ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

4301–4320 of 6,209 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

Skeletal muscle alterations in patients with acute Covid-19 and post-acute sequelae of Covid-19.

Soares, Madu N, Eggelbusch, Moritz, Naddaf, Elie et al.·Journal of cachexia, sarcopenia and muscle·2022

Many people with COVID-19 and long COVID experience muscle weakness and tiredness, especially after physical activity. This review examines what happens inside muscle cells in these patients, including muscle fiber shrinkage, changes in how muscles use energy, and immune cell buildup. The authors suggest that severe illness, lack of activity, low oxygen levels, and poor nutrition all contribute to these problems, similar to what happens in other serious conditions.

Post-Exertional Malaise

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

A common language for Gulf War Illness (GWI) research studies: GWI common data elements.

Cohen, Devra E, Sullivan, Kimberly A, McNeil, Rebecca B et al.·Life sciences·2022

This study created a standardized checklist of symptoms and tests that researchers should use when studying Gulf War Illness (GWI). Experts, veterans, and doctors worked together to decide which questions and measurements are most important to collect consistently across different research studies. This approach was based on a similar checklist already created for ME/CFS, allowing both conditions to use comparable research methods. Having this common language helps different research teams share and compare their findings more easily.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

[Long COVID: nosographic aspects and clinical epidemiology].

Abrignani, Maurizio G, Maloberti, Alessandro, Temporelli, Pier Luigi et al.·Giornale italiano di cardiologia (2006)·2022

Long COVID is a condition where people experience ongoing symptoms weeks or months after recovering from COVID-19 infection. Symptoms can include fatigue, difficulty thinking clearly, shortness of breath, muscle pain, sleep problems, and reduced ability to do daily activities. This review looks at how common long COVID is, who is most likely to develop it, and what we currently know about the condition.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Neurochemical abnormalities in chronic fatigue syndrome: a pilot magnetic resonance spectroscopy study at 7 Tesla.

Godlewska, Beata R, Williams, Stephen, Emir, Uzay E et al.·Psychopharmacology·2022

Researchers used a powerful brain scanning technique to measure chemicals in the brains of people with ME/CFS and compared them to healthy people. They found that people with ME/CFS had lower levels of three important brain chemicals: glutathione (which helps protect against cell damage), creatine (which helps produce energy), and myo-inositol (which is important for brain cell function). These findings suggest that ME/CFS may involve problems with energy production and cell damage in the brain.

Energy Metabolism

E3 PreliminaryMechanismPEM not requiredMechanistic

Sciatic-Vagal Nerve Stimulation by Electroacupuncture Alleviates Inflammatory Arthritis in Lyme Disease-Susceptible C3H Mice.

Akoolo, Lavoisier, Djokic, Vitomir, Rocha, Sandra C et al.·Frontiers in immunology·2022

This study tested whether electroacupuncture (a needle-based treatment that uses electrical stimulation) could reduce joint inflammation and symptoms in mice with Lyme disease. The researchers found that electroacupuncture reduced inflammation markers and immune cells in the joints, even though it didn't eliminate the Lyme bacteria itself. The anti-inflammatory effects lasted even after treatment stopped, suggesting this approach might help people with long-lasting Lyme disease symptoms.

Immune System

E3 PreliminaryPEM unclear

Epistemic in/justice in patient participation. A discourse analysis of the Dutch ME/CFS Health Council advisory process.

de Boer, Marjolein Lotte·Sociology of health & illness·2021

This study looked at how ME/CFS patients were involved in advising the Dutch Health Council between 2013-2018. The researchers found that patient representatives mainly shared medical/scientific knowledge about ME/CFS as a physical illness, avoiding discussion of psychological factors. While this approach helped patients be taken more seriously, it may have actually limited what kinds of knowledge and experiences patients could contribute, and it might reinforce incomplete understandings of the disease.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Benefits of micronutrient supplementation on nutritional status, energy metabolism, and subjective wellbeing.

Maggini, Silvia, Óvári, Veronika, Ferreres Giménez, Inmaculada et al.·Nutricion hospitalaria·2021

Your body needs several vitamins and minerals—like vitamins A, D, E, folate, iron, zinc, and selenium—to make energy in your cells. Many people, even in wealthy countries, don't get enough of these nutrients. Studies show that taking a combination of these micronutrients, sometimes with coenzyme Q10, may help reduce fatigue, improve thinking, and make people feel better overall.

Energy Metabolism

E3 PreliminaryDiagnosticPEM not requiredCross-Sectional

Testing a newly developed activity pacing framework for chronic pain/fatigue: a feasibility study.

