ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

4101–4120 of 6,188 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

Pushing the envelope: Immune mechanism and application landscape of macrophage-activating lipopeptide-2.

Liao, Daoyong, Su, Xiaoling, Wang, Jingyun et al.·Frontiers in immunology·2023

This review examines how a molecule called MALP-2, derived from a bacterium linked to ME/CFS, affects the immune system. Researchers found that MALP-2 can activate immune cells in ways that might help fight infections and heal tissues. The molecule is simple to make and could potentially be developed into treatments for various conditions.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

The viral origin of myalgic encephalomyelitis/chronic fatigue syndrome.

Hanson, Maureen R·PLoS pathogens·2023

This review examines the evidence that viral infections may trigger or contribute to ME/CFS. Researchers looked at how viruses could potentially cause the long-lasting fatigue, pain, and other symptoms that define this condition. The study explores possible mechanisms by which a viral infection might set off a chain of events leading to ME/CFS.

Immune System

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Accelerating discovery: A novel flow cytometric method for detecting fibrin(ogen) amyloid microclots using long COVID as a model.

Turner, Simone, Laubscher, Gert Jacobus, Khan, M Asad et al.·Heliyon·2023

Long COVID patients often have abnormal blood clotting that creates tiny, sticky clots resistant to the body's natural clot-dissolving processes. This study developed a faster, more reliable laboratory test using imaging flow cytometry to detect these microclots in blood samples. The new method successfully identified larger and more numerous microclots in Long COVID patients compared to healthy controls, and it could potentially be used in regular hospital labs to help diagnose and treat affected patients.

E3 PreliminaryCommentaryPEM not required

The Potential Role of Hypothalamic Phospholipid Liposomes in the Supportive Therapy of Some Manifestations of Post-COVID-19 Condition: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Brain Fog.

Menichetti, Francesco·Journal of clinical medicine·2023

This article discusses how a treatment called hypothalamic phospholipid liposomes might help with ME/CFS and brain fog symptoms in people with Long COVID. These liposomes are small fatty particles that are already available as a supportive treatment for brain and hormone-related problems. The authors suggest this treatment could be helpful based on how it works and their early clinical experiences, though more rigorous testing is still needed.

Cognitive Impairment

E3 PreliminaryCohortPEM unclearObservational

First insights into multidisciplinary and multispecialty long COVID networks-a SWOT analysis from the perspective of ambulatory health care professionals.

Stengel, Sandra, Gölz, Lea, Kolb, Joachim et al.·Frontiers in medicine·2023

This study looked at how two regional networks in Germany organized care for long COVID patients by having different doctors and therapists work together. Researchers interviewed healthcare professionals from these networks to understand what worked well, what was difficult, and what could be improved. Both networks focused on primary care doctors coordinating care with specialists, though they took slightly different approaches—one emphasized treating individual patients in clinics, while the other connected hospitals and community services across a wider region.

E3 PreliminaryPEM required

Case report: Rapid improvements of anorexia nervosa and probable myalgic encephalomyelitis/chronic fatigue syndrome upon metreleptin treatment during two dosing episodes.

Hebebrand, Johannes, Antel, Jochen, von Piechowski, Linda et al.·Frontiers in psychiatry·2023

This case report describes a 17-year-old boy who had both anorexia nervosa (an eating disorder) and probable ME/CFS (a condition causing extreme fatigue and pain after exertion). He was treated with a medication called metreleptin for short periods. Notably, the treatment appeared to improve not only his eating disorder symptoms but also his ME/CFS symptoms like fatigue and post-exertional muscle pain. This raises the possibility that metreleptin might help people with ME/CFS, especially those who have also lost significant weight.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM requiredObservational

Urine Metabolomics Exposes Anomalous Recovery after Maximal Exertion in Female ME/CFS Patients.

Glass, Katherine A, Germain, Arnaud, Huang, Yuhsin V et al.·International journal of molecular sciences·2023

Researchers tested urine samples from ME/CFS patients and healthy people before and after intense exercise. They found that healthy people's urine chemistry changed noticeably after exercise (showing normal recovery), but ME/CFS patients' urine chemistry barely changed. This suggests that ME/CFS patients' bodies may not be adapting properly to physical stress the way healthy bodies do.

Energy MetabolismPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Hypothetical framework for post-COVID 19 condition based on a fibromyalgia pathogenetic model.

Martínez-Lavín, Manuel, Miguel-Álvarez, Adriana·Clinical rheumatology·2023

This study compares three conditions that share similar symptoms: fibromyalgia, ME/CFS, and long COVID. All three cause fatigue, brain fog, and widespread pain. Researchers propose that these conditions may work through the same biological mechanism—specifically, problems with nerve fiber communication in the body—and suggest that long COVID may develop through the same pathway as fibromyalgia.

Neuroinflammation

E3 PreliminaryMechanismPEM requiredMechanistic

Stress-Induced Transcriptomic Changes in Females with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Reveal Disrupted Immune Signatures.

