ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

3981–4000 of 6,188 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

The Gut Microbiome and Symptom Burden After Kidney Transplantation: An Overview and Research Opportunities.

Lockwood, Mark B, Sung, Choa, Alvernaz, Suzanne A et al.·Biological research for nursing·2024

Kidney transplant patients often feel very tired and sick even after their new kidney works well. Scientists think the bacteria living in our digestive system might explain why this happens. Transplant medications can change these helpful bacteria, which may affect how our immune system, hormones, and brain work together. This article explores how fixing the gut bacteria might help transplant patients feel better.

Gut MicrobiomeImmune System

E3 PreliminaryCommentaryPEM unclearEditorial

A Practical Approach to Tailor the Term Long COVID for Diagnostics, Therapy and Epidemiological Research for Improved Long COVID Patient Care.

Hoffmann, Kathryn, Stingl, Michael, O'Mahony, Liam et al.·Infectious diseases and therapy·2024

This paper proposes a clearer way to define and categorize long COVID by splitting it into three distinct groups: ongoing COVID-19 symptoms, diseases triggered or worsened by COVID-19, and post-acute COVID condition (which includes symptoms like post-exertional malaise and brain fog). Using clearer definitions and standardized medical codes would help doctors diagnose patients more accurately and allow researchers to study long COVID more effectively.

Post-Exertional Malaise

E3 PreliminaryCohortPEM not requiredCross-Sectional

Cranial venous outflow insufficiency; rendered almost invisible to radiological imaging by circular reasoning. Rethinking normal craniocervical venous anatomy.

Higgins, J Nicholas P, Borchert, Robin J, Rao, Sarita et al.·Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2024

This study challenges how doctors define normal brain blood vessel patterns by examining 100 patients whose brain scans were reported as normal. Interestingly, nearly half had no final diagnosis, and many experienced symptoms like headaches, dizziness, and cognitive problems. The researchers suggest that some of these unexplained symptoms might actually be caused by subtle problems with how blood drains from the brain, rather than being 'all in the patient's head.'

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Core outcome measurement set for research and clinical practice in post-COVID-19 condition (long COVID) in children and young people: an international Delphi consensus study "PC-COS Children".

Seylanova, Nina, Chernyavskaya, Anastasia, Degtyareva, Natalia et al.·The European respiratory journal·2024

This study developed a standardized list of health outcomes and measurement tools that doctors and researchers should use when evaluating children and young people with long COVID. International experts from 37 countries agreed on seven key areas to measure: fatigue, post-exertion symptoms, changes in work or school, and cardiovascular, neurological, gastrointestinal, and physical problems. They also identified specific questionnaires that work best for measuring fatigue, digestive symptoms, thinking problems, and overall functioning.

Post-Exertional Malaise

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

BRIEF REPORT: Assessing Adherence and Competence in Delivering Telehealth Group Cognitive Behavioral Stress Management.

May, Marcella, Ream, Molly, Milrad, Sara F et al.·International journal of stress management·2024

This study developed a way to check whether therapists are properly delivering a stress management program called CBSM (Cognitive Behavioral Stress Management) when it's delivered online through video. The researchers watched 146 recorded therapy sessions with ME/CFS patients and their partners to see if therapists were following the program correctly and doing it well. They found that their checklist system worked fairly well, meaning different raters could agree on whether therapists were doing their job properly.

E3 PreliminaryReviewPEM unclearReview-Narrative

Long COVID's Impact on Patients, Workers, & Society: A review.

Kavanagh, Kevin T, Cormier, Lindsay E, Pontus, Christine et al.·Medicine·2024

About 1 in 10 people who recover from COVID-19 develop long COVID, and roughly 1 in 4 of those people struggle with daily activities like work and self-care. Brain damage has been found in some patients, leading to problems with memory, thinking clearly, and mood changes. The study reviews how long COVID affects patients' jobs, finances, and communities, and emphasizes that gentle recovery approaches work better than pushing too hard, which can cause setbacks lasting days or weeks.

