ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

4681–4700 of 6,209 studies

E3 PreliminaryGuidelinePEM requiredGuideline

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer.

Rowe, Peter C, Underhill, Rosemary A, Friedman, Kenneth J et al.·Frontiers in pediatrics·2017

This guide helps doctors understand and diagnose ME/CFS in children and teenagers. ME/CFS causes extreme tiredness and makes it hard for young people to do physical or mental activities—with symptoms often getting worse after even small efforts and lasting for days or longer. The guide explains that there is no single test for ME/CFS, so doctors must diagnose it based on symptoms and by ruling out other conditions, and recommends that treatment focus on finding the right balance between rest and activity.

Post-Exertional Malaise

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

XMRV and Public Health: The Retroviral Genome Is Not a Suitable Template for Diagnostic PCR, and Its Association with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Appears Unreliable.

Panelli, Simona, Lorusso, Lorenzo, Balestrieri, Alessandro et al.·Frontiers in public health·2017

This study investigated whether a virus called XMRV could be reliably detected in people with ME/CFS using standard testing methods. The researchers found that the tests designed to find this virus were not working properly—they were picking up false positives because the virus's genetic code looks very similar to parts of normal human DNA. This explains why different labs kept getting different results when trying to test for XMRV.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Same, Same But Different? Cognitive Behavioural Treatment Approaches for Paediatric CFS/ME and Depression.

Loades, M E, Chalder, T·Behavioural and cognitive psychotherapy·2017

Many young people with ME/CFS also experience depression, and both conditions can be treated with a talking therapy called cognitive behavioural therapy (CBT). This paper compares how CBT is used for these two conditions in children and teenagers, explaining that while the approaches share some similarities, they focus on different problems and use different strategies to help each condition.

Interventions

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Simultaneous determination of multiple bioactive components of Bu-zhong-yi-qi-tang in rat tissues by LC-MS/MS: Application to a tissue distribution study.

He, Min, Chen, Wenwen, Wang, Mengmeng et al.·Journal of chromatography. B, Analytical technologies in the biomedical and life sciences·2017

Researchers developed a precise laboratory test to measure seven active ingredients from Bu-zhong-yi-qi-tang, a traditional herbal medicine used in East Asia for digestive problems, cancer, and chronic fatigue. They gave this herb to rats and tracked where these ingredients ended up in the body, finding they concentrated mainly in the digestive system.

E3 PreliminaryMechanismPEM not requiredMechanistic

NLRP3 inflammasome activation mediates fatigue-like behaviors in mice via neuroinflammation.

Zhang, Ziteng, Ma, Xiujuan, Xia, Zhenna et al.·Neuroscience·2017

This study explored whether a specific immune system protein called NLRP3 might be involved in causing fatigue in mice. Researchers stressed mice with repeated swimming tests and found that stressed mice had higher levels of an inflammatory chemical (IL-1β) in their brains and showed fatigue-like behaviors. When they removed the NLRP3 protein in mice, the fatigue behaviors were reduced and inflammatory levels decreased, suggesting this protein may play a role in fatigue.

NeuroinflammationImmune System

E3 PreliminaryBehavioralPEM not requiredCase-Control

A Novel Approach to Treating CFS and Co-morbid Health Anxiety: A Case Study.

Daniels, Jo, Loades, Maria E·Clinical psychology & psychotherapy·2017

This study looked at treating ME/CFS in one patient who also had anxiety about their health. Instead of using standard treatments alone, doctors used a customized approach combining techniques for both the physical fatigue and the worry about health. After 8 sessions, the patient's symptoms improved significantly and stayed better a year later, suggesting this combined approach might help others with ME/CFS.

Interventions

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

'It feels sometimes like my house has burnt down, but I can see the sky': A qualitative study exploring patients' views of cognitive behavioural therapy for chronic fatigue syndrome.

Picariello, Federica, Ali, Sheila, Foubister, Caroline et al.·British journal of health psychology·2017

This study looked at what 13 ME/CFS patients thought about cognitive behavioural therapy (CBT), a talking therapy that helps people change unhelpful thinking patterns and behaviors. Most patients were satisfied with CBT and felt better, though not completely recovered. The study found that the personal support from a therapist and accepting that ME/CFS involves both physical and mental factors were important for success.

Interventions

E3 PreliminaryReviewPEM not requiredReview-Narrative

A sociological stance on fatigue and tiredness: Social inequalities, norms and representations.

Loriol, Marc·Neurophysiologie clinique = Clinical neurophysiology·2017

This study examines fatigue from a social perspective, looking at how people's work and living conditions, social environment, and cultural beliefs affect their experience of exhaustion. Rather than treating fatigue only as a medical problem, the authors explore how different groups in society experience and understand tiredness differently, and how societal expectations about work and productivity shape whether someone feels appropriately tired or dangerously exhausted.

