ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

4461–4480 of 6,163 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

Myalgia and chronic fatigue syndrome following immunization: macrophagic myofasciitis and animal studies support linkage to aluminum adjuvant persistency and diffusion in the immune system.

Gherardi, Romain K, Crépeaux, Guillemette, Authier, François-Jérome·Autoimmunity reviews·2019

This review examines whether ME/CFS could be triggered by aluminum-containing substances in certain vaccines. The authors present evidence that aluminum particles may persist in immune cells and travel to the brain, potentially causing the cognitive problems, muscle pain, and fatigue seen in ME/CFS. They argue this condition represents a broader category of vaccine-related adverse effects called ASIA.

NeuroinflammationImmune System

E3 PreliminaryCohortPEM unclearCross-Sectional

Hope, disappointment and perseverance: Reflections of people with Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis participating in biomedical research. A qualitative focus group study.

Lacerda, Eliana M, McDermott, Clare, Kingdon, Caroline C et al.·Health expectations : an international journal of public participation in health care and health policy·2019

Researchers asked people with ME/CFS and MS about their experiences participating in a major study that collected blood samples and health information. Patients shared their hopes and frustrations about research, what they want scientists to study next, and how they'd like findings to be shared with them. The participants felt that research progress is like slowly putting together a puzzle, and they emphasized how important collaboration and persistence are.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Establishment and evaluation of prediction model for multiple disease classification based on gut microbial data.

Bang, Sohyun, Yoo, DongAhn, Kim, Soo-Jin et al.·Scientific reports·2019

Researchers used artificial intelligence to analyze bacteria in the gut of patients with six different diseases, including ME/CFS, to see if gut bacteria patterns could help identify which disease a person has. They tested different computer learning methods and found that looking at bacteria at the genus level (a specific classification of microorganisms) worked best, and they identified certain bacterial groups that might serve as disease markers.

BiomarkersGut Microbiome

E3 PreliminaryPEM unclear

'It's like being a slave to your own body in a way': a qualitative study of adolescents with chronic fatigue syndrome.

Njølstad, Berit Widerøe, Mengshoel, Anne Marit, Sveen, Unni·Scandinavian journal of occupational therapy·2019

This study listened to seven teenagers with ME/CFS talk about how the illness changed their lives. Young people described feeling trapped in bodies that no longer worked the way they expected, missing out on activities with friends, and having to spend most of their time at home. However, the study also found that over time, many teens learned to accept their situation, adapted their daily activities, and rebuilt a sense of purpose and hope for the future.

E3 PreliminaryReviewPEM unclearReview-Narrative

Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?

Morris, Gerwyn, Maes, Michael, Berk, Michael et al.·Metabolic brain disease·2019

This study proposes a theory for how ME/CFS might develop, starting with an infection that triggers lasting problems in the body's immune system and stress response. The authors suggest that in genetically vulnerable people, this leads to a chain of events: increased inflammation, intestinal problems that allow bacteria-related substances to enter the bloodstream, nervous system dysfunction, and eventually a state where the immune system becomes exhausted and less able to fight back. This model tries to explain why ME/CFS patients have the specific symptoms and lab abnormalities doctors observe.

NeuroinflammationImmune System

E3 PreliminaryMechanismPEM unclearMechanistic

Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically Relevant Phenotyping of Women With Chronic Fatigue Syndrome.

Morris, Matthew C, Cooney, Katherine E, Sedghamiz, Hooman et al.·Clinical therapeutics·2019

This study used computer modeling to understand how hormones and immune system chemicals become unbalanced in ME/CFS. Researchers measured 17 immune markers in women with ME/CFS before, during, and after exercise, then created detailed mathematical models to predict what other hormones and chemicals might also be out of balance. The models suggested that two existing drugs (rintatolimod and rituximab) might help different subgroups of patients, depending on their specific hormone and immune profiles.

Immune System

E3 PreliminaryMechanismPEM unclearObservational

Modification of Immunological Parameters, Oxidative Stress Markers, Mood Symptoms, and Well-Being Status in CFS Patients after Probiotic Intake: Observations from a Pilot Study.

Venturini, Letizia, Bacchi, Sara, Capelli, Enrica et al.·Oxidative medicine and cellular longevity·2019

This study tested whether taking a specific combination of probiotic supplements (beneficial bacteria) could help people with ME/CFS. Researchers measured changes in immune function, inflammation markers, oxidative stress, and mood before and after patients took probiotics. The results showed improvements in well-being and reductions in inflammatory markers, though one patient experienced a temporary worsening of fatigue symptoms.

Immune System

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Assessing cellular energy dysfunction in CFS/ME using a commercially available laboratory test.

Tomas, Cara, Lodge, Tiffany A, Potter, Michelle et al.·Scientific reports·2019

This study tested a blood test called the Mitochondrial Energy Score (MES) that is marketed to diagnose ME/CFS by measuring how well cells produce energy. Researchers repeated the test in both ME/CFS patients and healthy people and found no difference between the two groups. They also discovered that waiting even 24 hours before processing blood samples changed the test results significantly, suggesting the test is not reliable enough to use for diagnosis.

