ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

4701–4720 of 6,188 studies

E3 PreliminaryMechanismPEM not requiredMechanistic

Investigation of the effects of vanilloids in chronic fatigue syndrome.

Sarvaiya, Kuldeep, Goswami, Sunita·Brain research bulletin·2016

This study tested whether compounds that affect a pain-sensing protein called TRPV1 could help reduce fatigue and related symptoms in an animal model of ME/CFS. Rats that were stressed through repeated swimming showed improvements in fatigue, muscle strength, mood, and stress hormone levels when treated with these compounds, suggesting that TRPV1 may play a role in ME/CFS symptoms.

Immune System

E3 PreliminaryCommentaryPEM unclearEditorial

Xenotropic Murine Leukemia Virus-Related Virus (XMRV) and the Safety of the Blood Supply.

Johnson, Andrew D, Cohn, Claudia S·Clinical microbiology reviews·2016

In 2009, a virus called XMRV was found in some ME/CFS patients and created significant concern about blood safety. However, scientists later discovered that the virus actually came from contaminated laboratory samples, not from patients' actual infections. This paper explains how the virus was traced back to a laboratory mouse and why it turned out not to be a real threat to ME/CFS patients or blood donors.

E3 PreliminaryDiagnosticPEM requiredMethods-Paper

Assessment of ME/CFS (Myalgic Encephalomyelitis/Chronic Fatigue Syndrome): A Case Study for Health Care Providers.

Brimmer, Dana J, Jones, James F, Boneva, Roumiana et al.·MedEdPORTAL : the journal of teaching and learning resources·2016

This study created an educational course to help medical students, physician assistants, and nursing students better understand ME/CFS and how to care for patients with this condition. The course used videos and slide presentations to teach about ME/CFS symptoms, diagnosis, and management. Students who completed the course showed improved knowledge about ME/CFS and developed more empathy for patients living with this illness.

Post-Exertional Malaise

E3 PreliminaryCommentaryPEM not requiredEditorial

Autoantibody pain.

Goebel, Andreas·Autoimmunity reviews·2016

Your immune system sometimes makes proteins called autoantibodies that attack your own body's tissues and nerves. This review explores how these autoantibodies might cause pain directly by interfering with nerve signals, rather than just causing inflammation. Interestingly, ME/CFS appears to involve this type of autoantibody-related pain mechanism, which could open doors to new treatments for conditions that currently don't respond well to standard pain medications.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Elevated Energy Production in Chronic Fatigue Syndrome Patients.

Lawson, Nick, Hsieh, Chung-Han, March, Dana et al.·Journal of nature and science·2016

This study examined how cells in ME/CFS patients produce energy. Surprisingly, researchers found that patients' blood cells actually produced MORE energy (ATP) than healthy controls, but much of this energy came from sources other than mitochondria (the cell's power plants). The study suggests that ME/CFS fatigue may not be caused by a lack of energy, but rather by an abnormal way the body is producing energy.

Energy Metabolism

E3 PreliminaryReviewPEM unclearReview-Narrative

Fecal Microbiota Transplantation: Current Applications, Effectiveness, and Future Perspectives.

Choi, Hyun Ho, Cho, Young-Seok·Clinical endoscopy·2016

This article reviews fecal microbiota transplantation (FMT), a treatment where healthy gut bacteria from a donor are transferred into a patient's digestive system to treat disease. The procedure can be done several different ways and has shown promise for treating many conditions, including chronic fatigue syndrome. However, many important questions remain unanswered about who should donate, how to do it safely long-term, and how to regulate it properly.

E3 PreliminaryReviewPEM unclearReview-Narrative

Fecal Microbiota Transplantation and Its Usage in Neuropsychiatric Disorders.

Evrensel, Alper, Ceylan, Mehmet Emin·Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology·2016

This review examines fecal microbiota transplantation (FMT)—a treatment where healthy gut bacteria from a donor are transferred to a patient—and its potential use in treating brain and mental health conditions. While FMT is already proven effective for certain gut infections and inflammatory bowel diseases, researchers are exploring whether it might help with conditions like ME/CFS, autism, and Parkinson's disease. Early results are promising, but much more research is needed to understand if it's safe and effective long-term.

Gut MicrobiomeImmune System

E3 PreliminaryDiagnosticPEM unclearObservational

"I Always Vet Things": Navigating Privacy and the Presentation of Self on Health Discussion Boards Among Individuals with Long-Term Conditions.

Brady, Ellen, Segar, Julia, Sanders, Caroline·Journal of medical Internet research·2016

This study asked 20 people with ME/CFS and 21 people with diabetes about how they share information on online health forums and what privacy means to them. The researchers found that people carefully decide what personal details to share online, changing their approach depending on the situation and who they're talking to. Rather than having simple rules about what's private or public, people make complex, individual decisions about how much of themselves to reveal.