Van Booven, Derek J, Gamer, Jackson, Joseph, Andrew et al.·International journal of molecular sciences·2023

This study looked at how the bodies of women with ME/CFS respond to exercise compared to healthy women. Researchers collected blood samples at three points: before exercise, during maximum effort, and during recovery. While healthy women's immune cells showed normal changes during exercise, women with ME/CFS showed unusual immune system activity specifically during the recovery period—the time when post-exertional malaise (worsening of symptoms) typically occurs.

Immune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM unclearMechanistic

A Proposed New Model to Explain the Role of Low Dose Non-DNA Targeted Radiation Exposure in Chronic Fatigue and Immune Dysfunction Syndrome.

Cocchetto, Alan, Seymour, Colin, Mothersill, Carmel·International journal of molecular sciences·2023

This study proposes a theory about how radiation exposure might trigger ME/CFS in some patients. The authors suggest that low-level radiation causes a chain reaction in the body involving free radicals (damaging molecules) and immune dysfunction, possibly linked to skin and blood cell problems. They reviewed evidence from people exposed to radiation (like after Chernobyl) who developed ME/CFS symptoms, to build a biological model explaining how this might happen.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Association of multiple sclerosis with chronic fatigue syndrome, restless legs syndrome, and various sleep disorders, along with the recent updates.

Prajjwal, Priyadarshi, Kalluru, Pavan K R, Marsool, Mohammed Dheyaa et al.·Annals of medicine and surgery (2012)·2023

This review examines how multiple sclerosis (MS) and ME/CFS are similar, particularly in how they cause fatigue and affect sleep. Both conditions involve damage to similar brain regions and may share genetic risk factors. The authors discuss how treatments like supervised exercise can help manage fatigue in both illnesses, though the underlying causes differ.

E3 PreliminaryCohortPEM unclearCase-Control

Case report: Recurrent cervical spinal stenosis masquerading as myalgic encephalomyelitis/chronic fatigue syndrome with orthostatic intolerance.

Edwards, Charles C, Edwards, Charles C, Heinlein, Scott et al.·Frontiers in neurology·2023

This case report describes a woman who was thought to have ME/CFS and experienced symptoms of dizziness upon standing (orthostatic intolerance). Doctors discovered she actually had cervical spinal stenosis—a narrowing of the spinal canal in her neck that was compressing her spinal cord. After surgery to relieve the compression, her ME/CFS and orthostatic intolerance symptoms improved significantly. Years later, her symptoms returned because the surgical implant shifted, compressing the spinal cord again. A second surgery provided similar improvement, suggesting that spinal stenosis may have been causing or worsening her ME/CFS symptoms rather than the other way around.

Autonomic Nervous System

E3 PreliminaryReviewPEM requiredReview-Narrative

A review of cytokine-based pathophysiology of Long COVID symptoms.

Low, Russell N, Low, Ryan J, Akrami, Athena·Frontiers in medicine·2023

This review examines how Long COVID may develop through a chain reaction of immune system problems. When the virus infects the body, it can trigger ongoing inflammation that affects both the immune system and the brain, potentially causing blood clots in small vessels. This combination may explain symptoms like fatigue, brain fog, and pain that Long COVID and ME/CFS patients experience.

NeuroinflammationPost-Exertional Malaise

E3 PreliminaryMechanismPEM unclearMechanistic

Serum from Myalgic encephalomyelitis/chronic fatigue syndrome patients causes loss of coherence in cellular circadian rhythms.

Wei, Heather, Adelsheim, Zoe, Fischer, Rita et al.·Journal of neuroimmunology·2023

This study found that blood serum from ME/CFS patients disrupts the internal 24-hour biological clock (circadian rhythm) in cells grown in the laboratory, compared to serum from healthy people. The disruption was linked to how severe patients' sleep problems were. While a protein called TGF-beta contributed to some rhythm changes, it didn't fully explain the effect, suggesting other unknown factors in ME/CFS patients' blood are responsible.

Immune System

E3 PreliminaryPEM unclear

The fragile process of Homecoming - Young women in recovery from severe ME/CFS.

Krabbe, Silje Helen, Groven, Karen Synne, Schrøder Bjorbækmo, Wenche et al.·International journal of qualitative studies on health and well-being·2023

This study followed 13 young women who recovered from severe ME/CFS that started during childhood or adolescence. Through in-depth interviews, researchers explored what helped them get better. The women described recovery as a slow, bumpy process that involved learning how their bodies worked and gradually gaining confidence, rather than a straight path to wellness.

E3 PreliminaryMechanismPEM requiredObservational

Clinical improvement of Long-COVID is associated with reduction in autoantibodies, lipids, and inflammation following therapeutic apheresis.

Achleitner, Martin, Steenblock, Charlotte, Dänhardt, Juliane et al.·Molecular psychiatry·2023

Researchers tested a treatment called therapeutic apheresis (a blood-cleaning procedure) in Long-COVID patients and found that those who improved had significant reductions in harmful immune molecules, fatty substances, and inflammatory markers in their blood. The study also showed that a blood protein called fibrinogen dropped by 70% after treatment, and abnormal blood clumping patterns disappeared. This suggests the treatment may work by removing specific harmful substances from the blood.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Epstein-Barr virus-acquired immunodeficiency in myalgic encephalomyelitis-Is it present in long COVID?