Post-Exertional Malaise

E3 PreliminaryPEM unclear

Patient experiences with requests for medical assistance in dying: Perspectives of those with complex chronic conditions.

Fruhstorfer, Clark, Kelly, Michaela, Spiegel, Laura et al.·Canadian family physician Medecin de famille canadien·2024

This Canadian study interviewed 16 people with chronic conditions like ME/CFS and fibromyalgia who had requested medical assistance in dying (MAID) because their suffering was not relieved by available treatments. Participants reported that the approval process gave them a sense of control and validation of their illness, even if they didn't immediately use it. Many found value in simply being listened to by researchers who took their experiences seriously.

E3 PreliminaryReviewPEM unclearReview-Narrative

Long Covid.

Zaidi, Asiya Kamber, Dehgani-Mobaraki, Puya·Progress in molecular biology and translational science·2024

Long COVID is a condition where people experience ongoing symptoms weeks or months after having COVID-19. This review examines what might cause Long COVID, including lingering virus in the body, problems with the immune system, and issues with blood vessels and nerves. The authors discuss how doctors can recognize and treat Long COVID, emphasizing that patients often need care from multiple specialists working together.

Immune SystemPost-Exertional Malaise

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Combining Topic Modeling, Sentiment Analysis, and Corpus Linguistics to Analyze Unstructured Web-Based Patient Experience Data: Case Study of Modafinil Experiences.

Walsh, Julia, Cave, Jonathan, Griffiths, Frances·Journal of medical Internet research·2024

Researchers analyzed nearly 70,000 posts from online forums and social media where people discussed their experiences taking modafinil, a wakefulness-promoting medication. They used computer programs to organize and understand what people wrote about how the drug affected them, what side effects they experienced, and whether it helped their symptoms. They found that most people reported positive experiences, but this contrasts sharply with what formal clinical trials have shown about modafinil's effectiveness.

Interventions

E3 PreliminaryReviewPEM not requiredReview-Narrative

Sjögren's syndrome.

Balint, Geza, Watson Buchanan, W, Kean, Colin A et al.·Inflammopharmacology·2024

Sjögren's syndrome is an autoimmune disease that causes dry eyes and dry mouth, often with swollen salivary glands. This review article explains that Sjögren's syndrome can occur on its own or alongside other autoimmune diseases like lupus or rheumatoid arthritis. Importantly, the authors note that Sjögren's syndrome has been linked to chronic fatigue syndrome and fibromyalgia, suggesting there may be shared features between these conditions.

Immune System

E3 PreliminaryCohortPEM unclearCase-Control

Acute Compartment Syndrome and Rhabdomyolysis Caused by a Single Electrical Muscle Stimulation in a 46-Year-Old Female Professional Athlete With Fibromyalgia, Chronic Fatigue Syndrome, and Myofascial Disorder: A Case Report.

von Deneen, Karen M, Alemayehu, Dereje Gobena, Khosla, Ajit·Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine·2024

This case report describes a 46-year-old female athlete with ME/CFS and fibromyalgia who experienced a serious muscle injury called rhabdomyolysis after just one session of electrical muscle stimulation (EMS) training. Her muscles broke down severely enough to cause compartment syndrome—a dangerous swelling in the muscle tissue—requiring intensive hospital care with fluids and medications. The report warns that people with ME/CFS and similar chronic conditions should be very cautious with EMS training because their bodies may react more severely to this type of exercise.

Post-Exertional Malaise

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Identification of stimuli that enhance human herpesvirus 6A (HHV-6A) replication and reconstitution.

Reich, Jana, Serdar, Dilan, Weißmann, Ann-Christin et al.·Journal of virology·2024

This study focuses on improving laboratory techniques for studying HHV-6A, a common virus that stays dormant in the body for life. Researchers tested different methods to grow this virus in the lab more efficiently, discovering that certain immune-suppressing drugs and low-oxygen conditions help the virus replicate better. While this doesn't directly treat ME/CFS patients, understanding how HHV-6A behaves in the lab is an important step toward developing better treatments.