E3 PreliminaryReviewPEM unclearReview-Narrative

Aluminum adjuvants of vaccines injected into the muscle: Normal fate, pathology and associated disease.

Gherardi, R K, Aouizerate, J, Cadusseau, J et al.·Morphologie : bulletin de l'Association des anatomistes·2016

This study reviews how aluminum compounds used in vaccines are processed by the body and whether they might cause long-term health problems. The researchers found that aluminum can persist in the body for extended periods, accumulate in organs, and in some cases may be associated with muscle pain, fatigue, and cognitive difficulties—a condition called macrophagic myofasciitis. The authors suggest that the long-term safety of aluminum-containing vaccines needs more careful examination.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Exercise-induced mitochondrial dysfunction: a myth or reality?

Ostojic, Sergej M·Clinical science (London, England : 1979)·2016

Exercise is usually good for your cells' energy factories (mitochondria), but this review asks whether extremely intense or exhausting exercise might actually damage them instead. The authors explore how very hard exercise could harm mitochondrial function and suggest this might explain some cases of chronic fatigue syndrome and muscle problems.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

The Putative Role of Viruses, Bacteria, and Chronic Fungal Biotoxin Exposure in the Genesis of Intractable Fatigue Accompanied by Cognitive and Physical Disability.

Morris, Gerwyn, Berk, Michael, Walder, Ken et al.·Molecular neurobiology·2016

This paper reviews how viruses (like EBV and cytomegalovirus), bacteria (like those causing Lyme disease), and mold exposure might cause ME/CFS in some patients. The authors explain that standard treatments like counseling and exercise have limited success, and suggest that doctors should look more carefully for hidden infections or past mold exposure when standard blood tests don't find an obvious cause.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Maximizing potential impact of experimental research into cognitive processes in health psychology: A systematic approach to material development.

Hughes, Alicia M, Gordon, Rola, Chalder, Trudie et al.·British journal of health psychology·2016

This paper is a guide for researchers on how to properly design experiments that test whether people with conditions like ME/CFS have unconscious biases in how they pay attention to and interpret information about their illness. The authors explain that many past studies used different, untested materials, making it hard to compare results. They provide a step-by-step process and practical tools to help researchers create better, standardized materials for these types of studies.

Cognitive Impairment

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Integrating Cell Phone Imaging with Magnetic Levitation (i-LEV) for Label-Free Blood Analysis at the Point-of-Living.

Baday, Murat, Calamak, Semih, Durmus, Naside Gozde et al.·Small (Weinheim an der Bergstrasse, Germany)·2016

Researchers developed a new technology that uses smartphones and magnetic fields to analyze blood cells without needing special dyes or labels. The system can identify and count white and red blood cells quickly and affordably, and it works in clinics, hospitals, and homes. This portable device could help doctors monitor patients with rare diseases, including ME/CFS, more easily and at lower cost.

Biomarkers

E3 PreliminaryCohortPEM unclearCross-Sectional

"You get to know the people and whether they're talking sense or not": Negotiating trust on health-related forums.

Brady, Ellen, Segar, Julia, Sanders, Caroline·Social science & medicine (1982)·2016

This study looked at how people with ME/CFS and diabetes use online forums to find health information and support. Researchers interviewed 40 people total and found that forum users trust advice from others with similar lived experiences, but they also value information from doctors and medical sources. Online forums can provide personalized support, though how comfortable someone is using the internet affects how well they can connect with others.

E3 PreliminaryReviewPEM unclearReview-Narrative

Clinical Uses of Membrane Lipid Replacement Supplements in Restoring Membrane Function and Reducing Fatigue in Chronic Diseases and Cancer.

Nicolson, Garth L, Rosenblatt, Steven, de Mattos, Gonzalo Ferreira et al.·Discoveries (Craiova, Romania)·2016

This study examines oral supplements containing special fats (lipids) and antioxidants designed to repair damaged cell membranes, which the authors suggest accumulate in aging and chronic diseases like ME/CFS. The researchers reviewed evidence suggesting these supplements may help reduce fatigue and restore energy-producing mitochondria in cells. The authors propose this approach could benefit people with various conditions including chronic fatigue syndrome, fibromyalgia, and other chronic illnesses.

Energy Metabolism

E3 PreliminaryReviewPEM not requiredReview-Narrative

ILLNESS IS WORK: Revisiting the concept of illness careers and recognizing the identity work of patients with ME/CFS.

Grue, Jan·Health (London, England : 1997)·2016

This study explores how people with ME/CFS manage their identity and daily life while dealing with an illness that society doesn't fully recognize or understand. The researchers use the concept of "illness as work" to show that patients are actively doing important identity work—constantly adapting to their condition, navigating medical systems, and coping with a stigmatized illness. This framework helps validate the real effort and agency that ME/CFS patients demonstrate every day.