Ruiz-Pablos, Manuel, Paiva, Bruno, Zabaleta, Aintzane·Journal of translational medicine·2023

This study proposes that a virus called Epstein-Barr virus (EBV) may play a central role in both ME/CFS and long COVID by gradually weakening the immune system. The researchers suggest that in people with certain genetic traits, EBV can hide in various body tissues and repeatedly reactivate, causing ongoing inflammation and exhaustion of the immune system. They hypothesize that long COVID may follow a similar pattern, possibly starting with a COVID-19 infection in people whose immune systems struggle to control EBV.

Immune System

E3 PreliminaryCohortPEM unclearCross-Sectional

Myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia are indistinguishable by their cerebrospinal fluid proteomes.

Schutzer, Steven E, Liu, Tao, Tsai, Chia-Feng et al.·Annals of medicine·2023

Researchers examined the fluid surrounding the brain and spinal cord in people with ME/CFS—some of whom also had fibromyalgia and some who did not. Using advanced technology to measure thousands of proteins in this fluid, they found no significant differences between the two groups. This suggests that ME/CFS and fibromyalgia may not be completely separate diseases, but rather may overlap or be related conditions.

Diagnostics

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

A synthetic data generation system for myalgic encephalomyelitis/chronic fatigue syndrome questionnaires.

Lacasa, Marcos, Prados, Ferran, Alegre, José et al.·Scientific reports·2023

This study created an artificial intelligence tool that can predict what ME/CFS patients might answer on symptom questionnaires. Researchers trained the tool using responses from 2,522 ME/CFS patients from a hospital in Spain, and it learned to predict answers accurately. The tool could help researchers study the disease more easily by generating realistic patient data for testing new ideas.

Diagnostics

E3 PreliminaryDiagnosticPEM requiredPreprintPreprint

A Mixed Methods System for the Assessment of Post Exertional Malaise in Encephalomyelitis/Chronic Fatigue Syndrome.

Stussman, Barbara, Calco, Brice, Norato, Gina et al.·medRxiv : the preprint server for health sciences·2023

This study looked at how to better measure post-exertional malaise (PEM)—the symptom flare-up that happens after activity in ME/CFS patients. Researchers asked 10 ME/CFS patients and 9 healthy people to do an exercise test, then tracked their symptoms over 72 hours using both rating scales and detailed interviews. They found that combining interviews with rating scales captured PEM patterns much better than rating scales alone, especially because rating scales sometimes hit their limits and couldn't show the full picture of symptom changes.

Post-Exertional Malaise

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Pushing the envelope: Immune mechanism and application landscape of macrophage-activating lipopeptide-2.

The viral origin of myalgic encephalomyelitis/chronic fatigue syndrome.

Accelerating discovery: A novel flow cytometric method for detecting fibrin(ogen) amyloid microclots using long COVID as a model.

The Potential Role of Hypothalamic Phospholipid Liposomes in the Supportive Therapy of Some Manifestations of Post-COVID-19 Condition: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Brain Fog.

First insights into multidisciplinary and multispecialty long COVID networks-a SWOT analysis from the perspective of ambulatory health care professionals.

Case report: Rapid improvements of anorexia nervosa and probable myalgic encephalomyelitis/chronic fatigue syndrome upon metreleptin treatment during two dosing episodes.

Urine Metabolomics Exposes Anomalous Recovery after Maximal Exertion in Female ME/CFS Patients.

Hypothetical framework for post-COVID 19 condition based on a fibromyalgia pathogenetic model.

Stress-Induced Transcriptomic Changes in Females with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Reveal Disrupted Immune Signatures.

A Proposed New Model to Explain the Role of Low Dose Non-DNA Targeted Radiation Exposure in Chronic Fatigue and Immune Dysfunction Syndrome.

Association of multiple sclerosis with chronic fatigue syndrome, restless legs syndrome, and various sleep disorders, along with the recent updates.

Case report: Recurrent cervical spinal stenosis masquerading as myalgic encephalomyelitis/chronic fatigue syndrome with orthostatic intolerance.

A review of cytokine-based pathophysiology of Long COVID symptoms.

Serum from Myalgic encephalomyelitis/chronic fatigue syndrome patients causes loss of coherence in cellular circadian rhythms.

The fragile process of Homecoming - Young women in recovery from severe ME/CFS.

Clinical improvement of Long-COVID is associated with reduction in autoantibodies, lipids, and inflammation following therapeutic apheresis.

Epstein-Barr virus-acquired immunodeficiency in myalgic encephalomyelitis-Is it present in long COVID?

Myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia are indistinguishable by their cerebrospinal fluid proteomes.

A synthetic data generation system for myalgic encephalomyelitis/chronic fatigue syndrome questionnaires.

A Mixed Methods System for the Assessment of Post Exertional Malaise in Encephalomyelitis/Chronic Fatigue Syndrome.

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