ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

3421–3440 of 6,209 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

Adaptive tasks, coping and quality of life of chronically ill patients: the cases of Parkinson's disease and chronic fatigue syndrome.

De Ridder, D T, Schreurs, K M, Bensing, J M·Journal of health psychology·1998

This study compared how people with Parkinson's disease and ME/CFS cope with the challenges their illnesses create and how this affects their quality of life. Researchers found that while both groups face similar types of challenges (like managing symptoms and adjusting daily life), the way these challenges affect quality of life differs between the two diseases. For people with ME/CFS, how patients think about and evaluate their illness challenges was more important in predicting their quality of life than the actual severity of their symptoms.

E2 ModerateCohortPEM not requiredCross-Sectional

Low levels of serum acylcarnitine in chronic fatigue syndrome and chronic hepatitis type C, but not seen in other diseases.

Kuratsune, H, Yamaguti, K, Lindh, G et al.·International journal of molecular medicine·1998

Researchers measured a substance called acylcarnitine in the blood of people with ME/CFS and compared it to healthy people and those with other diseases. They found that people with ME/CFS had significantly lower levels of this substance, and this same pattern appeared in both Japanese and Swedish patients. Importantly, this low level was only seen in ME/CFS and one other condition (chronic hepatitis C), not in other common diseases like diabetes or high blood pressure.

BiomarkersEnergy Metabolism

E2 ModerateCohortPEM not requiredCross-Sectional

Brain positron emission tomography (PET) in chronic fatigue syndrome: preliminary data.

Tirelli, U, Chierichetti, F, Tavio, M et al.·The American journal of medicine·1998

Researchers used a brain imaging technique called PET scans to measure energy use in the brains of 18 people with ME/CFS. They found that people with ME/CFS had lower energy use in a specific part of the brain (the brainstem) and part of the front of the brain compared to healthy people. Importantly, this pattern was different from what they saw in people with depression, suggesting ME/CFS may have its own distinct brain signature.

E2 ModerateCohortPEM not requiredCross-Sectional

Phosphate diabetes in patients with chronic fatigue syndrome.

De Lorenzo, F, Hargreaves, J, Kakkar, V V·Postgraduate medical journal·1998

This study explored whether some ME/CFS patients might actually have a rare kidney condition called phosphate diabetes, which prevents the kidneys from properly reabsorbing phosphate. Phosphate is important for muscle and nerve function, and low levels can cause fatigue, muscle pain, and depression—symptoms that overlap with ME/CFS. The researchers tested 87 ME/CFS patients and found that 9 of them also had phosphate diabetes.

Energy Metabolism

E2 ModerateBehavioralPEM not requiredCross-Sectional

Structure and Determinants of Illness Representations in Chronic Disease: A Comparison of Addison's Disease and Chronic Fatigue Syndrome.

Heijmans, M, De Ridder, D·Journal of health psychology·1998

This study looked at how people with ME/CFS and Addison's disease think about their illnesses—what they believe causes it, how long it will last, whether they can control it, and how it affects their lives. Researchers interviewed 98 ME/CFS patients and 63 Addison's disease patients and found that the two groups had quite different views about their conditions. However, the way these different beliefs connected to each other followed similar patterns in both groups.

E2 ModerateCohortPEM not requiredCross-Sectional

Influence of exhaustive treadmill exercise on cognitive functioning in chronic fatigue syndrome.

LaManca, J J, Sisto, S A, DeLuca, J et al.·The American journal of medicine·1998

This study looked at how exercise affects thinking and mental processing in people with ME/CFS compared to healthy people. Both groups did exhausting exercise on a treadmill, then took thinking tests right after and 24 hours later. People with ME/CFS performed worse on these thinking tests after exercise, particularly on tasks involving speed and attention, and their thinking stayed impaired the next day.

Post-Exertional Malaise

E2 ModerateBehavioralPEM not requiredCross-Sectional

Correlations among Epworth Sleepiness Scale scores, multiple sleep latency tests and psychological symptoms.

Olson, L G, Cole, M F, Ambrogetti, A·Journal of sleep research·1998

This study looked at whether a simple questionnaire about daytime sleepiness (the Epworth Sleepiness Scale) actually measures the same thing as a more complex sleep test that measures how quickly people fall asleep. The researchers found that these two tests don't measure the same thing—the questionnaire is influenced by mood and psychological symptoms, while the objective sleep test is not.

Sleep

E2 ModerateCohortPEM not requiredLongitudinal

Clinical and serologic follow-up in patients with neuroborreliosis.