Biomarkers

E3 PreliminaryReviewPEM requiredReview-Narrative

Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and the Emerging Osteopathic Approach: A Narrative Review.

Larrimore, Christopher, Ramnot, Amanda, Jaghab, Annmarie et al.·The Journal of the American Osteopathic Association·2019

This article reviews what scientists know about ME/CFS, including its symptoms, how it affects the body, and why it's hard to diagnose. The authors discuss both traditional medical approaches and osteopathic treatment (a type of hands-on therapy that focuses on the body's structure and function) as possible ways to help people with ME/CFS feel better. The review emphasizes that ME/CFS is a real, serious illness that deserves more awareness among doctors and better treatment options.

Immune SystemCognitive ImpairmentPost-Exertional Malaise

E3 PreliminaryCommentaryPEM requiredEditorial

Suggested pathology of systemic exertion intolerance disease: Impairment of the E3 subunit or crossover of swinging arms of the E2 subunit of the pyruvate dehydrogenase complex decreases regeneration of cofactor dihydrolipoic acid of the E2 subunit.

Bohne, Victoria J Berdikova, Bohne, Øyvind·Medical hypotheses·2019

This paper proposes that ME/CFS might result from a problem in how the body converts fuel into energy, specifically involving a protein complex called the pyruvate dehydrogenase complex. The researchers suggest that when this complex isn't working properly, it causes lactate (a byproduct of metabolism) to build up suddenly in the body, which could explain the exhaustion and post-exertional malaise (worsening after activity) that patients experience. They propose that the body isn't efficiently recycling important molecules needed for energy production, leading to low energy and fatigue.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM requiredObservational

Exercise-induce hyperalgesia, complement system and elastase activation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - a secondary analysis of experimental comparative studies.

Polli, Andrea, Van Oosterwijck, Jessica, Meeus, Mira et al.·Scandinavian journal of pain·2019

This study explored whether exercise-triggered immune system changes in ME/CFS patients are connected to increased pain sensitivity. Researchers compared immune markers and pain thresholds in ME/CFS patients and healthy people before and after two different types of exercise. They found a link between changes in a immune protein called C4a and pain sensitivity in ME/CFS patients, but this connection was weak and only showed up in some measurements.

Immune SystemPost-Exertional Malaise

E3 PreliminaryCohortPEM not requiredCase-Control

Acute oxalate nephropathy due to high vitamin C doses and exocrine pancreatic insufficiency.

Fijen, Lauré, Weijmer, Marcel·BMJ case reports·2019

This case report describes an elderly man with ME/CFS who developed serious kidney damage after taking high doses of vitamin C supplements. He also had a pancreatic condition that affected his ability to digest fats properly. The combination of these two factors caused harmful crystal buildup in his kidneys, leading to acute kidney failure that required dialysis treatment.

Energy Metabolism

E3 PreliminaryCohortPEM unclearCase-Control

Varied Presentation of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and the Needs for Classification and Clinician Education: A Case Series.

Martín-Martínez, Eva, Martín-Martínez, Mercedes·Clinical therapeutics·2019

This study looked at three individual ME/CFS patient cases to understand why this disease presents so differently from person to person. The researchers found that patients often wait years for a correct diagnosis because many doctors don't understand ME/CFS well, leading to misdiagnosis and delays in treatment. The study suggests that organizing patient information carefully could help doctors and researchers identify different subtypes of ME/CFS.

Diagnostics

E3 PreliminaryBehavioralPEM unclearCross-Sectional

The psychological impact of dependency in adults with chronic fatigue syndrome/myalgic encephalomyelitis: A qualitative exploration.

Williams, Ashley Mai, Christopher, Gary, Jenkinson, Elizabeth·Journal of health psychology·2019

This study interviewed adults with ME/CFS who rely on others for daily help and explored how this dependency affects their emotional health. Researchers found that people experience several psychological challenges, including feeling like they've lost their independence and identity, struggling with invisible symptoms others don't understand, and worrying about the future. The study suggests that better education for family and friends, improved communication strategies, and accepting the condition can help improve emotional well-being.

E3 PreliminaryCohortPEM not requiredCross-Sectional

"It's not one size fits all"; the use of videoconferencing for delivering therapy in a Specialist Paediatric Chronic Fatigue Service.

Haig-Ferguson, Andrew, Loades, Maria, Whittle, Charlotte et al.·Internet interventions·2019

This study looked at whether young people with ME/CFS could receive therapy through video calls (like Skype) instead of traveling to hospital appointments. Researchers interviewed 12 young patients, 6 parents, and 9 healthcare workers about their experiences. Most people found video appointments helpful for reducing travel, though some worried about privacy and felt that something was lost compared to face-to-face meetings.

