ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

4081–4100 of 6,209 studies

E3 PreliminaryGuidelinePEM unclearGuideline

Improving quality in adult long covid services: Findings from the LOCOMOTION quality improvement collaborative.

Darbyshire, Julie, Greenhalgh, Trisha, Bakerly, Nawar D et al.·Clinical medicine (London, England)·2024

This study looked at how ten long COVID clinics across the UK could improve their care for patients by sharing what they were learning with each other. From 2021 to 2023, clinic staff and patients met regularly to discuss the best ways to help people with long COVID, focusing on problems like breathing difficulties, heart rate issues, tiredness, and brain fog. The team created practical guides to help doctors provide better, more consistent care.

Autonomic Nervous SystemCognitive Impairment

E3 PreliminaryReviewPEM unclearReview-Narrative

The role of clinical neurophysiology in the definition and assessment of fatigue and fatigability.

Tankisi, Hatice, Versace, Viviana, Kuppuswamy, Annapoorna et al.·Clinical neurophysiology practice·2024

This review article explains how doctors and researchers can better understand fatigue and 'fatigability'—the reduced ability to sustain physical or mental effort. The authors describe different types of tests that can measure these problems objectively by looking at how the brain, nerves, and muscles work, rather than relying only on what patients report. These specialized tests may help identify the actual cause of fatigue in different conditions, including long COVID and ME/CFS.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Impact of Misdiagnosis in Case-Control Studies of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Malato, João, Graça, Luís, Sepúlveda, Nuno·Diagnostics (Basel, Switzerland)·2023

This study examined how misdiagnosis affects ME/CFS research results. The researchers found that when patients are incorrectly diagnosed with ME/CFS (or vice versa), it becomes much harder for studies to find real connections between potential causes and the disease. To get reliable results, studies need to include at least 500-1000 people per group, which is larger than many current ME/CFS studies.

Diagnostics

E3 PreliminaryMechanismPEM unclearMechanistic

Altered TRPM7-Dependent Calcium Influx in Natural Killer Cells of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients.

Du Preez, Stanley, Eaton-Fitch, Natalie, Smith, Peter K et al.·Biomolecules·2023

This study looked at how calcium moves into immune cells called NK cells in ME/CFS patients compared to healthy people. Researchers found that calcium enters these cells differently in ME/CFS patients—it flows in more slowly when activated but responds more strongly when blocked. This suggests a problem with a specific calcium channel called TRPM7 that may be involved in why NK cells don't work properly in ME/CFS.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

αβ and γδ T-cell responses to Epstein-Barr Virus: insights in immunocompetence, immune failure and therapeutic augmentation in transplant patients.

Eiz-Vesper, Britta, Ravens, Sarina, Maecker-Kolhoff, Britta·Current opinion in immunology·2023

This review article examines how the immune system responds to Epstein-Barr Virus (EBV), a common virus that can cause chronic fatigue syndrome and other serious diseases. The authors focus on understanding why some people's immune systems fail to control EBV, particularly in transplant patients, and discuss potential treatments that could help strengthen the immune response against this virus.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

Life changing response to successive surgical interventions on cranial venous outflow: A case report on chronic fatigue syndrome.

Higgins, J Nicholas P, Axon, Patrick R, Lever, Andrew M L·Frontiers in neurology·2023

This case report describes one patient with ME/CFS who had narrowing in the veins that drain blood from the brain. Surgery to open one of these narrowed veins led to significant improvement in fatigue and other symptoms over the follow-up period. The authors suggest that blocked brain venous drainage might explain ME/CFS symptoms in some patients, similar to a related condition called intracranial hypertension.

E3 PreliminaryCohortPEM requiredCase-Control

A case of post-COVID-19 myalgic encephalomyelitis/chronic fatigue syndrome characterized by post-exertional malaise and low serum acylcarnitine level.

Jinushi, Ryuhei, Nishiguchi, Sho, Masuda, Sakue et al.·Clinical case reports·2023

This study describes a patient who developed ME/CFS after recovering from COVID-19. The researchers found that this patient had lower-than-normal levels of acylcarnitine, a substance the body uses to produce energy. The study reviews existing research on how COVID-19 can lead to ME/CFS, a condition that causes severe fatigue and symptoms that worsen after physical activity.

BiomarkersPost-Exertional Malaise

E3 PreliminaryMechanismPEM requiredObservational

Clinical improvement of Long-COVID is associated with reduction in autoantibodies, lipids, and inflammation following therapeutic apheresis.