Treib, J, Fernandez, A, Haass, A et al.·Neurology·1998

Researchers followed 44 patients who had been treated for a tick-borne brain infection caused by Borrelia bacteria. Even though the patients' neurological symptoms improved after antibiotics, more than half continued to experience ongoing fatigue and other non-specific symptoms similar to chronic fatigue syndrome years later. Some patients also continued to show signs of Borrelia infection in their blood tests.

E2 ModerateCohortPEM not requiredCase-Control

Autonomic testing in patients with chronic fatigue syndrome.

De Becker, P, Dendale, P, De Meirleir, K et al.·The American journal of medicine·1998

This study tested how the nervous system that controls heart rate and blood pressure works in ME/CFS patients compared to healthy people. Researchers found that ME/CFS patients had higher heart rates and stronger stress responses when standing up, suggesting their bodies may be overactive in certain stress situations. However, these findings did not fully explain why ME/CFS patients experience fatigue and problems with exercise.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredObservational

Incidence, risk and prognosis of acute and chronic fatigue syndromes and psychiatric disorders after glandular fever.

White, P D, Thomas, J M, Amess, J et al.·The British journal of psychiatry : the journal of mental science·1998

This study followed 250 people who had either glandular fever (caused by Epstein-Barr virus) or a common cold to see how many developed long-lasting fatigue. Nearly half of those with glandular fever experienced severe tiredness immediately after infection, compared to only one-fifth with a common cold. About 9-22% of people with glandular fever developed chronic fatigue syndrome within six months, suggesting that this infection may trigger ME/CFS in some patients.

E2 ModerateCohortPEM not requiredCross-Sectional

Rhinitis symptoms in chronic fatigue syndrome.

Baraniuk, J N, Clauw, D J, Gaumond, E·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·1998

This study looked at whether people with ME/CFS have more nasal and sinus problems than the general population. Researchers compared 51 ME/CFS patients with healthy controls and people with allergies, using questionnaires and allergy skin tests. They found that most ME/CFS patients reported significant nasal and sinus symptoms, but about half of these cases appeared to be non-allergic in nature.

Immune System

E2 ModerateBehavioralPEM not requiredObservational

A naturalistic study of the chronic fatigue syndrome among women in primary care.

Saltzstein, B J, Wyshak, G, Hubbuch, J T et al.·General hospital psychiatry·1998

This study interviewed 15 women with ME/CFS about their experiences and what helped them cope with the illness. Researchers found that 60% of the women reported improvement or recovery. Having strong support from family and friends, a supportive doctor who believed in the diagnosis, and lower depression symptoms were associated with better outcomes.

E2 ModerateBehavioralPEM not requiredCase-Control

Chronic fatigue syndrome: identification of distinct subgroups on the basis of allergy and psychologic variables.

Borish, L, Schmaling, K, DiClementi, J D et al.·The Journal of allergy and clinical immunology·1998

This study looked at whether allergies and psychological factors play a role in ME/CFS. Researchers compared 18 people with ME/CFS to healthy controls, people with allergies, and people with depression. They found that people with ME/CFS had different immune molecules (called cytokines) in their blood compared to healthy people, similar to those with allergies. Interestingly, people with ME/CFS who also had certain psychological profiles showed different immune patterns, suggesting that both allergies and how the mind responds to them may contribute to ME/CFS in some patients.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

The role of delayed orthostatic hypotension in the pathogenesis of chronic fatigue.

Streeten, D H, Anderson, G H·Clinical autonomic research : official journal of the Clinical Autonomic Research Society·1998

This study looked at whether problems with blood pressure regulation—specifically a delayed drop in blood pressure when standing up—might explain why some people with chronic fatigue syndrome feel so exhausted. Researchers surveyed 431 patients with various neurological and hormonal disorders and found that fatigue was very common in people with delayed blood pressure drops and low cortisol levels (70-83%), but much less common in people with other conditions like multiple system atrophy (7-33%). This suggests a possible connection between blood pressure regulation problems and severe fatigue.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Urinary free cortisol excretion in chronic fatigue syndrome, major depression and in healthy volunteers.

Scott, L V, Dinan, T G·Journal of affective disorders·1998

This study measured a stress hormone called cortisol in urine samples from people with ME/CFS, people with depression, and healthy individuals. The researchers found that people with ME/CFS had lower cortisol levels than healthy people, while people with depression had higher levels. This suggests that ME/CFS and depression affect the body's stress response system in opposite ways.

Endocrine Disruption

E2 ModerateReviewPEM not requiredReview-Narrative

Relationship Between Chronic Fatigue Syndrome and Neurally Mediated Hypotension.

