Value-added reporting of antinuclear antibody testing by automated indirect immunofluorescence analysis.
Schouwers, Sofie, Bonnet, Myriam, Verschueren, Patrick et al.·Clinical chemistry and laboratory medicine·2014
This study tested a new automated machine system that measures antinuclear antibodies (ANA)—proteins the immune system sometimes makes that can indicate autoimmune diseases. Researchers found that the machine's measurement of fluorescence brightness (how bright the antibody signals are) correlates with disease likelihood: brighter signals were more likely to indicate rheumatic diseases like lupus or Sjögren's syndrome. This automated brightness measurement could help doctors better interpret ANA test results.