Examining the Institute of Medicine's Recommendations Regarding Chronic Fatigue Syndrome: Clinical Versus Research Criteria.
Jason, Leonard A, McManimen, Stephanie, Sunnquist, Madison et al.·Journal of neurology and psychology·2015
This study compared two different sets of diagnostic criteria for ME/CFS: one proposed by the Institute of Medicine for clinical use, and another (the Canadian criteria) recommended for research. Using patient data from the US, UK, and Norway, researchers found that patients meeting the research criteria were significantly more severely affected across multiple symptoms and daily functioning areas. This suggests the two criteria sets identify somewhat different groups of patients.