Antcliff, Deborah, Keenan, Anne-Maree, Keeley, Philip et al.·BMJ open·2021

This study tested whether a new framework could help healthcare professionals teach patients with chronic pain and fatigue (including ME/CFS) how to pace their activities more effectively. Patients attended a 6-week rehabilitation program and were asked about their pain, fatigue, mood, and quality of life before the program, at the end, and 3 months later. Most patients felt satisfied with the program, and those who completed it showed improvements in their ability to pace themselves and manage their symptoms.

Interventions

E3 PreliminaryPEM unclear

My experience of chronic fatigue syndrome.

BMJ paediatrics open·2021

This article is a personal account of one person's experience living with ME/CFS, published in a medical journal. It describes the journey of managing this condition and how it has affected daily life. While personal stories are valuable for understanding what patients go through, they are not the same as research that tests treatments or identifies causes.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

A comparison of approaches for combining predictive markers for personalised treatment recommendations.

Pierce, Matthias, Emsley, Richard·Trials·2021

This study compared three statistical methods for using blood test results (biomarkers) to predict which ME/CFS patients would benefit most from rehabilitation treatment. The researchers tested these methods using computer simulations and real data from a rehabilitation trial, to figure out the best way to combine multiple biomarkers to personalize treatment recommendations for individual patients.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrom: modern aspects of diagnosis and treatment].

Vorobyova, Yu D, Danilov, A B·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2021

This article reviews how ME/CFS develops by looking at both genes and environmental factors that trigger the illness. The authors explain known genetic problems found in ME/CFS patients, what can start the disease, and how these factors combine to cause the symptoms people experience. They also describe a systematic approach to diagnosing and treating ME/CFS.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Imaging and Manipulation of Stem and Progenitor Cells for Revealing the Novel Mechanism of Local Tissue Maintenance in the Brain].

Kataoka, Yosky·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·2021

This study examined special cells in the brain called glial progenitor cells that help maintain healthy brain tissue and manage inflammation. Researchers used imaging technology to track these cells and discovered that when these cells are removed, the brain develops harmful inflammation and immune activation. The findings suggest these cells may play a protective role and could be targeted to treat conditions associated with brain inflammation, including chronic fatigue syndrome.

Neuroinflammation

E3 PreliminaryMechanismPEM not requiredMechanistic

Inflammation plays a causal role in fatigue-like behavior induced by pelvic irradiation in mice.

Wolff, Brian S, Alshawi, Sarah A, Feng, Li Rebekah et al.·Brain, behavior, & immunity - health·2021

Researchers gave mice targeted radiation to the pelvis (similar to cancer treatment) and found that the mice became less active afterward—a fatigue-like behavior. They discovered that inflammation, particularly a protein called IL-6, plays a key role in causing this fatigue. When they reduced inflammation using a drug called minocycline or using mice genetically unable to trigger certain inflammatory pathways, the fatigue was reduced but not completely eliminated.

Immune System

E3 PreliminaryCommentaryPEM unclearEditorial

Identifying and Managing Suicidality in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Chu, Lily, Elliott, Meghan, Stein, Eleanor et al.·Healthcare (Basel, Switzerland)·2021

People with ME/CFS face a higher risk of suicidal thoughts and suicide than the general population. This article provides doctors with practical guidance on how to identify and help patients who may be struggling with these thoughts. The authors explain that ME/CFS makes this challenge harder because there are no proven treatments, symptoms are severe, and many healthcare providers don't fully understand the disease.

E3 PreliminaryCohortPEM not requiredObservational

Experiences Among School Personnel and School Nurses on Educational Adaptations for Students With CFS/ME: A Qualitative Interview Study.

Similä, Wenche Ann, Rø, Torstein Baade, Nøst, Torunn Hatlen·Frontiers in pediatrics·2021

This study asked teachers, counselors, and school nurses about their experiences helping students with ME/CFS stay in school and continue their education. The researchers found that it was harder to help these students before they received an official diagnosis, but things improved when schools worked together as a team, communicated well with families, and used digital learning tools.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Intestinal flora and neurological disorders].

Tang, Qianqian, Cao, Lihua·Sheng wu gong cheng xue bao = Chinese journal of biotechnology·2021

Your gut bacteria (microbiome) communicate with your brain through multiple pathways, including immune signals and nerve connections. When this gut-brain communication goes wrong, it may contribute to various neurological conditions, including chronic fatigue syndrome. This review summarizes what scientists know about how imbalanced gut bacteria might affect the nervous system and cause disease.

