemiology of chronic fatigue in San Francisco.

Steele, L, Dobbins, J G, Fukuda, K et al.·The American journal of medicine·1998

Researchers surveyed nearly 17,000 people in San Francisco to understand how common ME/CFS and related chronic fatigue conditions are. They found that about 2% of adults reported unexplained chronic fatigue, with only 0.2% meeting criteria for ME/CFS-like illness. The conditions were more common in women, people with lower incomes, and certain racial groups, but did not run in families.

E2 ModerateCohortPEM not requiredCross-Sectional

[31P-mr spectroscopy of peripheral skeletal musculature under load: demonstration of normal energy metabolites compared with metabolic muscle diseases].

Block, W, Träber, F, Kuhl, C K et al.·RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin·1998

Researchers used a special MRI scanner to measure how muscles use energy during exercise by looking at chemical changes in the calf. They found that healthy people used two different types of energy pathways during exercise, while people with ME/CFS showed unusual resting energy levels but normal recovery after exercise—unlike patients with genetic metabolic disorders, whose muscles recovered very slowly.

Biomarkers

E2 ModerateCohortPEM unclearCross-Sectional

Nasal secretion analysis in allergic rhinitis, cystic fibrosis, and nonallergic fibromyalgia/chronic fatigue syndrome subjects.

Baraniuk, J N, Clauw, D, Yuta, A et al.·American journal of rhinology·1998

Many people with ME/CFS experience nasal congestion and rhinitis symptoms, but don't test positive for allergies. This study analyzed nasal fluid from ME/CFS patients and compared it to people with allergies, cystic fibrosis, and healthy controls to understand what might be causing these symptoms. The researchers found that ME/CFS patients' nasal fluid looked similar to healthy controls, suggesting that the constant baseline secretion processes in the nose are not abnormal in ME/CFS.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Muscle fibre characteristics and lactate responses to exercise in chronic fatigue syndrome.

Lane, R J, Barrett, M C, Woodrow, D et al.·Journal of neurology, neurosurgery, and psychiatry·1998

Researchers examined muscle samples from 105 ME/CFS patients to understand why they have abnormal responses to exercise, particularly high lactate levels. They found that patients with high lactate responses had fewer type 1 muscle fibres (which are energy-efficient), but this wasn't because they were inactive—it appeared to be a specific muscle problem related to ME/CFS itself.

Post-Exertional Malaise

E2 ModerateBehavioralPEM not requiredObservational

Predictors of a medical-offset effect among patients receiving antidepressant therapy.

Thompson, D, Hylan, T R, McMullen, W et al.·The American journal of psychiatry·1998

This study looked at insurance records from nearly 1,700 people who started taking antidepressants for depression in the early 1990s. The researchers wanted to understand whether treating depression could also reduce overall healthcare costs. They found that patients with certain conditions—including chronic fatigue syndrome, anxiety, heart disease, and cancer—who stayed on antidepressants for at least 6 months tended to have lower medical bills overall.

E2 ModerateCohortPEM unclearCross-Sectional

[Incidence and clinical relevance of antibodies to phospholipids, serotonin and ganglioside in patients with sudden deafness and progressive inner ear hearing loss].

Heller, U, Becker, E W, Zenner, H P et al.·HNO·1998

This study looked at whether certain antibodies (proteins the immune system makes) are found more often in people with sudden or progressive hearing loss. Researchers found that about half of hearing loss patients had antibodies against phospholipids and about half to two-thirds had antibodies against serotonin and gangliosides. Interestingly, some patients with hearing loss also had symptoms of ME/CFS and fibromyalgia, suggesting these conditions may be connected through shared immune system abnormalities.

Immune System

E2 ModerateCohortPEM unclearObservational

The effects of nutritional supplements on the symptoms of fibromyalgia and chronic fatigue syndrome.

Dykman, K D, Tone, C, Ford, C et al.·Integrative physiological and behavioral science : the official journal of the Pavlovian Society·1998

This study looked at whether nutritional supplements might help reduce symptoms in 50 people with fibromyalgia and/or chronic fatigue syndrome. Researchers asked people about their symptoms when they started taking supplements and again nine months later. The people taking supplements reported significant improvement in their symptoms, with continued progress over the nine-month period.

E2 ModerateCohortPEM not requiredCross-Sectional

Attention and verbal learning in patients with chronic fatigue syndrome.

