Search and filter 6,145 studies by evidence level, diagnostic criteria, PEM status, and research domain. Each entry links to the original source.
Studies sorted by evidence level, then year. Browse by topic instead →
Evidence level (E0–E3) reflects study type and replication, not methodological quality. A weak systematic review still sits at E0. How evidence levels work →
441–460 of 510 studies
Houde, S C, Kampfe-Leacher, R·The Nurse practitioner·1997
This article explains what ME/CFS is and how doctors can recognize it. The main challenge is that ME/CFS doesn't show up on standard tests, so doctors need to rule out other conditions first. Treatment works best when it's tailored to each person's specific symptoms and needs.
Wessely, S·Scandinavian journal of work, environment & health·1997
This article examines how ME/CFS became recognized as a medical illness in modern times. The condition was largely unknown and unnamed until the 1980s, when it emerged under various labels including 'chronic Epstein-Barr virus syndrome' and later 'chronic fatigue syndrome.' The author discusses how different countries use different names for the condition and explores connections between ME/CFS and the concept of somatization—when stress or psychological factors manifest as physical symptoms.
Mounstephen, A, Sharpe, M·Occupational medicine (Oxford, England)·1997
This article reviews what doctors who work in occupational health need to know about ME/CFS to help their patients. The authors discuss what ME/CFS is, what might cause it, how patients typically recover, and practical ways to diagnose and manage the condition. They argue that occupational health doctors are in a good position to help improve outcomes for people with ME/CFS, particularly by improving education, rehabilitation programs, and support for staying in or returning to work.
Ross, E·Nursing times·1996
This article reviews the history of chronic fatigue syndrome (ME/CFS) and how it has been treated over time. ME/CFS is a real illness that affects 1 to 2.5 out of every 100 people. The article explains what doctors look for when diagnosing ME/CFS and describes the important role nurses play in helping patients manage and treat their condition.
Lieb, K, Dammann, G, Berger, M et al.·Der Nervenarzt·1996
ME/CFS is a disorder that causes persistent tiredness, but doctors cannot diagnose it with a simple blood test or scan. Instead, doctors use specific clinical criteria to identify the condition, while carefully ruling out other illnesses like depression or sleep problems that can look similar. Currently, there is no cure for ME/CFS, so treatment focuses on managing individual symptoms like poor sleep, pain, and mood changes with a combination of medical care and psychological support.
Salit, I E·The Journal of rheumatology·1996
This is a position paper from a medical expert on chronic fatigue syndrome (ME/CFS) published in a rheumatology journal in 1996. Rather than presenting new research data, the author provides professional guidance and recommendations on how to understand and approach ME/CFS as a medical condition. This type of paper helps establish clinical standards and best practices for doctors treating patients with ME/CFS.
Griffiths, R A, Beumont, P J, Moore, G M et al.·The Australian and New Zealand journal of psychiatry·1996
This study looked at three patients who were diagnosed with ME/CFS but also had eating disorders (anorexia nervosa or bulimia nervosa). The doctors found that proper screening for eating disorders is important because patients and families may focus on the ME/CFS diagnosis and miss the eating disorder, which delays appropriate treatment. Early identification of both conditions together can help reduce serious health problems.
Sterzl, I, Zamrazil, V·Vnitrni lekarstvi·1996
This review discusses how disorders of the endocrine system (hormone-producing glands) can cause fatigue and other symptoms that overlap with ME/CFS, making them difficult to distinguish. The authors highlight that some patients initially thought to have ME/CFS actually have treatable hormone conditions, particularly autoimmune thyroid disease or other glandular disorders. They also explore how problems with the stress-hormone system (the hypothalamus-pituitary-adrenal axis) might play a role in both endocrine disease and ME/CFS.
Sharpe, M·The Psychiatric clinics of North America·1996
ME/CFS is a serious illness that causes extreme tiredness, difficulty concentrating, muscle pain, and other physical symptoms that doctors cannot fully explain with standard tests. This review explains that ME/CFS involves both real physical changes in the body and emotional or social factors that affect how someone experiences the illness. The best approach to treating ME/CFS is to carefully assess each person's unique situation rather than debating whether it's purely medical or psychiatric.