E3 PreliminaryCommentaryPEM unclearEditorial

Investigating unexplained fatigue in general practice with a particular focus on CFS/ME.

Bansal, Amolak S·BMC family practice·2016

This paper looks at how doctors in general practice can identify ME/CFS in patients who come in complaining of unexplained tiredness. The authors explain that ME/CFS is a real condition with specific diagnostic criteria, and that normal blood tests (ruling out infections, thyroid problems, and other common causes) combined with careful clinical assessment can confidently diagnose it. They argue that early diagnosis in primary care can reduce patient worry and prevent unnecessary, costly tests.

Diagnostics

E3 PreliminaryCohortPEM unclearCross-Sectional

Intrinsic Functional Hypoconnectivity in Core Neurocognitive Networks Suggests Central Nervous System Pathology in Patients with Myalgic Encephalomyelitis: A Pilot Study.

Zinn, Marcie L, Zinn, Mark A, Jason, Leonard A·Applied psychophysiology and biofeedback·2016

Researchers used EEG brain scans to measure electrical activity and communication between brain regions in 9 ME/CFS patients and 9 healthy controls. They found that people with ME/CFS had weaker electrical activity in the back of the brain and reduced communication between three important brain networks that help with thinking, attention, and rest. These differences suggest that ME/CFS involves measurable changes in how the brain works.

Cognitive Impairment

E3 PreliminaryCohortPEM not requiredCase-Control

High-frequency rTMS for the Treatment of Chronic Fatigue Syndrome: A Case Series.

Kakuda, Wataru, Momosaki, Ryo, Yamada, Naoki et al.·Internal medicine (Tokyo, Japan)·2016

Researchers tested a brain stimulation technique called high-frequency rTMS on seven patients with ME/CFS. This non-invasive procedure uses magnetic pulses to stimulate a specific area of the brain involved in fatigue. Most patients experienced improvements in their fatigue symptoms, with only two experiencing mild side effects that required reducing the stimulation intensity.

E3 PreliminaryCohortPEM not requiredCross-Sectional

A concept mapping study evaluating the UK's first NHS generic fatigue clinic.

Hackett, Katie L, Lambson, Rebecca L, Strassheim, Victoria et al.·Health expectations : an international journal of public participation in health care and health policy·2016

This study looked at a new NHS clinic in Newcastle that treats people with fatigue from various causes, not just ME/CFS. Researchers asked 30 patients and 10 healthcare referrers what they needed from the clinic, then had 46 patients rate how important those needs were and how well the clinic was meeting them. The study identified eight key areas patients cared about—including how the clinic made them feel, communication, self-management support, and peer support—and found some areas working well and others needing improvement.

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Evidence browser

Investigation of the effects of vanilloids in chronic fatigue syndrome.

Xenotropic Murine Leukemia Virus-Related Virus (XMRV) and the Safety of the Blood Supply.

Assessment of ME/CFS (Myalgic Encephalomyelitis/Chronic Fatigue Syndrome): A Case Study for Health Care Providers.

Autoantibody pain.

Elevated Energy Production in Chronic Fatigue Syndrome Patients.

Fecal Microbiota Transplantation: Current Applications, Effectiveness, and Future Perspectives.

Fecal Microbiota Transplantation and Its Usage in Neuropsychiatric Disorders.

"I Always Vet Things": Navigating Privacy and the Presentation of Self on Health Discussion Boards Among Individuals with Long-Term Conditions.

Aluminum adjuvants of vaccines injected into the muscle: Normal fate, pathology and associated disease.

Exercise-induced mitochondrial dysfunction: a myth or reality?

The Putative Role of Viruses, Bacteria, and Chronic Fungal Biotoxin Exposure in the Genesis of Intractable Fatigue Accompanied by Cognitive and Physical Disability.

Maximizing potential impact of experimental research into cognitive processes in health psychology: A systematic approach to material development.

Integrating Cell Phone Imaging with Magnetic Levitation (i-LEV) for Label-Free Blood Analysis at the Point-of-Living.

"You get to know the people and whether they're talking sense or not": Negotiating trust on health-related forums.

Clinical Uses of Membrane Lipid Replacement Supplements in Restoring Membrane Function and Reducing Fatigue in Chronic Diseases and Cancer.

ILLNESS IS WORK: Revisiting the concept of illness careers and recognizing the identity work of patients with ME/CFS.

Investigating unexplained fatigue in general practice with a particular focus on CFS/ME.

Intrinsic Functional Hypoconnectivity in Core Neurocognitive Networks Suggests Central Nervous System Pathology in Patients with Myalgic Encephalomyelitis: A Pilot Study.

High-frequency rTMS for the Treatment of Chronic Fatigue Syndrome: A Case Series.

A concept mapping study evaluating the UK's first NHS generic fatigue clinic.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research