Achleitner, Martin, Steenblock, Charlotte, Dänhardt, Juliane et al.·Molecular psychiatry·2023

Researchers tested a treatment called therapeutic apheresis (a blood-cleaning procedure) in Long-COVID patients and found that those who improved had significant reductions in harmful immune molecules, fatty substances, and inflammatory markers in their blood. The study also showed that a blood protein called fibrinogen dropped by 70% after treatment, and abnormal blood clumping patterns disappeared. This suggests the treatment may work by removing specific harmful substances from the blood.

Immune SystemPost-Exertional Malaise

E3 PreliminaryCommentaryPEM not requiredEditorial

[Chronic fatigue: What investigations? And what for?].

Gramont, B, Goutte, J, Féasson, L et al.·La Revue de medecine interne·2023

When people feel tired all the time, doctors need to figure out why. This article explains how doctors should approach chronic fatigue: by asking careful questions, doing a physical exam, and using only necessary blood tests. It emphasizes that chronic fatigue often has multiple causes—physical, emotional, and life circumstances—working together, and that exercise testing and personalized activity programs are the most helpful treatments.

Diagnostics

E3 PreliminaryCohortPEM unclearObservational

Bodies in lockdown: Young women's narratives of falling severely ill with ME/CFS during childhood and adolescence.

Krabbe, Silje Helen, Mengshoel, Anne Marit, Schrøder Bjorbækmo, Wenche et al.·Health care for women international·2023

This study listened to the stories of 13 young women who became severely ill with ME/CFS during their childhood or teenage years. The researchers found that these women experienced a gradual loss of their normal, active lives, felt increasingly isolated and abandoned by others, and struggled with uncertainty about their future. The study highlights how challenging and life-altering this illness can be during crucial developmental years.

E3 PreliminaryCohortPEM unclear

Corona With Lyme: A Long COVID Case Study.

Thor, Danielle C, Suarez, Sergio·Cureus·2023

This study follows one 26-year-old medical student over three years as she developed and recovered from long COVID symptoms after an acute COVID-19 infection. The case documents her journey through various treatments and how her symptoms gradually improved over time. While this is just one person's experience, it provides insight into how long COVID can develop and potentially resolve.

Interventions

E3 PreliminaryPEM required

Case report: Rapid improvements of anorexia nervosa and probable myalgic encephalomyelitis/chronic fatigue syndrome upon metreleptin treatment during two dosing episodes.

Hebebrand, Johannes, Antel, Jochen, von Piechowski, Linda et al.·Frontiers in psychiatry·2023

This case report describes a 17-year-old boy who had both anorexia nervosa (an eating disorder) and probable ME/CFS (a condition causing extreme fatigue and pain after exertion). He was treated with a medication called metreleptin for short periods. Notably, the treatment appeared to improve not only his eating disorder symptoms but also his ME/CFS symptoms like fatigue and post-exertional muscle pain. This raises the possibility that metreleptin might help people with ME/CFS, especially those who have also lost significant weight.

Post-Exertional Malaise

E3 PreliminaryCohortPEM not requiredCase-Control

Oxygen-ozone autohemotherapy in breast cancer patients suffering from fatigue and musculoskeletal pain upon aromatase inhibitors treatment: a case-series study.

Tirelli, U, Valdenassi, L, Franzini, M et al.·European review for medical and pharmacological sciences·2023

This study looked at six breast cancer patients taking a hormone therapy drug (anastrozole) who experienced severe pain, weakness, and fatigue as side effects. These patients received oxygen-ozone therapy, a treatment where blood is mixed with ozone gas and returned to the body. After treatment, patients reported significant reductions in both pain and fatigue that lasted for several months.

Pain and Sensitization

E3 PreliminaryReviewPEM not requiredReview-Narrative

Pushing the envelope: Immune mechanism and application landscape of macrophage-activating lipopeptide-2.

Liao, Daoyong, Su, Xiaoling, Wang, Jingyun et al.·Frontiers in immunology·2023

This review examines how a molecule called MALP-2, derived from a bacterium linked to ME/CFS, affects the immune system. Researchers found that MALP-2 can activate immune cells in ways that might help fight infections and heal tissues. The molecule is simple to make and could potentially be developed into treatments for various conditions.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Astragalus polysaccharide ameliorated complex factor-induced chronic fatigue syndrome by modulating the gut microbiota and metabolites in mice.

Wei, Xintong, Xin, Jiayun, Chen, Wei et al.·Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2023

This study tested whether astragalus polysaccharide (APS), a compound from traditional Chinese medicine, could help with chronic fatigue syndrome in mice. The researchers found that APS improved fatigue-related symptoms by changing the bacteria in the gut, which led to more production of beneficial compounds called short-chain fatty acids that reduced inflammation and oxidative stress in the brain.

Gut MicrobiomeImmune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Integrated 'omics analysis for the gut microbiota response to moxibustion in a rat model of chronic fatigue syndrome.

