Molecular study of receptor for advanced glycation endproduct gene promoter and identification of specific HLA haplotypes possibly involved in chronic fatigue syndrome.
Carlo-Stella, N, Bozzini, S, De Silvestri, A et al.·International journal of immunopathology and pharmacology·2009
This study looked at two genes related to inflammation in 75 Italian ME/CFS patients and compared them to 141 healthy controls. The researchers found that certain genetic variations in the RAGE gene and immune system genes called HLA were more common in ME/CFS patients, suggesting these genetic differences might increase risk for the condition. The findings suggest ME/CFS may involve inherited factors that affect how the immune system responds.