E3 PreliminaryCohortPEM not requiredCase-Control

Cannabis-induced Acute Coronary Syndrome: A Coincidence or Not?

Landa, Eric, Vigandt, Erika, Andreev, Alexander et al.·Cureus·2019

This case report describes one patient who had a heart attack (myocardial infarction) shortly after smoking marijuana. The patient was a 42-year-old man with no previous heart problems who experienced chest pain at rest about one hour after using marijuana. The authors suggest that marijuana may have triggered the heart attack, though this is considered a rare occurrence.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Implementing guided ICBT for chronic pain and fatigue: A qualitative evaluation among therapists and managers.

van der Vaart, Rosalie, Worm-Smeitink, Margreet, Bos, Yvonne et al.·Internet interventions·2019

This study looked at how therapists and managers can successfully set up and use internet-based cognitive behavioral therapy (ICBT)—an online treatment for chronic pain and fatigue—in their clinics. Researchers interviewed staff from twelve mental health clinics to understand what helps or gets in the way when starting this new type of treatment. They found that success depends on factors like the quality of the online program, whether therapists feel confident using it, whether patients want to try online treatment, and whether the clinic has proper support and funding.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

RIFD - A brief clinical research interview for functional somatic disorders and health anxiety.

Petersen, Marie Weinreich, Schröder, Andreas, Jørgensen, Torben et al.·Journal of psychosomatic research·2019

Researchers developed a new interview tool called RIFD to help doctors identify people with chronic fatigue syndrome and similar conditions that cause long-term physical symptoms. Instead of relying only on questionnaires, trained doctors conducted phone interviews with nearly 1,600 people from Denmark to see if the tool could accurately spot cases. The interview was quick, easy to do, and people were satisfied with it.

E3 PreliminaryReviewPEM unclearReview-Narrative

Neurasthenia: Modern Malady or Historical Relic?

Overholser, James C, Beale, Eleanor E·The Journal of nervous and mental disease·2019

This article looks back at a condition called neurasthenia that doctors diagnosed frequently between 1869 and 1930, then largely abandoned. The authors found that many symptoms people with neurasthenia experienced—like exhaustion, mental fog, and physical weakness—are still seen today in conditions like chronic fatigue syndrome (ME/CFS) and fibromyalgia. By understanding neurasthenia's history, modern doctors may better recognize and treat these conditions and improve how they listen to their patients.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging.

Sztretye, Mónika, Dienes, Beatrix, Gönczi, Mónika et al.·Oxidative medicine and cellular longevity·2019

This review examines astaxanthin, a powerful natural antioxidant found in marine organisms, and how it might help protect cells from damage caused by oxidative stress—an imbalance that occurs in ME/CFS and many other diseases. The authors explain how astaxanthin may work by targeting and protecting mitochondria, the energy-producing structures in our cells. They suggest this compound could potentially help prevent or slow disease progression and aging-related health problems.

Energy Metabolism

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Myalgia and chronic fatigue syndrome following immunization: macrophagic myofasciitis and animal studies support linkage to aluminum adjuvant persistency and diffusion in the immune system.

Hope, disappointment and perseverance: Reflections of people with Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis participating in biomedical research. A qualitative focus group study.

Establishment and evaluation of prediction model for multiple disease classification based on gut microbial data.

'It's like being a slave to your own body in a way': a qualitative study of adolescents with chronic fatigue syndrome.

Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?

Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically Relevant Phenotyping of Women With Chronic Fatigue Syndrome.

Modification of Immunological Parameters, Oxidative Stress Markers, Mood Symptoms, and Well-Being Status in CFS Patients after Probiotic Intake: Observations from a Pilot Study.

Assessing cellular energy dysfunction in CFS/ME using a commercially available laboratory test.

Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and the Emerging Osteopathic Approach: A Narrative Review.

Suggested pathology of systemic exertion intolerance disease: Impairment of the E3 subunit or crossover of swinging arms of the E2 subunit of the pyruvate dehydrogenase complex decreases regeneration of cofactor dihydrolipoic acid of the E2 subunit.

Exercise-induce hyperalgesia, complement system and elastase activation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - a secondary analysis of experimental comparative studies.

Acute oxalate nephropathy due to high vitamin C doses and exocrine pancreatic insufficiency.

Varied Presentation of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and the Needs for Classification and Clinician Education: A Case Series.

The psychological impact of dependency in adults with chronic fatigue syndrome/myalgic encephalomyelitis: A qualitative exploration.

"It's not one size fits all"; the use of videoconferencing for delivering therapy in a Specialist Paediatric Chronic Fatigue Service.

Cannabis-induced Acute Coronary Syndrome: A Coincidence or Not?

Implementing guided ICBT for chronic pain and fatigue: A qualitative evaluation among therapists and managers.

RIFD - A brief clinical research interview for functional somatic disorders and health anxiety.

Neurasthenia: Modern Malady or Historical Relic?

Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging.

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