E3 PreliminaryMechanismPEM unclearMechanistic

Impaired calcium mobilization in natural killer cells from chronic fatigue syndrome/myalgic encephalomyelitis patients is associated with transient receptor potential melastatin 3 ion channels.

Nguyen, T, Johnston, S, Clarke, L et al.·Clinical and experimental immunology·2017

This study examined immune cells called natural killer cells in ME/CFS patients and healthy people to understand how calcium moves in and out of these cells. Researchers found that ME/CFS patients have lower levels of a specific channel (TRPM3) that helps control calcium movement in certain types of natural killer cells. The study suggests that problems with calcium signaling in these immune cells may contribute to how the immune system behaves differently in ME/CFS patients.

Immune System

E3 PreliminaryMechanismPEM unclear

Tenuous link between chronic fatigue syndrome and pyruvate dehydrogenase deficiency.

Bliksrud, Yngve Thomas·Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·2017

This study examined whether a specific metabolic enzyme problem called pyruvate dehydrogenase deficiency might be connected to ME/CFS. The researchers found only a weak or unclear link between this enzyme deficiency and ME/CFS symptoms, suggesting it is not a major cause of the illness for most patients.

Energy Metabolism

E3 PreliminaryBehavioralPEM unclearCross-Sectional

'It's personal to me': A qualitative study of depression in young people with CFS/ME.

Taylor, Anna K, Loades, Maria, Brigden, Amberly Lc et al.·Clinical child psychology and psychiatry·2017

This study talked with nine young people (aged 13-17) who have ME/CFS and depression to understand how these two conditions connect. Most young people felt that ME/CFS caused their depression because the illness stopped them doing activities they loved and changed their daily lives. Many also noticed that feeling sad made their ME/CFS symptoms worse, creating a difficult cycle. The researchers found that different combinations of treatments—like talking therapy, medicine, and careful activity planning—worked best for different people.

E3 PreliminaryReviewPEM unclearReview-Narrative

Epistemic injustice in healthcare encounters: evidence from chronic fatigue syndrome.

Blease, Charlotte, Carel, Havi, Geraghty, Keith·Journal of medical ethics·2017

Many doctors are uncertain whether ME/CFS is a real medical condition, and some patients report feeling disbelieved or suspected by healthcare providers. This study shows that patients with ME/CFS often experience unfair treatment in medical settings because doctors may not take their symptoms seriously. This type of dismissal—called epistemic injustice—can delay diagnosis and proper care for people with this serious illness.

Diagnostics

E3 PreliminaryGuidelinePEM not requiredGuideline

Group 6. Modalities and frequency of monitoring of patients with adrenal insufficiency. Patient education.

Guignat, Laurence, Proust-Lemoine, Emmanuelle, Reznik, Yves et al.·Annales d'endocrinologie·2017

This guideline explains how people with adrenal insufficiency (a condition where the body cannot make enough cortisol) should be monitored by their doctors and what they should learn to manage their condition safely. Patients need regular check-ups, should learn how to recognize warning signs of a crisis, know how to adjust their medication, and be able to give themselves emergency injections. The guideline emphasizes helping patients become independent in managing their illness and mentions that special care programs may help people with chronic fatigue avoid taking too much cortisol replacement.

E3 PreliminaryGuidelinePEM requiredGuideline

Myalgic encephalomyelitis: International Consensus Criteria.

Journal of internal medicine·2017

This guideline establishes internationally agreed-upon criteria for diagnosing ME/CFS, helping doctors around the world recognize the condition consistently. It brings together expert knowledge to create clear standards for who has ME/CFS based on symptoms like post-exertional malaise (worsening after activity), sleep problems, cognitive difficulties, and pain. Having a shared definition makes it easier for patients to get accurate diagnoses and for researchers to study the same condition across different countries.

Post-Exertional Malaise

E3 PreliminaryCommentaryPEM not requiredEditorial

Causes, assessment and management of fatigue in critically ill patients.

Cajanding, Ruff Jm·British journal of nursing (Mark Allen Publishing)·2017

Fatigue is one of the most distressing symptoms experienced by patients in intensive care units (ICUs), and it often continues long after patients leave the hospital. This article discusses what causes fatigue in critically ill patients, how doctors and nurses can better recognize and assess it, and what treatments might help. The authors emphasize that nurses play an important role in identifying patients at risk and managing their fatigue.

E3 PreliminaryMechanismPEM requiredCross-Sectional

Exercise - induced changes in cerebrospinal fluid miRNAs in Gulf War Illness, Chronic Fatigue Syndrome and sedentary control subjects.

Baraniuk, James N, Shivapurkar, Narayan·Scientific reports·2017

Researchers studied brain fluid from people with Gulf War Illness and chronic fatigue syndrome (CFS) before and after exercise to understand why exercise makes symptoms worse. They found that exercise changes certain molecules called microRNAs in the brain fluid, and these changes were different in people with CFS compared to Gulf War Illness patients. This suggests that the biological reasons these conditions cause post-exertional exhaustion may be different, even though the symptoms look similar.