Immune System

E3 PreliminaryMechanismPEM not requiredObservational

Exploring the central mechanism of mind-regulation electroacupuncture in treatment of chronic fatigue syndrome with anxiety and depression comorbidity based on functional magnetic resonance imaging.

Zeng, Xiangxin, Feng, Chuwen, Zhang, Muhua et al.·Zhongguo zhen jiu = Chinese acupuncture & moxibustion·2024

This study tested whether a specific type of acupuncture called 'mind-regulation electroacupuncture' could help people with ME/CFS who also have anxiety and depression. Researchers used brain imaging to see how the treatment changed activity patterns in the brains of 30 patients compared to 30 healthy people. After 2 weeks of treatment, patients reported less fatigue, anxiety, depression, and sleep problems, and their brain scans showed changes in areas related to emotions and fatigue.

E3 PreliminaryMechanismPEM not requiredMechanistic

An Exercise Immune Fitness Test to Unravel Disease Mechanisms-A Proof-of-Concept Heart Failure Study.

Bondar, Galyna, Mahapatra, Abhinandan Das, Bao, Tra-Mi et al.·Journal of clinical medicine·2024

This study examined how genes in immune cells respond to exercise in people with heart failure and healthy volunteers. Researchers took blood samples before, during, and after exercise on a stationary bike and looked for changes in gene activity. They found that certain genes responded differently to exercise depending on how fit someone was, suggesting that gene patterns might help doctors understand exercise capacity and predict outcomes.

Immune System

E3 PreliminaryCohortPEM unclearCase-Control

Clinical Remission After Therapeutic Apheresis in a Patient Suffering from Long Term Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Case Report.

Burgard, Harald·International medical case reports journal·2024

This case report describes one woman with ME/CFS for over 15 years who underwent a blood-cleaning treatment called double-filtration apheresis eight times over two years. After treatment, she experienced significant improvement in her fatigue, thinking problems, and other symptoms, with benefits that lasted over time. While this is promising, it is based on just one patient's experience and needs much larger studies to confirm whether this treatment works for others with ME/CFS.

Immune System

E3 PreliminaryMechanismPEM unclearCross-Sectional

Dysregulation of the Kynurenine Pathway, Cytokine Expression Pattern, and Proteomics Profile Link to Symptomology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Kavyani, Bahar, Ahn, Seong Beom, Missailidis, Daniel et al.·Molecular neurobiology·2024

This study found that ME/CFS patients have imbalances in a particular chemical pathway in their body (the kynurenine pathway) that appears connected to inflammation and symptom severity. The researchers discovered that higher levels of one early chemical in this pathway correlated with worse symptoms, while lower levels of later chemicals in the pathway might affect how cells produce energy. Interestingly, they also found that five of the most significantly changed proteins in ME/CFS patients are involved in gut health, suggesting the gut microbiome may play an important role in the disease.

BiomarkersGut MicrobiomeEnergy MetabolismImmune System

E3 PreliminaryMechanismPEM unclearMechanistic

Dysregulation of tetrahydrobiopterin metabolism in myalgic encephalomyelitis/chronic fatigue syndrome by pentose phosphate pathway.

Bulbule, Sarojini, Gottschalk, Carl Gunnar, Drosen, Molly E et al.·Journal of central nervous system disease·2024

Researchers found that patients with ME/CFS who experience dizziness upon standing have abnormally high levels of certain molecules called biopterins in their blood. The study discovered that these molecules are produced through an unusual metabolic pathway involving the breakdown of glucose, and this pathway appears to trigger inflammation in immune cells. This finding suggests a potential biochemical explanation for some ME/CFS symptoms.

Energy MetabolismImmune System

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Machine learning algorithms for detection of visuomotor neural control differences in individuals with PASC and ME.

Ahuja, Harit, Badhwar, Smriti, Edgell, Heather et al.·Frontiers in human neuroscience·2024

Researchers developed a new method using a simple headband that reads brain activity (EEG) to help identify people with long COVID or ME/CFS. The study used artificial intelligence to analyze brain patterns, and when trained on computer-generated synthetic data, the system was able to correctly identify these conditions 93% of the time. This approach could eventually help doctors diagnose and monitor these conditions more quickly.