Michiels, V, Cluydts, R, Fischler, B·Journal of the International Neuropsychological Society : JINS·1998

This study tested thinking and memory skills in 20 people with ME/CFS and compared them to 22 healthy people. The researchers found that people with ME/CFS had difficulty with attention tasks that required handling multiple pieces of information at once, and they performed worse on remembering spoken information. However, their ability to focus on a single thing while ignoring distractions appeared to work normally.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Chronic fatigue syndrome: physical and cardiovascular deconditioning.

De Lorenzo, F, Xiao, H, Mukherjee, M et al.·QJM : monthly journal of the Association of Physicians·1998

This study compared the hearts and bodies of 273 ME/CFS patients with 72 healthy people. Researchers found that ME/CFS patients had smaller hearts and blood vessels, along with changes in blood markers like cholesterol and blood cells. The study suggests that ME/CFS patients may experience physical deconditioning similar to what happens when people are very inactive.

E2 ModerateCohortPEM not requiredCross-Sectional

Serum neopterin and somatization in women with chemical intolerance, depressives, and normals.

Bell, I R, Patarca, R, Baldwin, C M et al.·Neuropsychobiology·1998

This study looked at a marker in the blood called neopterin, which may indicate immune system activation, in women with chemical sensitivity (difficulty tolerating everyday chemicals at low levels), women with depression, and healthy women. The researchers found that neopterin levels themselves were similar across groups, but in women with chemical sensitivity, higher neopterin levels were linked with more physical symptoms—a connection not seen in the other groups.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Impaired associative learning in chronic fatigue syndrome.

Servatius, R J, Tapp, W N, Bergen, M T et al.·Neuroreport·1998

This study tested whether people with ME/CFS have problems with how their brain learns and forms connections between different pieces of information. Researchers measured brain learning using a test where a gentle puff of air is paired with an eye blink stimulus. While ME/CFS patients could hear and feel the stimuli normally, they had difficulty learning to associate the two stimuli together—suggesting their brain's ability to form certain types of connections may be affected.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredCross-Sectional

Early life stress, negative paternal relationships, and chemical intolerance in middle-aged women: support for a neural sensitization model.

Bell, I R, Baldwin, C M, Russek, L G et al.·Journal of women's health·1998

This study looked at whether women with chemical sensitivity (difficulty tolerating everyday chemicals) had experienced more childhood stress or difficult relationships with their fathers compared to women with depression alone or women without these conditions. The researchers found that women with chemical sensitivity had weaker relationships with their fathers and showed signs of nervous system overactivity. The study suggests that repeated exposure to stress early in life might train the nervous system to react more strongly to chemicals and other triggers.

Autonomic Nervous System

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Correlations among Epworth Sleepiness Scale scores, multiple sleep latency tests and psychological symptoms.

Yersinia enterocolitica and the chronic fatigue syndrome.

A naturalistic study of the chronic fatigue syndrome among women in primary care.

Secretion of growth hormone in patients with chronic fatigue syndrome.

Coping and adaptive outcome in chronic fatigue syndrome: importance of illness cognitions.

Longitudinal changes associated with improvement in chronic fatigue patients.

Incidence, risk and prognosis of acute and chronic fatigue syndromes and psychiatric disorders after glandular fever.

Alteration of spatial-temporal parameters of gait in Chronic Fatigue Syndrome patients.

The epidemiology of chronic fatigue in San Francisco.

[31P-mr spectroscopy of peripheral skeletal musculature under load: demonstration of normal energy metabolites compared with metabolic muscle diseases].

Nasal secretion analysis in allergic rhinitis, cystic fibrosis, and nonallergic fibromyalgia/chronic fatigue syndrome subjects.

Muscle fibre characteristics and lactate responses to exercise in chronic fatigue syndrome.

Predictors of a medical-offset effect among patients receiving antidepressant therapy.

[Incidence and clinical relevance of antibodies to phospholipids, serotonin and ganglioside in patients with sudden deafness and progressive inner ear hearing loss].

The effects of nutritional supplements on the symptoms of fibromyalgia and chronic fatigue syndrome.

Attention and verbal learning in patients with chronic fatigue syndrome.

Chronic fatigue syndrome: physical and cardiovascular deconditioning.

Serum neopterin and somatization in women with chemical intolerance, depressives, and normals.

Impaired associative learning in chronic fatigue syndrome.

Early life stress, negative paternal relationships, and chemical intolerance in middle-aged women: support for a neural sensitization model.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research