Calkins, H, Rowe, PC·Cardiology in review·1998

This study explored a possible connection between ME/CFS and a condition called neurally mediated hypotension, where blood pressure drops suddenly due to problems with nerve signals that control blood vessels. Researchers found that when they treated patients for this blood pressure problem, about two-thirds of ME/CFS patients felt better. While these early results were promising, the study notes that larger, more rigorous trials were needed to confirm whether this treatment truly helps.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Detection of Mycoplasma genus and Mycoplasma fermentans by PCR in patients with Chronic Fatigue Syndrome.

Vojdani, A, Choppa, P C, Tagle, C et al.·FEMS immunology and medical microbiology·1998

Researchers tested blood samples from 100 ME/CFS patients and 50 healthy people to see if a bacterium called Mycoplasma fermentans was present. They found this bacterium's genetic material in more than a third of ME/CFS patients compared to only 8% of healthy controls. Patients with higher amounts of the bacterium also had stronger immune responses against it, suggesting their bodies were reacting to the infection.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Basal activity of the hypothalamic-pituitary-adrenal axis in patients with the chronic fatigue syndrome (neurasthenia).

Young, A H, Sharpe, M, Clements, A et al.·Biological psychiatry·1998

This study tested whether people with ME/CFS have abnormal levels of cortisol, a stress hormone, by measuring it in saliva and urine over 24 hours. The researchers found no difference in cortisol levels between people with ME/CFS and healthy controls, suggesting that the baseline cortisol system may not be impaired in this condition.

Endocrine Disruption

E2 ModerateCohortPEM not requiredObservational

Alteration of spatial-temporal parameters of gait in Chronic Fatigue Syndrome patients.

Saggini, R, Pizzigallo, E, Vecchiet, J et al.·Journal of the neurological sciences·1998

This study looked at how people with ME/CFS walk compared to healthy people. Researchers used specialized movement analysis tools to measure walking patterns in 12 patients and found clear differences in how smoothly and symmetrically they walked. Interestingly, these walking problems appeared right from the start of walking, not after fatigue set in, suggesting the issue may be related to how the brain controls movement rather than muscle tiredness.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Coping and adaptive outcome in chronic fatigue syndrome: importance of illness cognitions.

Heijmans, M J·Journal of psychosomatic research·1998

This study looked at how 98 ME/CFS patients' beliefs about their illness affected how they coped with it and their quality of life. The researchers found that patients who believed their illness was serious, couldn't be controlled, and couldn't be cured tended to cope passively and experienced worse physical functioning, social problems, and mental health issues. Importantly, these beliefs about the illness itself were stronger predictors of these outcomes than the coping strategies people used.

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Adaptive tasks, coping and quality of life of chronically ill patients: the cases of Parkinson's disease and chronic fatigue syndrome.

Low levels of serum acylcarnitine in chronic fatigue syndrome and chronic hepatitis type C, but not seen in other diseases.

Brain positron emission tomography (PET) in chronic fatigue syndrome: preliminary data.

Phosphate diabetes in patients with chronic fatigue syndrome.

Structure and Determinants of Illness Representations in Chronic Disease: A Comparison of Addison's Disease and Chronic Fatigue Syndrome.

Influence of exhaustive treadmill exercise on cognitive functioning in chronic fatigue syndrome.

Correlations among Epworth Sleepiness Scale scores, multiple sleep latency tests and psychological symptoms.

Clinical and serologic follow-up in patients with neuroborreliosis.

Autonomic testing in patients with chronic fatigue syndrome.

Incidence, risk and prognosis of acute and chronic fatigue syndromes and psychiatric disorders after glandular fever.

Rhinitis symptoms in chronic fatigue syndrome.

A naturalistic study of the chronic fatigue syndrome among women in primary care.

Chronic fatigue syndrome: identification of distinct subgroups on the basis of allergy and psychologic variables.

The role of delayed orthostatic hypotension in the pathogenesis of chronic fatigue.

Urinary free cortisol excretion in chronic fatigue syndrome, major depression and in healthy volunteers.

Relationship Between Chronic Fatigue Syndrome and Neurally Mediated Hypotension.

Detection of Mycoplasma genus and Mycoplasma fermentans by PCR in patients with Chronic Fatigue Syndrome.

Basal activity of the hypothalamic-pituitary-adrenal axis in patients with the chronic fatigue syndrome (neurasthenia).

Alteration of spatial-temporal parameters of gait in Chronic Fatigue Syndrome patients.

Coping and adaptive outcome in chronic fatigue syndrome: importance of illness cognitions.

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