Chaoran, L I, Yan, Yang, Chuwen, Feng et al.·Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan·2023

This study tested whether moxibustion (a traditional Chinese medicine technique using heat) could help treat chronic fatigue syndrome in rats. Researchers found that moxibustion improved fatigue-like symptoms and restored balance to the gut bacteria and chemical levels that were abnormal in fatigued rats. The results suggest that moxibustion may work by fixing problems in the gut microbiome (bacteria) and the metabolites (chemical byproducts) they produce.

Gut Microbiome

E3 PreliminaryReviewPEM not requiredReview-Narrative

Role of Tau protein in long COVID and potential therapeutic targets.

Marwaha, Bharat·Frontiers in cellular and infection microbiology·2023

Long COVID causes ongoing fatigue, breathing problems, brain fog, and other symptoms that can last months or years. This review suggests that a protein called tau—which is known to damage the brain in other diseases—may also be involved in Long COVID. The authors propose that future research should look for tau damage in Long COVID patients and that treatments designed to stop tau buildup might help.

NeuroinflammationBiomarkers

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Asthenia, mental fatigue and cognitive dysfunction].

Titova, N V, Bezdolny, Yu N, Katunina, E A·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2023

This article discusses asthenia, which is a condition characterized by extreme tiredness that affects daily functioning and productivity. The authors explain that it's important to distinguish between simple chronic tiredness and chronic fatigue syndrome (CFS), and that fatigue can affect both the body and the mind. The article reviews how the brain may be involved in causing fatigue and cognitive problems, and suggests that a combination treatment using specific medications may help patients with fatigue and thinking difficulties.

Cognitive Impairment

E3 PreliminaryMechanismPEM requiredMechanistic

Post-COVID exercise intolerance is associated with capillary alterations and immune dysregulations in skeletal muscles.

Aschman, Tom, Wyler, Emanuel, Baum, Oliver et al.·Acta neuropathologica communications·2023

Researchers examined muscle tissue from people with long COVID who experience fatigue and worsening symptoms after activity. They found that these patients had fewer blood vessels in their muscles, thicker vessel walls, and signs of immune cells that might have been triggered by the initial infection. These physical changes in the muscle's blood supply could explain why exercise makes their symptoms worse.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

The viral origin of myalgic encephalomyelitis/chronic fatigue syndrome.

Hanson, Maureen R·PLoS pathogens·2023

This review examines the evidence that viral infections may trigger or contribute to ME/CFS. Researchers looked at how viruses could potentially cause the long-lasting fatigue, pain, and other symptoms that define this condition. The study explores possible mechanisms by which a viral infection might set off a chain of events leading to ME/CFS.

Immune System

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Evidence Atlas

Evidence browser

Improving quality in adult long covid services: Findings from the LOCOMOTION quality improvement collaborative.

The role of clinical neurophysiology in the definition and assessment of fatigue and fatigability.

Impact of Misdiagnosis in Case-Control Studies of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Altered TRPM7-Dependent Calcium Influx in Natural Killer Cells of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients.

αβ and γδ T-cell responses to Epstein-Barr Virus: insights in immunocompetence, immune failure and therapeutic augmentation in transplant patients.

Life changing response to successive surgical interventions on cranial venous outflow: A case report on chronic fatigue syndrome.

A case of post-COVID-19 myalgic encephalomyelitis/chronic fatigue syndrome characterized by post-exertional malaise and low serum acylcarnitine level.

Clinical improvement of Long-COVID is associated with reduction in autoantibodies, lipids, and inflammation following therapeutic apheresis.

[Chronic fatigue: What investigations? And what for?].

Bodies in lockdown: Young women's narratives of falling severely ill with ME/CFS during childhood and adolescence.

Corona With Lyme: A Long COVID Case Study.

Case report: Rapid improvements of anorexia nervosa and probable myalgic encephalomyelitis/chronic fatigue syndrome upon metreleptin treatment during two dosing episodes.

Oxygen-ozone autohemotherapy in breast cancer patients suffering from fatigue and musculoskeletal pain upon aromatase inhibitors treatment: a case-series study.

Pushing the envelope: Immune mechanism and application landscape of macrophage-activating lipopeptide-2.

Astragalus polysaccharide ameliorated complex factor-induced chronic fatigue syndrome by modulating the gut microbiota and metabolites in mice.

Integrated 'omics analysis for the gut microbiota response to moxibustion in a rat model of chronic fatigue syndrome.

Role of Tau protein in long COVID and potential therapeutic targets.

[Asthenia, mental fatigue and cognitive dysfunction].

Post-COVID exercise intolerance is associated with capillary alterations and immune dysregulations in skeletal muscles.

The viral origin of myalgic encephalomyelitis/chronic fatigue syndrome.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

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