Diamantis, I·Praxis·1996
This case study describes a patient who developed chronic fatigue syndrome (ME/CFS) following a Lyme borreliosis infection (transmitted by tick bite). The report documents one person's experience, showing how a tick-borne infection may have triggered or contributed to the development of ME/CFS symptoms.
Wessely, S·Journal of the Royal College of Physicians of London·1996
This report from major medical colleges explains that ME/CFS is not caused by a single problem, but rather results from many different factors working together. The condition develops differently in different people, depending on what triggered it initially, what made them vulnerable to it, and what keeps it going. Understanding all these different pieces is important for helping patients recover.
Pankow, W, Feddersen, C O, von Wichert, P·Der Internist·1995
This 1995 study examines different treatment approaches for chronic fatigue syndrome. The authors review various therapeutic options that may help ME/CFS patients manage their symptoms. While specific details are limited due to the abstract not being available, this work represents an early clinical discussion of treatment strategies for this complex illness.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·1995
A group of South African medical experts created guidelines to help doctors recognize and treat chronic fatigue syndrome (CFS). The guidelines outline what symptoms and test results might help diagnose CFS, and suggest reasonable ways to manage the condition while keeping costs reasonable. However, the experts disagreed significantly about whether CFS is a real, distinct illness.
Jenzer, G·Der Nervenarzt·1995
This review examined whiplash injuries to the neck and the long-term complications some patients develop, called chronic whiplash syndrome. The authors found that whiplash injuries can cause a complex mix of symptoms similar to those seen in chronic fatigue syndrome and fibromyalgia, making diagnosis challenging. Most people recover well from whiplash, though some experience prolonged difficulties.
Hickie, I B, Lloyd, A R, Wakefield, D·The Medical journal of Australia·1995
This guideline helps doctors evaluate and treat ME/CFS by reviewing what we know about the condition. The authors found that while many medical and psychological factors can affect recovery, no single infection has been proven to cause ME/CFS. Treatment works best when doctors address all aspects of a patient's health—physical, mental, and social—rather than focusing on just one area.
Leitch, A G·QJM : monthly journal of the Association of Physicians·1995
This 1995 paper explores the history and naming of ME/CFS, comparing three different terms used to describe the condition: neurasthenia (an older term), myalgic encephalitis, and chronic fatigue syndrome. The author examines how the same illness has been called different names over time and in different places, which can create confusion about what the condition actually is.
Gantz, N M·Contemporary internal medicine·1995
This is an editorial article that addresses 10 frequently asked questions about chronic fatigue syndrome (ME/CFS). Rather than reporting new research data, the author discusses common questions patients and doctors have about the condition, its diagnosis, and management. The article aims to help clarify misconceptions and provide practical information about ME/CFS.
Trinidad, E E, Ramírez-Ronda, C·Boletin de la Asociacion Medica de Puerto Rico·1994
Chronic Fatigue Syndrome (ME/CFS) is a long-lasting illness that causes extreme tiredness and affects an estimated 24% of people. It was officially defined as a medical condition in 1988 after doctors recognized increasing numbers of patients with similar symptoms. The condition is more common in women aged 20-50 and is currently treated with supportive care to help manage symptoms.
Goldenberg, D L·Current opinion in rheumatology·1994
This 1994 review examined three related conditions—fibromyalgia, ME/CFS, and myofascial pain syndrome—that often overlap and remain poorly understood. The author noted that these conditions frequently occur alongside Lyme disease and other medical or psychiatric illnesses. New research at that time suggested that problems with how the central nervous system (the brain and spinal cord) processes signals might play a role in fibromyalgia and ME/CFS.
Sternon, J, Decaux, G, Hoffmann, G·Revue medicale de Bruxelles·1994
This paper describes how doctors can diagnose ME/CFS using specific criteria and discusses what might cause the condition. The authors note that viral infections may trigger ME/CFS, and that anxiety or depression can make symptoms worse. Importantly, they found that some patients improve on their own after a few years, though most don't respond well to available treatments.
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Thematic groupings by clinical question or research area.
PET imaging and other studies providing evidence for brain inflammation in ME/CFS.
NeurologyMetabolomics and mitochondrial function studies revealing energy metabolism disruption.
MetabolismStudies identifying potential biological markers for ME/CFS diagnosis and stratification.
Biomarker