Biomarkers

E3 PreliminaryMechanismPEM not requiredMechanistic

Repeated cold stress, an animal model for fibromyalgia, elicits proprioceptor-induced chronic pain with microglial activation in mice.

Wakatsuki, Koji, Kiryu-Seo, Sumiko, Yasui, Masaya et al.·Journal of neuroinflammation·2024

Researchers used mice exposed to repeated cold stress to study how chronic pain develops, similar to fibromyalgia. They found that sensory nerve cells (proprioceptors) become overactive and trigger immune cells in the nervous system called microglia to become inflamed. When they reduced microglial activity with a drug, the pain improved, suggesting that this immune activation along nerve pathways may be a key driver of long-lasting pain.

Neuroinflammation

E3 PreliminaryMechanismPEM unclearMechanistic

Investigation into the restoration of TRPM3 ion channel activity in post-COVID-19 condition: a potential pharmacotherapeutic target.

Sasso, Etianne Martini, Muraki, Katsuhiko, Eaton-Fitch, Natalie et al.·Frontiers in immunology·2024

This study looked at a tiny channel (called TRPM3) that sits on immune cells called NK cells, which help fight infections. Researchers found that both ME/CFS and post-COVID patients have a broken version of this channel. Importantly, they discovered that a drug called naltrexone (NTX) could fix this broken channel in lab-grown cells from post-COVID patients, suggesting it might help real patients feel better.

Immune System

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The Gut Microbiome and Symptom Burden After Kidney Transplantation: An Overview and Research Opportunities.

A Practical Approach to Tailor the Term Long COVID for Diagnostics, Therapy and Epidemiological Research for Improved Long COVID Patient Care.

Cranial venous outflow insufficiency; rendered almost invisible to radiological imaging by circular reasoning. Rethinking normal craniocervical venous anatomy.

Core outcome measurement set for research and clinical practice in post-COVID-19 condition (long COVID) in children and young people: an international Delphi consensus study "PC-COS Children".

BRIEF REPORT: Assessing Adherence and Competence in Delivering Telehealth Group Cognitive Behavioral Stress Management.

Long COVID's Impact on Patients, Workers, & Society: A review.

Patient experiences with requests for medical assistance in dying: Perspectives of those with complex chronic conditions.

Long Covid.

Combining Topic Modeling, Sentiment Analysis, and Corpus Linguistics to Analyze Unstructured Web-Based Patient Experience Data: Case Study of Modafinil Experiences.

Sjögren's syndrome.

Acute Compartment Syndrome and Rhabdomyolysis Caused by a Single Electrical Muscle Stimulation in a 46-Year-Old Female Professional Athlete With Fibromyalgia, Chronic Fatigue Syndrome, and Myofascial Disorder: A Case Report.

Identification of stimuli that enhance human herpesvirus 6A (HHV-6A) replication and reconstitution.

Exploring the central mechanism of mind-regulation electroacupuncture in treatment of chronic fatigue syndrome with anxiety and depression comorbidity based on functional magnetic resonance imaging.

An Exercise Immune Fitness Test to Unravel Disease Mechanisms-A Proof-of-Concept Heart Failure Study.

Clinical Remission After Therapeutic Apheresis in a Patient Suffering from Long Term Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Case Report.

Dysregulation of the Kynurenine Pathway, Cytokine Expression Pattern, and Proteomics Profile Link to Symptomology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Dysregulation of tetrahydrobiopterin metabolism in myalgic encephalomyelitis/chronic fatigue syndrome by pentose phosphate pathway.

Machine learning algorithms for detection of visuomotor neural control differences in individuals with PASC and ME.

Repeated cold stress, an animal model for fibromyalgia, elicits proprioceptor-induced chronic pain with microglial activation in mice.

Investigation into the restoration of TRPM3 ion channel activity in post-COVID-19 condition: a potential pharmacotherapeutic target.

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