Post-Exertional Malaise

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

Inducing Somatic Symptoms in Functional Syndrome Patients: Effects of Manipulating State Negative Affect.

Van Den Houte, Maaike, Bogaerts, Katleen, Van Diest, Ilse et al.·Psychosomatic medicine·2017

This study looked at whether negative emotions can trigger or worsen physical symptoms in people with ME/CFS and fibromyalgia. Researchers showed patients and healthy people emotionally negative, neutral, and positive pictures, then asked them to report what physical symptoms they felt. Patients with ME/CFS and fibromyalgia reported more symptoms after viewing negative pictures, while healthy people did not. The effect was stronger in patients who had difficulty recognizing their own feelings or who became deeply absorbed in things.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

RE: "MULTI-SITE CLINICAL ASSESSMENT OF MYALGIC ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME (MCAM): DESIGN AND IMPLEMENTATION OF A PROSPECTIVE/RETROSPECTIVE ROLLING COHORT STUDY".

American journal of epidemiology·2017

This study describes how researchers set up a large project to better understand and diagnose ME/CFS across multiple medical centers. The researchers created a system to carefully collect information about ME/CFS patients over time, combining both new patient data and information from medical records. This kind of organized approach helps scientists learn more about the condition and how to recognize it accurately.

E3 PreliminaryCohortPEM unclearCross-Sectional

"It´s incredible how much I´ve had to fight." Negotiating medical uncertainty in clinical encounters.

Lian, Olaug S, Robson, Catherine·International journal of qualitative studies on health and well-being·2017

This study asked 256 people with long-term unexplained fatigue in Norway to describe their experiences with doctors. Most patients felt their doctors didn't believe them, gave unhelpful psychological explanations, didn't do proper physical exams, and didn't listen to what they knew about their own condition. Patients described these encounters using words like 'fighting' and 'war,' showing how stressful and adversarial these medical visits felt.

Diagnostics

E3 PreliminaryDiagnosticPEM unclearCross-Sectional

Assessing current functioning as a measure of significant reduction in activity level.

Thorpe, Taylor, McManimen, Stephanie, Gleason, Kristen et al.·Fatigue : biomedicine, health & behavior·2016

ME/CFS diagnosis requires patients to show a significant drop in their activity levels, but doctors haven't agreed on how to measure this drop consistently. This study tested whether a common health survey (the SF-36) could accurately measure when someone's activities have substantially decreased. The researchers found that certain parts of this survey do a good job of identifying major reductions in functioning and can distinguish ME/CFS patients from healthy people.

Diagnostics

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Evidence browser

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer.

XMRV and Public Health: The Retroviral Genome Is Not a Suitable Template for Diagnostic PCR, and Its Association with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Appears Unreliable.

Same, Same But Different? Cognitive Behavioural Treatment Approaches for Paediatric CFS/ME and Depression.

Simultaneous determination of multiple bioactive components of Bu-zhong-yi-qi-tang in rat tissues by LC-MS/MS: Application to a tissue distribution study.

NLRP3 inflammasome activation mediates fatigue-like behaviors in mice via neuroinflammation.

A Novel Approach to Treating CFS and Co-morbid Health Anxiety: A Case Study.

'It feels sometimes like my house has burnt down, but I can see the sky': A qualitative study exploring patients' views of cognitive behavioural therapy for chronic fatigue syndrome.

A sociological stance on fatigue and tiredness: Social inequalities, norms and representations.

Impaired calcium mobilization in natural killer cells from chronic fatigue syndrome/myalgic encephalomyelitis patients is associated with transient receptor potential melastatin 3 ion channels.

Tenuous link between chronic fatigue syndrome and pyruvate dehydrogenase deficiency.

'It's personal to me': A qualitative study of depression in young people with CFS/ME.

Epistemic injustice in healthcare encounters: evidence from chronic fatigue syndrome.

Group 6. Modalities and frequency of monitoring of patients with adrenal insufficiency. Patient education.

Myalgic encephalomyelitis: International Consensus Criteria.

Causes, assessment and management of fatigue in critically ill patients.

Exercise - induced changes in cerebrospinal fluid miRNAs in Gulf War Illness, Chronic Fatigue Syndrome and sedentary control subjects.

Inducing Somatic Symptoms in Functional Syndrome Patients: Effects of Manipulating State Negative Affect.

RE: "MULTI-SITE CLINICAL ASSESSMENT OF MYALGIC ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME (MCAM): DESIGN AND IMPLEMENTATION OF A PROSPECTIVE/RETROSPECTIVE ROLLING COHORT STUDY".

"It´s incredible how much I´ve had to fight." Negotiating medical uncertainty in clinical encounters.

Assessing current functioning as a measure of significant reduction in activity level.

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