Neuroinflammation

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Current state about researches on selection of experimental indexs mechanisms of acupuncture underlying improvement of chronic fatigue syndrome].

Li, Yan-Hui, Ma, Qiao-Lin, Hu, Bin et al.·Zhen ci yan jiu = Acupuncture research·2021

This review examined research from the past 10 years on how acupuncture may help chronic fatigue syndrome by looking at four main body systems: immune function, stress hormones and brain chemistry, the body's ability to handle cellular damage, and cell signaling pathways. The researchers found evidence that acupuncture appears to work through multiple mechanisms rather than just one, potentially helping the body recover from CFS through different pathways.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Post-COVID-19 syndrome: epidemiology, diagnostic criteria and pathogenic mechanisms involved.

Carod-Artal, F J·Revista de neurologia·2021

Many people who have had COVID-19, even mild cases, don't fully recover and experience long-lasting symptoms for months afterward. This article reviews what we know about post-COVID-19 syndrome, including who gets it, what symptoms they have, and what might be causing it. Common symptoms include fatigue, breathing problems, difficulty concentrating, anxiety, and depression. The exact biological reasons why this happens are still unknown, though experts think abnormal immune and inflammatory responses may play a role.

DiagnosticsCognitive Impairment

E3 PreliminaryReviewPEM unclearReview-Narrative

Persistent Brainstem Dysfunction in Long-COVID: A Hypothesis.

Yong, Shin Jie·ACS chemical neuroscience·2021

This paper suggests that long-COVID symptoms may be caused by damage to the brainstem, a part of the brain that controls basic functions like breathing, heart rate, and digestion. The authors propose that the coronavirus may directly infect the brainstem or cause inflammation there, and because brain cells heal slowly, this damage could persist long after the initial infection. This theory could help explain why long-COVID patients experience lasting fatigue, breathing problems, and other widespread symptoms.

Neuroinflammation

E3 PreliminaryPEM unclear

Sick of the Sick Role: Narratives of What "Recovery" Means to People With CFS/ME.

Cheshire, Anna, Ridge, Damien, Clark, Lucy V et al.·Qualitative health research·2021

This study asked 19 people with ME/CFS what "recovery" means to them—some had improved and some had gotten worse after trying a self-help treatment. The researchers found that recovery doesn't mean the same thing to everyone. While some people wanted to be completely symptom-free, many others just wanted to feel "normal" again and stop being defined by their illness, even if symptoms remained. Some people actually didn't want to return to their old lifestyle, thinking it might have caused their illness in the first place.

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Evidence browser

Skeletal muscle alterations in patients with acute Covid-19 and post-acute sequelae of Covid-19.

A common language for Gulf War Illness (GWI) research studies: GWI common data elements.

[Long COVID: nosographic aspects and clinical epidemiology].

Neurochemical abnormalities in chronic fatigue syndrome: a pilot magnetic resonance spectroscopy study at 7 Tesla.

Sciatic-Vagal Nerve Stimulation by Electroacupuncture Alleviates Inflammatory Arthritis in Lyme Disease-Susceptible C3H Mice.

Epistemic in/justice in patient participation. A discourse analysis of the Dutch ME/CFS Health Council advisory process.

Benefits of micronutrient supplementation on nutritional status, energy metabolism, and subjective wellbeing.

Testing a newly developed activity pacing framework for chronic pain/fatigue: a feasibility study.

My experience of chronic fatigue syndrome.

A comparison of approaches for combining predictive markers for personalised treatment recommendations.

[Chronic fatigue syndrom: modern aspects of diagnosis and treatment].

[Imaging and Manipulation of Stem and Progenitor Cells for Revealing the Novel Mechanism of Local Tissue Maintenance in the Brain].

Inflammation plays a causal role in fatigue-like behavior induced by pelvic irradiation in mice.

Identifying and Managing Suicidality in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Experiences Among School Personnel and School Nurses on Educational Adaptations for Students With CFS/ME: A Qualitative Interview Study.

[Intestinal flora and neurological disorders].

[Current state about researches on selection of experimental indexs mechanisms of acupuncture underlying improvement of chronic fatigue syndrome].

Post-COVID-19 syndrome: epidemiology, diagnostic criteria and pathogenic mechanisms involved.

Persistent Brainstem Dysfunction in Long-COVID: A Hypothesis.

Sick of the Sick Role: Narratives of What "Recovery" Means to People With CFS/ME.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research